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VTMRFCVVGGGISGLVAAYRLRRAAGPHADITLLDPADRLGGILRTERVGGQWLDVGAEAFVARRPEMPA LLAELGLAGRQIATSGARPLIYSGARLHPLPQGTLQGIPAQASSLLGLVDDATVAQIIDERARPFAWRPG SDPSVADVVGDRFGMQVVYRSVDPLLTGVYAGSSATIGLRSAVPTLAAALDRGAPSLTDAVRDALPPPVT GSVFGALDGGYRVLLEELQRRAAVRWAQVTAVRVDRDANGWLVFDDEGTNWNADGVVLAVPAPALPALIE HVAPRTAAAARRIRVASAAVVALALPGGTPIPQQSGVLVATGEAGSLNAKAVTLSSRKWGRRGNVELLRL SFGRYGDDLARSTGDEDLLAWSTRDLNTLFGITVDPVDWHIQRWIDAMPQYGPGHLDLVAELRAGLPPNL AVTGSYLDGIGVPACVGAATRAALTLVKTGVAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2781 | hemG | - | 100% (453) | protoporphyrinogen oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2696c | hemY | 1e-169 | 67.12% (444) | protoporphyrinogen oxidase |
| M. gilvum PYR-GCK | Mflv_3918 | - | 1e-180 | 71.59% (447) | protoporphyrinogen oxidase |
| M. tuberculosis H37Rv | Rv2677c | hemY | 1e-169 | 67.12% (444) | protoporphyrinogen oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 1e-161 | 63.70% (449) | protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_2985c | - | 1e-136 | 57.76% (438) | protoporphyrinogen oxidase |
| M. marinum M | MMAR_2039 | hemY | 1e-165 | 66.67% (441) | protoporphyrinogen oxidase HemY |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3311 | hemY | 1e-164 | 66.21% (441) | protoporphyrinogen oxidase |
| M. vanbaalenii PYR-1 | Mvan_2482 | - | 0.0 | 73.56% (450) | protoporphyrinogen oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3918|M.gilvum_PYR-GCK ----MSVAARYCVVGGGISGLVAAYRLRVAAGPDAVITVLDPADRLGGIL
Mvan_2482|M.vanbaalenii_PYR-1 --MSTAVPARYCVVGGGISGLVAAYRLRVAAGPDASITLLDPADRLGGVL
MSMEG_2781|M.smegmatis_MC2_155 ------MTMRFCVVGGGISGLVAAYRLRRAAGPHADITLLDPADRLGGIL
MMAR_2039|M.marinum_M -----MTPGSYCVVGGGISGLTAAFRLRLAVGEDALITLLDPSDRLGGIL
MUL_3311|M.ulcerans_Agy99 -----MTPGSYCVVGGGISGLTAAFRLRLAVGEDALITLLDPSDRLGGIL
Mb2696c|M.bovis_AF2122/97 -----MTPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGVL
Rv2677c|M.tuberculosis_H37Rv -----MTPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGVL
MLBr_01044|M.leprae_Br4923 -----MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDRLGGVL
MAB_2985c|M.abscessus_ATCC_199 MTPQPSGSPSIAIVGGGISGLTAAYRLRRELGDDARISLYDPAGQLGGIL
. .:********.:*:*** * .. *:: :*..:***:*
Mflv_3918|M.gilvum_PYR-GCK RTERIGGQAIDVGAEAFVARRPEVPALLGELGLSGRQITTTGARPLIYSE
Mvan_2482|M.vanbaalenii_PYR-1 RTERIGGQLLDVGAEAFVARRPEVPALLGELGLSGRQIVPSGARPLIYSE
MSMEG_2781|M.smegmatis_MC2_155 RTERVGGQWLDVGAEAFVARRPEMPALLAELGLAGRQIATSGARPLIYSG
MMAR_2039|M.marinum_M RTERVGGQPMDLGAEAFVVRRPEMPALLAELGLSGLQRSTTGARPLIYSC
MUL_3311|M.ulcerans_Agy99 RTERVGGQPMDLGAEAFVVRRPEMPALLAELGLSGLQRSTTGARPLIYSC
Mb2696c|M.bovis_AF2122/97 RTEHIGGQPMDLGAEAFVLRRPEMPALLAELGLSDRQLASTGARPLIYSQ
Rv2677c|M.tuberculosis_H37Rv RTEHIGGQPMDLGAEAFVLRRPEMPALLAELGLSDRQLASTGARPLIYSQ
MLBr_01044|M.leprae_Br4923 RTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSERQRATTDARPLIYSQ
MAB_2985c|M.abscessus_ATCC_199 RTITLGEHRIDIGAEAFITRRPEVLDLLDELGLADRTLDTTGARPLIYAG
** :* : :*:*****: ****: ** ****: .:.******:
Mflv_3918|M.gilvum_PYR-GCK GRLHQLPTDTVNGIPSRPSALSGLVDDATVRWMLDEPRRPLVWRSGADPT
Mvan_2482|M.vanbaalenii_PYR-1 GRLHPLPKDTVQGIPSRPEALAGLVDDATIRWMLDEPRRPFSWCQGADPS
MSMEG_2781|M.smegmatis_MC2_155 ARLHPLPQGTLQGIPAQASSLLGLVDDATVAQIIDERARPFAWRPGSDPS
MMAR_2039|M.marinum_M QELHPLPTGTVMGIPASARSLAGLVDDATIAQIEAEPDRPLHWRPGGDPA
MUL_3311|M.ulcerans_Agy99 QELHPLPTGTVMGIPASARSLADLVDDATIAQIEAEPDRPLHWRPGGDPA
Mb2696c|M.bovis_AF2122/97 QRLHPLPPQTVVGIPSSAGSMAGLVDDATLARIDAEAARPFTWQVGSDPA
Rv2677c|M.tuberculosis_H37Rv QRLHPLPPQTVVGIPSSAGSMAGLVDDATLARIDAEAARPFTWQVGSDPA
MLBr_01044|M.leprae_Br4923 QRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAEAVRPLSWEPGSDPA
MAB_2985c|M.abscessus_ATCC_199 GGLHPLPARTVNGIPASASSVVGLVDEETVARIDSEPQRDMHWTVGAEPT
** ** *: ***: . :: .***: *: : * * : * *.:*:
Mflv_3918|M.gilvum_PYR-GCK VAELVGERFGEQVVVRSVDPLLAGVYAGSAATIGMRAAAPTVAAALDNGA
Mvan_2482|M.vanbaalenii_PYR-1 VAELVGDRFGEQVVIRSVDPLLSGVYAGSAATIGIRAGAPTVAAALDGGA
MSMEG_2781|M.smegmatis_MC2_155 VADVVGDRFGMQVVYRSVDPLLTGVYAGSSATIGLRSAVPTLAAALDRGA
MMAR_2039|M.marinum_M VAELVAERFGEQTVTRSVDPLLCGVYAGSAATIGVRAAIPAVAAALDRGA
MUL_3311|M.ulcerans_Agy99 VAELVAERFGEQTVTRSVDPLLCGVYAGSAATIGVRAAIPAVAAALDRGA
Mb2696c|M.bovis_AF2122/97 VADLVADRFGDQVVARSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRGA
Rv2677c|M.tuberculosis_H37Rv VADLVADRFGDQVVARSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRGA
MLBr_01044|M.leprae_Br4923 MAELVADRFGEQAVARLVDPLLGGVYAGSAATIGLRAGAPSVAAALDCGA
MAB_2985c|M.abscessus_ATCC_199 VADLVALRFGPQVVARLVDPLLGGVYAGSAATTGLRTAAPGIARALDEGA
:*::*. *** *.* * ***** ******:** *:*:. * :* *** **
Mflv_3918|M.gilvum_PYR-GCK RSLTEAVVAALPPPRAGSVFGAIDGGYQVLLDELVRRSGLQWAQVAARGV
Mvan_2482|M.vanbaalenii_PYR-1 RSLTEAVTRALPPPQAGAVFGAIDGGYQVLVDELVRRSWLEWAQVSVRSV
MSMEG_2781|M.smegmatis_MC2_155 PSLTDAVRDALPPPVTGSVFGALDGGYRVLLEELQRRAAVRWAQVTAVRV
MMAR_2039|M.marinum_M TSLTEAVRQSLPPASVGPVFGALTGGYQVLVEELVARSGVQWVQAAVSKI
MUL_3311|M.ulcerans_Agy99 TSLTEAVRQSLPPASAGPVFGALTGGYQVLVEELVARSGVQWVQAAVSKI
Mb2696c|M.bovis_AF2122/97 TSVTDAVRQALPPGSGGPVFGALDGGYQVLLDGLVRRSRVHWVRARVVQL
Rv2677c|M.tuberculosis_H37Rv TSVTDAVRQALPPGSGGPVFGALDGGYQVLLDGLVRRSRVHWVRARVVQL
MLBr_01044|M.leprae_Br4923 TSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELVRRSRLQWVAATVVGL
MAB_2985c|M.abscessus_ATCC_199 GSLLAAARQALPPISDSGIFGAVDGGYAVLVEELWSRARAEHVQVAVTGI
*: *. .*** . :***: *** **:: * *: . . . . :
Mflv_3918|M.gilvum_PYR-GCK HPVRAGWEVVDDEGGHWPADAVVLAVPAPRLPALLA---ELAPHSADIAR
Mvan_2482|M.vanbaalenii_PYR-1 GRGARGWEVLDDEGTRWPADAVVLAVPAPRLPALVA---DIAPRTAAAAR
MSMEG_2781|M.smegmatis_MC2_155 DRDANGWLVFDDEGTNWNADGVVLAVPAPALPALIE---HVAPRTAAAAR
MMAR_2039|M.marinum_M EP---GWALHDDAGRRWHADAVILAIPAPRLVRILDGVDGVDPRSVAAAS
MUL_3311|M.ulcerans_Agy99 EP---GWALHDDAGRRWHADAVILAIPAPRLVRILDGVDGVDPRSVAAAS
Mb2696c|M.bovis_AF2122/97 ER---GWVLRDETGGRWQADAVILAVPAPRLARLVD---GIAPRTHAAAR
Rv2677c|M.tuberculosis_H37Rv ER---GWVLRDETGGRWQADAVILAVPAPRLARLVD---GIAPRTHAAAR
MLBr_01044|M.leprae_Br4923 DRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQ---QIAPRTVAAAS
MAB_2985c|M.abscessus_ATCC_199 ERDGAGWAVTGEGGLTDAVDAVIVAVPAPRAAAILE---AVAPESAAAAR
** : .: * .*.*::*:*** :: : *.: *
Mflv_3918|M.gilvum_PYR-GCK RIPVASAAVVALALPGGTPLPEQSGVLVAG--RGPLHTKAVTLSSRKWGR
Mvan_2482|M.vanbaalenii_PYR-1 RIPVASAAVVALALPGGTPLPEQSGVLVAG--QGRLRAKAVTLSSKKWGR
MSMEG_2781|M.smegmatis_MC2_155 RIRVASAAVVALALPGGTPIPQQSGVLVATGEAGSLNAKAVTLSSRKWGR
MMAR_2039|M.marinum_M RVRSASSAVVALAVPADTPFPQCSGVLVAN--GEPLRAKAITLSSRKWGI
MUL_3311|M.ulcerans_Agy99 RVRSASSAVVALAVPADTPFPQCSGVLVAN--GEPLRAKAITLSSRKWGI
Mb2696c|M.bovis_AF2122/97 QIVSASSAVVALAVPGGTAFPHCSGVLVAG--DESPHAKAITLSSRKWGQ
Rv2677c|M.tuberculosis_H37Rv QIVSASSAVVALAVPGGTAFPHCSGVLVAG--DESPHAKAITLSSRKWGQ
MLBr_01044|M.leprae_Br4923 RIVSASSAVVALSVPRDTTFPQNSGVLVAS--GERLRAKAVTLSSRKWGL
MAB_2985c|M.abscessus_ATCC_199 TIPVASSVVVALTLPGDAPIPANSGVLVAS--GEALHTKAITFSTSKWGL
: **:.****::* .:.:* ****** .:**:*:*: ***
Mflv_3918|M.gilvum_PYR-GCK RG-SAEMLRLSYGRFGDDLARSTGDDELLAWADEDLATLFGIAVEPVDAR
Mvan_2482|M.vanbaalenii_PYR-1 RA-NVEMVRLSYGRFGDDLARSTGDEDLLAWAAQDLSVLFGISVDPVDSR
MSMEG_2781|M.smegmatis_MC2_155 RG-NVELLRLSFGRYGDDLARSTGDEDLLAWSTRDLNTLFGITVDPVDWH
MMAR_2039|M.marinum_M QG-DVQQLRISFGRFGDDLAERVSDHQLLSWARDDLATVFGVTVDPVDSR
MUL_3311|M.ulcerans_Agy99 QG-DVQQLRISFGRFGDDLAERVSDHQLLSWARDDLATVFGVTVDPVDSR
Mb2696c|M.bovis_AF2122/97 RG-DVALLRLSFGRFGDEPALTASDDQLLAWAADDLVTVFGVAVDPVDVR
Rv2677c|M.tuberculosis_H37Rv RG-DVALLRLSFGRFGDEPALTASDDQLLAWAADDLVTVFGVAVDPVDVR
MLBr_01044|M.leprae_Br4923 QG-DTQLVRLSFGKFGDQVASTASDDELLAWAVSDLAAVFDVTVDPVDVC
MAB_2985c|M.abscessus_ATCC_199 RGRSTQVVRLSYGRFGDTVARATTDEQLRHWAVADLEAVLGAGIVPVNSA
:. .. :*:*:*::** * . *.:* *: ** .::. : **:
Mflv_3918|M.gilvum_PYR-GCK VVRWIDAMPQYGPGHADRVADLRAGLPRGLAVAGAYLDGIGVPACVASAA
Mvan_2482|M.vanbaalenii_PYR-1 VVRWIDALPQYGPGHAALVAELRAGLPGGLAVAGAYLDGIGVPACVAAAT
MSMEG_2781|M.smegmatis_MC2_155 IQRWIDAMPQYGPGHLDLVAELRAGLPPNLAVTGSYLDGIGVPACVGAAT
MMAR_2039|M.marinum_M VQRWIEAMPQYGPGHGELVAQVRAGLPPTLAVAGSYLDGIGVPACVGAAS
MUL_3311|M.ulcerans_Agy99 VQRWIEAMPRYGPGHGVLVAQVRAGLPPTLAVAGSYLDGIGVPACVGAAS
Mb2696c|M.bovis_AF2122/97 VRRWIEAMPQYGPGHADVVAELRAGLPPTLAVAGSYLDGIGVPACVGAAG
Rv2677c|M.tuberculosis_H37Rv VRRWIEAMPQYGPGHADVVAELRAGLPPTLAVAGSYLDGIGVPACVGAAG
MLBr_01044|M.leprae_Br4923 VQRWIDAMPQYGPGHADLVAEVRAGLPPTLVVAGSHMDGIGVPACISAAG
MAB_2985c|M.abscessus_ATCC_199 VARWIDAMPQYGPGHAEVVDAIRSGLPSGIAVAGSYLDGIGVPACVASAS
: ***:*:*:***** * :*:*** :.*:*:::********:.:*
Mflv_3918|M.gilvum_PYR-GCK RAVASLVAGSSVGQ--
Mvan_2482|M.vanbaalenii_PYR-1 RAVAALVVDGR-----
MSMEG_2781|M.smegmatis_MC2_155 RAALTLVKTGVAR---
MMAR_2039|M.marinum_M RAVDGIVGALNPQVAR
MUL_3311|M.ulcerans_Agy99 RAVDGVVGALNPQVAR
Mb2696c|M.bovis_AF2122/97 RAVTSVIEALDAQVAR
Rv2677c|M.tuberculosis_H37Rv RAVTSVIEALDAQVAR
MLBr_01044|M.leprae_Br4923 R----AIEALQAEVAR
MAB_2985c|M.abscessus_ATCC_199 QAAQASVARWRHG---
: :