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VITGAGSGLGAGLARYACGLGMTVVLADIDRDAVAALRDELAAGGGAAHDAACDVRDPAAVQDLADRAYD IGPVRLLVNNAGIEQFGYLWDTPVVNWQRVMDVNVSGVFYGVRAFLPKMMAAGQQAWVWNIASVGAVVAM PLQAPYIVSKHAVLSLTECLHLEVQATGHDDHVHVQAVLPGPVRSNIFESAGGVDPDAATDAAAAEAHRS AMLGIKAASMDALEAAEMIFRQSTEGHFYLHTHPESVGAAMRERAKVLAAQQAPRLRTETRFDSAPD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3031 | - | - | 100% (277) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. avium 104 | MAV_2275 | - | 2e-26 | 35.79% (190) | short chain dehydrogenase |
| M. avium 104 | MAV_3670 | - | 5e-25 | 39.06% (192) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 8e-26 | 35.42% (192) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4561 | - | 1e-107 | 69.57% (276) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2214c | ephD | 8e-26 | 35.42% (192) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 6e-25 | 35.26% (190) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0143c | - | 1e-26 | 33.33% (249) | putative oxidoreductase EphD |
| M. marinum M | MMAR_3259 | ephD | 4e-26 | 36.90% (187) | short-chain dehydrogenase EphD |
| M. smegmatis MC2 155 | MSMEG_2876 | - | 1e-111 | 72.56% (277) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3042 | - | 1e-100 | 67.03% (276) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3574 | ephD | 3e-26 | 36.90% (187) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2873 | - | 1e-102 | 67.27% (275) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 MPATQ---QMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
Rv2214c|M.tuberculosis_H37Rv MPATQ---QMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
MMAR_3259|M.marinum_M MSATR---QAPQQFVDSAGGVRIAVYEEGNPDGPTVVLVHGFPDSHVLWD
MUL_3574|M.ulcerans_Agy99 MPATK---QAPQQFVDSAGGVRIAVYEEGNPDSPTVVLVHGFPDSHVLWD
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
Rv2214c|M.tuberculosis_H37Rv GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
MMAR_3259|M.marinum_M GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
MUL_3574|M.ulcerans_Agy99 GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
Rv2214c|M.tuberculosis_H37Rv GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
MMAR_3259|M.marinum_M GQPVHVLGHDWGSVAIWEYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
MUL_3574|M.ulcerans_Agy99 GQPVHVLGHDWGSVAIWDYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMV
Rv2214c|M.tuberculosis_H37Rv LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMV
MMAR_3259|M.marinum_M LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVRRNMV
MUL_3574|M.ulcerans_Agy99 LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVRRNMV
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPVQ
Rv2214c|M.tuberculosis_H37Rv GDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPVQ
MMAR_3259|M.marinum_M DNLPLDRIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPVQ
MUL_3574|M.ulcerans_Agy99 DNLPLDQIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPVQ
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MAB_0143c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3042|M.thermoresistible__bu --------------------------------------------------
Mvan_2873|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2876|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3031|M.avium_104 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 LIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Rv2214c|M.tuberculosis_H37Rv LIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MMAR_3259|M.marinum_M LIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MUL_3574|M.ulcerans_Agy99 LIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MAB_0143c|M.abscessus_ATCC_199 -------------------------------------------MKTAI--
TH_3042|M.thermoresistible__bu -------------------VDAHEVFGGGVAVITGAGHGVGAGLARYAAS
Mvan_2873|M.vanbaalenii_PYR-1 ------------------MSDAREIFGGGVAVITGAGNGIGAGLARHAAA
MSMEG_2876|M.smegmatis_MC2_155 ------------------MSQARETFGGGVAVITGAGAGIGAGLARYAHR
Mflv_4561|M.gilvum_PYR-GCK -------------------MSARGTFAGGVAVITGAGAGIGAGLARYASS
MAV_3031|M.avium_104 -------------------------------MITGAGSGLGAGLARYACG
Mb2237c|M.bovis_AF2122/97 FADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFAR
Rv2214c|M.tuberculosis_H37Rv FADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFAR
MMAR_3259|M.marinum_M FADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFAR
MUL_3574|M.ulcerans_Agy99 FADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFAR
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
MAB_0143c|M.abscessus_ATCC_199 --------------------------------ITGAGSGIGRETARLFAS
:**** *:* *
TH_3042|M.thermoresistible__bu LGMTVVLADVDAAAIAALRGELPGS----VGQVCDVRDPDALEMLAARVY
Mvan_2873|M.vanbaalenii_PYR-1 LGMTVVLADIDEQAIGALSDELPGS----FASGCDVRDPEALEMLAAQVY
MSMEG_2876|M.smegmatis_MC2_155 LGMTVVLADVDEAAAAALRDELRADGGTAVAEKCDVRDPDAVADLADRTY
Mflv_4561|M.gilvum_PYR-GCK LGMTVVLVDIDAGAVAGLRAELEAAGGVAVDAMCDVRDPVAVQELADRVY
MAV_3031|M.avium_104 LGMTVVLADIDRDAVAALRDELAAGGGAAHDAACDVRDPAAVQDLADRAY
Mb2237c|M.bovis_AF2122/97 EGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERVS
Rv2214c|M.tuberculosis_H37Rv EGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERVS
MMAR_3259|M.marinum_M EGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQVS
MUL_3574|M.ulcerans_Agy99 EGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQVS
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
MAB_0143c|M.abscessus_ATCC_199 QGHRVVLADIDIHAAEAATDQIVAAGGRASAYQLDVADEQQWETFGKWTD
* :*: *:* : :: . ** * :. .
TH_3042|M.thermoresistible__bu SEVGPVRLLVNNAGIEQFGYLWDTPVPNWDRLVSVNVSGVFYGIRAFLPR
Mvan_2873|M.vanbaalenii_PYR-1 SDIGPVRLLINNAGVEQFGYLWDTPVANWNRVMDINVSGVFHGVKAFLPR
MSMEG_2876|M.smegmatis_MC2_155 RDLGPVRLLVNNAGVEQFGYLWDTPVANWNRVMDINVSGVFHGVRAFLPK
Mflv_4561|M.gilvum_PYR-GCK RDVGPVRLLVNNAGVEQFGYLWDTPVANWNRIMDINVDGVFHGVRAFLPK
MAV_3031|M.avium_104 -DIGPVRLLVNNAGIEQFGYLWDTPVVNWQRVMDVNVSGVFYGVRAFLPK
Mb2237c|M.bovis_AF2122/97 AEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQR
Rv2214c|M.tuberculosis_H37Rv AEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQR
MMAR_3259|M.marinum_M ATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQR
MUL_3574|M.ulcerans_Agy99 ATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQR
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQR
MAB_0143c|M.abscessus_ATCC_199 SEFGPADLLVNNAGIMDWGGFVDMTAEQWQRTMDIDLMSVIYGSRIFAQQ
* :::****: : * : * . :::* : ::: .*. : * :
TH_3042|M.thermoresistible__bu MIDAGAPAWVWNLSSIGGVAAVPLQAPYIMSKHAVLALTECLRLEVELAG
Mvan_2873|M.vanbaalenii_PYR-1 MIAAGAPAWVWNLSSIGGVAAVPLQAPYIVSKHAVLALTECLRLEVELAG
MSMEG_2876|M.smegmatis_MC2_155 MMAHGSPAWVWNLSSIGGVAAVPLQAPYIISKHAVLALTECLRLEVQLAG
Mflv_4561|M.gilvum_PYR-GCK MIDAGTPAWVWNMSSIGGVAVVPLQAPYIVTKHAVLALTECLHLEVRHAG
MAV_3031|M.avium_104 MMAAGQQAWVWNIASVGAVVAMPLQAPYIVSKHAVLSLTECLHLEVQATG
Mb2237c|M.bovis_AF2122/97 LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELD---
Rv2214c|M.tuberculosis_H37Rv LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELD---
MMAR_3259|M.marinum_M LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELD---
MUL_3574|M.ulcerans_Agy99 LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELD---
MLBr_00862|M.leprae_Br4923 LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELD---
MAB_0143c|M.abscessus_ATCC_199 MIDAGVRGHIVNISSGAAFLPHKMIAAYGTAKAAVLMASQSLRVELR---
:: * . : *::* .. :.* :* *. ::.*: *:
TH_3042|M.thermoresistible__bu HADRITVQAVLPGAVKSNIFEAAG-GVDD----GDVAAAEAQRAAMLDIK
Mvan_2873|M.vanbaalenii_PYR-1 HGHFIHVQAVLPGAVKSNIFEAAG-GVDASAAGTDVAAAEAQREAMLDIK
MSMEG_2876|M.smegmatis_MC2_155 HDDHVHVQAVLPGAVKSNIFEAAG-GVDSGQDGADVNAAESQREAMLDIK
Mflv_4561|M.gilvum_PYR-GCK H-DHIHVQAVLPGAVVSNIFESAR-GVDDS-DSEAVTAAESQRAAMLDIK
MAV_3031|M.avium_104 HDDHVHVQAVLPGPVRSNIFESAG-GVDPD-AATDAAAAEAHRSAMLGIK
Mb2237c|M.bovis_AF2122/97 -AAGVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDKMFALR
Rv2214c|M.tuberculosis_H37Rv -AAGVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDKMFALR
MMAR_3259|M.marinum_M -AADVGLTTICPGVINTNIVNTTRFDAPPGKGGDQVDGRRGQIDKMFALR
MUL_3574|M.ulcerans_Agy99 -AADVGLTTICPGVINTNIVNTTRFDAPPGKGGDQLDGRRGQIDKMFALR
MLBr_00862|M.leprae_Br4923 -AVGVGLTTICPGVIDTNIIQSTRIDTP-TAKQERVRDRRGQLDMMFRLR
MAB_0143c|M.abscessus_ATCC_199 -RHRIGVSAICPGVINTNLIANG---QRAGISEDDQQRWHAQAGKIQSIS
: : :: ** : :*:. ..: : :
TH_3042|M.thermoresistible__bu AAAMDPVEAARVVFEQAAAGEFYLLTQPEYVGGAMAERAAVLTERRAPVL
Mvan_2873|M.vanbaalenii_PYR-1 AAAMDPVEAAEVVFEQSAQDVFYLLTQPDYVGSAMAERAGVLTSQVPPQL
MSMEG_2876|M.smegmatis_MC2_155 AAAMDPIDAAEAIFEQSARGAFYLLTQPEYVGSAMAERAQVLISQVPPQL
Mflv_4561|M.gilvum_PYR-GCK AAAMDPVAAAEVVFDQAAAGEFYLLTQPGYVSSAMTERARVLSTRQAPQL
MAV_3031|M.avium_104 AASMDALEAAEMIFRQSTEGHFYLHTHPESVGAAMRERAKVLAAQQAPRL
Mb2237c|M.bovis_AF2122/97 SYGPD--KVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARL
Rv2214c|M.tuberculosis_H37Rv SYGPD--KVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARL
MMAR_3259|M.marinum_M SYGPD--KVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTARM
MUL_3574|M.ulcerans_Agy99 SYGPD--KVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTARM
MLBr_00862|M.leprae_Br4923 RYGPD--KVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARI
MAB_0143c|M.abscessus_ATCC_199 YAGPD--KVARAIERSVRHNWAVVPVNPESWFIYGLYRLSPSFSRTLTGI
. * .* : . * * : . :
TH_3042|M.thermoresistible__bu RTEQRFDPARH-----------
Mvan_2873|M.vanbaalenii_PYR-1 RTQRRFEPDRH-----------
MSMEG_2876|M.smegmatis_MC2_155 RTERRFDPAKH-----------
Mflv_4561|M.gilvum_PYR-GCK RTERRFDPAKH-----------
MAV_3031|M.avium_104 RTETRFDSAPD-----------
Mb2237c|M.bovis_AF2122/97 RVI-------------------
Rv2214c|M.tuberculosis_H37Rv RVI-------------------
MMAR_3259|M.marinum_M RVI-------------------
MUL_3574|M.ulcerans_Agy99 RVI-------------------
MLBr_00862|M.leprae_Br4923 RVI-------------------
MAB_0143c|M.abscessus_ATCC_199 GSFELADGLMSRLQPLLNRVAK