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TTVQNFIDGQLVDSTSGATMPLVDPSTGEQYGTAPVSNEQDIDNAYAAAARAFKEWKKTTPSQRQKALLD FADEVERNADALVAAEGRNTGKPDHVTAAEEIPPMVDQIRFFAGAARVLEGKSAGEYMADHTSWIRREPI GVIGQVAPWNYPMMMAIWKICPAIAAGNTVVIKPSDTTPVTTVMLAELAAKYLPAGVLNVVTGDRVTGAS LVAHPTPEMVAITGSVAAGKAVAVSAGGNLKRTHLELGGKAPVIVFDDADLAAAAEGIATAGYFNAGQDC TAATRVLASASIAADLTAALAEQAKGATTTFGRAAGDEDAWVPPVNNVNQMERVLSFFSDIPSHATVAVG GNRQGDKGFYVEPTVIGGLRQADRLIQQEIFGPVITVQSFSDEEEAIGWANGVEYGLASSVWTKDVSRAL RVSNALDFGCVWINTHIPLVAEMPHGGFKSSGHGKDLSMYGLEDYTRIKHVMAYTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2580 | - | - | 100% (477) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1572 | - | e-111 | 44.49% (472) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1468 | - | 4e-77 | 37.21% (481) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0467 | - | 2e-75 | 36.44% (483) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3819 | - | 0.0 | 94.97% (477) | gamma-aminobutyraldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0458 | - | 2e-75 | 36.44% (483) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 2e-49 | 30.55% (455) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4203 | - | 1e-155 | 57.56% (476) | putative aldehyde dehydrogenase |
| M. marinum M | MMAR_2610 | - | 1e-170 | 61.65% (472) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 1e-84 | 39.15% (470) | betaine-aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1665 | - | 1e-111 | 44.33% (476) | gamma-aminobutyraldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3284 | - | 6e-75 | 37.34% (482) | PUTATIVE eptc-inducible aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2789 | - | 1e-112 | 45.36% (463) | gamma-aminobutyraldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2580|M.vanbaalenii_PYR-1 ----------------MTTVQNFIDGQLVDST---SGATMPLVDPSTGEQ
Mflv_3819|M.gilvum_PYR-GCK ----------------MTTVKNFIGGELVDST---GGATMPLIDPSTGEQ
MMAR_2610|M.marinum_M -------------MVEKKVFHNIIGGEIQATP---DGNTMDIVNPSTGEV
MAB_4203|M.abscessus_ATCC_1997 --------------MPDSVLQNYIDGQFVDALSLKSSEPIDLINPVDESV
MSMEG_1665|M.smegmatis_MC2_155 --------------MAVKVASSWINGASVETS----GETHQIIDPATGKS
MUL_2789|M.ulcerans_Agy99 ------------MTTTVSVAGSWINGAAHSTG----GRQHAVINPATQET
Mb0467|M.bovis_AF2122/97 MTVFSRPGSAGALMSYESRYQNFIGGQWVAPV---HGRYFENPTPVTGQP
Rv0458|M.tuberculosis_H37Rv MTVFSRPGSAGALMSYESRYQNFIGGQWVAPV---HGRYFENPTPVTGQP
TH_3284|M.thermoresistible__bu -------------MSFESRYDNFIGGEWVAPV---GGEYFENPSPVTGQP
MAV_1897|M.avium_104 ---MTDTTISNGVTEQLVHFDLVIGGESVAAE---SGRTYDSIDPYTALP
MLBr_02573|M.leprae_Br4923 -------------------------------------MSIATINPATGET
*
Mvan_2580|M.vanbaalenii_PYR-1 YGTAPVSNEQDIDNAYAAAARAFKE-WKKTTPSQRQKALLDFADEVERNA
Mflv_3819|M.gilvum_PYR-GCK YGTAPVSNEQDIDNAYAAASGAFKE-WKKTTPSQRQKALLDFADEVERNA
MMAR_2610|M.marinum_M YASAPNSSGKDVDDAFTAAAKAFES-WRWSTPSERQRALLRLADLIEDNA
MAB_4203|M.abscessus_ATCC_1997 VGRAPVSNLEDVNAAVAAAERAFES-WGRSTPSFRQQALLKLADAIEAHT
MSMEG_1665|M.smegmatis_MC2_155 VSEYNLATAADVDTAVAAARAAFPA-WAGATPAERSAVLAKLAKLADEHA
MUL_2789|M.ulcerans_Agy99 IAELALATPADVDHAVVAARRALPQ-WAGVTTAERSAVLAELADLLEQRA
Mb0467|M.bovis_AF2122/97 FCEVPRSDAADIDKALDAAHAAAPG-WGKTAPAERAAILNMIADRIDKNA
Rv0458|M.tuberculosis_H37Rv FCEVPRSDAADIDKALDAAHAAAPG-WGKTAPAERAAILNMIADRIDKNA
TH_3284|M.thermoresistible__bu FCEVARSTEADIDKALDAAHAAAPA-WGKTAPAERALILNRIADRIEANL
MAV_1897|M.avium_104 WARVPDCGPADVDRAVAAARAALRGPWGQLTGTARGKLLWRLGELIAREA
MLBr_02573|M.leprae_Br4923 VKTFTPTTQDEVEDAIARAYARFDN-YRHTTFTQRAKWANATADLLEAEA
::: * * : : : * .. .
Mvan_2580|M.vanbaalenii_PYR-1 DALVAAEGRNTGKPDHVTAAEEIPPMVDQIRFFAGAARVLEGK-SAGEYM
Mflv_3819|M.gilvum_PYR-GCK DALVAAEGRNTGKPNHVTTVEEIPPMVDQIRFFAGAARVLEGK-SAGEYM
MMAR_2610|M.marinum_M EELVALECENTGKPISLTMSEEIPPMVDQIRFFAGAARVLEGR-SQGEYM
MAB_4203|M.abscessus_ATCC_1997 DEIVDAQCRNTGQPKAVIAAEEVAVSADQIRFFAGAARLVEGK-SAGEYM
MSMEG_1665|M.smegmatis_MC2_155 EQFVAEEVSQTGKPVRLATEFDVPGSVDNIDFFAGAARHLEGK-ATAEYS
MUL_2789|M.ulcerans_Agy99 PELIAEEVCQTGKPLRLAEEFDVPGSVDNIRFFAGAARRLPGQ-ATAEYS
Mb0467|M.bovis_AF2122/97 AALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGA-LSQID-
Rv0458|M.tuberculosis_H37Rv AALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGA-LSQID-
TH_3284|M.thermoresistible__bu ESIALAESWDNGKPIRETLNADIPLAVDHFRYFAGAIRAQEGS-LSQID-
MAV_1897|M.avium_104 ESLAELEVRDGGKLVREMIG-QMKALPDYYIYYAGLADKLQGE-VVPVDK
MLBr_02573|M.leprae_Br4923 NQSAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAV
: *: : . : .
Mvan_2580|M.vanbaalenii_PYR-1 ADHTSWIRREPIGVIGQVAPWNYPMMMAIWKICPAIAAGNTVVIKPSDTT
Mflv_3819|M.gilvum_PYR-GCK ADHTSWIRREPVGVIGQVAPWNYPMMMAIWKICPAVAAGNTVVIKPSDTT
MMAR_2610|M.marinum_M RGHTSSIRREPVGPVAQVAPWNYPMMMAVWKFAPALAAGCTVVLKPSDTT
MAB_4203|M.abscessus_ATCC_1997 EGFTSYVRREPIGVVGQVTPWNYPFMMAIWKIGPALAAGNTVVLKPSDTT
MSMEG_1665|M.smegmatis_MC2_155 GDHTSSIRREAVGVVATITPWNYPLQMAVWKVIPALAAGCAVVIKPAEIT
MUL_2789|M.ulcerans_Agy99 ADHTSSIRREAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELT
Mb0467|M.bovis_AF2122/97 EDTVAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVLKPAEQT
Rv0458|M.tuberculosis_H37Rv EDTVAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVLKPAEQT
TH_3284|M.thermoresistible__bu DDTVAYHFHEPLGVVGQIIPWNFPILMATWKLAPALAAGNAVVLKPAEQT
MAV_1897|M.avium_104 PNFFVYTRHEPVGVVGAITPWNSPLLLLTWKLAAGLAAGCTFVVKPSDHT
MLBr_02573|M.leprae_Br4923 GASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNV
:.:* : : *** *: ..: ** . ::* :. .
Mvan_2580|M.vanbaalenii_PYR-1 PVTTVMLAELAAKY-LPAGVLNVVTGD-RVTGASLVAHPTPEMVAITGSV
Mflv_3819|M.gilvum_PYR-GCK PVTTVMLAELAAKH-LPPGVLNVVTGD-RVTGANLVSHPTPEMVAITGSV
MMAR_2610|M.marinum_M PASSYWMVEKMQEI-FPPGVCNLVCGD-RDTGAALVAHPVPQLVSITGST
MAB_4203|M.abscessus_ATCC_1997 PESTLVLARLTKGI-LPDGVFNVVLGT-AATGSDLVSHPAIGLVSITGSV
MSMEG_1665|M.smegmatis_MC2_155 PLTTLTLARLASEAGLPDGVFNVVTGSGAEVGTALAGHRDVDVVTFTGST
MUL_2789|M.ulcerans_Agy99 PLTTLTLARLAAEAGLPDGVLNVVTGLGADVGAALAAHPGVDLVTFTGST
Mb0467|M.bovis_AF2122/97 PASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKVAFTGET
Rv0458|M.tuberculosis_H37Rv PASVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKVAFTGET
TH_3284|M.thermoresistible__bu PASVMYLMSLIGDL-LPPGVVNVVNGFGVEAGKPLASSNRIAKIAFTGET
MAV_1897|M.avium_104 PASTLAFAKLFAEAGFPPGVINVVTGWGPQTGAALAAHPDVDKIAFTGST
MLBr_02573|M.leprae_Br4923 PQCALYLADVIARGGFPEDCFQTLLIS-ANGVEAILRDPRVAAATLTGSE
* : :* . : : : ::**.
Mvan_2580|M.vanbaalenii_PYR-1 AAGKAVAVSAGGNLKRTHLELGGKAPVIVFDD--ADLAAAAEGIATA---
Mflv_3819|M.gilvum_PYR-GCK AAGKAVAVSAGGNLKRTHLELGGKAPVIVFDD--ADLAATAEGIATA---
MMAR_2610|M.marinum_M RAGMAVAASAANDLKRAHLELGGKAPVVIFND--ADIAAAVEGLTAA---
MAB_4203|M.abscessus_ATCC_1997 RAGIAVATSAAGQLKRSHLELGGKAPAVVFGD--VDIDKAALGIAQA---
MSMEG_1665|M.smegmatis_MC2_155 AVGRKVMASAAVHGHRTQLELGGKAPFVVFSD--ADLDAAVQGAVAG---
MUL_2789|M.ulcerans_Agy99 AVGRKVMAAAATHGRRTQLELGGKAPFVVFDD--ADLDAAIQGAVAG---
Mb0467|M.bovis_AF2122/97 TTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTM
Rv0458|M.tuberculosis_H37Rv TTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTM
TH_3284|M.thermoresistible__bu TTGRLIMQYASQNLIPVTLELGGKSPNIFFADVMAASDDFCDKALEGFTM
MAV_1897|M.avium_104 ATGISVGKAAIDNMTRFTLELGGKSAQVVFDD--ADLDAAANGVIAG--V
MLBr_02573|M.leprae_Br4923 PAGQAVGAIAGNEIKPTVLELGGSDPFIVMPS--ADLDAAVATAVTG---
.* : * . *****. . :.: . . .
Mvan_2580|M.vanbaalenii_PYR-1 GYFNAGQDCTAATRVLASASIAADLTAALAEQAKGATTTFGRAAGDEDAW
Mflv_3819|M.gilvum_PYR-GCK GYFNAGQDCTAATRVLASASIAADLTAALAEQAKGATTTFGRPADDEDAW
MMAR_2610|M.marinum_M GYFNAGQDCTAATRLIIQDGIYDEFLSAMAESVAGTRT--GYDPADEDIL
MAB_4203|M.abscessus_ATCC_1997 AFFNAGQDCTAATRVIVHESIHDDFVNALDTAAQTLRP---GLPDDPDSF
MSMEG_1665|M.smegmatis_MC2_155 ALINTGQDCTAATRAIVARELYDDFVAGVAEVMGKIVVG---DPHDPDTD
MUL_2789|M.ulcerans_Agy99 AVINSGQDCTAATRAIVARELCHDFVAGVADVMSTVVIG---DPMDPDTD
Mb0467|M.bovis_AF2122/97 FALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQG---DPLDTETM
Rv0458|M.tuberculosis_H37Rv FALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQG---DPLDTETM
TH_3284|M.thermoresistible__bu FALNQGEVCTCPSRSLIQADIYDEFLELATIRTKAVRQG---DPLDTETM
MAV_1897|M.avium_104 FAAT-GQTCLAGSRLLVHESVADALVERIVARASTIKLG---DPKDPATE
MLBr_02573|M.leprae_Br4923 RVQNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVG---DPTDPDTD
. *: * . .* : : : . *
Mvan_2580|M.vanbaalenii_PYR-1 VPPVNNVNQMERVLSFFSDIPSH-ATVAVGGN----RQGDKG-FYVEPTV
Mflv_3819|M.gilvum_PYR-GCK VPPVNNVNQMERVLSFFSDIPSH-ATVAVGGN----RQGDKG-FYVEPTV
MMAR_2610|M.marinum_M FGPINNSNQMRHIDGLVSRAPAH-ARILAGGK----QKDCAG-FFYEPTL
MAB_4203|M.abscessus_ATCC_1997 YGPMNNINHFTTVTEKLDNLPAH-ATVVTGGK----RWGETG-YFIEPTI
MSMEG_1665|M.smegmatis_MC2_155 LGPLISYAHRDKVAGMVARAPQQGGRVVTGGE----APDLPG-AFYRPTL
MUL_2789|M.ulcerans_Agy99 IGPLISLAHRDRVADILAKAPAQGARIVVGGR----IPDLAG-AFYLPTL
Mb0467|M.bovis_AF2122/97 LGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTI
Rv0458|M.tuberculosis_H37Rv LGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTI
TH_3284|M.thermoresistible__bu VGAQASNDQLEKILSYIDIGRSEGATVVTGGERAELGGDLSGGYYVQPTI
MAV_1897|M.avium_104 MGPVSNQPQYEKVLSHFASAREQGATVAYGGE---PAGELGG-FFVKPTV
MLBr_02573|M.leprae_Br4923 VGPLATESGRAQVEQQVDAAAAAGAVIRCGGK----RPDRPG-WFYPPTV
. . : . . : **. * : **:
Mvan_2580|M.vanbaalenii_PYR-1 IGGLRQADRLIQQEIFGPVITVQSFSDEEEAIGWANGVEYGLASSVWTKD
Mflv_3819|M.gilvum_PYR-GCK VGGLRQDDRLIQQEIFGPVITVQSFTDEDEAIGYANGVEYGLASSVWTKD
MMAR_2610|M.marinum_M IVDLQQDDELIQTEIFGPVVTAQRFSDEQQALSFANGTEYGLASSVWTKD
MAB_4203|M.abscessus_ATCC_1997 VTGVRQDDAIVQEETFGPILTVQSFADAGEALRLANGVRYALASSVWTKD
MSMEG_1665|M.smegmatis_MC2_155 IADVDESSEVYRDEIFGPVLTVRSFTDDDDALRQANDTEYGLAASAWTRD
MUL_2789|M.ulcerans_Agy99 LADVGEQSQAYREEIFGPVLTVRAHDGDDDALRQANDTDYGLAASAWTRD
Mb0467|M.bovis_AF2122/97 FTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRD
Rv0458|M.tuberculosis_H37Rv FTGTN-NMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRD
TH_3284|M.thermoresistible__bu FTGDN-SMRIFQEEIFGPVVAVTSFTDYDDAIRIANDTLYGLGAGVWSRD
MAV_1897|M.avium_104 LTGVDRSMRAVAEEVFGPVLAVMTFTDEDEAIAAANDTEFGLAAGVWTKD
MLBr_02573|M.leprae_Br4923 ITDITKDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQN
. . * ***: :. . :*: ** . :.*.:..*:::
Mvan_2580|M.vanbaalenii_PYR-1 VSRALRVSNALDFGCVWINTHIPLVAEMPHGGFKSSGHGKDLSMYGLEDY
Mflv_3819|M.gilvum_PYR-GCK VSRALRVSNALDFGCVWINTHIPLVAEMPHGGFKSSGHGKDLSMYGLEDY
MMAR_2610|M.marinum_M VDTAARMGARLDFGCVWINTHIPLVAEMPHGGFKHSGYGKDLSMYGFEDY
MAB_4203|M.abscessus_ATCC_1997 HATAETFTRELNFGCVWVNCHIPLVAEMPHGGFKYSGYGKDLSAYSVEDY
MSMEG_1665|M.smegmatis_MC2_155 VYRAQRASREINAGCVWINDHIPIISEMPHGGVGASGFGKDMSDYSFEEY
MUL_2789|M.ulcerans_Agy99 VYRAQRASREISAGCVWINDHIPIVSEMPHGGVAASGFGNDMSEYSFDEY
Mb0467|M.bovis_AF2122/97 GNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQMMLQHY
Rv0458|M.tuberculosis_H37Rv GNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQMMLQHY
TH_3284|M.thermoresistible__bu GNTAYRAGRDIKAGRVWTNCYHVYPAHAAFGGYKQSGIGRENHTMMLDHY
MAV_1897|M.avium_104 VHRAHRVAARLNAGTVWVNAYRVVSPHVPFGGMGHSGIGRENGIDAVKDF
MLBr_02573|M.leprae_Br4923 ESEQRHFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREF
: * *: * .. ..** ** *.: . .:
Mvan_2580|M.vanbaalenii_PYR-1 TRIKHVMAYTG----------------
Mflv_3819|M.gilvum_PYR-GCK TRIKHVMAYTG----------------
MMAR_2610|M.marinum_M TRIKHVMHYHGFEG-------------
MAB_4203|M.abscessus_ATCC_1997 TRIKHIMSAHA----------------
MSMEG_1665|M.smegmatis_MC2_155 LTIKHVMSDITGVAEKEWHRTIFNKR-
MUL_2789|M.ulcerans_Agy99 LTIKHVMSDITGVAEKPWHRTIFSTRI
Mb0467|M.bovis_AF2122/97 QHTKNLLVSYSDKALGFF---------
Rv0458|M.tuberculosis_H37Rv QHTKNLLVSYSDKALGFF---------
TH_3284|M.thermoresistible__bu QQTKNLLVSYSTKAQGFF---------
MAV_1897|M.avium_104 TETKAVWVELSGATRDPFTLG------
MLBr_02573|M.leprae_Br4923 CNIKTVWIA------------------
* :