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MPGPTLDPDAAARVASFGPIPPMHERGLDAVRAGVENTPVPDDMPAMASIEERCAPGPDGPIPLRIYRPT DATDASVVVYFHGGGMVMGSNRSFEPLARALAAGSTATVVSVDYRLAPEHPAPAQFVDCSAVTTWVAENA TSLGVDPARLAVAGDSAGGSLAAAVTLAARDCGGPVICAQVLMYPGLDRDMAAPSMVAMPDAPLLSRADI DYMHELADDGVGAPHDAYRIPAYAEDLSGLPPAIVVTGECDPIRDWGERYAQRLRDARVQTTLTRYPGMY HGFLMRPDGTARGRLAMAEIGALLRAKFAEPLPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4562 | - | - | 100% (314) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4203 | - | 2e-48 | 41.00% (261) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_3735 | - | 6e-46 | 43.18% (264) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1434c | lipH | 2e-51 | 42.71% (288) | lipase LipH |
| M. tuberculosis H37Rv | Rv1399c | lipH | 2e-51 | 42.71% (288) | lipase LipH |
| M. leprae Br4923 | MLBr_00314 | - | 1e-11 | 24.29% (247) | putative esterase |
| M. abscessus ATCC 19977 | MAB_0078 | - | 7e-51 | 43.36% (286) | putative lipase/esterase |
| M. marinum M | MMAR_2209 | lipI | 2e-44 | 38.75% (289) | lipase LipI |
| M. avium 104 | MAV_3032 | - | 1e-125 | 71.02% (314) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2875 | - | 1e-125 | 70.06% (314) | esterase |
| M. thermoresistible (build 8) | TH_2802 | - | 1e-130 | 72.38% (315) | PUTATIVE esterase |
| M. ulcerans Agy99 | MUL_1795 | lipI | 2e-44 | 38.75% (289) | lipase LipI |
| M. vanbaalenii PYR-1 | Mvan_2872 | - | 1e-120 | 68.59% (312) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1434c|M.bovis_AF2122/97 ---MTEPTVARPDIDPVLKMLLDTFPVTFT----AADGVEVARARLRQLK
Rv1399c|M.tuberculosis_H37Rv ---MTEPTVARPDIDPVLKMLLDTFPVTFT----AADGVEVARARLRQLK
MMAR_2209|M.marinum_M MPSLDKTADEKPAIDPIMQKVLDAVPFRLS----TEDGIDAVRQRLRDLP
MUL_1795|M.ulcerans_Agy99 MPSLDKTADEKPAIDPIMQKVLDAVPFRLS----TEDGIDAVRQRLRDLP
TH_2802|M.thermoresistible__bu -----MNHP-VPPLDPDAAARIASLGPPAP---MRRRGLQAVRDAIESAP
Mvan_2872|M.vanbaalenii_PYR-1 -----MNDPHRPALDPDAAARVAAFGPPVP---IRDRGLQAVRDAIESAP
MSMEG_2875|M.smegmatis_MC2_155 MTTSPPSPPQGPPLDPDAAARIAGFGKPAP---VRDRGLETVRAAIESAP
Mflv_4562|M.gilvum_PYR-GCK -------MP-GPTLDPDAAARVASFGPIPP---MHERGLDAVRAGVENTP
MAV_3032|M.avium_104 --------MTSPPLDPDAAARIASFGETAP---MRQRGLPAVRAGLESAP
MAB_0078|M.abscessus_ATCC_1997 -----------MTLDPQLAALLPALNAGFPR--VEKMTGAQARAAIRARY
MLBr_00314|M.leprae_Br4923 MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILAVGSYVPQLPWPFGL
.* : . . :
Mb1434c|M.bovis_AF2122/97 TPPELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDN---LPVVVYYHGG
Rv1399c|M.tuberculosis_H37Rv TPPELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDN---LPVVVYYHGG
MMAR_2209|M.marinum_M RRP-VHPELRVEDRAIDGPGGS-IPIRIYWPPISPDATDPLPVVLFFHGG
MUL_1795|M.ulcerans_Agy99 RRP-VHPELRVEDRAIDGPGGS-IPIRIYWPPISPDATDPLPVVLFFHGG
TH_2802|M.thermoresistible__bu LPTDMP-AMASIVDRAVPGPGGDIPVRIHRPERGCGDP--APAVLYFHGG
Mvan_2872|M.vanbaalenii_PYR-1 PPTDMP-TMADIGDAEVAGPGGRVPVRIYRPAN-DGGP--CPVIVHLHGG
MSMEG_2875|M.smegmatis_MC2_155 LPSDMP-PMAEIVDRTVPASDREIGVRVYRPEQVGHDG--APVILHFHGG
Mflv_4562|M.gilvum_PYR-GCK VPDDMP-AMASIEERCAPGPDGPIPLRIYRPTD--ATD--ASVVVYFHGG
MAV_3032|M.avium_104 RPATMP-EMASVTEALVPSAAGGIPVRIYRPTT--DSG--VAVLVYLHGG
MAB_0078|M.abscessus_ATCC_1997 VPPARPLPMRSVTDECVYAFGGELPIRVYRPAV--PGP--LPTVVFAHGG
MLBr_00314|M.leprae_Br4923 IDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGG
: :: . ::. ***
Mb1434c|M.bovis_AF2122/97 GWSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALR
Rv1399c|M.tuberculosis_H37Rv GWSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALR
MMAR_2209|M.marinum_M GFVMGDLDTHDGTCRQHAVGADTLVVSVDYRLAPEHPYPAAIQDAWAATR
MUL_1795|M.ulcerans_Agy99 GFVMGDLDTHDGTCRQHAVGADTLVVSVDYRLAPEHPYPAAIQDAWAATR
TH_2802|M.thermoresistible__bu GLVMGSNHSFEPLARGLAAASGAVVVAVDYRLAPEHPPPAQFDDAWATTR
Mvan_2872|M.vanbaalenii_PYR-1 GLVMGSNRSFEPMARAMAAASGAAVVAVDYRLAPENPPPAQFEDAWTVTK
MSMEG_2875|M.smegmatis_MC2_155 GLVMGSVHSFEPLARGLAAAAGAVVVAVDYRLAPEYPPPAQFDDAYAATE
Mflv_4562|M.gilvum_PYR-GCK GMVMGSNRSFEPLARALAAGSTATVVSVDYRLAPEHPAPAQFVDCSAVTT
MAV_3032|M.avium_104 GLVMGSNRSFEPLARELASASAATVVAVDYRLAPESPPPAQFDDAYAATE
MAB_0078|M.abscessus_ATCC_1997 GFVFCDLDSHDGLCRRLAAGIPAVVVSVDYRRAPEHRWPTAAQDMFLAAC
MLBr_00314|M.leprae_Br4923 AFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQ
. . :. . : : :: *:** *: *
Mb1434c|M.bovis_AF2122/97 WVGENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGG---PPLVFQL
Rv1399c|M.tuberculosis_H37Rv WVGENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGG---PPLVFQL
MMAR_2209|M.marinum_M WVADHGSTIGADLNRVAVAGDSAGGTIAAVIAQQARDNADGPIPPIAFQL
MUL_1795|M.ulcerans_Agy99 WVADHRSTIGADLNRVAVAGDSAGGTIAAVIAQQARDNADGPIPPIAFQL
TH_2802|M.thermoresistible__bu WVAAHADELGLDTSRLAVAGDSAGGALAAAVALAARDRGG---PELLAQL
Mvan_2872|M.vanbaalenii_PYR-1 WVAADAERLRFDPGKIVVSGDSAGGGLAAAVTLAARDEGG---PRLFAQV
MSMEG_2875|M.smegmatis_MC2_155 WVARHAEELGVDARRLVVAGDSAGGGLAAAVALAARDHGG---PAIFAQV
Mflv_4562|M.gilvum_PYR-GCK WVAENATSLGVDPARLAVAGDSAGGSLAAAVTLAARDCGG---PVICAQV
MAV_3032|M.avium_104 WVSRKAGELGVDADRLAVIGDSAGGSLAAAVALAARDRRG---PPICAQV
MAB_0078|M.abscessus_ATCC_1997 WVTRNAPTLGGDPARVLVCGDSAGGNLAAVTTLMARDLGG---PVLAGQI
MLBr_00314|M.leprae_Br4923 WLRR----LGYDPEQIVLAGDSAGGYLALALAQRLQDVGEEPAALVAISP
*: : * :: : ****** :: . : :* . : .
Mb1434c|M.bovis_AF2122/97 LWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPT
Rv1399c|M.tuberculosis_H37Rv LWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPT
MMAR_2209|M.marinum_M LWYPSTMWDQTLPSFTENATGEVLDVKAIADFSRWYAGDTDLSNP---PA
MUL_1795|M.ulcerans_Agy99 LWYPSTMWDQTLPSFTENATGEVLDVKAIADFSRWYAGDTDLSNP---PA
TH_2802|M.thermoresistible__bu LMYPGLDRDLAAPSIVAMPEAPMLSRDDIVYLHELADLGAGTPHD----P
Mvan_2872|M.vanbaalenii_PYR-1 LMYPGLDRDMAAPSILANPHAPMLTHDDIVYLHELADIGAGTSHD----T
MSMEG_2875|M.smegmatis_MC2_155 LLYPGLDRDMGAQSIVEMPDAPMLSRDDILYMHDLADIGAGSPHD----P
Mflv_4562|M.gilvum_PYR-GCK LMYPGLDRDMAAPSMVAMPDAPLLSRADIDYMHELADDGVGAPHD----A
MAV_3032|M.avium_104 LLYPGLDRDMSVASIAAMPDAPLLIRDDIDYMHALVDGDAGPPTD----P
MAB_0078|M.abscessus_ATCC_1997 LIYPVLDADFDTPSYRSCGSGYYNTRAAMQWYWDQYLPDPALRDH----P
MLBr_00314|M.leprae_Br4923 LLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDK---PE
* . . :
Mb1434c|M.bovis_AF2122/97 TLAPGNAD-LSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEP
Rv1399c|M.tuberculosis_H37Rv TLAPGNAD-LSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEP
MMAR_2209|M.marinum_M GMAPGRAENLANLPAAYIAVAGHDPLRDDGIRYGELLAAAGVSVEVHNAG
MUL_1795|M.ulcerans_Agy99 GMAPGRAENLANLPAAYIAVAGHDPLRDDGIRYGELLAAAGVSVEVHNAG
TH_2802|M.thermoresistible__bu YRVPAYATDLGGLPQTIIVTGACDPIRDWGERYAGRLRDAGVQTTVTRYP
Mvan_2872|M.vanbaalenii_PYR-1 RRVPAYATDLTGLPQAIMVTGELDPISDWGERYAARLRDAGVQTTVTRYP
MSMEG_2875|M.smegmatis_MC2_155 YRVPAYADDLRGLPQAIVVTGECDPIRDWGERYADRLRAARVQTTLTRYP
Mflv_4562|M.gilvum_PYR-GCK YRIPAYAEDLSGLPPAIVVTGECDPIRDWGERYAQRLRDARVQTTLTRYP
MAV_3032|M.avium_104 YLVPAYAADLSGLPPAIVVTAGCDPIRDWGERYADRLRDAGVQTTVTRYP
MAB_0078|M.abscessus_ATCC_1997 YAAPLRA-DLSGLPPAVVVTARYDPPCSEGEAYAAALREAGVPVRYRRYD
MLBr_00314|M.leprae_Br4923 ELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWP
.** : : .. : . . * . * .
Mb1434c|M.bovis_AF2122/97 TMVHGYVNFALVVPAAAEATGRGLAALKRALHA-----------------
Rv1399c|M.tuberculosis_H37Rv TMVHGYVNFALVVPAAAEATGRGLAALKRALHA-----------------
MMAR_2209|M.marinum_M SLVHGYIGYAGVVPAATTAMERGLAALRVALHG-----------------
MUL_1795|M.ulcerans_Agy99 SLVHGYIGYAGVVPAATTAMERGLAALRIALHG-----------------
TH_2802|M.thermoresistible__bu GMYHGFLMRYESTARGRLALAEIGALLRAKFANPLPF-------------
Mvan_2872|M.vanbaalenii_PYR-1 GIYHGFLMRSEATARGRLAMAEIGALLRAKFANPLPFTTPLRCR------
MSMEG_2875|M.smegmatis_MC2_155 GMYHGFLMRYEATARGRLALAETGALLRAKFADPLPFAG-----------
Mflv_4562|M.gilvum_PYR-GCK GMYHGFLMRPDGTARGRLAMAEIGALLRAKFAEPLPF-------------
MAV_3032|M.avium_104 GMYHGFLMRSDATARGRLAIAEIGGLLRAKFTHPLRFDVPITGRHSTPTR
MAB_0078|M.abscessus_ATCC_1997 NAIHGFMTMPG------LELADAGIQRLCRDVGEMLG-------------
MLBr_00314|M.leprae_Br4923 GQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL--------
* :