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NDPHRPALDPDAAARVAAFGPPVPIRDRGLQAVRDAIESAPPPTDMPTMADIGDAEVAGPGGRVPVRIYR PANDGGPCPVIVHLHGGGLVMGSNRSFEPMARAMAAASGAAVVAVDYRLAPENPPPAQFEDAWTVTKWVA ADAERLRFDPGKIVVSGDSAGGGLAAAVTLAARDEGGPRLFAQVLMYPGLDRDMAAPSILANPHAPMLTH DDIVYLHELADIGAGTSHDTRRVPAYATDLTGLPQAIMVTGELDPISDWGERYAARLRDAGVQTTVTRYP GIYHGFLMRSEATARGRLAMAEIGALLRAKFANPLPFTTPLRCR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2872 | - | - | 100% (325) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2672 | - | 4e-46 | 40.07% (292) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2162 | - | 8e-40 | 39.33% (267) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1434c | lipH | 2e-45 | 37.01% (308) | lipase LipH |
| M. gilvum PYR-GCK | Mflv_4562 | - | 1e-120 | 68.59% (312) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1399c | lipH | 2e-45 | 37.01% (308) | lipase LipH |
| M. leprae Br4923 | MLBr_00314 | - | 3e-12 | 23.60% (250) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2814 | - | 3e-49 | 43.94% (264) | lipase LipH |
| M. marinum M | MMAR_0576 | - | 7e-44 | 38.52% (283) | monooxygenase |
| M. avium 104 | MAV_3032 | - | 1e-115 | 65.52% (319) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2875 | - | 1e-126 | 70.57% (316) | esterase |
| M. thermoresistible (build 8) | TH_2802 | - | 1e-138 | 75.24% (319) | PUTATIVE esterase |
| M. ulcerans Agy99 | MUL_1794 | lipH | 1e-41 | 35.44% (316) | lipase LipH |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M MSDAHHTDVDVVVAGAGFAGLYAAYRLRRAGHSMRIFEAGDDIGGTWYWN
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M RYPGARVDIPSVDYMYSFDPDWSRDWQWSEKYATQPEILRYLNHVADKHD
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M LRRDIQFGTRVTHAHWDDDAGRYRVRTDRGDEIICRYLIMATGCLSVPKD
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M LDIDGIENFTGELYFTSRWPHEPVDFTGKRVGVVGTGSSGIQSIPLIAAQ
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M AAQVVVFQRTPCFSIPAHNGPISPDKLAQLADDDAYRRAARYSFGGVPME
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M RSLTPTFSVSAEERRQRYERAWQLGELLEALNLYADEMINPLANSEFAEF
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M IRDKIRATVHDPQTAEALCPSGYPVGSKRLCLDSNYYATFNLPQVRLVDL
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M RNQPLLGVTKTGIDTVGESFEFDAIVFATGFDAVTGALAAIDIVGRNGLA
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M LGDKWAPGPSTYLGLTTEGFPNLFLIAGPNSPSVLSNMAVSIEQHVDFVA
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1794|M.ulcerans_Agy99 --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M DALSYLREHGFDRIEPTELAEAGWMQHSDDAASITLFPQANSWYVGANIP
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------MTEPTVARPDID
Rv1399c|M.tuberculosis_H37Rv --------------------------------------MTEPTVARPDID
MUL_1794|M.ulcerans_Agy99 --------------------------------------MTEQISTRPGID
MAB_2814|M.abscessus_ATCC_1997 ------------------------------------------MTATAGID
Mvan_2872|M.vanbaalenii_PYR-1 ----------------------------------------MNDPHRPALD
TH_2802|M.thermoresistible__bu ----------------------------------------MNHP-VPPLD
MSMEG_2875|M.smegmatis_MC2_155 -----------------------------------MTTSPPSPPQGPPLD
Mflv_4562|M.gilvum_PYR-GCK -------------------------------------------MPGPTLD
MAV_3032|M.avium_104 -------------------------------------------MTSPPLD
MMAR_0576|M.marinum_M GKPRTFMAYTAGVDVYRVACEEVVARDYLGFRLSGPNGSQCNDGVVRRLQ
MLBr_00314|M.leprae_Br4923 -----------------------------------MAISAGAPVEIVESG
Mb1434c|M.bovis_AF2122/97 PVLKMLLDTFPVT--FTAAD-GVEVARARLRQLKTP-----PELLPELRI
Rv1399c|M.tuberculosis_H37Rv PVLKMLLDTFPVT--FTAAD-GVEVARARLRQLKTP-----PELLPELRI
MUL_1794|M.ulcerans_Agy99 PILKMLLDAVPMT--FCAAD-GVELARERLAALKAP-----PELLPDLRT
MAB_2814|M.abscessus_ATCC_1997 PIIVKILEAVPIQ--LVSPD-GPQASRDAYRAIATAR----PPWIEVANI
Mvan_2872|M.vanbaalenii_PYR-1 PDAAARVAAFGPP--VPIRDRGLQAVRDAIESAPPP-----TDMPTMADI
TH_2802|M.thermoresistible__bu PDAAARIASLGPP--APMRRRGLQAVRDAIESAPLP-----TDMPAMASI
MSMEG_2875|M.smegmatis_MC2_155 PDAAARIAGFGKP--APVRDRGLETVRAAIESAPLP-----SDMPPMAEI
Mflv_4562|M.gilvum_PYR-GCK PDAAARVASFGPI--PPMHERGLDAVRAGVENTPVP-----DDMPAMASI
MAV_3032|M.avium_104 PDAAARIASFGET--APMRQRGLPAVRAGLESAPRP-----ATMPEMASV
MMAR_0576|M.marinum_M PDIQMVLEQLEALGLPPLESLPADQARALMNEMNLAR----PPGPDVGEI
MLBr_00314|M.leprae_Br4923 PSIAARLASLTSR----LTIRPILAVGSYVPQLPWPFGLIDHAARVLLPV
* : . .
Mb1434c|M.bovis_AF2122/97 EERTVGYDGLTDIPVRVYWPPVV--RDN-LPVVVYYHGGGWSLGGLDTHD
Rv1399c|M.tuberculosis_H37Rv EERTVGYDGLTDIPVRVYWPPVV--RDN-LPVVVYYHGGGWSLGGLDTHD
MUL_1794|M.ulcerans_Agy99 EDRKIGYGELTDIPVRTYWPTVE--PDWVLPVVVYYHGGGWALGSLDTHD
MAB_2814|M.abscessus_ATCC_1997 EDRTIP-GPAGEIPVRIYSPAEG--GVR--PVFVLIHGGGWVIGDLDTHD
Mvan_2872|M.vanbaalenii_PYR-1 GDAEVA-GPGGRVPVRIYRPAN---DGGPCPVIVHLHGGGLVMGSNRSFE
TH_2802|M.thermoresistible__bu VDRAVP-GPGGDIPVRIHRPERG--CGDPAPAVLYFHGGGLVMGSNHSFE
MSMEG_2875|M.smegmatis_MC2_155 VDRTVP-ASDREIGVRVYRPEQV--GHDGAPVILHFHGGGLVMGSVHSFE
Mflv_4562|M.gilvum_PYR-GCK EERCAP-GPDGPIPLRIYRPTD----ATDASVVVYFHGGGMVMGSNRSFE
MAV_3032|M.avium_104 TEALVP-SAAGGIPVRIYRPTT----DSGVAVLVYLHGGGLVMGSNRSFE
MMAR_0576|M.marinum_M VDGTLP-GAAGPLAYRLYRPAS----PGPHPVVVYFHGGGWVLGDHTSDD
MLBr_00314|M.leprae_Br4923 TNAARAEVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGGAFLGCGANSHR
: : . .: ***. . :
Mb1434c|M.bovis_AF2122/97 PVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGG
Rv1399c|M.tuberculosis_H37Rv PVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGG
MUL_1794|M.ulcerans_Agy99 HVARAHAVGAEAIVVSVDYRLAPEHPYPAGIEDSWAALRWVGEHAHELGG
MAB_2814|M.abscessus_ATCC_1997 AVARAAAVQADAVVVSVDYRLAPEHPYPAAVEDCWAALQWVHEHAAEIGG
Mvan_2872|M.vanbaalenii_PYR-1 PMARAMAAASGAAVVAVDYRLAPENPPPAQFEDAWTVTKWVAADAERLRF
TH_2802|M.thermoresistible__bu PLARGLAAASGAVVVAVDYRLAPEHPPPAQFDDAWATTRWVAAHADELGL
MSMEG_2875|M.smegmatis_MC2_155 PLARGLAAAAGAVVVAVDYRLAPEYPPPAQFDDAYAATEWVARHAEELGV
Mflv_4562|M.gilvum_PYR-GCK PLARALAAGSTATVVSVDYRLAPEHPAPAQFVDCSAVTTWVAENATSLGV
MAV_3032|M.avium_104 PLARELASASAATVVAVDYRLAPESPPPAQFDDAYAATEWVSRKAGELGV
MMAR_0576|M.marinum_M PLCRDLCVLSDTLIVSVDYRHAPEHRFPAALDDGWAAVQWIAEHAGELGG
MLBr_00314|M.leprae_Br4923 RLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRR----LGY
: . . : : :: *:** *: . * *: :
Mb1434c|M.bovis_AF2122/97 DPSRIAVAGDSAGGNISAVMAQLARDVGG---PPLVFQLLWYPTTMADLS
Rv1399c|M.tuberculosis_H37Rv DPSRIAVAGDSAGGNISAVMAQLARDVGG---PPLVFQLLWYPTTMADLS
MUL_1794|M.ulcerans_Agy99 DPNRIAVAGDSAGGNISAIMAQLARDHAGNGAPNLVFQLLWYPSCVGDLA
MAB_2814|M.abscessus_ATCC_1997 DPGRLAVGGDSAGGNLSAVMAQLARDNGI----DLAFQVLWYPATTFDTT
Mvan_2872|M.vanbaalenii_PYR-1 DPGKIVVSGDSAGGGLAAAVTLAARDEGG---PRLFAQVLMYPGLDRDMA
TH_2802|M.thermoresistible__bu DTSRLAVAGDSAGGALAAAVALAARDRGG---PELLAQLLMYPGLDRDLA
MSMEG_2875|M.smegmatis_MC2_155 DARRLVVAGDSAGGGLAAAVALAARDHGG---PAIFAQVLLYPGLDRDMG
Mflv_4562|M.gilvum_PYR-GCK DPARLAVAGDSAGGSLAAAVTLAARDCGG---PVICAQVLMYPGLDRDMA
MAV_3032|M.avium_104 DADRLAVIGDSAGGSLAAAVALAARDRRG---PPICAQVLLYPGLDRDMS
MMAR_0576|M.marinum_M IPGQLVVSGWSAGAGIAAVVCHLARDAGA---PSIVGQALLTPVTDFDPT
MLBr_00314|M.leprae_Br4923 DPEQIVLAGDSAGGYLALALAQRLQDVGEEPAALVAISPLLQLAKKGKQA
. ::.: * ***. :: : :* : . * .
Mb1434c|M.bovis_AF2122/97 LPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPTTLAPGNADLSG
Rv1399c|M.tuberculosis_H37Rv LPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPTTLAPGNADLSG
MUL_1794|M.ulcerans_Agy99 LPSFSENATAPILDLEVIDAFLSWYVPDLDVSDHTALPATLAPGNGDLTG
MAB_2814|M.abscessus_ATCC_1997 LPSMVENAEAPVLDFKTVGALSKWYLG--DTNPATAGPTLVPARAENFEG
Mvan_2872|M.vanbaalenii_PYR-1 APSILANPHAPMLTHDDIVYLHELADIG---AGTSHDTRRVPAYATDLTG
TH_2802|M.thermoresistible__bu APSIVAMPEAPMLSRDDIVYLHELADLG---AGTPHDPYRVPAYATDLGG
MSMEG_2875|M.smegmatis_MC2_155 AQSIVEMPDAPMLSRDDILYMHDLADIG---AGSPHDPYRVPAYADDLRG
Mflv_4562|M.gilvum_PYR-GCK APSMVAMPDAPLLSRADIDYMHELADDG---VGAPHDAYRIPAYAEDLSG
MAV_3032|M.avium_104 VASIAAMPDAPLLIRDDIDYMHALVDGD---AGPPTDPYLVPAYAADLSG
MMAR_0576|M.marinum_M RGSYLENADGYGLTAPLMQWFFDHYADP----DVRTDPRIAPLRAPDLSA
MLBr_00314|M.leprae_Br4923 HPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEE--LYEPLDHIAPG
. . : : .
Mb1434c|M.bovis_AF2122/97 LPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALV
Rv1399c|M.tuberculosis_H37Rv LPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALV
MUL_1794|M.ulcerans_Agy99 LPPAFIGTAEHDPLRDDGARYAELLTAAGIAAEWCNEPNLVHGYVSFAVV
MAB_2814|M.abscessus_ATCC_1997 LAPAFIGTAQFDPLRDDGAKYAELLRDAGVPVQLHNAPTLIHGYLGYADI
Mvan_2872|M.vanbaalenii_PYR-1 LPQAIMVTGELDPISDWGERYAARLRDAGVQTTVTRYPGIYHGFLMRSEA
TH_2802|M.thermoresistible__bu LPQTIIVTGACDPIRDWGERYAGRLRDAGVQTTVTRYPGMYHGFLMRYES
MSMEG_2875|M.smegmatis_MC2_155 LPQAIVVTGECDPIRDWGERYADRLRAARVQTTLTRYPGMYHGFLMRYEA
Mflv_4562|M.gilvum_PYR-GCK LPPAIVVTGECDPIRDWGERYAQRLRDARVQTTLTRYPGMYHGFLMRPDG
MAV_3032|M.avium_104 LPPAIVVTAGCDPIRDWGERYADRLRDAGVQTTVTRYPGMYHGFLMRSDA
MMAR_0576|M.marinum_M LPPAIVVAAEFDPLRDEGIEYAEALAAAGVPTELVRARGHTHLSLTMVDV
MLBr_00314|M.leprae_Br4923 LPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPM
*. ::: .. : : . . * * . : . *
Mb1434c|M.bovis_AF2122/97 VPAAAEATGRGLAALKRALHA-----------------
Rv1399c|M.tuberculosis_H37Rv VPAAAEATGRGLAALKRALHA-----------------
MUL_1794|M.ulcerans_Agy99 VPSAAEATSRGLATLRKVLHY-----------------
MAB_2814|M.abscessus_ATCC_1997 VPSATEERDLSLAALKQALHG-----------------
Mvan_2872|M.vanbaalenii_PYR-1 TARGRLAMAEIGALLRAKFANPLPFTTPLRCR------
TH_2802|M.thermoresistible__bu TARGRLALAEIGALLRAKFANPLPF-------------
MSMEG_2875|M.smegmatis_MC2_155 TARGRLALAETGALLRAKFADPLPFAG-----------
Mflv_4562|M.gilvum_PYR-GCK TARGRLAMAEIGALLRAKFAEPLPF-------------
MAV_3032|M.avium_104 TARGRLAIAEIGGLLRAKFTHPLRFDVPITGRHSTPTR
MMAR_0576|M.marinum_M VVSGAPIRAQLAGALRGFFAIGAAVPA-----------
MLBr_00314|M.leprae_Br4923 VPEATLSLRQISQYIREATASKASRDRQSL--------
. . ::