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DGGDGPTLNNGGVPGRIRRGVPLRVGLVAAMLLLVACGLLASGIAVTTIMQHSLMNRVDDTLLDASRGWA QVPRRVLTVPMEGPNPARPPSDFYVRAVDPDGHVWMEVNDREAEPALPEDNDVGSEPVTVASVDHSHVQW RAMTVRGLSGELTTVAIDLSDVKSTVRSLVYTQAGFGVAVLVVLGIAGYAVVHRSLRPLSEVEQTAAAIA AGQLDRRVPERDPRTEVGRLSLALNGMLAQIQRAMASSEASAEQARTSEDRMRRFITDASHELRTPLTTI RGFAELYRQGAARDVEMLMSRIESESRRMGLLVEDLLLLARLDAQRPLDRHRVDLLTLATDAVHDAQSIA PKRSIKMEVFDGPGTPEVLGDEPRLRQVLSNLVANALQHTPETAAVTVRVGTDGNDAVVEVCDEGPGMRP EDAQRVFERFYRTDTSRARASGGTGLGLSIVDSLVYAHGGRVSVTTAPGQGSRFRVSLPRIADAGPDAGP DAEVPVSSAQLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5174 | - | - | 100% (503) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_4428 | - | 1e-67 | 36.41% (541) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_2295 | - | 1e-57 | 35.09% (493) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 0.0 | 71.09% (467) | two component system response sensor kinase membrane |
| M. gilvum PYR-GCK | Mflv_1582 | - | 0.0 | 86.43% (479) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0758 | phoR | 0.0 | 71.09% (467) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_00774 | mtrB | 4e-39 | 33.93% (333) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 1e-170 | 65.19% (497) | putative sensor histidine kinase PhoR |
| M. marinum M | MMAR_4941 | phoR | 0.0 | 73.99% (469) | two-component system response phosphate sensor kinase, PhoR |
| M. avium 104 | MAV_0703 | - | 0.0 | 77.35% (468) | sensor histidine kinase PhoR |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 0.0 | 82.69% (468) | sensor histidine kinase PhoR |
| M. thermoresistible (build 8) | TH_0463 | mtrB | 9e-40 | 30.34% (445) | TWO COMPONENT SENSORY TRANSDUCTION HISTIDINE KINASE MTRB |
| M. ulcerans Agy99 | MUL_0464 | phoR | 0.0 | 73.77% (469) | two component system response phosphate sensor kinase, PhoR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0781|M.bovis_AF2122/97 ----------MARH-------------------LRGRLPLRVRLVAATLI
Rv0758|M.tuberculosis_H37Rv ----------MARH-------------------LRGRLPLRVRLVAATLI
MMAR_4941|M.marinum_M ----------MAER-------------------LPRAVPLRVGLVAATLA
MUL_0464|M.ulcerans_Agy99 ----------MAER-------------------LPRAVQLRVGLVAATLA
MAV_0703|M.avium_104 ---------MVVTR-------------------PRRGLPLRVGLVAATLA
Mvan_5174|M.vanbaalenii_PYR-1 ----------MDGG---DGPTLNNGGVPGR---IRRGVPLRVGLVAAMLL
Mflv_1582|M.gilvum_PYR-GCK ----------MSSASPDERSNLNNGDVAGRRRYLRRGVPLRVALVAATLL
MSMEG_5870|M.smegmatis_MC2_155 ----------MNRG--------------------RRGIPLRVGLVAAALV
MAB_0674|M.abscessus_ATCC_1997 ----MAWDTYCASRDERLREEQLALLVAVPG--VRRGVPLRVSLVVGTLV
MLBr_00774|M.leprae_Br4923 --MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFG
TH_0463|M.thermoresistible__bu VAMIFSSRRRIR---GRSGPLLRGFGALGRALGHLWRRSLQLRVVALTLG
*:: :*. :
Mb0781|M.bovis_AF2122/97 LVATGLVASGIAVTSMLQHRLTS---RIDRVLLEEAQIWAQITLPLAPDP
Rv0758|M.tuberculosis_H37Rv LVATGLVASGIAVTSMLQHRLTS---RIDRVLLEEAQIWAQITLPLAPDP
MMAR_4941|M.marinum_M LVLCGLLASGVAVTSILRHSLVS---RIDSTLLEASRTWAQASWRHSMPS
MUL_0464|M.ulcerans_Agy99 LVLCGLLASGVAVTSILRHSLVS---RIDSTLLEASRTWAQASWRHSMPS
MAV_0703|M.avium_104 LVACGLAVSGIAVTSILRHSLVS---RIDSTLLDASRGWAQAPRRQSSSA
Mvan_5174|M.vanbaalenii_PYR-1 LVACGLLASGIAVTTIMQHSLMN---RVDDTLLDASRGWAQVPRRVLTVP
Mflv_1582|M.gilvum_PYR-GCK LVACGLLASGIAVTTIMQHSLMN---RVDDTLLDASRGWAQVPRRLPTIT
MSMEG_5870|M.smegmatis_MC2_155 LVACGLLASGIAVTSIMRHTEVS---RIDQTLLDASRSWAQAPRRAPTTP
MAB_0674|M.abscessus_ATCC_1997 LVALGLVASGIAVTTTMQRTMMN---RADRELIDAANGWANRP--PPPPP
MLBr_00774|M.leprae_Br4923 LSLAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETR
TH_0463|M.thermoresistible__bu LSLAVIVVLGFVLTSQITDRILEVKVQAAIEEIERARNTVSGIVGGEETR
* : . *..:*: : . : :: :. .
Mb0781|M.bovis_AF2122/97 YPIHNPDRPPSRFYVRVISPDGQSYTALNDNT-AIPAVPANNDVGRHPTT
Rv0758|M.tuberculosis_H37Rv YPGHNPDRPPSRFYVRVISPDGQSYTALNDNT-AIPAVPANNDVGRHPTT
MMAR_4941|M.marinum_M VEGPDPARPPSKFYVRSISPDGRAMTAINDRN-AEPALPADNDVGSDPTT
MUL_0464|M.ulcerans_Agy99 VEGPDPARPPSKFYVRSISPDGRAMTAINDRN-AEPALPADNDVGSDPTT
MAV_0703|M.avium_104 YEGPDPGRPPSKFYVRGVSTDGTPFTAINDRN-AEPALPADNDVGPNPTT
Mvan_5174|M.vanbaalenii_PYR-1 MEGPNPARPPSDFYVRAVDPDGHVWMEVNDRE-AEPALPEDNDVGSEPVT
Mflv_1582|M.gilvum_PYR-GCK VDDPNPARPPSDFYVRGIDPDGHVWMLINDRE-AEPELPADNNVGPEPRT
MSMEG_5870|M.smegmatis_MC2_155 LEGPNPARPPSNFYVRGFDEDGRTWIAVNDRE-AEPALPENNDVGPVPVT
MAB_0674|M.abscessus_ATCC_1997 AFETTRHRPPSLFFIRTTDDRGRVVIMLNDRARADPDLPFDNDVGGRPVT
MLBr_00774|M.leprae_Br4923 SLDSSLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVD
TH_0463|M.thermoresistible__bu SLDSSLQLARNTLIDR-KADEGSGLAGTFDAVLVVPGDGPRAATTAGPVQ
. . : : * * * . *
Mb0781|M.bovis_AF2122/97 LPS------IGGSKTLWRAVSVR--------------------ASDGYLT
Rv0758|M.tuberculosis_H37Rv LPS------IGGSKTLWRAVSVR--------------------ASDGYLT
MMAR_4941|M.marinum_M LPS------VNGSNIEWRAVSVH--------------------GPQGGLT
MUL_0464|M.ulcerans_Agy99 LPS------VNGSNIEWRAVSVH--------------------GPQGGLT
MAV_0703|M.avium_104 LPS------VNGSDIQWRAVSVR--------------------GPHG-LT
Mvan_5174|M.vanbaalenii_PYR-1 VAS------VDHSHVQWRAMTVR--------------------GLSGELT
Mflv_1582|M.gilvum_PYR-GCK VGS------VDHSDVQWRAMTVR--------------------GLRGELT
MSMEG_5870|M.smegmatis_MC2_155 VGS------IDKSNVEWRAMTVR--------------------GPNGELT
MAB_0674|M.abscessus_ATCC_1997 VRS------SDGG-TEWRAVSRH--------------------DALGGYT
MLBr_00774|M.leprae_Br4923 QVPNSLRGFIKAGQAAYQYATVHTEGFSGPALIIGTPT---SSQVTNLEL
TH_0463|M.thermoresistible__bu QIPTGLRDFVKAGQVSYQYATVHTDNFAGPALLVGSPTGSSTSSVTNLEL
. . :: : : .
Mb0781|M.bovis_AF2122/97 TVAIDLADVRSTVRSLVLLQVGIGSAVLVVLGVAGYAVVRRSLRPLAEFE
Rv0758|M.tuberculosis_H37Rv TVAIDLADVRSTVRSLVLLQVGIGSAVLVVPGVAGYAVVRRSLRPLAEFE
MMAR_4941|M.marinum_M TVAIDLSDVQHTVRSLVWLQIGIGAGVLVVVGLAGFAVVQRSLRPLSEVE
MUL_0464|M.ulcerans_Agy99 TVAIDLSDVQHTVRSLVWLQIGIGAGVLVVVGLAGFAVVQRSLRPLSEVE
MAV_0703|M.avium_104 TVAIDLSDVQHTVSSLVWLQIGIGVAVLAVVGIASFAVVQRSLRPLVEVE
Mvan_5174|M.vanbaalenii_PYR-1 TVAIDLSDVKSTVRSLVYTQAGFGVAVLVVLGIAGYAVVHRSLRPLSEVE
Mflv_1582|M.gilvum_PYR-GCK TVAIDLSDVKSTMRSLVYTQVGIGAAVLLVLGIAGYAVVHRSLRPLSEVE
MSMEG_5870|M.smegmatis_MC2_155 TVAIDLSEVQSSVRALVWSQVGIGAAVLLVLGVVGYVVVHRSLRPLVEVE
MAB_0674|M.abscessus_ATCC_1997 TVARDITDVRTTVRDLLWLQVAIGIAVLTVLGVAGYWLVHRSLRPLAEVE
MLBr_00774|M.leprae_Br4923 YLIFPLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVPVRSAS
TH_0463|M.thermoresistible__bu YLIFPLNNEESTIALVRGTIATGGLVLLGLLAAISLLVARQVVLPVRSAS
: : : . :: : * :* : . . : :: : *: . .
Mb0781|M.bovis_AF2122/97 QTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAE
Rv0758|M.tuberculosis_H37Rv QTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAE
MMAR_4941|M.marinum_M QTAAAIASGQLDRRVPERDPRTEVGQLSLAMNGMLSQIQVALAASEDSAE
MUL_0464|M.ulcerans_Agy99 QTAAAIASGQLDRRVPERDPRTEVGQLSLAMNGMLSQIQVALAASEDSAE
MAV_0703|M.avium_104 QTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQQALASSESSAE
Mvan_5174|M.vanbaalenii_PYR-1 QTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQRAMASSEASAE
Mflv_1582|M.gilvum_PYR-GCK QTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQHAMALSESSAE
MSMEG_5870|M.smegmatis_MC2_155 RTAAAIAAGQLDRRVPERDPRTEVGRLSSALNGMLAQIQRAVAASEASAE
MAB_0674|M.abscessus_ATCC_1997 ATAADIAAGHLDRRVPERDPRTEVGRLSLALNGMLAQIQRAVADSEKSAK
MLBr_00774|M.leprae_Br4923 RIAERFAEGHLSERMPVRG-EDDMARLAVSFNDMAESLSRQITQLEEFGN
TH_0463|M.thermoresistible__bu RIAERFAEGHLTERMPVRG-EDDMARLAMSFNDMAESLSRQITQLEEFGN
* :. *:* .*:* . ::.:*: ::*.* .:. :: * .:
Mb0781|M.bovis_AF2122/97 KARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIE
Rv0758|M.tuberculosis_H37Rv KARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIE
MMAR_4941|M.marinum_M KARSSEERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLSRIE
MUL_0464|M.ulcerans_Agy99 KARSSEERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLSRIE
MAV_0703|M.avium_104 KARGSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLSRIE
Mvan_5174|M.vanbaalenii_PYR-1 QARTSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVEMLMSRIE
Mflv_1582|M.gilvum_PYR-GCK KARSSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVEMLMGRIK
MSMEG_5870|M.smegmatis_MC2_155 QARSSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDIEMLMGRIE
MAB_0674|M.abscessus_ATCC_1997 AARTSEERMRRFITDASHELRTPLTTIRGYAELYRQGAATDTELVLGRIE
MLBr_00774|M.leprae_Br4923 LQR-------RFTSDVSHELRTPLTTVRMAADLIYDHSSDLDPTLRRSTE
TH_0463|M.thermoresistible__bu LQR-------RFTSDVSHELRTPLTTVRMAADLIHDNSADLDPALRRSIE
* :* :*.**********:* *:* : :: : :
Mb0781|M.bovis_AF2122/97 ---SEASRMGLLVDDLLLLARLDA-HRPLELCRVDLLALASDAAHDARAM
Rv0758|M.tuberculosis_H37Rv ---SEASRMGLLVDDLLLLARLDA-HRPLELCRVDLLALASDAAHDARAM
MMAR_4941|M.marinum_M ---SEASRMGLLVDDLLTLARLDV-QRPLERNRVDLLVLAADAVHDARAI
MUL_0464|M.ulcerans_Agy99 ---SEASRMGLLVDDLLTLARLDV-QRPLERNRVDLLVLAADAVHDARAI
MAV_0703|M.avium_104 ---SEASRMGLLVDDLLLLARLDV-QRPLEHHRVDLLALASDAVHDAQAM
Mvan_5174|M.vanbaalenii_PYR-1 ---SESRRMGLLVEDLLLLARLDA-QRPLDRHRVDLLTLATDAVHDAQSI
Mflv_1582|M.gilvum_PYR-GCK ---SESRRMGLLVEDLLLLARLDA-QRPLEHRRVDLLALASDTVHDAQSI
MSMEG_5870|M.smegmatis_MC2_155 ---SESRRMGLLVEDLLLLARLDA-QRPLERRRVDLLALATDAVHDAQSI
MAB_0674|M.abscessus_ATCC_1997 ---GESTRMGQLVEDLLLLARLDA-HRPMEQRLVDLLVLATDAVHDAKAT
MLBr_00774|M.leprae_Br4923 LMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMVNNALGNVGHL
TH_0463|M.thermoresistible__bu LMVSELDRFESLLNDLLEISRHDAGVAELSVESVDLRSTVRSALDNVGHL
.* *: *::*** ::* *. :. *** . .: :.
Mb0781|M.bovis_AF2122/97 DPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVR
Rv0758|M.tuberculosis_H37Rv DPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVR
MMAR_4941|M.marinum_M DRKRAITVEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTPDSADVTVR
MUL_0464|M.ulcerans_Agy99 DRKRAITVEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTPDSADVTVR
MAV_0703|M.avium_104 DPKRTITLEVLDGPGTPEVFGDEPRIRQVLGNLIANALQHTPESADVTVR
Mvan_5174|M.vanbaalenii_PYR-1 APKRSIKMEVFDGPGTPEVLGDEPRLRQVLSNLVANALQHTPETAAVTVR
Mflv_1582|M.gilvum_PYR-GCK APKRRIRMEVFDGPGTPEVLGDEARLRQVLSNLVANALQHTPESAGVTVR
MSMEG_5870|M.smegmatis_MC2_155 APKRRVKMEVFDGPGTPEVLGDEARLRQVIGNLVANAVQHTPETAGITVR
MAB_0674|M.abscessus_ATCC_1997 APERDVELEVFDGPGTPEVIGDELRLRQVLGNLVSNALGHT--TAAVRVR
MLBr_00774|M.leprae_Br4923 AEEAGIELLVDMPVDEVIAEVDARRVERILRNLIANAIDHS-EHKPVRIR
TH_0463|M.thermoresistible__bu ADDAGIELLMDLPEHEVIAEVDSRRVERILRNLIANAIDHA-ERKPVRIR
. : : : . * *:.::: **:.**: *: : :*
Mb0781|M.bovis_AF2122/97 VGTEGDDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLS
Rv0758|M.tuberculosis_H37Rv VGTEGDDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLS
MMAR_4941|M.marinum_M VGTAGQNAVLEVADKGPGMPAEDAARVFERFYRTDSSRARASGGTGLGLS
MUL_0464|M.ulcerans_Agy99 VGTAGENAVLEVADKGPGMPAEDAARVFERFYRTDSSRARASGGTGLGLS
MAV_0703|M.avium_104 VGTDGDDAVLEVADRGPGMNEQDASRVFERFYRTDSSRARASGGTGLGLS
Mvan_5174|M.vanbaalenii_PYR-1 VGTDGNDAVVEVCDEGPGMRPEDAQRVFERFYRTDTSRARASGGTGLGLS
Mflv_1582|M.gilvum_PYR-GCK VGTADDTAIVEVCDEGPGMTGEDAQRVFERFYRADSSRARASGGTGLGLS
MSMEG_5870|M.smegmatis_MC2_155 VGTDGDNAVLEVCDEGPGMSQEDARRVFERFYRADTSRTRASGGTGLGLS
MAB_0674|M.abscessus_ATCC_1997 VGTEGDDAVLEVIDRGPGMTKTDAERVFERFYRADSSRTRSSGGTGLGLS
MLBr_00774|M.leprae_Br4923 MAADEDTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLA
TH_0463|M.thermoresistible__bu MAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLA
:.: : . : * * * *: : **.**:*:*.**.* ********:
Mb0781|M.bovis_AF2122/97 IVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLS-----------
Rv0758|M.tuberculosis_H37Rv IVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLS-----------
MMAR_4941|M.marinum_M IVHSLVKAHGGDVTLTTAPGEGCCFRVTLPRVSEAAVEL-----------
MUL_0464|M.ulcerans_Agy99 IVHSLVKAHGGDVTLTTAPGEGCCFRVTLPRVSEAAVEL-----------
MAV_0703|M.avium_104 IVESLVRAHGGTVGVTTAPGQGCCFRVTLPRISDVPAVQ-----------
Mvan_5174|M.vanbaalenii_PYR-1 IVDSLVYAHGGRVSVTTAPGQGSRFRVSLPRIADAGP-------------
Mflv_1582|M.gilvum_PYR-GCK IVDSLVYAHGGRVSVTTAPGCGCRFTVRLPRVTDERLREEQATDERLREE
MSMEG_5870|M.smegmatis_MC2_155 IVDSLVYAHGGTVKVTTALGKGSRFTVSLPRIADLPARL-----------
MAB_0674|M.abscessus_ATCC_1997 IVDALTAAHGGTVTVHTAPGAGCRFEVRLPRADMTDDDADVDEPE-----
MLBr_00774|M.leprae_Br4923 ISIEDARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQP
TH_0463|M.thermoresistible__bu ISVEDARLHQGRLEAWGEPGKGACFRLTLPLVRGHKVTTSPLPLKPMDES
* . * * : * *. * : **
Mb0781|M.bovis_AF2122/97 -----------------LTPVVPGPP---
Rv0758|M.tuberculosis_H37Rv -----------------LTPVVPGPP---
MMAR_4941|M.marinum_M -----------------TEPVS-------
MUL_0464|M.ulcerans_Agy99 -----------------TEPVS-------
MAV_0703|M.avium_104 -----------------AS----------
Mvan_5174|M.vanbaalenii_PYR-1 -----------DAGPDAEVPVSSAQLG--
Mflv_1582|M.gilvum_PYR-GCK QMPAPEHAGEESRGEQTDVPVSATAPTPP
MSMEG_5870|M.smegmatis_MC2_155 -----------------------------
MAB_0674|M.abscessus_ATCC_1997 -----SATPDAAASEPKIVRASRSESAQP
MLBr_00774|M.leprae_Br4923 SPQASTAGQQHGTQRQRLREHAERSR---
TH_0463|M.thermoresistible__bu GARAAQRANRH-------REPAGEGV---