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VSTAVPARYCVVGGGISGLVAAYRLRVAAGPDASITLLDPADRLGGVLRTERIGGQLLDVGAEAFVARRP EVPALLGELGLSGRQIVPSGARPLIYSEGRLHPLPKDTVQGIPSRPEALAGLVDDATIRWMLDEPRRPFS WCQGADPSVAELVGDRFGEQVVIRSVDPLLSGVYAGSAATIGIRAGAPTVAAALDGGARSLTEAVTRALP PPQAGAVFGAIDGGYQVLVDELVRRSWLEWAQVSVRSVGRGARGWEVLDDEGTRWPADAVVLAVPAPRLP ALVADIAPRTAAAARRIPVASAAVVALALPGGTPLPEQSGVLVAGQGRLRAKAVTLSSKKWGRRANVEMV RLSYGRFGDDLARSTGDEDLLAWAAQDLSVLFGISVDPVDSRVVRWIDALPQYGPGHAALVAELRAGLPG GLAVAGAYLDGIGVPACVAAATRAVAALVVDGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2482 | - | - | 100% (453) | protoporphyrinogen oxidase |
| M. vanbaalenii PYR-1 | Mvan_1178 | - | 1e-06 | 35.42% (96) | amine oxidase |
| M. vanbaalenii PYR-1 | Mvan_5578 | - | 7e-05 | 35.44% (79) | amine oxidase (flavin-containing) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2696c | hemY | 1e-167 | 67.57% (444) | protoporphyrinogen oxidase |
| M. gilvum PYR-GCK | Mflv_3918 | - | 0.0 | 82.51% (446) | protoporphyrinogen oxidase |
| M. tuberculosis H37Rv | Rv2677c | hemY | 1e-167 | 67.57% (444) | protoporphyrinogen oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 1e-165 | 66.36% (440) | protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_2985c | - | 1e-138 | 56.76% (444) | protoporphyrinogen oxidase |
| M. marinum M | MMAR_2039 | hemY | 1e-163 | 65.10% (447) | protoporphyrinogen oxidase HemY |
| M. avium 104 | MAV_3890 | - | 2e-05 | 32.33% (133) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2781 | hemG | 0.0 | 73.56% (450) | protoporphyrinogen oxidase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3311 | hemY | 1e-162 | 64.88% (447) | protoporphyrinogen oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2482|M.vanbaalenii_PYR-1 ----------------------MSTAVPARYCVVGGGISGLVAAYRLRV-
Mflv_3918|M.gilvum_PYR-GCK ------------------------MSVAARYCVVGGGISGLVAAYRLRV-
MSMEG_2781|M.smegmatis_MC2_155 --------------------------MTMRFCVVGGGISGLVAAYRLRR-
MMAR_2039|M.marinum_M -------------------------MTPGSYCVVGGGISGLTAAFRLRL-
MUL_3311|M.ulcerans_Agy99 -------------------------MTPGSYCVVGGGISGLTAAFRLRL-
Mb2696c|M.bovis_AF2122/97 -------------------------MTPRSYCVVGGGISGLTSAYRLRQ-
Rv2677c|M.tuberculosis_H37Rv -------------------------MTPRSYCVVGGGISGLTSAYRLRQ-
MLBr_01044|M.leprae_Br4923 -------------------------MTSRSYCVVGGGISGLTAAYRLRV-
MAB_2985c|M.abscessus_ATCC_199 --------------------MTPQPSGSPSIAIVGGGISGLTAAYRLRR-
MAV_3890|M.avium_104 MTAGATDRRRRILPAPTGLPDAGALPSRPRVAVVGGGIAGLTAATGLAER
.:*****:**.:* *
Mvan_2482|M.vanbaalenii_PYR-1 AAGPDASITLLDPADRLGGVLRTERIGGQLLDVGAEAFVARRPEVPALLG
Mflv_3918|M.gilvum_PYR-GCK AAGPDAVITVLDPADRLGGILRTERIGGQAIDVGAEAFVARRPEVPALLG
MSMEG_2781|M.smegmatis_MC2_155 AAGPHADITLLDPADRLGGILRTERVGGQWLDVGAEAFVARRPEMPALLA
MMAR_2039|M.marinum_M AVGEDALITLLDPSDRLGGILRTERVGGQPMDLGAEAFVVRRPEMPALLA
MUL_3311|M.ulcerans_Agy99 AVGEDALITLLDPSDRLGGILRTERVGGQPMDLGAEAFVVRRPEMPALLA
Mb2696c|M.bovis_AF2122/97 AVGDDATITLFEPADRLGGVLRTEHIGGQPMDLGAEAFVLRRPEMPALLA
Rv2677c|M.tuberculosis_H37Rv AVGDDATITLFEPADRLGGVLRTEHIGGQPMDLGAEAFVLRRPEMPALLA
MLBr_01044|M.leprae_Br4923 ATGDDVAITLFDPGDRLGGVLRTECVGGQPMDLGAEAFLLRRPEVPALLA
MAB_2985c|M.abscessus_ATCC_199 ELGDDARISLYDPAGQLGGILRTITLGEHRIDIGAEAFITRRPEVLDLLD
MAV_3890|M.avium_104 GVAVEVIEREHYLGGRVGGWTEHHDGTDLAMNRGFHAFFRQYYNLRALLA
. .. ..::** . :: * .**. : :: **
Mvan_2482|M.vanbaalenii_PYR-1 ELGLSGRQIVPSGARPLIYSEGRLHPLP----KDTVQGIPSRPEALAGLV
Mflv_3918|M.gilvum_PYR-GCK ELGLSGRQITTTGARPLIYSEGRLHQLP----TDTVNGIPSRPSALSGLV
MSMEG_2781|M.smegmatis_MC2_155 ELGLAGRQIATSGARPLIYSGARLHPLP----QGTLQGIPAQASSLLGLV
MMAR_2039|M.marinum_M ELGLSGLQRSTTGARPLIYSCQELHPLP----TGTVMGIPASARSLAGLV
MUL_3311|M.ulcerans_Agy99 ELGLSGLQRSTTGARPLIYSCQELHPLP----TGTVMGIPASARSLADLV
Mb2696c|M.bovis_AF2122/97 ELGLSDRQLASTGARPLIYSQQRLHPLP----PQTVVGIPSSAGSMAGLV
Rv2677c|M.tuberculosis_H37Rv ELGLSDRQLASTGARPLIYSQQRLHPLP----PQTVVGIPSSAGSMAGLV
MLBr_01044|M.leprae_Br4923 ELGLSERQRATTDARPLIYSQQRLHSLP----PDTVAGIPSSATSVAGLV
MAB_2985c|M.abscessus_ATCC_199 ELGLADRTLDTTGARPLIYAGGGLHPLP----ARTVNGIPASASSVVGLV
MAV_3890|M.avium_104 RLDPRLRMLVPVNDYPLIDAAGRRDSFRGLPRTPPLNAMAFAVRSPTFRL
.*. . . *** : . : .: .:. : :
Mvan_2482|M.vanbaalenii_PYR-1 DDATIRWMLDEPRRPFSWCQGADPSVAELVGDRFGEQV-VIRSVDPLLSG
Mflv_3918|M.gilvum_PYR-GCK DDATVRWMLDEPRRPLVWRSGADPTVAELVGERFGEQV-VVRSVDPLLAG
MSMEG_2781|M.smegmatis_MC2_155 DDATVAQIIDERARPFAWRPGSDPSVADVVGDRFGMQV-VYRSVDPLLTG
MMAR_2039|M.marinum_M DDATIAQIEAEPDRPLHWRPGGDPAVAELVAERFGEQT-VTRSVDPLLCG
MUL_3311|M.ulcerans_Agy99 DDATIAQIEAEPDRPLHWRPGGDPAVAELVAERFGEQT-VTRSVDPLLCG
Mb2696c|M.bovis_AF2122/97 DDATLARIDAEAARPFTWQVGSDPAVADLVADRFGDQV-VARSVDPLLSG
Rv2677c|M.tuberculosis_H37Rv DDATLARIDAEAARPFTWQVGSDPAVADLVADRFGDQV-VARSVDPLLSG
MLBr_01044|M.leprae_Br4923 DDATVARIGAEAVRPLSWEPGSDPAMAELVADRFGEQA-VARLVDPLLGG
MAB_2985c|M.abscessus_ATCC_199 DEETVARIDSEPQRDMHWTVGAEPTVADLVALRFGPQV-VARLVDPLLGG
MAV_3890|M.avium_104 RDFARIDARAAAPLAAVSVPGTYRRLDHIDAATFLEDIRFPEAARHLAFE
: : * : .: . * : . . . *
Mvan_2482|M.vanbaalenii_PYR-1 VYAGSAATIGIRAGAPTVAAALDGGARSLTEAVTRALPPPQAGAVFGAID
Mflv_3918|M.gilvum_PYR-GCK VYAGSAATIGMRAAAPTVAAALDNGARSLTEAVVAALPPPRAGSVFGAID
MSMEG_2781|M.smegmatis_MC2_155 VYAGSSATIGLRSAVPTLAAALDRGAPSLTDAVRDALPPPVTGSVFGALD
MMAR_2039|M.marinum_M VYAGSAATIGVRAAIPAVAAALDRGATSLTEAVRQSLPPASVGPVFGALT
MUL_3311|M.ulcerans_Agy99 VYAGSAATIGVRAAIPAVAAALDRGATSLTEAVRQSLPPASAGPVFGALT
Mb2696c|M.bovis_AF2122/97 VYAGSAATIGLRAAAPSVAAALDRGATSVTDAVRQALPPGSGGPVFGALD
Rv2677c|M.tuberculosis_H37Rv VYAGSAATIGLRAAAPSVAAALDRGATSVTDAVRQALPPGSGGPVFGALD
MLBr_01044|M.leprae_Br4923 VYAGSAATIGLRAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALD
MAB_2985c|M.abscessus_ATCC_199 VYAGSAATTGLRTAAPGIARALDEGAGSLLAAARQALPPISDSGIFGAVD
MAV_3890|M.avium_104 VFSRSFFADPAKLSAAELATMFHIYFLGSAEGLIFDVPSAN-------YD
*:: * : : . . :* :. . . :*.
Mvan_2482|M.vanbaalenii_PYR-1 GGYQVLVDELVRRSWLEWAQVSVRSVGRGARGWEVLDDEGTRWPADAVVL
Mflv_3918|M.gilvum_PYR-GCK GGYQVLLDELVRRSGLQWAQVAARGVHPVRAGWEVVDDEGGHWPADAVVL
MSMEG_2781|M.smegmatis_MC2_155 GGYRVLLEELQRRAAVRWAQVTAVRVDRDANGWLVFDDEGTNWNADGVVL
MMAR_2039|M.marinum_M GGYQVLVEELVARSGVQWVQAAVSKIEP---GWALHDDAGRRWHADAVIL
MUL_3311|M.ulcerans_Agy99 GGYQVLVEELVARSGVQWVQAAVSKIEP---GWALHDDAGRRWHADAVIL
Mb2696c|M.bovis_AF2122/97 GGYQVLLDGLVRRSRVHWVRARVVQLER---GWVLRDETGGRWQADAVIL
Rv2677c|M.tuberculosis_H37Rv GGYQVLLDGLVRRSRVHWVRARVVQLER---GWVLRDETGGRWQADAVIL
MLBr_01044|M.leprae_Br4923 GGYQVLIDELVRRSRLQWVAATVVGLDRGTCGWTLVDDTGACWSADGVIL
MAB_2985c|M.abscessus_ATCC_199 GGYAVLVEELWSRARAEHVQVAVTGIERDGAGWAVTGEGGLTDAVDAVIV
MAV_3890|M.avium_104 SALWQPLRSYLEQRHVRFRLGTSVGSIDAANRFAVHTDTDEELEVDAVVL
.. : : . : : : . .*.*::
Mvan_2482|M.vanbaalenii_PYR-1 AVPAPRLPALVA---DIAPRTAAAARRIPVASAAVVALALPGGTPLPEQS
Mflv_3918|M.gilvum_PYR-GCK AVPAPRLPALLA---ELAPHSADIARRIPVASAAVVALALPGGTPLPEQS
MSMEG_2781|M.smegmatis_MC2_155 AVPAPALPALIE---HVAPRTAAAARRIRVASAAVVALALPGGTPIPQQS
MMAR_2039|M.marinum_M AIPAPRLVRILDGVDGVDPRSVAAASRVRSASSAVVALAVPADTPFPQCS
MUL_3311|M.ulcerans_Agy99 AIPAPRLVRILDGVDGVDPRSVAAASRVRSASSAVVALAVPADTPFPQCS
Mb2696c|M.bovis_AF2122/97 AVPAPRLARLVD---GIAPRTHAAARQIVSASSAVVALAVPGGTAFPHCS
Rv2677c|M.tuberculosis_H37Rv AVPAPRLARLVD---GIAPRTHAAARQIVSASSAVVALAVPGGTAFPHCS
MLBr_01044|M.leprae_Br4923 AVPAPRLVRLLQ---QIAPRTVAAASRIVSASSAVVALSVPRDTTFPQNS
MAB_2985c|M.abscessus_ATCC_199 AVPAPRAAAILE---AVAPESAAAARTIPVASSVVVALTLPGDAPIPANS
MAV_3890|M.avium_104 ATDVAGLQRIVAASRGLANGEWRDRIAGLRTAPPFAVHRFWLDRPVSPRR
* .. :: : ::. ... . . ...
Mvan_2482|M.vanbaalenii_PYR-1 GVLVAG----------------------QGRLRAKAVTLSSKKWGRRA-N
Mflv_3918|M.gilvum_PYR-GCK GVLVAG----------------------RGPLHTKAVTLSSRKWGRRG-S
MSMEG_2781|M.smegmatis_MC2_155 GVLVATG--------------------EAGSLNAKAVTLSSRKWGRRG-N
MMAR_2039|M.marinum_M GVLVAN----------------------GEPLRAKAITLSSRKWGIQG-D
MUL_3311|M.ulcerans_Agy99 GVLVAN----------------------GEPLRAKAITLSSRKWGIQG-D
Mb2696c|M.bovis_AF2122/97 GVLVAG----------------------DESPHAKAITLSSRKWGQRG-D
Rv2677c|M.tuberculosis_H37Rv GVLVAG----------------------DESPHAKAITLSSRKWGQRG-D
MLBr_01044|M.leprae_Br4923 GVLVAS----------------------GERLRAKAVTLSSRKWGLQG-D
MAB_2985c|M.abscessus_ATCC_199 GVLVAS----------------------GEALHTKAITFSTSKWGLRGRS
MAV_3890|M.avium_104 PAFLGTAGHKPLDNISVLDRYEREARAWAGAHHGSVVELHSYALDSAPSG
.::. . ..: : : . .
Mvan_2482|M.vanbaalenii_PYR-1 VEMVRLSYGRFGDDLARSTGDEDLLAWAAQDLSVLFGISVDPVDSRVVRW
Mflv_3918|M.gilvum_PYR-GCK AEMLRLSYGRFGDDLARSTGDDELLAWADEDLATLFGIAVEPVDARVVRW
MSMEG_2781|M.smegmatis_MC2_155 VELLRLSFGRYGDDLARSTGDEDLLAWSTRDLNTLFGITVDPVDWHIQRW
MMAR_2039|M.marinum_M VQQLRISFGRFGDDLAERVSDHQLLSWARDDLATVFGVTVDPVDSRVQRW
MUL_3311|M.ulcerans_Agy99 VQQLRISFGRFGDDLAERVSDHQLLSWARDDLATVFGVTVDPVDSRVQRW
Mb2696c|M.bovis_AF2122/97 VALLRLSFGRFGDEPALTASDDQLLAWAADDLVTVFGVAVDPVDVRVRRW
Rv2677c|M.tuberculosis_H37Rv VALLRLSFGRFGDEPALTASDDQLLAWAADDLVTVFGVAVDPVDVRVRRW
MLBr_01044|M.leprae_Br4923 TQLVRLSFGKFGDQVASTASDDELLAWAVSDLAAVFDVTVDPVDVCVQRW
MAB_2985c|M.abscessus_ATCC_199 TQVVRLSYGRFGDTVARATTDEQLRHWAVADLEAVLGAGIVPVNSAVARW
MAV_3890|M.avium_104 AAALRELRRIYPETAAAQIVHETLLHRSDCPLFAPGGYPHRPTVVTPTPG
. :* : : * .. * : * . . *.
Mvan_2482|M.vanbaalenii_PYR-1 IDALPQYGPGHAALVAELRAGLPGGLAVAGAYLDGIGVP----ACVAAAT
Mflv_3918|M.gilvum_PYR-GCK IDAMPQYGPGHADRVADLRAGLPRGLAVAGAYLDGIGVP----ACVASAA
MSMEG_2781|M.smegmatis_MC2_155 IDAMPQYGPGHLDLVAELRAGLPPNLAVTGSYLDGIGVP----ACVGAAT
MMAR_2039|M.marinum_M IEAMPQYGPGHGELVAQVRAGLPPTLAVAGSYLDGIGVP----ACVGAAS
MUL_3311|M.ulcerans_Agy99 IEAMPRYGPGHGVLVAQVRAGLPPTLAVAGSYLDGIGVP----ACVGAAS
Mb2696c|M.bovis_AF2122/97 IEAMPQYGPGHADVVAELRAGLPPTLAVAGSYLDGIGVP----ACVGAAG
Rv2677c|M.tuberculosis_H37Rv IEAMPQYGPGHADVVAELRAGLPPTLAVAGSYLDGIGVP----ACVGAAG
MLBr_01044|M.leprae_Br4923 IDAMPQYGPGHADLVAEVRAGLPPTLVVAGSHMDGIGVP----ACISAAG
MAB_2985c|M.abscessus_ATCC_199 IDAMPQYGPGHAEVVDAIRSGLPSGIAVAGSYLDGIGVP----ACVASAS
MAV_3890|M.avium_104 LLLASDTVR-IDLPVALMERAATTGWSAANHLLKRWGLAGHPLVTVPTEG
: . * :. . . .:. :. *:. . : :
Mvan_2482|M.vanbaalenii_PYR-1 RAVAALVVDGR------
Mflv_3918|M.gilvum_PYR-GCK RAVASLVAGSSVGQ---
MSMEG_2781|M.smegmatis_MC2_155 RAALTLVKTGVAR----
MMAR_2039|M.marinum_M RAVDGIVGALNPQVAR-
MUL_3311|M.ulcerans_Agy99 RAVDGVVGALNPQVAR-
Mb2696c|M.bovis_AF2122/97 RAVTSVIEALDAQVAR-
Rv2677c|M.tuberculosis_H37Rv RAVTSVIEALDAQVAR-
MLBr_01044|M.leprae_Br4923 R----AIEALQAEVAR-
MAB_2985c|M.abscessus_ATCC_199 QAAQASVARWRHG----
MAV_3890|M.avium_104 RSRLLRWLANREGATRS
: