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TPQPSGSPSIAIVGGGISGLTAAYRLRRELGDDARISLYDPAGQLGGILRTITLGEHRIDIGAEAFITRR PEVLDLLDELGLADRTLDTTGARPLIYAGGGLHPLPARTVNGIPASASSVVGLVDEETVARIDSEPQRDM HWTVGAEPTVADLVALRFGPQVVARLVDPLLGGVYAGSAATTGLRTAAPGIARALDEGAGSLLAAARQAL PPISDSGIFGAVDGGYAVLVEELWSRARAEHVQVAVTGIERDGAGWAVTGEGGLTDAVDAVIVAVPAPRA AAILEAVAPESAAAARTIPVASSVVVALTLPGDAPIPANSGVLVASGEALHTKAITFSTSKWGLRGRSTQ VVRLSYGRFGDTVARATTDEQLRHWAVADLEAVLGAGIVPVNSAVARWIDAMPQYGPGHAEVVDAIRSGL PSGIAVAGSYLDGIGVPACVASASQAAQASVARWRHG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2985c | - | - | 100% (458) | protoporphyrinogen oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2696c | hemY | 1e-138 | 58.24% (443) | protoporphyrinogen oxidase |
| M. gilvum PYR-GCK | Mflv_3918 | - | 1e-140 | 58.96% (441) | protoporphyrinogen oxidase |
| M. tuberculosis H37Rv | Rv2677c | hemY | 1e-138 | 58.24% (443) | protoporphyrinogen oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 1e-141 | 57.33% (450) | protoporphyrinogen oxidase |
| M. marinum M | MMAR_2039 | hemY | 1e-135 | 57.40% (446) | protoporphyrinogen oxidase HemY |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2781 | hemG | 1e-136 | 57.76% (438) | protoporphyrinogen oxidase |
| M. thermoresistible (build 8) | TH_1141 | - | 3e-05 | 25.47% (322) | dehydrogenase |
| M. ulcerans Agy99 | MUL_3311 | hemY | 1e-133 | 56.73% (446) | protoporphyrinogen oxidase |
| M. vanbaalenii PYR-1 | Mvan_2482 | - | 1e-137 | 56.76% (444) | protoporphyrinogen oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2039|M.marinum_M ------MTPGSYCVVGGGISGLTAAFRLRLAVGEDALITLLDPSDRLGGI
MUL_3311|M.ulcerans_Agy99 ------MTPGSYCVVGGGISGLTAAFRLRLAVGEDALITLLDPSDRLGGI
Mb2696c|M.bovis_AF2122/97 ------MTPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGV
Rv2677c|M.tuberculosis_H37Rv ------MTPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGV
MLBr_01044|M.leprae_Br4923 ------MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGV
Mflv_3918|M.gilvum_PYR-GCK -----MSVAARYCVVGGGISGLVAAYRLRVAAGPDAVITVLDPADRLGGI
Mvan_2482|M.vanbaalenii_PYR-1 ---MSTAVPARYCVVGGGISGLVAAYRLRVAAGPDASITLLDPADRLGGV
MSMEG_2781|M.smegmatis_MC2_155 -------MTMRFCVVGGGISGLVAAYRLRRAAGPHADITLLDPADRLGGI
MAB_2985c|M.abscessus_ATCC_199 -MTPQPSGSPSIAIVGGGISGLTAAYRLRRELGDDARISLYDPAGQLGGI
TH_1141|M.thermoresistible__bu MTSNTGTSVSRVVVIGGGYAGVMAANRLRLDP--SVDVTLINPRPDFVER
::*** :*: :* *** . ::: :* :
MMAR_2039|M.marinum_M LRTERVGGQPMDLGAEAFVVRRPEMPALLAELGLSGLQRSTTGARPLIYS
MUL_3311|M.ulcerans_Agy99 LRTERVGGQPMDLGAEAFVVRRPEMPALLAELGLSGLQRSTTGARPLIYS
Mb2696c|M.bovis_AF2122/97 LRTEHIGGQPMDLGAEAFVLRRPEMPALLAELGLSDRQLASTGARPLIYS
Rv2677c|M.tuberculosis_H37Rv LRTEHIGGQPMDLGAEAFVLRRPEMPALLAELGLSDRQLASTGARPLIYS
MLBr_01044|M.leprae_Br4923 LRTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSERQRATTDARPLIYS
Mflv_3918|M.gilvum_PYR-GCK LRTERIGGQAIDVGAEAFVARRPEVPALLGELGLSGRQITTTGARPLIYS
Mvan_2482|M.vanbaalenii_PYR-1 LRTERIGGQLLDVGAEAFVARRPEVPALLGELGLSGRQIVPSGARPLIYS
MSMEG_2781|M.smegmatis_MC2_155 LRTERVGGQWLDVGAEAFVARRPEMPALLAELGLAGRQIATSGARPLIYS
MAB_2985c|M.abscessus_ATCC_199 LRTITLGEHRIDIGAEAFITRRPEVLDLLDELGLADRTLDTTGARPLIYA
TH_1141|M.thermoresistible__bu IRLHQLVTGSDDAVVDFATVLHPDVRLVVDTA----ERIDAADRSVALAS
:* : * .: :*:: :: .:. : :
MMAR_2039|M.marinum_M CQELHPLPTGTVMGIPASARSLAGLVDDATIAQIEAEPDRPLHWRPGGDP
MUL_3311|M.ulcerans_Agy99 CQELHPLPTGTVMGIPASARSLADLVDDATIAQIEAEPDRPLHWRPGGDP
Mb2696c|M.bovis_AF2122/97 QQRLHPLPPQTVVGIPSSAGSMAGLVDDATLARIDAEAARPFTWQVGSDP
Rv2677c|M.tuberculosis_H37Rv QQRLHPLPPQTVVGIPSSAGSMAGLVDDATLARIDAEAARPFTWQVGSDP
MLBr_01044|M.leprae_Br4923 QQRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAEAVRPLSWEPGSDP
Mflv_3918|M.gilvum_PYR-GCK EGRLHQLPTDTVNGIPSRPSALSGLVDDATVRWMLDEPRRPLVWRSGADP
Mvan_2482|M.vanbaalenii_PYR-1 EGRLHPLPKDTVQGIPSRPEALAGLVDDATIRWMLDEPRRPFSWCQGADP
MSMEG_2781|M.smegmatis_MC2_155 GARLHPLPQGTLQGIPAQASSLLGLVDDATVAQIIDERARPFAWRPGSDP
MAB_2985c|M.abscessus_ATCC_199 GGGLHPLPARTVNGIPASASSVVGLVDEETVARIDSEPQRDMHWTVGAEP
TH_1141|M.thermoresistible__bu GGTVSYDHLIYAVGSNAGPSTVPGVGEFAYSVTEFEDAQR----------
: * : . :: .: : : *
MMAR_2039|M.marinum_M AVAELVAERFGEQTVTRSVDPLLCGVYAGSAATIGVRAAIPAVAAALDRG
MUL_3311|M.ulcerans_Agy99 AVAELVAERFGEQTVTRSVDPLLCGVYAGSAATIGVRAAIPAVAAALDRG
Mb2696c|M.bovis_AF2122/97 AVADLVADRFGDQVVARSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRG
Rv2677c|M.tuberculosis_H37Rv AVADLVADRFGDQVVARSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRG
MLBr_01044|M.leprae_Br4923 AMAELVADRFGEQAVARLVDPLLGGVYAGSAATIGLRAGAPSVAAALDCG
Mflv_3918|M.gilvum_PYR-GCK TVAELVGERFGEQVVVRSVDPLLAGVYAGSAATIGMRAAAPTVAAALDNG
Mvan_2482|M.vanbaalenii_PYR-1 SVAELVGDRFGEQVVIRSVDPLLSGVYAGSAATIGIRAGAPTVAAALDGG
MSMEG_2781|M.smegmatis_MC2_155 SVADVVGDRFGMQVVYRSVDPLLTGVYAGSSATIGLRSAVPTLAAALDRG
MAB_2985c|M.abscessus_ATCC_199 TVADLVALRFGPQVVARLVDPLLGGVYAGSAATTGLRTAAPGIARALDEG
TH_1141|M.thermoresistible__bu ---------LRRAVDARPCDAPITVVGAGPTG--------LEMAAELAEQ
: . * *. : * **.:. :* *
MMAR_2039|M.marinum_M ATSLTEAVRQSLPPASVGPVFGALTGGYQVLVEELVARSGVQWVQAAVSK
MUL_3311|M.ulcerans_Agy99 ATSLTEAVRQSLPPASAGPVFGALTGGYQVLVEELVARSGVQWVQAAVSK
Mb2696c|M.bovis_AF2122/97 ATSVTDAVRQALPPGSGGPVFGALDGGYQVLLDGLVRRSRVHWVRARVVQ
Rv2677c|M.tuberculosis_H37Rv ATSVTDAVRQALPPGSGGPVFGALDGGYQVLLDGLVRRSRVHWVRARVVQ
MLBr_01044|M.leprae_Br4923 ATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELVRRSRLQWVAATVVG
Mflv_3918|M.gilvum_PYR-GCK ARSLTEAVVAALPPPRAGSVFGAIDGGYQVLLDELVRRSGLQWAQVAARG
Mvan_2482|M.vanbaalenii_PYR-1 ARSLTEAVTRALPPPQAGAVFGAIDGGYQVLVDELVRRSWLEWAQVSVRS
MSMEG_2781|M.smegmatis_MC2_155 APSLTDAVRDALPPPVTGSVFGALDGGYRVLLEELQRRAAVRWAQVTAVR
MAB_2985c|M.abscessus_ATCC_199 AGSLLAAARQALPPISDSGIFGAVDGGYAVLVEELWSRARAEHVQVAVTG
TH_1141|M.thermoresistible__bu GRTVTLVG-DAIGPYLSEPGWRAVA--------KRFRRLGVRTVEARVAE
. :: . .: * : *: * . . . .
MMAR_2039|M.marinum_M IEP---GWALHDDAGRRWHADAVILAIPAPRLVRILDGVDGVDPRSVAAA
MUL_3311|M.ulcerans_Agy99 IEP---GWALHDDAGRRWHADAVILAIPAPRLVRILDGVDGVDPRSVAAA
Mb2696c|M.bovis_AF2122/97 LER---GWVLRDETGGRWQADAVILAVPAPRLARLVD---GIAPRTHAAA
Rv2677c|M.tuberculosis_H37Rv LER---GWVLRDETGGRWQADAVILAVPAPRLARLVD---GIAPRTHAAA
MLBr_01044|M.leprae_Br4923 LDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQ---QIAPRTVAAA
Mflv_3918|M.gilvum_PYR-GCK VHPVRAGWEVVDDEGGHWPADAVVLAVPAPRLPALLA---ELAPHSADIA
Mvan_2482|M.vanbaalenii_PYR-1 VGRGARGWEVLDDEGTRWPADAVVLAVPAPRLPALVA---DIAPRTAAAA
MSMEG_2781|M.smegmatis_MC2_155 VDRDANGWLVFDDEGTNWNADGVVLAVPAPALPALIE---HVAPRTAAAA
MAB_2985c|M.abscessus_ATCC_199 IERDGAGWAVTGEGGLTDAVDAVIVAVPAPRAAAILE---AVAPESAAAA
TH_1141|M.thermoresistible__bu VRAD--AVLLADGRRLDSAVTVWTAGFAVPDLAARSG-------------
: . : . . ....*
MMAR_2039|M.marinum_M SRVRSASSAVVALAVPADTPFPQCSGVLVAN--GEPLRAKAITLSSRKWG
MUL_3311|M.ulcerans_Agy99 SRVRSASSAVVALAVPADTPFPQCSGVLVAN--GEPLRAKAITLSSRKWG
Mb2696c|M.bovis_AF2122/97 RQIVSASSAVVALAVPGGTAFPHCSGVLVAG--DESPHAKAITLSSRKWG
Rv2677c|M.tuberculosis_H37Rv RQIVSASSAVVALAVPGGTAFPHCSGVLVAG--DESPHAKAITLSSRKWG
MLBr_01044|M.leprae_Br4923 SRIVSASSAVVALSVPRDTTFPQNSGVLVAS--GERLRAKAVTLSSRKWG
Mflv_3918|M.gilvum_PYR-GCK RRIPVASAAVVALALPGGTPLPEQSGVLVAG--RGPLHTKAVTLSSRKWG
Mvan_2482|M.vanbaalenii_PYR-1 RRIPVASAAVVALALPGGTPLPEQSGVLVAG--QGRLRAKAVTLSSKKWG
MSMEG_2781|M.smegmatis_MC2_155 RRIRVASAAVVALALPGGTPIPQQSGVLVATGEAGSLNAKAVTLSSRKWG
MAB_2985c|M.abscessus_ATCC_199 RTIPVASSVVVALTLPGDAPIPANSGVLVAS--GEALHTKAITFSTSKWG
TH_1141|M.thermoresistible__bu ----LSTDAIGRLRTDETLTSVDDDRIVAAG-DAAAPSGQPLRMSCQAAG
:: .: * . . ::.* :.: :* *
MMAR_2039|M.marinum_M IQG-DVQQLRISFGRFGDDLAERVSDHQLLSWARDDLATVFGVTVDP-VD
MUL_3311|M.ulcerans_Agy99 IQG-DVQQLRISFGRFGDDLAERVSDHQLLSWARDDLATVFGVTVDP-VD
Mb2696c|M.bovis_AF2122/97 QRG-DVALLRLSFGRFGDEPALTASDDQLLAWAADDLVTVFGVAVDP-VD
Rv2677c|M.tuberculosis_H37Rv QRG-DVALLRLSFGRFGDEPALTASDDQLLAWAADDLVTVFGVAVDP-VD
MLBr_01044|M.leprae_Br4923 LQG-DTQLVRLSFGKFGDQVASTASDDELLAWAVSDLAAVFDVTVDP-VD
Mflv_3918|M.gilvum_PYR-GCK RRG-SAEMLRLSYGRFGDDLARSTGDDELLAWADEDLATLFGIAVEP-VD
Mvan_2482|M.vanbaalenii_PYR-1 RRA-NVEMVRLSYGRFGDDLARSTGDEDLLAWAAQDLSVLFGISVDP-VD
MSMEG_2781|M.smegmatis_MC2_155 RRG-NVELLRLSFGRYGDDLARSTGDEDLLAWSTRDLNTLFGITVDP-VD
MAB_2985c|M.abscessus_ATCC_199 LRGRSTQVVRLSYGRFGDTVARATTDEQLRHWAVADLEAVLGAGIVP-VN
TH_1141|M.thermoresistible__bu PLG----------AQAADTVLSRIAGDRPAPLDQAFAGQCISLGRDAGII
. .: .* .. :. . :
MMAR_2039|M.marinum_M SRVQRWIEAMPQYGPGHGELVAQVRAGLPPTLAVAGSYLDGIGVPACVGA
MUL_3311|M.ulcerans_Agy99 SRVQRWIEAMPRYGPGHGVLVAQVRAGLPPTLAVAGSYLDGIGVPACVGA
Mb2696c|M.bovis_AF2122/97 VRVRRWIEAMPQYGPGHADVVAELRAGLPPTLAVAGSYLDGIGVPACVGA
Rv2677c|M.tuberculosis_H37Rv VRVRRWIEAMPQYGPGHADVVAELRAGLPPTLAVAGSYLDGIGVPACVGA
MLBr_01044|M.leprae_Br4923 VCVQRWIDAMPQYGPGHADLVAEVRAGLPPTLVVAGSHMDGIGVPACISA
Mflv_3918|M.gilvum_PYR-GCK ARVVRWIDAMPQYGPGHADRVADLRAGLPRGLAVAGAYLDGIGVPACVAS
Mvan_2482|M.vanbaalenii_PYR-1 SRVVRWIDALPQYGPGHAALVAELRAGLPGGLAVAGAYLDGIGVPACVAA
MSMEG_2781|M.smegmatis_MC2_155 WHIQRWIDAMPQYGPGHLDLVAELRAGLPPNLAVTGSYLDGIGVPACVGA
MAB_2985c|M.abscessus_ATCC_199 SAVARWIDAMPQYGPGHAEVVDAIRSGLPSGIAVAGSYLDGIGVPACVAS
TH_1141|M.thermoresistible__bu QLARRDDTAIPVFLSGRAAAWVKERVCRGTIWALAREARR-PGSYLWLKG
* *:* : .*: * .:: * : .
MMAR_2039|M.marinum_M ASRAVDGIVGALNPQVAR
MUL_3311|M.ulcerans_Agy99 ASRAVDGVVGALNPQVAR
Mb2696c|M.bovis_AF2122/97 AGRAVTSVIEALDAQVAR
Rv2677c|M.tuberculosis_H37Rv AGRAVTSVIEALDAQVAR
MLBr_01044|M.leprae_Br4923 AGR----AIEALQAEVAR
Mflv_3918|M.gilvum_PYR-GCK AARAVASLVAGSSVGQ--
Mvan_2482|M.vanbaalenii_PYR-1 ATRAVAALVVDGR-----
MSMEG_2781|M.smegmatis_MC2_155 ATRAALTLVKTGVAR---
MAB_2985c|M.abscessus_ATCC_199 ASQAAQASVARWRHG---
TH_1141|M.thermoresistible__bu GRRPAQPALDEMAVS---
. : :