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VSARGTFAGGVAVITGAGAGIGAGLARYASSLGMTVVLVDIDAGAVAGLRAELEAAGGVAVDAMCDVRDP VAVQELADRVYRDVGPVRLLVNNAGVEQFGYLWDTPVANWNRIMDINVDGVFHGVRAFLPKMIDAGTPAW VWNMSSIGGVAVVPLQAPYIVTKHAVLALTECLHLEVRHAGHDHIHVQAVLPGAVVSNIFESARGVDDSD SEAVTAAESQRAAMLDIKAAAMDPVAAAEVVFDQAAAGEFYLLTQPGYVSSAMTERARVLSTRQAPQLRT ERRFDPAKH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4561 | - | - | 100% (289) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2216 | - | 3e-27 | 34.60% (237) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2937 | - | 2e-24 | 31.90% (210) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 1e-30 | 32.35% (238) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 1e-30 | 32.35% (238) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 6e-29 | 31.91% (235) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3919c | - | 3e-30 | 40.19% (209) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_3259 | ephD | 1e-29 | 33.47% (239) | short-chain dehydrogenase EphD |
| M. avium 104 | MAV_3031 | - | 1e-107 | 69.57% (276) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_2876 | - | 1e-124 | 77.51% (289) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3042 | - | 1e-117 | 73.79% (290) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3160 | - | 1e-29 | 39.02% (205) | short-chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2873 | - | 1e-112 | 72.32% (289) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 MPATQ---QMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
Rv2214c|M.tuberculosis_H37Rv MPATQ---QMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
MMAR_3259|M.marinum_M MSATR---QAPQQFVDSAGGVRIAVYEEGNPDGPTVVLVHGFPDSHVLWD
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
Rv2214c|M.tuberculosis_H37Rv GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
MMAR_3259|M.marinum_M GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
Rv2214c|M.tuberculosis_H37Rv GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
MMAR_3259|M.marinum_M GQPVHVLGHDWGSVAIWEYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMV
Rv2214c|M.tuberculosis_H37Rv LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMV
MMAR_3259|M.marinum_M LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVRRNMV
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPVQ
Rv2214c|M.tuberculosis_H37Rv GDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPVQ
MMAR_3259|M.marinum_M DNLPLDRIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPVQ
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 LIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Rv2214c|M.tuberculosis_H37Rv LIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MMAR_3259|M.marinum_M LIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MUL_3160|M.ulcerans_Agy99 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu -------------------VDAHEVFGGGVAVITGAGHGVGAGLARYAAS
Mvan_2873|M.vanbaalenii_PYR-1 ------------------MSDAREIFGGGVAVITGAGNGIGAGLARHAAA
MSMEG_2876|M.smegmatis_MC2_155 ------------------MSQARETFGGGVAVITGAGAGIGAGLARYAHR
Mflv_4561|M.gilvum_PYR-GCK -------------------MSARGTFAGGVAVITGAGAGIGAGLARYASS
MAV_3031|M.avium_104 -------------------------------MITGAGSGLGAGLARYACG
Mb2237c|M.bovis_AF2122/97 FADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFAR
Rv2214c|M.tuberculosis_H37Rv FADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFAR
MMAR_3259|M.marinum_M FADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFAR
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
MUL_3160|M.ulcerans_Agy99 -------------MFKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQ
MAB_3919c|M.abscessus_ATCC_199 ----------------------MKNFDNKVAVITGAGSGIGRSLALALAQ
:**** *:* *
TH_3042|M.thermoresistible__bu LGMTVVLADVDAAAIAALRGELPGS----VGQVCDVRDPDALEMLAARVY
Mvan_2873|M.vanbaalenii_PYR-1 LGMTVVLADIDEQAIGALSDELPGS----FASGCDVRDPEALEMLAAQVY
MSMEG_2876|M.smegmatis_MC2_155 LGMTVVLADVDEAAAAALRDELRADGGTAVAEKCDVRDPDAVADLADRTY
Mflv_4561|M.gilvum_PYR-GCK LGMTVVLVDIDAGAVAGLRAELEAAGGVAVDAMCDVRDPVAVQELADRVY
MAV_3031|M.avium_104 LGMTVVLADIDRDAVAALRDELAAGGGAAHDAACDVRDPAAVQDLADRAY
Mb2237c|M.bovis_AF2122/97 EGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERVS
Rv2214c|M.tuberculosis_H37Rv EGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERVS
MMAR_3259|M.marinum_M EGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQVS
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
MUL_3160|M.ulcerans_Agy99 RGADLALCDINDTAVADTAQTARGFGHDVITRRVDVSDPEQMTAFADATL
MAB_3919c|M.abscessus_ATCC_199 RGARLALSDIDTAGVADTAGRCEKAGATAIPFELDVADRAAVYAHAADVK
* :.: *:: ** * : * .
TH_3042|M.thermoresistible__bu SEVGPVRLLVNNAGIEQFGYLWDTPVPNWDRLVSVNVSGVFYGIRAFLPR
Mvan_2873|M.vanbaalenii_PYR-1 SDIGPVRLLINNAGVEQFGYLWDTPVANWNRVMDINVSGVFHGVKAFLPR
MSMEG_2876|M.smegmatis_MC2_155 RDLGPVRLLVNNAGVEQFGYLWDTPVANWNRVMDINVSGVFHGVRAFLPK
Mflv_4561|M.gilvum_PYR-GCK RDVGPVRLLVNNAGVEQFGYLWDTPVANWNRIMDINVDGVFHGVRAFLPK
MAV_3031|M.avium_104 -DIGPVRLLVNNAGIEQFGYLWDTPVVNWQRVMDVNVSGVFYGVRAFLPK
Mb2237c|M.bovis_AF2122/97 AEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQR
Rv2214c|M.tuberculosis_H37Rv AEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQR
MMAR_3259|M.marinum_M ATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQR
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQR
MUL_3160|M.ulcerans_Agy99 GHFGGVDLLVNNAGVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFLPA
MAB_3919c|M.abscessus_ATCC_199 NEFGQVNLVFNNAGVALSADVKDMEWDDFDWLMNINFWGVAHGTKAFLPH
* ::.****: . . * ::: :: :*. ** .**
TH_3042|M.thermoresistible__bu MIDAGAPAWVWNLSSIGGVAAVPLQAPYIMSKHAVLALTECLRLEVELAG
Mvan_2873|M.vanbaalenii_PYR-1 MIAAGAPAWVWNLSSIGGVAAVPLQAPYIVSKHAVLALTECLRLEVELAG
MSMEG_2876|M.smegmatis_MC2_155 MMAHGSPAWVWNLSSIGGVAAVPLQAPYIISKHAVLALTECLRLEVQLAG
Mflv_4561|M.gilvum_PYR-GCK MIDAGTPAWVWNMSSIGGVAVVPLQAPYIVTKHAVLALTECLHLEVRHAG
MAV_3031|M.avium_104 MMAAGQQAWVWNIASVGAVVAMPLQAPYIVSKHAVLSLTECLHLEVQATG
Mb2237c|M.bovis_AF2122/97 LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAAG
Rv2214c|M.tuberculosis_H37Rv LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAAG
MMAR_3259|M.marinum_M LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAAD
MLBr_00862|M.leprae_Br4923 LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVG
MUL_3160|M.ulcerans_Agy99 MIESGRGGHVVNLSSAAGLLANPALSAYSATKFAVLGLSEALRIELEPHR
MAB_3919c|M.abscessus_ATCC_199 LIESG-DGHIVNVSSVFGLMGIPSQSAYNAAKFAVRGFTESLRQEIRAAK
:: * . : *::* . :.* :* *. :::.*: *:
TH_3042|M.thermoresistible__bu HADRITVQAVLPGAVKSNIFEAAGGVDD----GDVAAAEAQRAAMLDIKA
Mvan_2873|M.vanbaalenii_PYR-1 HGHFIHVQAVLPGAVKSNIFEAAGGVDASAAGTDVAAAEAQREAMLDIKA
MSMEG_2876|M.smegmatis_MC2_155 HDDHVHVQAVLPGAVKSNIFEAAGGVDSGQDGADVNAAESQREAMLDIKA
Mflv_4561|M.gilvum_PYR-GCK H-DHIHVQAVLPGAVVSNIFESARGVDDS-DSEAVTAAESQRAAMLDIKA
MAV_3031|M.avium_104 HDDHVHVQAVLPGPVRSNIFESAGGVDPD-AATDAAAAEAHRSAMLGIKA
Mb2237c|M.bovis_AF2122/97 ----VGLTTICPGVIDTNIVATTG-FHAP-GTDEEKIDGRRGQIDKMFAL
Rv2214c|M.tuberculosis_H37Rv ----VGLTTICPGVIDTNIVATTG-FHAP-GTDEEKIDGRRGQIDKMFAL
MMAR_3259|M.marinum_M ----VGLTTICPGVINTNIVNTTR-FDAPPGKGGDQVDGRRGQIDKMFAL
MLBr_00862|M.leprae_Br4923 ----VGLTTICPGVIDTNIIQSTR-IDTP-TAKQERVRDRRGQLDMMFRL
MUL_3160|M.ulcerans_Agy99 ----IGVTAICPGVINTAITKASP-IRGA-----GDTEGRRQRLTVTYQR
MAB_3919c|M.abscessus_ATCC_199 F--PVGVTCVHPGGIKTNIASSARGIPDG-----VDRETVRKGFQLMAIT
: : : ** : : * :: . :
TH_3042|M.thermoresistible__bu AAMDPVEAARVVFEQAAAGEFYLLTQPEYVGGAMAERAAVL---------
Mvan_2873|M.vanbaalenii_PYR-1 AAMDPVEAAEVVFEQSAQDVFYLLTQPDYVGSAMAERAGVL---------
MSMEG_2876|M.smegmatis_MC2_155 AAMDPIDAAEAIFEQSARGAFYLLTQPEYVGSAMAERAQVL---------
Mflv_4561|M.gilvum_PYR-GCK AAMDPVAAAEVVFDQAAAGEFYLLTQPGYVSSAMTERARVL---------
MAV_3031|M.avium_104 ASMDALEAAEMIFRQSTEGHFYLHTHPESVGAAMRERAKVL---------
Mb2237c|M.bovis_AF2122/97 RSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQ---------
Rv2214c|M.tuberculosis_H37Rv RSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQ---------
MMAR_3259|M.marinum_M RSYGPDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPP---------
MLBr_00862|M.leprae_Br4923 RRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQ---------
MUL_3160|M.ulcerans_Agy99 RGYTPARAARNILRAVERNKAVAPVAAEAHVMYVLSRIMPP---------
MAB_3919c|M.abscessus_ATCC_199 R---PDSAARIILRGVEKNRPRVLIGPDARVFDAIPRIIGPRYEDLMAPF
. .* :. . *
TH_3042|M.thermoresistible__bu --TERRAPVLRTEQRFDPARH
Mvan_2873|M.vanbaalenii_PYR-1 --TSQVPPQLRTQRRFEPDRH
MSMEG_2876|M.smegmatis_MC2_155 --ISQVPPQLRTERRFDPAKH
Mflv_4561|M.gilvum_PYR-GCK --STRQAPQLRTERRFDPAKH
MAV_3031|M.avium_104 --AAQQAPRLRTETRFDSAPD
Mb2237c|M.bovis_AF2122/97 --ALRSTARLRVI--------
Rv2214c|M.tuberculosis_H37Rv --ALRSTARLRVI--------
MMAR_3259|M.marinum_M --ALRSTARMRVI--------
MLBr_00862|M.leprae_Br4923 --VLRSTARIRVI--------
MUL_3160|M.ulcerans_Agy99 --LARWVSAQMAKAAK-----
MAB_3919c|M.abscessus_ATCC_199 YGMGRYGIGKKIAGRFGIEL-
: