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TPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGVLRTEHIGGQPMDLGAEAFVLRRPEMPA LLAELGLSDRQLASTGARPLIYSQQRLHPLPPQTVVGIPSSAGSMAGLVDDATLARIDAEAARPFTWQVG SDPAVADLVADRFGDQVVARSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRGATSVTDAVRQALPPGSG GPVFGALDGGYQVLLDGLVRRSRVHWVRARVVQLERGWVLRDETGGRWQADAVILAVPAPRLARLVDGIA PRTHAAARQIVSASSAVVALAVPGGTAFPHCSGVLVAGDESPHAKAITLSSRKWGQRGDVALLRLSFGRF GDEPALTASDDQLLAWAADDLVTVFGVAVDPVDVRVRRWIEAMPQYGPGHADVVAELRAGLPPTLAVAGS YLDGIGVPACVGAAGRAVTSVIEALDAQVAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2677c | hemY | - | 100% (452) | protoporphyrinogen oxidase |
| M. tuberculosis H37Rv | Rv0449c | - | 9e-07 | 25.91% (328) | hypothetical protein Rv0449c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2696c | hemY | 0.0 | 100.00% (452) | protoporphyrinogen oxidase |
| M. gilvum PYR-GCK | Mflv_3918 | - | 1e-165 | 66.89% (441) | protoporphyrinogen oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 0.0 | 75.38% (455) | protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_2985c | - | 1e-138 | 58.24% (443) | protoporphyrinogen oxidase |
| M. marinum M | MMAR_2039 | hemY | 0.0 | 73.19% (455) | protoporphyrinogen oxidase HemY |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2781 | hemG | 1e-168 | 67.12% (444) | protoporphyrinogen oxidase |
| M. thermoresistible (build 8) | TH_0685 | - | 7e-06 | 27.21% (294) | PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE |
| M. ulcerans Agy99 | MUL_3311 | hemY | 0.0 | 72.97% (455) | protoporphyrinogen oxidase |
| M. vanbaalenii PYR-1 | Mvan_2482 | - | 1e-167 | 67.57% (444) | protoporphyrinogen oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3918|M.gilvum_PYR-GCK ----MSVAARYCVVGGGISGLVAAYRLRVAAGPDAVITVLDPADRLGGIL
Mvan_2482|M.vanbaalenii_PYR-1 --MSTAVPARYCVVGGGISGLVAAYRLRVAAGPDASITLLDPADRLGGVL
MSMEG_2781|M.smegmatis_MC2_155 ------MTMRFCVVGGGISGLVAAYRLRRAAGPHADITLLDPADRLGGIL
Rv2677c|M.tuberculosis_H37Rv -----MTPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGVL
Mb2696c|M.bovis_AF2122/97 -----MTPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGVL
MLBr_01044|M.leprae_Br4923 -----MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVL
MMAR_2039|M.marinum_M -----MTPGSYCVVGGGISGLTAAFRLRLAVGEDALITLLDPSDRLGGIL
MUL_3311|M.ulcerans_Agy99 -----MTPGSYCVVGGGISGLTAAFRLRLAVGEDALITLLDPSDRLGGIL
MAB_2985c|M.abscessus_ATCC_199 MTPQPSGSPSIAIVGGGISGLTAAYRLRRELGDDARISLYDPAGQLGGIL
TH_0685|M.thermoresistible__bu -------VVDVVVVGAGFAGLTAAREL---TGLGYEVVVFEGRDRVGGRS
:**.*::**.:* .* * : : : .::**
Mflv_3918|M.gilvum_PYR-GCK RTERIGGQAIDVGAEAFVARRPEVPALLGELGLSGRQITTTGARPLIYSE
Mvan_2482|M.vanbaalenii_PYR-1 RTERIGGQLLDVGAEAFVARRPEVPALLGELGLSGRQIVPSGARPLIYSE
MSMEG_2781|M.smegmatis_MC2_155 RTERVGGQWLDVGAEAFVARRPEMPALLAELGLAGRQIATSGARPLIYSG
Rv2677c|M.tuberculosis_H37Rv RTEHIGGQPMDLGAEAFVLRRPEMPALLAELGLSDRQLASTGARPLIYSQ
Mb2696c|M.bovis_AF2122/97 RTEHIGGQPMDLGAEAFVLRRPEMPALLAELGLSDRQLASTGARPLIYSQ
MLBr_01044|M.leprae_Br4923 RTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSERQRATTDARPLIYSQ
MMAR_2039|M.marinum_M RTERVGGQPMDLGAEAFVVRRPEMPALLAELGLSGLQRSTTGARPLIYSC
MUL_3311|M.ulcerans_Agy99 RTERVGGQPMDLGAEAFVVRRPEMPALLAELGLSGLQRSTTGARPLIYSC
MAB_2985c|M.abscessus_ATCC_199 RTITLGEHRIDIGAEAFITRRPEVLDLLDELGLADRTLDTTGARPLIYAG
TH_0685|M.thermoresistible__bu YTATLAGVPVDLGATFVGPGQTAVTGLAAELGCPTVGTYHQGNNLILWRG
* :. :*:** . :. : * *** . . . :::
Mflv_3918|M.gilvum_PYR-GCK GRLHQLPTDTVNGIPSRPSALSGLVDDATVRWMLDEPRRPLVWRSGADPT
Mvan_2482|M.vanbaalenii_PYR-1 GRLHPLPKDTVQGIPSRPEALAGLVDDATIRWMLDEPRRPFSWCQGADPS
MSMEG_2781|M.smegmatis_MC2_155 ARLHPLPQGTLQGIPAQASSLLGLVDDATVAQIIDERARPFAWRPGSDPS
Rv2677c|M.tuberculosis_H37Rv QRLHPLPPQTVVGIPSSAGSMAGLVDDATLARIDAEAARPFTWQVGSDPA
Mb2696c|M.bovis_AF2122/97 QRLHPLPPQTVVGIPSSAGSMAGLVDDATLARIDAEAARPFTWQVGSDPA
MLBr_01044|M.leprae_Br4923 QRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAEAVRPLSWEPGSDPA
MMAR_2039|M.marinum_M QELHPLPTGTVMGIPASARSLAGLVDDATIAQIEAEPDRPLHWRPGGDPA
MUL_3311|M.ulcerans_Agy99 QELHPLPTGTVMGIPASARSLADLVDDATIAQIEAEPDRPLHWRPGGDPA
MAB_2985c|M.abscessus_ATCC_199 GGLHPLPARTVNGIPASASSVVGLVDEETVARIDSEPQRDMHWTVGAEPT
TH_0685|M.thermoresistible__bu ---RLKSYRSTIPTLSILELLDVSRIQWRFERLCRQIPVGEPWRAPAAHR
: . : : : : . : : * .
Mflv_3918|M.gilvum_PYR-GCK VAELVGERFGEQVVVRSVDPLLAGVYAGSAATIGMRAAAPTVAAALDNGA
Mvan_2482|M.vanbaalenii_PYR-1 VAELVGDRFGEQVVIRSVDPLLSGVYAGSAATIGIRAGAPTVAAALDGGA
MSMEG_2781|M.smegmatis_MC2_155 VADVVGDRFGMQVVYRSVDPLLTGVYAGSSATIGLRSAVPTLAAALDRGA
Rv2677c|M.tuberculosis_H37Rv VADLVADRFGDQVVARSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRGA
Mb2696c|M.bovis_AF2122/97 VADLVADRFGDQVVARSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRGA
MLBr_01044|M.leprae_Br4923 MAELVADRFGEQAVARLVDPLLGGVYAGSAATIGLRAGAPSVAAALDCGA
MMAR_2039|M.marinum_M VAELVAERFGEQTVTRSVDPLLCGVYAGSAATIGVRAAIPAVAAALDRGA
MUL_3311|M.ulcerans_Agy99 VAELVAERFGEQTVTRSVDPLLCGVYAGSAATIGVRAAIPAVAAALDRGA
MAB_2985c|M.abscessus_ATCC_199 VADLVALRFGPQVVARLVDPLLGGVYAGSAATTGLRTAAPGIARALDEGA
TH_0685|M.thermoresistible__bu LDTMSLDRWLRSVYASASTRDLMAIMARVTWGCEPHQVSMLHAARYVKAA
: : *: .. * .: * : : * .*
Mflv_3918|M.gilvum_PYR-GCK RSLTEAVVAALPPPRAGSVFG--AIDGGYQVLLDELVRRSGLQWAQVAAR
Mvan_2482|M.vanbaalenii_PYR-1 RSLTEAVTRALPPPQAGAVFG--AIDGGYQVLVDELVRRSWLEWAQVSVR
MSMEG_2781|M.smegmatis_MC2_155 PSLTDAVRDALPPPVTGSVFG--ALDGGYRVLLEELQRRAAVRWAQVTAV
Rv2677c|M.tuberculosis_H37Rv TSVTDAVRQALPPGSGGPVFG--ALDGGYQVLLDGLVRRSRVHWVRARVV
Mb2696c|M.bovis_AF2122/97 TSVTDAVRQALPPGSGGPVFG--ALDGGYQVLLDGLVRRSRVHWVRARVV
MLBr_01044|M.leprae_Br4923 TSLMEAVRQGLPPVAAGPVFG--ALDGGYQVLIDELVRRSRLQWVAATVV
MMAR_2039|M.marinum_M TSLTEAVRQSLPPASVGPVFG--ALTGGYQVLVEELVARSGVQWVQAAVS
MUL_3311|M.ulcerans_Agy99 TSLTEAVRQSLPPASAGPVFG--ALTGGYQVLVEELVARSGVQWVQAAVS
MAB_2985c|M.abscessus_ATCC_199 GSLLAAARQALPPISDSGIFG--AVDGGYAVLVEELWSRARAEHVQVAVT
TH_0685|M.thermoresistible__bu GGLGRMLDVEGGAQQDRFPAGTQQIAQRMAEELDGAEPGSRVRLGAPVRR
.: . * : :: : .
Mflv_3918|M.gilvum_PYR-GCK GVHPVRAGWEVVDDEGGHWPADAVVLAVPAPRLPALLA---ELAPHSADI
Mvan_2482|M.vanbaalenii_PYR-1 SVGRGARGWEVLDDEGTRWPADAVVLAVPAPRLPALVA---DIAPRTAAA
MSMEG_2781|M.smegmatis_MC2_155 RVDRDANGWLVFDDEGTNWNADGVVLAVPAPALPALIE---HVAPRTAAA
Rv2677c|M.tuberculosis_H37Rv QLER---GWVLRDETGGRWQADAVILAVPAPRLARLVD---GIAPRTHAA
Mb2696c|M.bovis_AF2122/97 QLER---GWVLRDETGGRWQADAVILAVPAPRLARLVD---GIAPRTHAA
MLBr_01044|M.leprae_Br4923 GLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQ---QIAPRTVAA
MMAR_2039|M.marinum_M KIEP---GWALHDDAGRRWHADAVILAIPAPRLVRILDGVDGVDPRSVAA
MUL_3311|M.ulcerans_Agy99 KIEP---GWALHDDAGRRWHADAVILAIPAPRLVRILDGVDGVDPRSVAA
MAB_2985c|M.abscessus_ATCC_199 GIERDGAGWAVTGEGGLTDAVDAVIVAVPAPRAAAILE---AVAPESAAA
TH_0685|M.thermoresistible__bu ITRNPDGTVTVHTGSGDGVTAGAVVVAVPPAHRDAIEFDP-ALPPRHTAL
: * ...*::*:*.. : : *.
Mflv_3918|M.gilvum_PYR-GCK ARRIPVASAAVVALALPGGTPLPEQSGVLVAG--RGPLHTKAVTLSSRKW
Mvan_2482|M.vanbaalenii_PYR-1 ARRIPVASAAVVALALPGGTPLPEQSGVLVAG--QGRLRAKAVTLSSKKW
MSMEG_2781|M.smegmatis_MC2_155 ARRIRVASAAVVALALPGGTPIPQQSGVLVATGEAGSLNAKAVTLSSRKW
Rv2677c|M.tuberculosis_H37Rv ARQIVSASSAVVALAVPGGTAFPHCSGVLVAG--DESPHAKAITLSSRKW
Mb2696c|M.bovis_AF2122/97 ARQIVSASSAVVALAVPGGTAFPHCSGVLVAG--DESPHAKAITLSSRKW
MLBr_01044|M.leprae_Br4923 ASRIVSASSAVVALSVPRDTTFPQNSGVLVAS--GERLRAKAVTLSSRKW
MMAR_2039|M.marinum_M ASRVRSASSAVVALAVPADTPFPQCSGVLVAN--GEPLRAKAITLSSRKW
MUL_3311|M.ulcerans_Agy99 ASRVRSASSAVVALAVPADTPFPQCSGVLVAN--GEPLRAKAITLSSRKW
MAB_2985c|M.abscessus_ATCC_199 ARTIPVASSVVVALTLPGDAPIPANSGVLVAS--GEALHTKAITFSTSKW
TH_0685|M.thermoresistible__bu PGHWPQG--MLSKAYAAYDTPFWRADGRSGEALSDDGPVFITFDVSPDEN
. . : . .:.: .* :. .*. :
Mflv_3918|M.gilvum_PYR-GCK GRRG-SAEMLRLSYGRFGDDLARSTGDD---ELLAWADEDLATLFGIAVE
Mvan_2482|M.vanbaalenii_PYR-1 GRRA-NVEMVRLSYGRFGDDLARSTGDE---DLLAWAAQDLSVLFGISVD
MSMEG_2781|M.smegmatis_MC2_155 GRRG-NVELLRLSFGRYGDDLARSTGDE---DLLAWSTRDLNTLFGITVD
Rv2677c|M.tuberculosis_H37Rv GQRG-DVALLRLSFGRFGDEPALTASDD---QLLAWAADDLVTVFGVAVD
Mb2696c|M.bovis_AF2122/97 GQRG-DVALLRLSFGRFGDEPALTASDD---QLLAWAADDLVTVFGVAVD
MLBr_01044|M.leprae_Br4923 GLQG-DTQLVRLSFGKFGDQVASTASDD---ELLAWAVSDLAAVFDVTVD
MMAR_2039|M.marinum_M GIQG-DVQQLRISFGRFGDDLAERVSDH---QLLSWARDDLATVFGVTVD
MUL_3311|M.ulcerans_Agy99 GIQG-DVQQLRISFGRFGDDLAERVSDH---QLLSWARDDLATVFGVTVD
MAB_2985c|M.abscessus_ATCC_199 GLRGRSTQVVRLSYGRFGDTVARATTDE---QLRHWAVADLEAVLGAGIV
TH_0685|M.thermoresistible__bu GPGILLGFTDARTFDPLSPDRRRDKALHGFAKLFGDAALKPIDYLDFCWG
* ::. . . .* : . :.
Mflv_3918|M.gilvum_PYR-GCK PVDARVVRWIDAMP-----QYGPGHADRVADLRAGLPRGLAVAGAYLDGI
Mvan_2482|M.vanbaalenii_PYR-1 PVDSRVVRWIDALP-----QYGPGHAALVAELRAGLPGGLAVAGAYLDGI
MSMEG_2781|M.smegmatis_MC2_155 PVDWHIQRWIDAMP-----QYGPGHLDLVAELRAGLPPNLAVTGSYLDGI
Rv2677c|M.tuberculosis_H37Rv PVDVRVRRWIEAMP-----QYGPGHADVVAELRAGLPPTLAVAGSYLDGI
Mb2696c|M.bovis_AF2122/97 PVDVRVRRWIEAMP-----QYGPGHADVVAELRAGLPPTLAVAGSYLDGI
MLBr_01044|M.leprae_Br4923 PVDVCVQRWIDAMP-----QYGPGHADLVAEVRAGLPPTLVVAGSHMDGI
MMAR_2039|M.marinum_M PVDSRVQRWIEAMP-----QYGPGHGELVAQVRAGLPPTLAVAGSYLDGI
MUL_3311|M.ulcerans_Agy99 PVDSRVQRWIEAMP-----RYGPGHGVLVAQVRAGLPPTLAVAGSYLDGI
MAB_2985c|M.abscessus_ATCC_199 PVNSAVARWIDAMP-----QYGPGHAEVVDAIRSGLPSGIAVAGSYLDGI
TH_0685|M.thermoresistible__bu CDDFAPGGPTAAVPPGSWTEFGPWLREPVDQIYWAGTETADQWTGFLDGA
: *:* .:** * : . . ..:**
Mflv_3918|M.gilvum_PYR-GCK GVPACVASAARAVASLVAGSSVGQ--
Mvan_2482|M.vanbaalenii_PYR-1 GVPACVAAATRAVAALVVDGR-----
MSMEG_2781|M.smegmatis_MC2_155 GVPACVGAATRAALTLVKTGVAR---
Rv2677c|M.tuberculosis_H37Rv GVPACVGAAGRAVTSVIEALDAQVAR
Mb2696c|M.bovis_AF2122/97 GVPACVGAAGRAVTSVIEALDAQVAR
MLBr_01044|M.leprae_Br4923 GVPACISAAGR----AIEALQAEVAR
MMAR_2039|M.marinum_M GVPACVGAASRAVDGIVGALNPQVAR
MUL_3311|M.ulcerans_Agy99 GVPACVGAASRAVDGVVGALNPQVAR
MAB_2985c|M.abscessus_ATCC_199 GVPACVASASQAAQASVARWRHG---
TH_0685|M.thermoresistible__bu -----VRSGQRAAAEVHRRLSSGG--
: :. :