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TRTVVVTGAGSGIGRAIANTLAQRNWRVVVTDVNAAAASEVAAALPNPPAGHESAQLDVTSPENAAAVAS DVSERLGLDAWVSNAGISFMHRFLDAPIERYEQTMDVNLKGVFVCGQAAAREMVRAGIPGMIVNTASMAG KQGRVPFLSDYVASKFGVVGLTQAMAYELGEHGITVNCVCPGFVETPMQSRELQWEAELRGTTPDGVRAM MIADTPLGRLEQADDVARAVAFLLSDDARFITGEALAVNGGAYMD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2620 | - | - | 100% (256) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4157 | - | 2e-38 | 39.84% (251) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4185 | - | 2e-36 | 37.50% (256) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 7e-32 | 35.97% (253) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3779 | - | 1e-134 | 91.80% (256) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2857c | - | 7e-32 | 35.97% (253) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 3e-29 | 32.81% (256) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4680c | - | 1e-32 | 38.65% (251) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4715 | - | 1e-34 | 39.04% (251) | 3-oxoacyl- |
| M. avium 104 | MAV_1395 | - | 2e-37 | 41.94% (248) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3112 | - | 1e-101 | 72.33% (253) | estradiol 17-beta-dehydrogenase 8 |
| M. thermoresistible (build 8) | TH_3102 | - | 2e-35 | 37.80% (254) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 6e-35 | 39.68% (252) | 3-oxoacyl- |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2882c|M.bovis_AF2122/97 ---------MMD--LSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Rv2857c|M.tuberculosis_H37Rv ---------MMD--LSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Mvan_2620|M.vanbaalenii_PYR-1 ---------MTR----------TVVVTGAGSGIGRAIANTLAQRNWRVVV
Mflv_3779|M.gilvum_PYR-GCK ---------MTR----------TVVVTGAGSGIGRAIASTLAQRDWRVVV
MSMEG_3112|M.smegmatis_MC2_155 ---------MSTPANSTPDTPSTVVVTGAGSGIGRAIATTLAERGWRVVA
MAB_4680c|M.abscessus_ATCC_199 ---------MNG--NSALLQGKNVIVTGGARGLGAAFSRHIVSQGGRVVI
MMAR_4715|M.marinum_M ----------MK----------TAVVTGGASGIGLAIARRLRADGIDVAT
MUL_0315|M.ulcerans_Agy99 ----------MRPDSSPSWCTITSVVTGGASGIGLAIARRLSADGTDVAT
TH_3102|M.thermoresistible__bu ----------LK----------NAVVTGGGSGIGQAVAARLRADGYHVAT
MAV_1395|M.avium_104 ----------------------MAVVTGGGSGIGRAIVERLAHDGHRVAV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
::**. *:* * : . :.
Mb2882c|M.bovis_AF2122/97 GDVDVEAGGAAADELSG-----LFVPTDVCDEDAVNGLFDGAAETYGRID
Rv2857c|M.tuberculosis_H37Rv GDVDVEAGGAAADELSG-----LFVPTDVCDEDAVNGLFDGAAETYGRID
Mvan_2620|M.vanbaalenii_PYR-1 TDVNAAAASEVAAALPNPPAGHESAQLDVTSPENAAAVASDVSERLG-LD
Mflv_3779|M.gilvum_PYR-GCK TDVNGEAARSVAAELPNPSAGHESAPLDVTSPDAAAAVASDIAERFG-LD
MSMEG_3112|M.smegmatis_MC2_155 TDVDVAAADETASSLSG--SGHESARLDVTDPAQASALADDVADRIG-LG
MAB_4680c|M.abscessus_ATCC_199 ADVLDGDGRQLAAELGD---AARFTHLDVTDAEQWRELIDTTLAGFGTIT
MMAR_4715|M.marinum_M LDLKTPDGE-------------LAFSADVTNRSQVDAALTAIRQRLGPVT
MUL_0315|M.ulcerans_Agy99 LDLKTPDGG-------------LAFSADVTNRSQVDAALAAIRQRLGPVT
TH_3102|M.thermoresistible__bu IDLKPGDDE-------------FSHAADVTDRAQVDAAFDAIRTQLGPVT
MAV_1395|M.avium_104 LDVNEEAAEKVAARVAADGAHAIAVPTDVAESASVAAAFESVRRALGSVQ
MLBr_01807|M.leprae_Br4923 THRASVVPDWFFG-----------VECDVTDNDAIGAAFKAVEEHQGPVE
. ** . * :
Mb2882c|M.bovis_AF2122/97 IAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLAG
Rv2857c|M.tuberculosis_H37Rv IAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLAG
Mvan_2620|M.vanbaalenii_PYR-1 AWVSNAGIS--FMHRFLDAPIERYEQTMDVNLKGVFVCGQAAAREMVRAG
Mflv_3779|M.gilvum_PYR-GCK AWVSNAGIS--FMHRFLDAPIERFDQTMDVNLKGVFVCGQAAAREMVRSG
MSMEG_3112|M.smegmatis_MC2_155 AWVSNAGIS--AMAHFVDISAEQLDRSLDVNLKGVFFCGQAAARAMIRTG
MAB_4680c|M.abscessus_ATCC_199 GLVNNAGIS--SAAMVADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAHG
MMAR_4715|M.marinum_M ILVNAAGLD--GFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAG
MUL_0315|M.ulcerans_Agy99 ILVNAAGLD--GFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAG
TH_3102|M.thermoresistible__bu ILVNAAGLD--LFRRFTDISFEDWERVINVNLHGVFHCIQAVLPDMIEAG
MAV_1395|M.avium_104 VLVTSAAIT--GFKPFAEITIEDWNRHLAVNLTGTFLCLQAALPDMVEAG
MLBr_01807|M.leprae_Br4923 VLVANAGIT--SDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQR
. *.: . : :** ..: : . *
Mb2882c|M.bovis_AF2122/97 K-GSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIRVN
Rv2857c|M.tuberculosis_H37Rv K-GSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIRVN
Mvan_2620|M.vanbaalenii_PYR-1 IPGMIVNTASMAGKQGRVPFLSDYVASKFGVVGLTQAMAYELGEHGITVN
Mflv_3779|M.gilvum_PYR-GCK VPGVIVNTASMAGKQGRVPFLADYVASKFGVVGLTQAMAYELGEHGITVN
MSMEG_3112|M.smegmatis_MC2_155 VRGTIVNTASMAAKQGRVPFLADYVASKFGVLGLTQAMAFELAAHGITVN
MAB_4680c|M.abscessus_ATCC_199 C-GSIVNISSAAGLVG-LALTSGYGASKWGVRGLSKVAAIELGRERIRVN
MMAR_4715|M.marinum_M W-GRIVNISSSSTHSG-TPYMTHYVAAKSAVNGLTKALALEYGPSGITVN
MUL_0315|M.ulcerans_Agy99 W-GRIVNISSSSTHSG-TPYMTHYVAAKSAVNGLTKALALEYGPSGITVN
TH_3102|M.thermoresistible__bu W-GRIVNISSSSTHSG-APYMAPYVAAKSGVNGLTKTLALEYGPAGITVN
MAV_1395|M.avium_104 W-GRVVTISSTAAQTG-SPRQGHYSASKGGVIALTRTIALEYAAHGITAN
MLBr_01807|M.leprae_Br4923 F-GRYIFMGSVVGLSG-VPGQANYAASKSGLIGMARSLARELGSRSITAN
* : .* * . * *:* .: .::: . : . * .*
Mb2882c|M.bovis_AF2122/97 ALCPGPVNTPLLQELFAKNPERAARRMVH--------VPLGRFAEPDEIA
Rv2857c|M.tuberculosis_H37Rv ALCPGPVNTPLLQELFAKNPERAARRMVH--------VPLGRFAEPDEIA
Mvan_2620|M.vanbaalenii_PYR-1 CVCPGFVETPMQSRELQWEAELRGTTPDGVRAMMIADTPLGRLEQADDVA
Mflv_3779|M.gilvum_PYR-GCK CVCPGFVETPMQSRELEWEAELRGTTPDGVRAMMIADTPLGRLEQADDVA
MSMEG_3112|M.smegmatis_MC2_155 SVCPGFVATPMQTRELEWEAKLSGSTPDGVRQSWIDATPLGRLQTPDDVA
MAB_4680c|M.abscessus_ATCC_199 SVHPGVIYTPMTAKEGFREGE--GNMP---------IAAMGRVGNADEVA
MMAR_4715|M.marinum_M AVPPGFIDTPMLRNAAAQGHLGDIEQNIAR-------TPVRRIGKPEDIA
MUL_0315|M.ulcerans_Agy99 AVPPGFIDTPMLRNAAAQGHLGDIEQNIAR-------TPVRRIGKPEDIA
TH_3102|M.thermoresistible__bu AVPPGFIDTPMLRAAAAKGYLGDIDKTIEA-------TPVRRMGKPEDIA
MAV_1395|M.avium_104 TVPPFSVDTPMLRAAQEAGNLPPVKYLAKA-------SPVGRLGTGEDIA
MLBr_01807|M.leprae_Br4923 VVAPGFIDTEMTRAMDSKYQEAALQAI-----------PLGRIGAVEEIA
: * : * : .: *. :::*
Mb2882c|M.bovis_AF2122/97 AAVAFLASDDASFITASTFLVDGGISSAYVTPL----
Rv2857c|M.tuberculosis_H37Rv AAVAFLASDDASFITASTFLVDGGISSAYVTPL----
Mvan_2620|M.vanbaalenii_PYR-1 RAVAFLLSDDARFITGEALAVNGGAYMD---------
Mflv_3779|M.gilvum_PYR-GCK RAVAFLLSDDARFITGEALAVNGGAYMD---------
MSMEG_3112|M.smegmatis_MC2_155 RAVAFLVSEDARFITGEALSVNGGAYMD---------
MAB_4680c|M.abscessus_ATCC_199 GAVAYLLSDAASYVTGAELAVDGGWTAGPTLTTITGQ
MMAR_4715|M.marinum_M AACAFLVSEEAGYITGQILGVNGGRNT----------
MUL_0315|M.ulcerans_Agy99 AACAFLVSEEAGYITGQILGVNGGRNT----------
TH_3102|M.thermoresistible__bu AACAFLISEEAGYITGQILGVNGGRNT----------
MAV_1395|M.avium_104 AACAFLCSDEAGYITGQIIGVNGGEVI----------
MLBr_01807|M.leprae_Br4923 GAVSFLASEDAGYISGAVIPVDGGLGMGH--------
* ::* *: * :::. : *:**