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STPANSTPDTPSTVVVTGAGSGIGRAIATTLAERGWRVVATDVDVAAADETASSLSGSGHESARLDVTDP AQASALADDVADRIGLGAWVSNAGISAMAHFVDISAEQLDRSLDVNLKGVFFCGQAAARAMIRTGVRGTI VNTASMAAKQGRVPFLADYVASKFGVLGLTQAMAFELAAHGITVNSVCPGFVATPMQTRELEWEAKLSGS TPDGVRQSWIDATPLGRLQTPDDVARAVAFLVSEDARFITGEALSVNGGAYMD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3112 | - | - | 100% (264) | estradiol 17-beta-dehydrogenase 8 |
| M. smegmatis MC2 155 | MSMEG_0294 | fabG | 2e-38 | 41.04% (251) | 3-oxoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_4800 | - | 2e-38 | 41.87% (246) | 3-oxoacyl-(acyl-carrier-protein) reductase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 2e-36 | 39.37% (254) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_3779 | - | 1e-101 | 73.12% (253) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 2e-36 | 39.37% (254) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-28 | 34.26% (251) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0514 | - | 6e-32 | 43.85% (187) | oxidoreductase EphD |
| M. marinum M | MMAR_4715 | - | 1e-34 | 40.73% (248) | 3-oxoacyl- |
| M. avium 104 | MAV_1395 | - | 4e-38 | 41.13% (248) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3102 | - | 7e-40 | 42.28% (246) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 3e-34 | 39.92% (248) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_2620 | - | 1e-101 | 72.33% (253) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3779|M.gilvum_PYR-GCK ---------MTR----------TVVVTGAGSGIGRAIASTLAQRDWRVVV
Mvan_2620|M.vanbaalenii_PYR-1 ---------MTR----------TVVVTGAGSGIGRAIANTLAQRNWRVVV
MSMEG_3112|M.smegmatis_MC2_155 ---------MSTPANSTPDTPSTVVVTGAGSGIGRAIATTLAERGWRVVA
MMAR_4715|M.marinum_M ----------MK----------TAVVTGGASGIGLAIARRLRADGIDVAT
MUL_0315|M.ulcerans_Agy99 ----------MRPDSSPSWCTITSVVTGGASGIGLAIARRLSADGTDVAT
TH_3102|M.thermoresistible__bu ----------LK----------NAVVTGGGSGIGQAVAARLRADGYHVAT
MAV_1395|M.avium_104 ----------------------MAVVTGGGSGIGRAIVERLAHDGHRVAV
Mb1976|M.bovis_AF2122/97 -------------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLC
Rv1941|M.tuberculosis_H37Rv -------------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLC
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAB_0514|M.abscessus_ATCC_1997 ------------MRLLPAPKPGLVVVTGAGSGIGRAIAIQFAKGGAEVVA
:***. *** *:. : . *
Mflv_3779|M.gilvum_PYR-GCK TDVNGEAARSVAAELPNPSAGHESAPLDVTSPDAAAAVASDIAERFG-LD
Mvan_2620|M.vanbaalenii_PYR-1 TDVNAAAASEVAAALPNPPAGHESAQLDVTSPENAAAVASDVSERLG-LD
MSMEG_3112|M.smegmatis_MC2_155 TDVDVAAADETASSLSG--SGHESARLDVTDPAQASALADDVADRIG-LG
MMAR_4715|M.marinum_M LDLKTPDGE-------------LAFSADVTNRSQVDAALTAIRQRLGPVT
MUL_0315|M.ulcerans_Agy99 LDLKTPDGG-------------LAFSADVTNRSQVDAALAAIRQRLGPVT
TH_3102|M.thermoresistible__bu IDLKPGDDE-------------FSHAADVTDRAQVDAAFDAIRTQLGPVT
MAV_1395|M.avium_104 LDVNEEAAEKVAARVAADGAHAIAVPTDVAESASVAAAFESVRRALGSVQ
Mb1976|M.bovis_AF2122/97 ADIDGDAADAAATKIG---CGAAACRVDVSDEQQIIAMVDACVAAFGGVD
Rv1941|M.tuberculosis_H37Rv ADIDGDAADAAATKIG---CGAAACRVDVSDEQQIIAMVDACVAAFGGVD
MLBr_01807|M.leprae_Br4923 THR--------ASVVP---DWFFGVECDVTDNDAIGAAFKAVEEHQGPVE
MAB_0514|M.abscessus_ATCC_1997 SDVDLTTAQETAQIIHGKGHRAVAFQLDVTDPAAWERFAEQVRAEYGVPD
. . **:. *
Mflv_3779|M.gilvum_PYR-GCK AWVSNAGISFMHRFLDAPIERFDQTMDVNLKGVFVCGQAAAREMVRSGVP
Mvan_2620|M.vanbaalenii_PYR-1 AWVSNAGISFMHRFLDAPIERYEQTMDVNLKGVFVCGQAAAREMVRAGIP
MSMEG_3112|M.smegmatis_MC2_155 AWVSNAGISAMAHFVDISAEQLDRSLDVNLKGVFFCGQAAARAMIRTGVR
MMAR_4715|M.marinum_M ILVNAAGLDGFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAGW-
MUL_0315|M.ulcerans_Agy99 ILVNAAGLDGFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAGW-
TH_3102|M.thermoresistible__bu ILVNAAGLDLFRRFTDISFEDWERVINVNLHGVFHCIQAVLPDMIEAGW-
MAV_1395|M.avium_104 VLVTSAAITGFKPFAEITIEDWNRHLAVNLTGTFLCLQAALPDMVEAGW-
Mb1976|M.bovis_AF2122/97 KLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGG-
Rv1941|M.tuberculosis_H37Rv KLVANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGG-
MLBr_01807|M.leprae_Br4923 VLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRF-
MAB_0514|M.abscessus_ATCC_1997 VLVNNAGIMVGGRFFDLEQEHWEKQFRVNVFGVAYGGRVFGKQMAERGRG
* *.: : * :: : :*: *. : *
Mflv_3779|M.gilvum_PYR-GCK GVIVNTASMAGKQGRVPFLADYVASKFGVVGLTQAMAYELGEHGITVNCV
Mvan_2620|M.vanbaalenii_PYR-1 GMIVNTASMAGKQGRVPFLSDYVASKFGVVGLTQAMAYELGEHGITVNCV
MSMEG_3112|M.smegmatis_MC2_155 GTIVNTASMAAKQGRVPFLADYVASKFGVLGLTQAMAFELAAHGITVNSV
MMAR_4715|M.marinum_M GRIVNISSSSTHSG-TPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAV
MUL_0315|M.ulcerans_Agy99 GRIVNISSSSTHSG-TPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAV
TH_3102|M.thermoresistible__bu GRIVNISSSSTHSG-APYMAPYVAAKSGVNGLTKTLALEYGPAGITVNAV
MAV_1395|M.avium_104 GRVVTISSTAAQTG-SPRQGHYSASKGGVIALTRTIALEYAAHGITANTV
Mb1976|M.bovis_AF2122/97 GAIVNLSSLAGQVA-VGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTL
Rv1941|M.tuberculosis_H37Rv GAIVNLSSLAGQVA-VGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTL
MLBr_01807|M.leprae_Br4923 GRYIFMGSVVGLSG-VPGQANYAASKSGLIGMARSLARELGSRSITANVV
MAB_0514|M.abscessus_ATCC_1997 GQIVNIASAGAITP-TPLFPAYSASKAAVKMLSECMRMELGPKGIGVSAV
* : .* * :* .: ::. * .* . :
Mflv_3779|M.gilvum_PYR-GCK CPGFVETPMQSRELEWEAELRGTTPDG------VRAMMIADTPLGRLEQA
Mvan_2620|M.vanbaalenii_PYR-1 CPGFVETPMQSRELQWEAELRGTTPDG------VRAMMIADTPLGRLEQA
MSMEG_3112|M.smegmatis_MC2_155 CPGFVATPMQTRELEWEAKLSGSTPDG------VRQSWIDATPLGRLQTP
MMAR_4715|M.marinum_M PPGFIDTPMLR-----NAAAQGHLGD--------IEQNIARTPVRRIGKP
MUL_0315|M.ulcerans_Agy99 PPGFIDTPMLR-----NAAAQGHLGD--------IEQNIARTPVRRIGKP
TH_3102|M.thermoresistible__bu PPGFIDTPMLR-----AAAAKGYLGD--------IDKTIEATPVRRMGKP
MAV_1395|M.avium_104 PPFSVDTPMLR-----AAQEAGNLPP--------VKYLAKASPVGRLGTG
Mb1976|M.bovis_AF2122/97 LPAFVDTPMQQ-----TAMAMFDGALGA-----GGARSMIARLQGRMAAP
Rv1941|M.tuberculosis_H37Rv LPAFVDTPMQQ-----TAMAMFDGALGA-----GGARSMIARLQGRMAAP
MLBr_01807|M.leprae_Br4923 APGFIDTEMTR-----AMDSKYQEAA------------LQAIPLGRIGAV
MAB_0514|M.abscessus_ATCC_1997 CPGFINTNIGVNATVAGLDVRDDVRERANNMMRAFQSSAPMRVLDQLIGP
* : * : ::
Mflv_3779|M.gilvum_PYR-GCK DDVARAVAFLLSDDARFITGEALAVNGGAYMD------------------
Mvan_2620|M.vanbaalenii_PYR-1 DDVARAVAFLLSDDARFITGEALAVNGGAYMD------------------
MSMEG_3112|M.smegmatis_MC2_155 DDVARAVAFLVSEDARFITGEALSVNGGAYMD------------------
MMAR_4715|M.marinum_M EDIAAACAFLVSEEAGYITGQILGVNGGRNT-------------------
MUL_0315|M.ulcerans_Agy99 EDIAAACAFLVSEEAGYITGQILGVNGGRNT-------------------
TH_3102|M.thermoresistible__bu EDIAAACAFLISEEAGYITGQILGVNGGRNT-------------------
MAV_1395|M.avium_104 EDIAAACAFLCSDEAGYITGQIIGVNGGEVI-------------------
Mb1976|M.bovis_AF2122/97 EEMAGIVVFLLSDDASMITGTTQIADGGTIAALW----------------
Rv1941|M.tuberculosis_H37Rv EEMAGIVVFLLSDDASMITGTTQIADGGTIAALW----------------
MLBr_01807|M.leprae_Br4923 EEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-----------------
MAB_0514|M.abscessus_ATCC_1997 PQVARAAVRAARYNFAVAPVRPEAWLGYFLSRLLPGLNRHFMYPIPYWLG
::* : . *
Mflv_3779|M.gilvum_PYR-GCK ----------------------------------
Mvan_2620|M.vanbaalenii_PYR-1 ----------------------------------
MSMEG_3112|M.smegmatis_MC2_155 ----------------------------------
MMAR_4715|M.marinum_M ----------------------------------
MUL_0315|M.ulcerans_Agy99 ----------------------------------
TH_3102|M.thermoresistible__bu ----------------------------------
MAV_1395|M.avium_104 ----------------------------------
Mb1976|M.bovis_AF2122/97 ----------------------------------
Rv1941|M.tuberculosis_H37Rv ----------------------------------
MLBr_01807|M.leprae_Br4923 ----------------------------------
MAB_0514|M.abscessus_ATCC_1997 LDIDTLIPRLQRLIDNVAERTPTPRLTETEQSPV