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TASSRAPSMVSTVRTRTVAVVCAALSVISIAAVVGLSALVDVYTQRHVDLAARVLDFAASSHDETNPLDP VDFAKTLPRNTTVIFADRGGTHTVWSTSSSRSAESDVDSLLRQCAPTNDIVDATMGGHPVRARALRFDNP VVIGNRTTGWRATADTAVVALGARSATKLTRVMAAVAAITGIATMIGAAAATTVLVRRTMSPLTRLTTAV QGLGPRPRAGSLPRGAGSRFREAATLTEAIADLVDRRARAEEELREFIANTSHELRTPLTKIQGWSELYF QRPPTAVHTDRAMQSIVEECDRMRAMIDGLSMLARAQEIPELATEDVDVCALCRTVAEDVAVISPGCRVR TDIPEQPILIAAHSDRITQVLRNIVGNSLVHGGPDVCIGIRVAADSHGVSIDVTDDGHGIPAEHHPSLFA RNYSAAEGGSGLGLAIVRAIVTSYGGDVSLRSVAGEGTAVTLHFP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2335 | - | - | 100% (466) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_5174 | - | 2e-32 | 28.34% (367) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_4428 | - | 9e-32 | 29.75% (316) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 2e-35 | 29.51% (349) | two component system response sensor kinase membrane |
| M. gilvum PYR-GCK | Mflv_2267 | - | 7e-34 | 31.17% (308) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0758 | phoR | 2e-35 | 29.51% (349) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_02440 | - | 2e-22 | 31.11% (270) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_2582 | - | 7e-37 | 29.91% (331) | putative two component sensor kinase |
| M. marinum M | MMAR_4941 | phoR | 2e-33 | 29.24% (342) | two-component system response phosphate sensor kinase, PhoR |
| M. avium 104 | MAV_0305 | - | 4e-38 | 31.79% (324) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_4989 | - | 1e-33 | 31.51% (311) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2452 | - | 1e-23 | 28.19% (298) | PUTATIVE putative sensor histidine kinase PhoR |
| M. ulcerans Agy99 | MUL_0464 | phoR | 2e-33 | 29.24% (342) | two component system response phosphate sensor kinase, PhoR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0781|M.bovis_AF2122/97 ----------------MARHLRGRLPLRVRLVAATLILVATGLVASGIAV
Rv0758|M.tuberculosis_H37Rv ----------------MARHLRGRLPLRVRLVAATLILVATGLVASGIAV
MMAR_4941|M.marinum_M ----------------MAERLPRAVPLRVGLVAATLALVLCGLLASGVAV
MUL_0464|M.ulcerans_Agy99 ----------------MAERLPRAVQLRVGLVAATLALVLCGLLASGVAV
Mflv_2267|M.gilvum_PYR-GCK MSSSPRAERTPAPVLRP----PRTWSLRTRLILTQLLLLAVVCAGVGVAT
MSMEG_4989|M.smegmatis_MC2_155 MFFVPRADAPRAAVGGTRWWSPRTWPLRARLVGTQVALLAVVCLSIGLAT
MAV_0305|M.avium_104 -----MADTR------------RVWSLRLRLLVGQIVVLALVCLGITAVT
MAB_2582|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2452|M.thermoresistible__bu -----MTSEPPSPSGRPRWRRLLPSAARTRIIGWVLLLVMVALGVVTLTT
Mvan_2335|M.vanbaalenii_PYR-1 -------------MTASSRAPSMVSTVRTRTVAVVCAALSVISIAAVVGL
MLBr_02440|M.leprae_Br4923 --------------------------------MFSALLLAGVLSGLAFVV
Mb0781|M.bovis_AF2122/97 TSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYP--------------
Rv0758|M.tuberculosis_H37Rv TSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYP--------------
MMAR_4941|M.marinum_M TSILRHSLVSRIDSTLLEASRTWAQASWRHSMPSVE--------------
MUL_0464|M.ulcerans_Agy99 TSILRHSLVSRIDSTLLEASRTWAQASWRHSMPSVE--------------
Mflv_2267|M.gilvum_PYR-GCK EFALQRFLMNQLDEQVIEAGRRSSMIFEFGPPPPPGMGMPPPPGVGMPPP
MSMEG_4989|M.smegmatis_MC2_155 EFALQRFLMHQLDEQLLEAGRRSAAIYEL-PPPPRGFLPLFPPGMG----
MAV_0305|M.avium_104 ELALNHHLVKQLDGQLAGTSFRSALMYPE-PNHP----------------
MAB_2582|M.abscessus_ATCC_1997 ---MNRFLNTQLDEQVRDAGNRSVVLFELGPPPPLS--------------
TH_2452|M.thermoresistible__bu WRLMVSSIDARMDEALHIEVDEFEELTASGLNPRTG--------------
Mvan_2335|M.vanbaalenii_PYR-1 SALVDVYTQRHVDLAARVLDFAASSHDETNPLDPVD--------------
MLBr_02440|M.leprae_Br4923 GIVAGIRLSPRLIERRQRLANEWAGITVLQMLQRII--------------
::
Mb0781|M.bovis_AF2122/97 -------------------IHNPDRPPSRFYVRVISPDGQSYTALNDNTA
Rv0758|M.tuberculosis_H37Rv -------------------GHNPDRPPSRFYVRVISPDGQSYTALNDNTA
MMAR_4941|M.marinum_M -------------------GPDPARPPSKFYVRSISPDGRAMTAINDRNA
MUL_0464|M.ulcerans_Agy99 -------------------GPDPARPPSKFYVRSISPDGRAMTAINDRNA
Mflv_2267|M.gilvum_PYR-GCK PGVGMPVPPVGPPPRRGHHMMIRDEGPGPAFLNAPGQAILTVGAVVSDGR
MSMEG_4989|M.smegmatis_MC2_155 ------------PPGRHLRVFDPEQGPGPGFLNAPGQAARTVGAVVSPDG
MAV_0305|M.avium_104 ---------------RHEHSPYPRPGPGPRFLDAPGQPAGMVAAVVSHGK
MAB_2582|M.abscessus_ATCC_1997 ------------LPRPLANGWRPTDGPGPAFLDAPGQSIGMVGAVAVNGH
TH_2452|M.thermoresistible__bu -------------APFTGVAEVIREAIAYNLARPNEKFLGYVDGEYHTQS
Mvan_2335|M.vanbaalenii_PYR-1 ------------------FAKTLPRNTTVIFADRGGTHTVWSTSSSRSAE
MLBr_02440|M.leprae_Br4923 ----------------------------ALMPLGAAVVDTYRDVVYLNEQ
Mb0781|M.bovis_AF2122/97 IPAVPANNDVGRHPTTLPSIG-----------------GSKTLWRAVSVR
Rv0758|M.tuberculosis_H37Rv IPAVPANNDVGRHPTTLPSIG-----------------GSKTLWRAVSVR
MMAR_4941|M.marinum_M EPALPADNDVGSDPTTLPSVN-----------------GSNIEWRAVSVH
MUL_0464|M.ulcerans_Agy99 EPALPADNDVGSDPTTLPSVN-----------------GSNIEWRAVSVH
Mflv_2267|M.gilvum_PYR-GCK ADDAGMIATDGSRTEISDVAARQLATVAVGGRPHTVDLDGLGRYRVVAFP
MSMEG_4989|M.smegmatis_MC2_155 SVDAGVITSDGDRQEVSAAAARQLAAIPATREPQTIDLDGLGRYRLIGLH
MAV_0305|M.avium_104 TVDAGYLTSSGTRDALTSTAQTQLEQIAGSRAPVTVNLDGLGRYRVVAAP
MAB_2582|M.abscessus_ATCC_1997 VTEAARITADGSRERLSPQACREVEGLLQQSTS-TVDLDHAGLYRLVTMP
TH_2452|M.thermoresistible__bu RQEPGFPEVLAGDDAFTERVATVTEPVEG-----SYDHPEVGEVRYLAIP
Mvan_2335|M.vanbaalenii_PYR-1 SDVDSLLRQCAPTNDIVDATMGGHPVRAR---ALRFDNPVVIGNRTTGWR
MLBr_02440|M.leprae_Br4923 AKELGLVRD-----------------------------RQLDDQAWRAAQ
Mb0781|M.bovis_AF2122/97 ASDGY-----LTTVAIDLADVRSTVRSLVLLQVGIGSAVLVVLGVAGYAV
Rv0758|M.tuberculosis_H37Rv ASDGY-----LTTVAIDLADVRSTVRSLVLLQVGIGSAVLVVPGVAGYAV
MMAR_4941|M.marinum_M GPQGG-----LTTVAIDLSDVQHTVRSLVWLQIGIGAGVLVVVGLAGFAV
MUL_0464|M.ulcerans_Agy99 GPQGG-----LTTVAIDLSDVQHTVRSLVWLQIGIGAGVLVVVGLAGFAV
Mflv_2267|M.gilvum_PYR-GCK SHMEG----EAVVAGLPTTDVDDTLFWVAVIFGVVAVVALMAAGTAGAVI
MSMEG_4989|M.smegmatis_MC2_155 PRHGGP---QTIVTGLPNSVVDDTLLWVLGMFCVIAAVALIAAITAGTLL
MAV_0305|M.avium_104 SRNGS----DIIVTGLSMANIDATLIRMLVIFGIVTVIALAAATIAGVVI
MAB_2582|M.abscessus_ATCC_1997 TNGGA-----VIVTGLPAEGVGQTLSSVFGIICVVGAAALITAIGAGIVI
TH_2452|M.thermoresistible__bu VTMAGDPAQGVIVAAYLGDAERAAADDAARLMLLVGAATLFGAIGAAWLV
Mvan_2335|M.vanbaalenii_PYR-1 ATADT------AVVALGARSATKLTRVMAAVAAITGIATMIGAAAATTVL
MLBr_02440|M.leprae_Br4923 QALGG----------------DDVEFDLLPGKRPAAGRSGLSVHGHARLL
:
Mb0781|M.bovis_AF2122/97 VRRSLRPLAEFEQTAAAIGAGQLDR----------RVPQWHPRTEVGRLS
Rv0758|M.tuberculosis_H37Rv VRRSLRPLAEFEQTAAAIGAGQLDR----------RVPQWHPRTEVGRLS
MMAR_4941|M.marinum_M VQRSLRPLSEVEQTAAAIASGQLDR----------RVPERDPRTEVGQLS
MUL_0464|M.ulcerans_Agy99 VQRSLRPLSEVEQTAAAIASGQLDR----------RVPERDPRTEVGQLS
Mflv_2267|M.gilvum_PYR-GCK VRRQLAPLARVSEAAQQVADLELDRGEVRLPTPIVKVDPAAAQTEVGQLG
MSMEG_4989|M.smegmatis_MC2_155 IRRQFAPLARVSATAREVADLELERGEVRLPTPIVPVDPAVAHTEVGQLG
MAV_0305|M.avium_104 IRRALAPLRRVAQTAREVADLPLARGEVELPVRVRESD-ANPSTEVGQLG
MAB_2582|M.abscessus_ATCC_1997 IRRQLDPLSQVATAAQEVAELELHRGEVNLPTPIIDVASNRTHTELGQLG
TH_2452|M.thermoresistible__bu AGRILRPLRDVADTARTITDTDLSR----------RIPSRGEGDEMDSLV
Mvan_2335|M.vanbaalenii_PYR-1 VRRTMSPLTRLTTAVQGLGPRPRAG--------SLPRGAGSRFREAATLT
MLBr_02440|M.leprae_Br4923 SEKDRRFAVVFVHDQSDYVRMEAAR-------------------------
: .
Mb0781|M.bovis_AF2122/97 LALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIR
Rv0758|M.tuberculosis_H37Rv LALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIR
MMAR_4941|M.marinum_M LAMNGMLSQIQVALAASEDSAEKARSSEERMRRFITDASHELRTPLTTIR
MUL_0464|M.ulcerans_Agy99 LAMNGMLSQIQVALAASEDSAEKARSSEERMRRFITDASHELRTPLTTIR
Mflv_2267|M.gilvum_PYR-GCK SALNRMLDRIAGALSAR-------HASETRVRQFVADASHELRTPLAAIR
MSMEG_4989|M.smegmatis_MC2_155 TSLNRMLDRIASALSAR-------HASETRVRQFVADASHELRTPLAAIR
MAV_0305|M.avium_104 AALNRMLDHIADALSAR-------QASETRVRQFVADASHELRTPLAAIR
MAB_2582|M.abscessus_ATCC_1997 AALNRMLERIDDALSAR-------HVSETRVRQFVADASHELRTPLAAIS
TH_2452|M.thermoresistible__bu RTINGMLDRIEAGVSAQ--------------RRFIDDAGHELRTPITIVR
Mvan_2335|M.vanbaalenii_PYR-1 EAIADLVDRRAR--------------AEEELREFIANTSHELRTPLTKIQ
MLBr_02440|M.leprae_Br4923 -------------------------------RDFVANVSHELKTPVGAMA
* *: :..***:**: :
Mb0781|M.bovis_AF2122/97 GFAELYRQGAAR---DVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPL
Rv0758|M.tuberculosis_H37Rv GFAELYRQGAAR---DVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPL
MMAR_4941|M.marinum_M GFAELYRQGAAR---DVAMLLSRIESEASRMGLLVDDLLTLARLDVQRPL
MUL_0464|M.ulcerans_Agy99 GFAELYRQGAAR---DVAMLLSRIESEASRMGLLVDDLLTLARLDVQRPL
Mflv_2267|M.gilvum_PYR-GCK GYTELAQRKQAELPDDVAHAMSRVESETARMTQLVEDMLLLARLDTGRPL
MSMEG_4989|M.smegmatis_MC2_155 GYTELAQRKRGELPDDVAHAMSRVESETSRMTQLVEDMLLLARLDAGRPL
MAV_0305|M.avium_104 GYTELTQR-MGDDREAVAQAMSRVASETERMTRLVEDLLLLARLDSGRPL
MAB_2582|M.abscessus_ATCC_1997 GYAELARRNHDALPTDVAHAMSRVQSEAARMTELVEDLLLLARLDSGRPL
TH_2452|M.thermoresistible__bu GHLEVLDPDDPD---DVRSTVALVDDELVRMNRMVTDLLLLARSEQPTFL
Mvan_2335|M.vanbaalenii_PYR-1 GWSELYFQRPPT-AVHTDRAMQSIVEECDRMRAMIDGLSMLARAQEIPEL
MLBr_02440|M.leprae_Br4923 LLAEALLASADD-AETVSRFAEKVLIEANRLGYMVAELIELSRLQGAERL
* . : * *: :: : *:* : *
Mb0781|M.bovis_AF2122/97 E-LCRVDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQ
Rv0758|M.tuberculosis_H37Rv E-LCRVDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQ
MMAR_4941|M.marinum_M E-RNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDEPRLRQ
MUL_0464|M.ulcerans_Agy99 E-RNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDEPRLRQ
Mflv_2267|M.gilvum_PYR-GCK D-RDSVDLTRLVVDAVSDAHVAAPDHVWELDLPDEP--LTVCGDEARLHQ
MSMEG_4989|M.smegmatis_MC2_155 E-RDRVELSRLVVDTVSDAHVAGPQHKWSLDLPEDA--VVIDGDEARLHQ
MAV_0305|M.avium_104 E-REPVDLSRLAVDAVNDAHVAGPDHQWELDLPEEP--VVITGDAARLHQ
MAB_2582|M.abscessus_ATCC_1997 A-QEPVDLSRLVVDAASDAHIAASEHRWLLNLPEDP--VIVCGDTPRLHQ
TH_2452|M.thermoresistible__bu T-PEPTDIGALTRAIFDKVVQLGDRDYQLQSVAEVT----AVLDAQRITQ
Mvan_2335|M.vanbaalenii_PYR-1 A-TEDVDVCALCRTVAEDVAVISPGCRVRTDIPEQP--ILIAAHSDRITQ
MLBr_02440|M.leprae_Br4923 PNVTDIDVDIIVSEAIARHKVAADTAAIEVRT-DPPSGLRVLGDQTLLVT
:: : : . . :
Mb0781|M.bovis_AF2122/97 VLRNLVANAIQHTPESADVTVRVG-TEGDDAILEVADDGPGMSQEDALRV
Rv0758|M.tuberculosis_H37Rv VLRNLVANAIQHTPESADVTVRVG-TEGDDAILEVADDGPGMSQEDALRV
MMAR_4941|M.marinum_M VLSNLVGNALQHTPDSADVTVRVG-TAGQNAVLEVADKGPGMPAEDAARV
MUL_0464|M.ulcerans_Agy99 VLSNLVGNALQHTPDSADVTVRVG-TAGENAVLEVADKGPGMPAEDAARV
Mflv_2267|M.gilvum_PYR-GCK VLANLLANAGIHTPAGTTVTTSLTATDTGDVLVRVVDDGPGIPARLQPDV
MSMEG_4989|M.smegmatis_MC2_155 VMANLLANARTHTPPGTSVTVALSADAEGWVTVAVTDDGPGIAPELLPDV
MAV_0305|M.avium_104 VLTNLLANARVHTGAGTVVTTRLS-TEPAHTVLQVIDNGPGIPAELQSEV
MAB_2582|M.abscessus_ATCC_1997 VVANLLSNCRIHTPPGTTVTVTLR-SDGNSTYLTVADDGPGIPAGQQNEI
TH_2452|M.thermoresistible__bu ALIALADNACRYTRDGDWIAVGSG-LYDGWLRFWVSDSGPGVSDADRDRI
Mvan_2335|M.vanbaalenii_PYR-1 VLRNIVGNSLVHGGPDVCIGIRVA-ADSHGVSIDVTDDGHGIPAEHHPSL
MLBr_02440|M.leprae_Br4923 ALANLVSNAIAYSPGGSLVSISRR-RRGDNIEIAVTDRGIGIALEDQERV
.: : *. : . : . * * * *:. :
Mb0781|M.bovis_AF2122/97 FERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCFRV
Rv0758|M.tuberculosis_H37Rv FERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCFRV
MMAR_4941|M.marinum_M FERFYRTDSSRARASGGTGLGLSIVHSLVKAHGGDVTLTTAPGEGCCFRV
MUL_0464|M.ulcerans_Agy99 FERFYRTDSSRARASGGTGLGLSIVHSLVKAHGGDVTLTTAPGEGCCFRV
Mflv_2267|M.gilvum_PYR-GCK FERFARGDTSRSRRGGSTGLGLAIVAAVVRAHHGTISLHSVPGR-TEFAV
MSMEG_4989|M.smegmatis_MC2_155 FERFARGDSSRSRREGSTGLGLAIVAAVVKAHGGVIDVTSRPGE-TRFVV
MAV_0305|M.avium_104 FERFARGDSSRSRKGGSTGLGLAIVSAVVKAHNGTISVNSSPGH-TEFTV
MAB_2582|M.abscessus_ATCC_1997 FERFARGDTSRSRRAGSTGLGLAIAAAVIKAHHGEIRVNSVAGE-TVFTI
TH_2452|M.thermoresistible__bu FERFARG-SAGGQRSDGAGLGLSIVRAIAGAHGGHVDLDTVVGRGSTFTI
Mvan_2335|M.vanbaalenii_PYR-1 FAR------NYSAAEGGSGLGLAIVRAIVTSYGGDVSLRSVAGEGTAVTL
MLBr_02440|M.leprae_Br4923 FERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSIGVWSKPGTGSTFTL
* * . ..:****:*. : : * : : : * . :
Mb0781|M.bovis_AF2122/97 SLPRVSDVDQLSLTPVVPGPP-----------------------------
Rv0758|M.tuberculosis_H37Rv SLPRVSDVDQLSLTPVVPGPP-----------------------------
MMAR_4941|M.marinum_M TLPRVSEAAVELTEPVS---------------------------------
MUL_0464|M.ulcerans_Agy99 TLPRVSEAAVELTEPVS---------------------------------
Mflv_2267|M.gilvum_PYR-GCK VLPGDTQAVHSVGPR-----------------------------------
MSMEG_4989|M.smegmatis_MC2_155 RLPG---AAHS---------------------------------------
MAV_0305|M.avium_104 RLPPNGWQPHASA-------------------------------------
MAB_2582|M.abscessus_ATCC_1997 TLPTAGTQHGAFTEKLP---------------------------------
TH_2452|M.thermoresistible__bu TIPAVLEAPWPAS-------------------------------------
Mvan_2335|M.vanbaalenii_PYR-1 HFP-----------------------------------------------
MLBr_02440|M.leprae_Br4923 SIPAAMPLYQDNDEQSGQPRGCDMWLNRPQREEEEFKSMTPAQAMMQSEV
:*
Mb0781|M.bovis_AF2122/97 -------------------
Rv0758|M.tuberculosis_H37Rv -------------------
MMAR_4941|M.marinum_M -------------------
MUL_0464|M.ulcerans_Agy99 -------------------
Mflv_2267|M.gilvum_PYR-GCK -------------------
MSMEG_4989|M.smegmatis_MC2_155 -------------------
MAV_0305|M.avium_104 -------------------
MAB_2582|M.abscessus_ATCC_1997 -------------------
TH_2452|M.thermoresistible__bu -------------------
Mvan_2335|M.vanbaalenii_PYR-1 -------------------
MLBr_02440|M.leprae_Br4923 TRGNVNDKCPDCGGRGIAG