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TTSPPSPPQGPPLDPDAAARIAGFGKPAPVRDRGLETVRAAIESAPLPSDMPPMAEIVDRTVPASDREIG VRVYRPEQVGHDGAPVILHFHGGGLVMGSVHSFEPLARGLAAAAGAVVVAVDYRLAPEYPPPAQFDDAYA ATEWVARHAEELGVDARRLVVAGDSAGGGLAAAVALAARDHGGPAIFAQVLLYPGLDRDMGAQSIVEMPD APMLSRDDILYMHDLADIGAGSPHDPYRVPAYADDLRGLPQAIVVTGECDPIRDWGERYADRLRAARVQT TLTRYPGMYHGFLMRYEATARGRLALAETGALLRAKFADPLPFAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2875 | - | - | 100% (326) | esterase |
| M. smegmatis MC2 155 | MSMEG_3059 | - | 1e-52 | 44.98% (289) | esterase |
| M. smegmatis MC2 155 | MSMEG_3829 | - | 2e-42 | 37.58% (306) | esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1434c | lipH | 4e-51 | 41.42% (309) | lipase LipH |
| M. gilvum PYR-GCK | Mflv_4562 | - | 1e-125 | 70.06% (314) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1399c | lipH | 4e-51 | 41.42% (309) | lipase LipH |
| M. leprae Br4923 | MLBr_00314 | - | 2e-12 | 23.83% (235) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2039 | - | 4e-49 | 40.55% (291) | lipase LipH (carboxylesterase) |
| M. marinum M | MMAR_0576 | - | 2e-45 | 42.16% (268) | monooxygenase |
| M. avium 104 | MAV_3032 | - | 1e-123 | 71.88% (313) | alpha/beta hydrolase domain-containing protein |
| M. thermoresistible (build 8) | TH_2802 | - | 1e-143 | 77.96% (313) | PUTATIVE esterase |
| M. ulcerans Agy99 | MUL_1989 | lipN | 2e-44 | 37.30% (311) | lipase/esterase LipN |
| M. vanbaalenii PYR-1 | Mvan_2872 | - | 1e-126 | 70.57% (316) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2039|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M MSDAHHTDVDVVVAGAGFAGLYAAYRLRRAGHSMRIFEAGDDIGGTWYWN
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2039|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M RYPGARVDIPSVDYMYSFDPDWSRDWQWSEKYATQPEILRYLNHVADKHD
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2039|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M LRRDIQFGTRVTHAHWDDDAGRYRVRTDRGDEIICRYLIMATGCLSVPKD
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2039|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M LDIDGIENFTGELYFTSRWPHEPVDFTGKRVGVVGTGSSGIQSIPLIAAQ
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2039|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M AAQVVVFQRTPCFSIPAHNGPISPDKLAQLADDDAYRRAARYSFGGVPME
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2039|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M RSLTPTFSVSAEERRQRYERAWQLGELLEALNLYADEMINPLANSEFAEF
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2039|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M IRDKIRATVHDPQTAEALCPSGYPVGSKRLCLDSNYYATFNLPQVRLVDL
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2039|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M RNQPLLGVTKTGIDTVGESFEFDAIVFATGFDAVTGALAAIDIVGRNGLA
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 --------------------------------------------------
Rv1399c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2039|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_1989|M.ulcerans_Agy99 --------------------------------------------------
TH_2802|M.thermoresistible__bu --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M LGDKWAPGPSTYLGLTTEGFPNLFLIAGPNSPSVLSNMAVSIEQHVDFVA
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 -------------------------------------MTEPT--------
Rv1399c|M.tuberculosis_H37Rv -------------------------------------MTEPT--------
MAB_2039|M.abscessus_ATCC_1997 -------------------------------------MTSP---------
MUL_1989|M.ulcerans_Agy99 -------------------------------------MTNSLPGETDLHP
TH_2802|M.thermoresistible__bu --------------------------------------------------
Mvan_2872|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2875|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4562|M.gilvum_PYR-GCK --------------------------------------------------
MAV_3032|M.avium_104 --------------------------------------------------
MMAR_0576|M.marinum_M DALSYLREHGFDRIEPTELAEAGWMQHSDDAASITLFPQANSWYVGANIP
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
Mb1434c|M.bovis_AF2122/97 -------------------------------------------VARPDID
Rv1399c|M.tuberculosis_H37Rv -------------------------------------------VARPDID
MAB_2039|M.abscessus_ATCC_1997 ------------------------------------------------VD
MUL_1989|M.ulcerans_Agy99 ETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKRLITRGRSVIIDGNTLD
TH_2802|M.thermoresistible__bu ----------------------------------------MNHP-VPPLD
Mvan_2872|M.vanbaalenii_PYR-1 ----------------------------------------MNDPHRPALD
MSMEG_2875|M.smegmatis_MC2_155 -----------------------------------MTTSPPSPPQGPPLD
Mflv_4562|M.gilvum_PYR-GCK ------------------------------------------MP-GPTLD
MAV_3032|M.avium_104 -------------------------------------------MTSPPLD
MMAR_0576|M.marinum_M GKPRTFMAYTAGVDVYRVACEEVVARDYLGFRLSGPNGSQCNDGVVRRLQ
MLBr_00314|M.leprae_Br4923 -----------------------------------MAISAGAPVEIVESG
Mb1434c|M.bovis_AF2122/97 PVLKMLLDTFP-VTFTA---ADGVEVARARLRQLKTPPELLPEL-RIEER
Rv1399c|M.tuberculosis_H37Rv PVLKMLLDTFP-VTFTA---ADGVEVARARLRQLKTPPELLPEL-RIEER
MAB_2039|M.abscessus_ATCC_1997 PLLMSVLEASPAVQLDR---PEDLTLARESRRHAAPSDAQLPTVGRVKDT
MUL_1989|M.ulcerans_Agy99 PALQLMLSGMRVVGLDGLVIDDDLAASRAHMREAMLGFPGPQIHVDVEEL
TH_2802|M.thermoresistible__bu PDAAARIASLGPPAPMR---RRGLQAVRDAIESAPLPTD-MPAMASIVDR
Mvan_2872|M.vanbaalenii_PYR-1 PDAAARVAAFGPPVPIR---DRGLQAVRDAIESAPPPTD-MPTMADIGDA
MSMEG_2875|M.smegmatis_MC2_155 PDAAARIAGFGKPAPVR---DRGLETVRAAIESAPLPSD-MPPMAEIVDR
Mflv_4562|M.gilvum_PYR-GCK PDAAARVASFGPIPPMH---ERGLDAVRAGVENTPVPDD-MPAMASIEER
MAV_3032|M.avium_104 PDAAARIASFGETAPMR---QRGLPAVRAGLESAPRPAT-MPEMASVTEA
MMAR_0576|M.marinum_M PDIQMVLEQLEALGLPP-LESLPADQARALMNEMNLARPPGPDVGEIVDG
MLBr_00314|M.leprae_Br4923 PSIAARLASLTSRLTIRPILAVGSYVPQLPWPFGLIDHAARVLLPVTNAA
* : :
Mb1434c|M.bovis_AF2122/97 TVGYDGLTDIPVRVYWPP--VVRDNLPVVVYYHGGGWSLGGLDTHDPVAR
Rv1399c|M.tuberculosis_H37Rv TVGYDGLTDIPVRVYWPP--VVRDNLPVVVYYHGGGWSLGGLDTHDPVAR
MAB_2039|M.abscessus_ATCC_1997 SIPVTDAPPIAVRIYWPAGFESAGELPLVLYYHGGGFALGSIDTHDWVAR
MUL_1989|M.ulcerans_Agy99 TLPGP-AGDISARHYRPP---GDAAAPLLVFYHGGGWALGDLDTHDAVCR
TH_2802|M.thermoresistible__bu AVPGP-GGDIPVRIHRPERG-CGDPAPAVLYFHGGGLVMGSNHSFEPLAR
Mvan_2872|M.vanbaalenii_PYR-1 EVAGP-GGRVPVRIYRPAN--DGGPCPVIVHLHGGGLVMGSNRSFEPMAR
MSMEG_2875|M.smegmatis_MC2_155 TVPAS-DREIGVRVYRPEQV-GHDGAPVILHFHGGGLVMGSVHSFEPLAR
Mflv_4562|M.gilvum_PYR-GCK CAPGP-DGPIPLRIYRPTD---ATDASVVVYFHGGGMVMGSNRSFEPLAR
MAV_3032|M.avium_104 LVPSA-AGGIPVRIYRPTT---DSGVAVLVYLHGGGLVMGSNRSFEPLAR
MMAR_0576|M.marinum_M TLPGA-AGPLAYRLYRPAS---PGPHPVVVYFHGGGWVLGDHTSDDPLCR
MLBr_00314|M.leprae_Br4923 RAEVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGGAFLGCGANSHRRLVE
. ::. ***. . : : .
Mb1434c|M.bovis_AF2122/97 AHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSR
Rv1399c|M.tuberculosis_H37Rv AHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSR
MAB_2039|M.abscessus_ATCC_1997 SICAHIEAVVVSVDYRLAPENPYPAAVDDAFAALSWAAEHAPELGADPAR
MUL_1989|M.ulcerans_Agy99 LTCRDAGIHVLAIDYRLSPEHRAPAAIDDAFAAFEWAHAHAAELGALPGR
TH_2802|M.thermoresistible__bu GLAAASGAVVVAVDYRLAPEHPPPAQFDDAWATTRWVAAHADELGLDTSR
Mvan_2872|M.vanbaalenii_PYR-1 AMAAASGAAVVAVDYRLAPENPPPAQFEDAWTVTKWVAADAERLRFDPGK
MSMEG_2875|M.smegmatis_MC2_155 GLAAAAGAVVVAVDYRLAPEYPPPAQFDDAYAATEWVARHAEELGVDARR
Mflv_4562|M.gilvum_PYR-GCK ALAAGSTATVVSVDYRLAPEHPAPAQFVDCSAVTTWVAENATSLGVDPAR
MAV_3032|M.avium_104 ELASASAATVVAVDYRLAPESPPPAQFDDAYAATEWVSRKAGELGVDADR
MMAR_0576|M.marinum_M DLCVLSDTLIVSVDYRHAPEHRFPAALDDGWAAVQWIAEHAGELGGIPGQ
MLBr_00314|M.leprae_Br4923 TLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRR----LGYDPEQ
. :: ::** *: . * * * . :
Mb1434c|M.bovis_AF2122/97 IAVAGDSAGGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTEN
Rv1399c|M.tuberculosis_H37Rv IAVAGDSAGGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTEN
MAB_2039|M.abscessus_ATCC_1997 IAVAGDSAGGNLATVAAQLAEIRGGPHLKFQLLWYPGTTSDLSLPSVVEN
MUL_1989|M.ulcerans_Agy99 VAVGGDSAGGNLAAVVSQLARDSGGPAPIFQWLIYPRTDFAGRTRSASLF
TH_2802|M.thermoresistible__bu LAVAGDSAGGALAAAVALAARDRGGPELLAQLLMYPGLDRDLAAPSIVAM
Mvan_2872|M.vanbaalenii_PYR-1 IVVSGDSAGGGLAAAVTLAARDEGGPRLFAQVLMYPGLDRDMAAPSILAN
MSMEG_2875|M.smegmatis_MC2_155 LVVAGDSAGGGLAAAVALAARDHGGPAIFAQVLLYPGLDRDMGAQSIVEM
Mflv_4562|M.gilvum_PYR-GCK LAVAGDSAGGSLAAAVTLAARDCGGPVICAQVLMYPGLDRDMAAPSMVAM
MAV_3032|M.avium_104 LAVIGDSAGGSLAAAVALAARDRRGPPICAQVLLYPGLDRDMSVASIAAM
MMAR_0576|M.marinum_M LVVSGWSAGAGIAAVVCHLARDAGAPSIVGQALLTPVTDFDPTRGSYLEN
MLBr_00314|M.leprae_Br4923 IVLAGDSAGGYLALALAQRLQDVGEEPAALVAISPLLQLAKKGKQAHPNA
:.: * ***. :: . . : :
Mb1434c|M.bovis_AF2122/97 ADAPILDRDVIDAFLAWYVPGL--DISDHTMLPTTLAPGNADLSGLPPAF
Rv1399c|M.tuberculosis_H37Rv ADAPILDRDVIDAFLAWYVPGL--DISDHTMLPTTLAPGNADLSGLPPAF
MAB_2039|M.abscessus_ATCC_1997 ADGPVLSRDIMRIFGQAYLGELS-ETADPTALPFTVAPVNGKLDGLPPAY
MUL_1989|M.ulcerans_Agy99 ARGFLLTKRDIDWFHSQYLKGSGIEPTDPRVSPLRAES----LAGLAPAL
TH_2802|M.thermoresistible__bu PEAPMLSRDDIVYLHELADLGAG-----TPHDPYRVPAYATDLGGLPQTI
Mvan_2872|M.vanbaalenii_PYR-1 PHAPMLTHDDIVYLHELADIGAG-----TSHDTRRVPAYATDLTGLPQAI
MSMEG_2875|M.smegmatis_MC2_155 PDAPMLSRDDILYMHDLADIGAG-----SPHDPYRVPAYADDLRGLPQAI
Mflv_4562|M.gilvum_PYR-GCK PDAPLLSRADIDYMHELADDGVG-----APHDAYRIPAYAEDLSGLPPAI
MAV_3032|M.avium_104 PDAPLLIRDDIDYMHALVDGDAG-----PPTDPYLVPAYAADLSGLPPAI
MMAR_0576|M.marinum_M ADGYGLTAPLMQWFFDHYADPDV------RTDPRIAPLRAPDLSALPPAI
MLBr_00314|M.leprae_Br4923 KTDAMFPPKAFDALGRLVASSAAKN-KVDDKPEELYEPLDHIAPGLPRTL
: : : .*. :
Mb1434c|M.bovis_AF2122/97 IGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALVVPAAA
Rv1399c|M.tuberculosis_H37Rv IGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALVVPAAA
MAB_2039|M.abscessus_ATCC_1997 IATAQHDPLRDDGKIYATRLADAGVPVQLRNADTLVHGYLDFARIVPAAN
MUL_1989|M.ulcerans_Agy99 IAVAGFDPLRDEGENYATALRAAGTPVDLRAMGSLTHGFLNLFPLGGGCA
TH_2802|M.thermoresistible__bu IVTGACDPIRDWGERYAGRLRDAGVQTTVTRYPGMYHGFLMRYESTARGR
Mvan_2872|M.vanbaalenii_PYR-1 MVTGELDPISDWGERYAARLRDAGVQTTVTRYPGIYHGFLMRSEATARGR
MSMEG_2875|M.smegmatis_MC2_155 VVTGECDPIRDWGERYADRLRAARVQTTLTRYPGMYHGFLMRYEATARGR
Mflv_4562|M.gilvum_PYR-GCK VVTGECDPIRDWGERYAQRLRDARVQTTLTRYPGMYHGFLMRPDGTARGR
MAV_3032|M.avium_104 VVTAGCDPIRDWGERYADRLRDAGVQTTVTRYPGMYHGFLMRSDATARGR
MMAR_0576|M.marinum_M VVAAEFDPLRDEGIEYAEALAAAGVPTELVRARGHTHLSLTMVDVVVSGA
MLBr_00314|M.leprae_Br4923 IHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEAT
: .. : : . . * * . . . : *
Mb1434c|M.bovis_AF2122/97 EATGRGLAALKRALHA-----------------
Rv1399c|M.tuberculosis_H37Rv EATGRGLAALKRALHA-----------------
MAB_2039|M.abscessus_ATCC_1997 EEFRLSLDACKTALQASPRPKAGP---------
MUL_1989|M.ulcerans_Agy99 AATSELISALRAHLTRV----------------
TH_2802|M.thermoresistible__bu LALAEIGALLRAKFANPLPF-------------
Mvan_2872|M.vanbaalenii_PYR-1 LAMAEIGALLRAKFANPLPFTTPLRCR------
MSMEG_2875|M.smegmatis_MC2_155 LALAETGALLRAKFADPLPFAG-----------
Mflv_4562|M.gilvum_PYR-GCK LAMAEIGALLRAKFAEPLPF-------------
MAV_3032|M.avium_104 LAIAEIGGLLRAKFTHPLRFDVPITGRHSTPTR
MMAR_0576|M.marinum_M PIRAQLAGALRGFFAIGAAVPA-----------
MLBr_00314|M.leprae_Br4923 LSLRQISQYIREATASKASRDRQSL--------
: