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TPGSYCVVGGGISGLTAAFRLRLAVGEDALITLLDPSDRLGGILRTERVGGQPMDLGAEAFVVRRPEMPA LLAELGLSGLQRSTTGARPLIYSCQELHPLPTGTVMGIPASARSLADLVDDATIAQIEAEPDRPLHWRPG GDPAVAELVAERFGEQTVTRSVDPLLCGVYAGSAATIGVRAAIPAVAAALDRGATSLTEAVRQSLPPASA GPVFGALTGGYQVLVEELVARSGVQWVQAAVSKIEPGWALHDDAGRRWHADAVILAIPAPRLVRILDGVD GVDPRSVAAASRVRSASSAVVALAVPADTPFPQCSGVLVANGEPLRAKAITLSSRKWGIQGDVQQLRISF GRFGDDLAERVSDHQLLSWARDDLATVFGVTVDPVDSRVQRWIEAMPRYGPGHGVLVAQVRAGLPPTLAV AGSYLDGIGVPACVGAASRAVDGVVGALNPQVAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3311 | hemY | - | 100% (455) | protoporphyrinogen oxidase |
| M. ulcerans Agy99 | MUL_1281 | aofH_1 | 4e-06 | 20.53% (341) | flavin-containing monoamine oxidase AofH_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2696c | hemY | 0.0 | 72.97% (455) | protoporphyrinogen oxidase |
| M. gilvum PYR-GCK | Mflv_3918 | - | 1e-162 | 65.77% (444) | protoporphyrinogen oxidase |
| M. tuberculosis H37Rv | Rv2677c | hemY | 0.0 | 72.97% (455) | protoporphyrinogen oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 1e-179 | 70.74% (458) | protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_2985c | - | 1e-133 | 56.73% (446) | protoporphyrinogen oxidase |
| M. marinum M | MMAR_2039 | hemY | 0.0 | 98.90% (455) | protoporphyrinogen oxidase HemY |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2781 | hemG | 1e-163 | 66.21% (441) | protoporphyrinogen oxidase |
| M. thermoresistible (build 8) | TH_0076 | - | 2e-06 | 24.71% (518) | phytoene dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2482 | - | 1e-162 | 64.88% (447) | protoporphyrinogen oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3918|M.gilvum_PYR-GCK ----MSVAARYCVVGGGISGLVAAYRLRVAAGPDAVITVLDPADRLGGIL
Mvan_2482|M.vanbaalenii_PYR-1 --MSTAVPARYCVVGGGISGLVAAYRLRVAAGPDASITLLDPADRLGGVL
MSMEG_2781|M.smegmatis_MC2_155 ------MTMRFCVVGGGISGLVAAYRLRRAAGPHADITLLDPADRLGGIL
MUL_3311|M.ulcerans_Agy99 -----MTPGSYCVVGGGISGLTAAFRLRLAVGEDALITLLDPSDRLGGIL
MMAR_2039|M.marinum_M -----MTPGSYCVVGGGISGLTAAFRLRLAVGEDALITLLDPSDRLGGIL
Mb2696c|M.bovis_AF2122/97 -----MTPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGVL
Rv2677c|M.tuberculosis_H37Rv -----MTPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGVL
MLBr_01044|M.leprae_Br4923 -----MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVL
MAB_2985c|M.abscessus_ATCC_199 MTPQPSGSPSIAIVGGGISGLTAAYRLRRELGDDARISLYDPAGQLGGIL
TH_0076|M.thermoresistible__bu MRTVTGRPDHIVVVGAGLAGLSAALHL---AGRGRSVTVVERGAHPGGRM
. :**.*::** :* :* * ::: : . : ** :
Mflv_3918|M.gilvum_PYR-GCK RTERIGGQAIDVGAEAFVARRPEVPALLGELGLSGRQITTTGARPLIYSE
Mvan_2482|M.vanbaalenii_PYR-1 RTERIGGQLLDVGAEAFVARRPEVPALLGELGLSGRQIVPSGARPLIYSE
MSMEG_2781|M.smegmatis_MC2_155 RTERVGGQWLDVGAEAFVARRPEMPALLAELGLAGRQIATSGARPLIYSG
MUL_3311|M.ulcerans_Agy99 RTERVGGQPMDLGAEAFVVRRPEMPALLAELGLSGLQRSTTGARPLIYSC
MMAR_2039|M.marinum_M RTERVGGQPMDLGAEAFVVRRPEMPALLAELGLSGLQRSTTGARPLIYSC
Mb2696c|M.bovis_AF2122/97 RTEHIGGQPMDLGAEAFVLRRPEMPALLAELGLSDRQLASTGARPLIYSQ
Rv2677c|M.tuberculosis_H37Rv RTEHIGGQPMDLGAEAFVLRRPEMPALLAELGLSDRQLASTGARPLIYSQ
MLBr_01044|M.leprae_Br4923 RTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSERQRATTDARPLIYSQ
MAB_2985c|M.abscessus_ATCC_199 RTITLGEHRIDIGAEAFITRRPEVLDLLDELGLADRTLDTTGARPLIYAG
TH_0076|M.thermoresistible__bu GRLDVHGYRLDTGPTVLTMP-EILDETFAAVGSSVADRLDLKPVVPAYRA
: :* *. .: : : :* : . *
Mflv_3918|M.gilvum_PYR-GCK GRLHQLPTDTVNGIPSRPSALSGLVDDATVR-WMLDEPRRPLVWRSGADP
Mvan_2482|M.vanbaalenii_PYR-1 GRLHPLPKDTVQGIPSRPEALAGLVDDATIR-WMLDEPRRPFSWCQGADP
MSMEG_2781|M.smegmatis_MC2_155 ARLHPLPQGTLQGIPAQASSLLGLVDDATVA-QIIDERARPFAWRPGSDP
MUL_3311|M.ulcerans_Agy99 QELHPLPTGTVMGIPASARSLADLVDDATIA-QIEAEPDRPLHWRPGGDP
MMAR_2039|M.marinum_M QELHPLPTGTVMGIPASARSLAGLVDDATIA-QIEAEPDRPLHWRPGGDP
Mb2696c|M.bovis_AF2122/97 QRLHPLPPQTVVGIPSSAGSMAGLVDDATLA-RIDAEAARPFTWQVGSDP
Rv2677c|M.tuberculosis_H37Rv QRLHPLPPQTVVGIPSSAGSMAGLVDDATLA-RIDAEAARPFTWQVGSDP
MLBr_01044|M.leprae_Br4923 QRLHSLPPDTVAGIPSSATSVAGLVDDATVA-RIGAEAVRPLSWEPGSDP
MAB_2985c|M.abscessus_ATCC_199 GGLHPLPARTVNGIPASASSVVGLVDEETVA-RIDSEPQRDMHWTVGAEP
TH_0076|M.thermoresistible__bu EFADGSGLDVHTDPAAMADEITRFAGGAQAAGYLQLRNWLDLLYRTEFDR
. . . .: . : :.. : . : : :
Mflv_3918|M.gilvum_PYR-GCK TVAELVGERFGEQVVVRSVDPLLAGVYAGSAATIGMRAAAPTVAAALDNG
Mvan_2482|M.vanbaalenii_PYR-1 SVAELVGDRFGEQVVIRSVDPLLSGVYAGSAATIGIRAGAPTVAAALDGG
MSMEG_2781|M.smegmatis_MC2_155 SVADVVGDRFGMQVVYRSVDPLLTGVYAGSSATIGLRSAVPTLAAALDRG
MUL_3311|M.ulcerans_Agy99 AVAELVAERFGEQTVTRSVDPLLCGVYAGSAATIGVRAAIPAVAAALDRG
MMAR_2039|M.marinum_M AVAELVAERFGEQTVTRSVDPLLCGVYAGSAATIGVRAAIPAVAAALDRG
Mb2696c|M.bovis_AF2122/97 AVADLVADRFGDQVVARSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRG
Rv2677c|M.tuberculosis_H37Rv AVADLVADRFGDQVVARSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRG
MLBr_01044|M.leprae_Br4923 AMAELVADRFGEQAVARLVDPLLGGVYAGSAATIGLRAGAPSVAAALDCG
MAB_2985c|M.abscessus_ATCC_199 TVADLVALRFGPQVVARLVDPLLGGVYAGSAATTGLRTAAPGIARALDEG
TH_0076|M.thermoresistible__bu FIAANFDSPL-SLVSPHLAKLVALGGFRRWEKVMRRFITDERLLRVFTFQ
:* . : . : .. : * : . : .:
Mflv_3918|M.gilvum_PYR-GCK ARSLTEAVVAALPPPRAGSVFGAID------GGYQVLLDELVRRSGLQ--
Mvan_2482|M.vanbaalenii_PYR-1 ARSLTEAVTRALPPPQAGAVFGAID------GGYQVLVDELVRRSWLE--
MSMEG_2781|M.smegmatis_MC2_155 APSLTDAVRDALPPPVTGSVFGALD------GGYRVLLEELQRRAAVR--
MUL_3311|M.ulcerans_Agy99 ATSLTEAVRQSLPPASAGPVFGALT------GGYQVLVEELVARSGVQ--
MMAR_2039|M.marinum_M ATSLTEAVRQSLPPASVGPVFGALT------GGYQVLVEELVARSGVQ--
Mb2696c|M.bovis_AF2122/97 ATSVTDAVRQALPPGSGGPVFGALD------GGYQVLLDGLVRRSRVH--
Rv2677c|M.tuberculosis_H37Rv ATSVTDAVRQALPPGSGGPVFGALD------GGYQVLLDGLVRRSRVH--
MLBr_01044|M.leprae_Br4923 ATSLMEAVRQGLPPVAAGPVFGALD------GGYQVLIDELVRRSRLQ--
MAB_2985c|M.abscessus_ATCC_199 AGSLLAAARQALPPISDSGIFGAVD------GGYAVLVEELWSRARAE--
TH_0076|M.thermoresistible__bu ALYVGVPPQRALAVYAVIAYMDTVNGVYFPAGGVRAVPEALAAAARDAGV
* : . .*. :.:: ** .: : * :
Mflv_3918|M.gilvum_PYR-GCK --WAQVAARGVHPVR-AGWEVVDDEGGHWPADAVVLAVPAPRLPALLA--
Mvan_2482|M.vanbaalenii_PYR-1 --WAQVSVRSVGRGA-RGWEVLDDEGTRWPADAVVLAVPAPRLPALVA--
MSMEG_2781|M.smegmatis_MC2_155 --WAQVTAVRVDRDA-NGWLVFDDEGTNWNADGVVLAVPAPALPALIE--
MUL_3311|M.ulcerans_Agy99 --WVQAAVSKIEP----GWALHDDAGRRWHADAVILAIPAPRLVRILDGV
MMAR_2039|M.marinum_M --WVQAAVSKIEP----GWALHDDAGRRWHADAVILAIPAPRLVRILDGV
Mb2696c|M.bovis_AF2122/97 --WVRARVVQLER----GWVLRDETGGRWQADAVILAVPAPRLARLVD--
Rv2677c|M.tuberculosis_H37Rv --WVRARVVQLER----GWVLRDETGGRWQADAVILAVPAPRLARLVD--
MLBr_01044|M.leprae_Br4923 --WVAATVVGLDRGT-CGWTLVDDTGACWSADGVILAVPAPRLVRLLQ--
MAB_2985c|M.abscessus_ATCC_199 --HVQVAVTGIERDG-AGWAVTGEGGLTDAVDAVIVAVPAPRAAAILE--
TH_0076|M.thermoresistible__bu EFCYRERVTGLERSGDRVTAVHTDTGRRLAADVVVLTTELPDSYRLLG--
. : : : * .* *::: * ::
Mflv_3918|M.gilvum_PYR-GCK -ELAPHSADIARRIPVASAAVVALALPGGTPLPEQSGVLVAG--------
Mvan_2482|M.vanbaalenii_PYR-1 -DIAPRTAAAARRIPVASAAVVALALPGGTPLPEQSGVLVAG--------
MSMEG_2781|M.smegmatis_MC2_155 -HVAPRTAAAARRIRVASAAVVALALPGGTPIPQQSGVLVATG-------
MUL_3311|M.ulcerans_Agy99 DGVDPRSVAAASRVRSASSAVVALAVPADTPFPQCSGVLVAN--------
MMAR_2039|M.marinum_M DGVDPRSVAAASRVRSASSAVVALAVPADTPFPQCSGVLVAN--------
Mb2696c|M.bovis_AF2122/97 -GIAPRTHAAARQIVSASSAVVALAVPGGTAFPHCSGVLVAG--------
Rv2677c|M.tuberculosis_H37Rv -GIAPRTHAAARQIVSASSAVVALAVPGGTAFPHCSGVLVAG--------
MLBr_01044|M.leprae_Br4923 -QIAPRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLVAS--------
MAB_2985c|M.abscessus_ATCC_199 -AVAPESAAAARTIPVASSVVVALTLPGDAPIPANSGVLVAS--------
TH_0076|M.thermoresistible__bu ----RRPRRPARLRPAPSAVVAHVGCRRAEPAPPHHTILFGSAWEQTFRD
.. * .*:.*. : . * :*..
Mflv_3918|M.gilvum_PYR-GCK ---------RGPLHTKAVTLSSRKWGRRG-----------SAEMLRLSYG
Mvan_2482|M.vanbaalenii_PYR-1 ---------QGRLRAKAVTLSSKKWGRRA-----------NVEMVRLSYG
MSMEG_2781|M.smegmatis_MC2_155 --------EAGSLNAKAVTLSSRKWGRRG-----------NVELLRLSFG
MUL_3311|M.ulcerans_Agy99 ---------GEPLRAKAITLSSRKWGIQG-----------DVQQLRISFG
MMAR_2039|M.marinum_M ---------GEPLRAKAITLSSRKWGIQG-----------DVQQLRISFG
Mb2696c|M.bovis_AF2122/97 ---------DESPHAKAITLSSRKWGQRG-----------DVALLRLSFG
Rv2677c|M.tuberculosis_H37Rv ---------DESPHAKAITLSSRKWGQRG-----------DVALLRLSFG
MLBr_01044|M.leprae_Br4923 ---------GERLRAKAVTLSSRKWGLQG-----------DTQLVRLSFG
MAB_2985c|M.abscessus_ATCC_199 ---------GEALHTKAITFSTSKWGLRGR----------STQVVRLSYG
TH_0076|M.thermoresistible__bu IIDDGRLMRDPSLLVSRPTAGDASLAPDGRDLLYILAPAPNTAAGRIDWD
.. * . . . . .. *:.:.
Mflv_3918|M.gilvum_PYR-GCK RFGDDLARSTGDDELLAWADEDLATLFGIAVEPVDARVVRWIDAMPQYGP
Mvan_2482|M.vanbaalenii_PYR-1 RFGDDLARSTGDEDLLAWAAQDLSVLFGISVDPVDSRVVRWIDALPQYGP
MSMEG_2781|M.smegmatis_MC2_155 RYGDDLARSTGDEDLLAWSTRDLNTLFGITVDPVDWHIQRWIDAMPQYGP
MUL_3311|M.ulcerans_Agy99 RFGDDLAERVSDHQLLSWARDDLATVFGVTVDPVDSRVQRWIEAMPRYGP
MMAR_2039|M.marinum_M RFGDDLAERVSDHQLLSWARDDLATVFGVTVDPVDSRVQRWIEAMPQYGP
Mb2696c|M.bovis_AF2122/97 RFGDEPALTASDDQLLAWAADDLVTVFGVAVDPVDVRVRRWIEAMPQYGP
Rv2677c|M.tuberculosis_H37Rv RFGDEPALTASDDQLLAWAADDLVTVFGVAVDPVDVRVRRWIEAMPQYGP
MLBr_01044|M.leprae_Br4923 KFGDQVASTASDDELLAWAVSDLAAVFDVTVDPVDVCVQRWIDAMPQYGP
MAB_2985c|M.abscessus_ATCC_199 RFGDTVARATTDEQLRHWAVADLEAVLGAGIVPVNSAVARWIDAMPQYGP
TH_0076|M.thermoresistible__bu LLGDGYAEEMLNAVSARLPESTVDAEMLHVVNPADWERQGMAAGTPFALA
** * : . : . : : *.: . * .
Mflv_3918|M.gilvum_PYR-GCK GHADRVADLRAG-----LPRGLAVAGAYLDGIGVPACVASAARAVASLVA
Mvan_2482|M.vanbaalenii_PYR-1 GHAALVAELRAG-----LPGGLAVAGAYLDGIGVPACVAAATRAVAALVV
MSMEG_2781|M.smegmatis_MC2_155 GHLDLVAELRAG-----LPPNLAVTGSYLDGIGVPACVGAATRAALTLVK
MUL_3311|M.ulcerans_Agy99 GHGVLVAQVRAG-----LPPTLAVAGSYLDGIGVPACVGAASRAVDGVVG
MMAR_2039|M.marinum_M GHGELVAQVRAG-----LPPTLAVAGSYLDGIGVPACVGAASRAVDGIVG
Mb2696c|M.bovis_AF2122/97 GHADVVAELRAG-----LPPTLAVAGSYLDGIGVPACVGAAGRAVTSVIE
Rv2677c|M.tuberculosis_H37Rv GHADVVAELRAG-----LPPTLAVAGSYLDGIGVPACVGAAGRAVTSVIE
MLBr_01044|M.leprae_Br4923 GHADLVAEVRAG-----LPPTLVVAGSHMDGIGVPACISAAGR----AIE
MAB_2985c|M.abscessus_ATCC_199 GHAEVVDAIRSG-----LPSGIAVAGSYLDGIGVPACVASASQAAQASVA
TH_0076|M.thermoresistible__bu HTFSQTGPFRPGNMVRGVANAVLAGGSTVPGVGIPTALLSGRLAADRITG
. .*.* :. : . *: : *:*:*:.: :.
Mflv_3918|M.gilvum_PYR-GCK GSSVGQ--
Mvan_2482|M.vanbaalenii_PYR-1 DGR-----
MSMEG_2781|M.smegmatis_MC2_155 TGVAR---
MUL_3311|M.ulcerans_Agy99 ALNPQVAR
MMAR_2039|M.marinum_M ALNPQVAR
Mb2696c|M.bovis_AF2122/97 ALDAQVAR
Rv2677c|M.tuberculosis_H37Rv ALDAQVAR
MLBr_01044|M.leprae_Br4923 ALQAEVAR
MAB_2985c|M.abscessus_ATCC_199 RWRHG---
TH_0076|M.thermoresistible__bu AAR-----