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FFVPRADAPRAAVGGTRWWSPRTWPLRARLVGTQVALLAVVCLSIGLATEFALQRFLMHQLDEQLLEAGR RSAAIYELPPPPRGFLPLFPPGMGPPGRHLRVFDPEQGPGPGFLNAPGQAARTVGAVVSPDGSVDAGVIT SDGDRQEVSAAAARQLAAIPATREPQTIDLDGLGRYRLIGLHPRHGGPQTIVTGLPNSVVDDTLLWVLGM FCVIAAVALIAAITAGTLLIRRQFAPLARVSATAREVADLELERGEVRLPTPIVPVDPAVAHTEVGQLGT SLNRMLDRIASALSARHASETRVRQFVADASHELRTPLAAIRGYTELAQRKRGELPDDVAHAMSRVESET SRMTQLVEDMLLLARLDAGRPLERDRVELSRLVVDTVSDAHVAGPQHKWSLDLPEDAVVIDGDEARLHQV MANLLANARTHTPPGTSVTVALSADAEGWVTVAVTDDGPGIAPELLPDVFERFARGDSSRSRREGSTGLG LAIVAAVVKAHGGVIDVTSRPGETRFVVRLPGAAHS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4989 | - | - | 100% (527) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_2915 | - | 5e-96 | 41.45% (509) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 9e-63 | 36.73% (520) | sensor histidine kinase PhoR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3790c | - | 1e-139 | 58.66% (479) | putative two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_2267 | - | 0.0 | 67.05% (528) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3764c | - | 1e-139 | 58.66% (479) | two component sensor kinase |
| M. leprae Br4923 | MLBr_00774 | mtrB | 5e-28 | 30.16% (315) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_2582 | - | 1e-140 | 57.75% (471) | putative two component sensor kinase |
| M. marinum M | MMAR_5316 | tcrY | 1e-145 | 58.57% (502) | two-component sensor kinase TcrY |
| M. avium 104 | MAV_0305 | - | 1e-147 | 59.20% (500) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2452 | - | 3e-34 | 32.59% (313) | PUTATIVE putative sensor histidine kinase PhoR |
| M. ulcerans Agy99 | MUL_4625 | trcS | 2e-74 | 35.13% (501) | two component sensor histidine kinase TrcS |
| M. vanbaalenii PYR-1 | Mvan_4428 | - | 0.0 | 68.21% (519) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3790c|M.bovis_AF2122/97 ----------------------------------------------MGIT
Rv3764c|M.tuberculosis_H37Rv ----------------------------------------------MGIT
MAV_0305|M.avium_104 ---------------MADTRRV-----WSLRLRLLVGQIVVLALVCLGIT
MMAR_5316|M.marinum_M ---------------MSSNRLVRRPGAWSLRLRLLVGQILVLAVVCVGIT
Mflv_2267|M.gilvum_PYR-GCK ---MSSSPRAERTPAPV----LRPPRTWSLRTRLILTQLLLLAVVCAGVG
Mvan_4428|M.vanbaalenii_PYR-1 ----------------M----FRSPRSWSLRSRLIVIQVLLLAAACAGIA
MSMEG_4989|M.smegmatis_MC2_155 ---MFFVPRADAPRAAVGGTRWWSPRTWPLRARLVGTQVALLAVVCLSIG
MAB_2582|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4625|M.ulcerans_Agy99 -----------------------------MRWQLLLGVLAVVTIVLVAVG
TH_2452|M.thermoresistible__bu --------MTSEPPSPSGRPRWRRLLPSAARTRIIGWVLLLVMVALGVVT
MLBr_00774|M.leprae_Br4923 MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLS
Mb3790c|M.bovis_AF2122/97 AATEMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRRETHNY----
Rv3764c|M.tuberculosis_H37Rv AATEMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRHETHNY----
MAV_0305|M.avium_104 AVTELALNHHLVKQLDGQLAGTSFRSALMYPE--PNHP-RHEHSPY----
MMAR_5316|M.marinum_M AATELALHHHLVAQLDGQLGGTSHRSALMYPE--SSHRFWRHQHRY----
Mflv_2267|M.gilvum_PYR-GCK VATEFALQRFLMNQLDEQVIEAGRRSSMIFEFGPPPPPGMGMPPPPGVGM
Mvan_4428|M.vanbaalenii_PYR-1 VATEFALQRFLMNQLDEQVVEAGRRSSVIFELGPPPPP--GMRPPP---M
MSMEG_4989|M.smegmatis_MC2_155 LATEFALQRFLMHQLDEQLLEAGRRSAAIYELPPPPRGFLPLFPPG---M
MAB_2582|M.abscessus_ATCC_1997 ------MNRFLNTQLDEQVRDAGNRSVVLFELGPPPPLSLPRPLAN----
MUL_4625|M.ulcerans_Agy99 GVSVLSLRGYVTAMNDAEVVESMHAFSHAYARYRNGEHTSIHTGTP----
TH_2452|M.thermoresistible__bu LTTWRLMVSSIDARMDEALHIEVDEFEELTASGLNPRTGAPFTGVA----
MLBr_00774|M.leprae_Br4923 LAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEE----
: : :
Mb3790c|M.bovis_AF2122/97 --------------------------IRSGPGPRFLDAPGQPAGMVAAVV
Rv3764c|M.tuberculosis_H37Rv --------------------------IRSGPGPRFLDAPGQPAGMVAAVV
MAV_0305|M.avium_104 --------------------------PRPGPGPRFLDAPGQPAGMVAAVV
MMAR_5316|M.marinum_M --------------------------WRPGPGPRFLDAPGQPAGMVGAVV
Mflv_2267|M.gilvum_PYR-GCK PPPPGVGMPVPPVGPPPRRGHHMMIRDE-GPGPAFLNAPGQAILTVGAVV
Mvan_4428|M.vanbaalenii_PYR-1 PPPG--AMVAP---PPPGQGHRIVIRDDQGPGPAFLNAPGQAIYTVGALV
MSMEG_4989|M.smegmatis_MC2_155 GPPG---------------RHLRVFDPEQGPGPGFLNAPGQAARTVGAVV
MAB_2582|M.abscessus_ATCC_1997 G-----------------------WRPTDGPGPAFLDAPGQSIGMVGAVA
MUL_4625|M.ulcerans_Agy99 -----------------------------PLSQALLEFTGQTPGNLIAVM
TH_2452|M.thermoresistible__bu ------------------------EVIREAIAYNLARPNEKFLGYVDGEY
MLBr_00774|M.leprae_Br4923 ---------------------------TRSLDSSLQLARNTLTSKTDPTS
:
Mb3790c|M.bovis_AF2122/97 SDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRV
Rv3764c|M.tuberculosis_H37Rv SDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRV
MAV_0305|M.avium_104 SHGKTVDAGYLTSSGTRDALTSTAQTQLEQIAGSRAPVTVNLDGLGRYRV
MMAR_5316|M.marinum_M RDGKAIVAGYLTNSGDRAEISPTAQAQLAAVAGSQDPVTLNLDGLGRYRV
Mflv_2267|M.gilvum_PYR-GCK SDGRADDAGMIATDGSRTEISDVAARQLATVAVGGRPHTVDLDGLGRYRV
Mvan_4428|M.vanbaalenii_PYR-1 SAGQVEEAGVITADGSRAQVSATAAGQLAAVAVDERPHTVDLDGLGRYRV
MSMEG_4989|M.smegmatis_MC2_155 SPDGSVDAGVITSDGDRQEVSAAAARQLAAIPATREPQTIDLDGLGRYRL
MAB_2582|M.abscessus_ATCC_1997 VNGHVTEAARITADGSRERLSPQACREVEGLLQQSTS-TVDLDHAGLYRL
MUL_4625|M.ulcerans_Agy99 RDGVVIGSAVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLGSLGSYQV
TH_2452|M.thermoresistible__bu HTQSRQEPGFPEVLAGDDAFTERVATVTEPVEG--SYDHPEVGEVRYLAI
MLBr_00774|M.leprae_Br4923 GAGLVGAFDAVLIVPGDGPRTATTAGPVDQVPNSLRGFIKAGQAAYQYAT
.
Mb3790c|M.bovis_AF2122/97 LAAPS-RNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAG-I
Rv3764c|M.tuberculosis_H37Rv LAAPS-RNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAG-I
MAV_0305|M.avium_104 VAAPS-RNGSDIIVTGLSMANIDATLIRMLVIFGIVTVIALAAATIAG-V
MMAR_5316|M.marinum_M VSALS-RRGDELIVTGLSMSDVDATMIRMLIIFGIVTIVALVAATTAG-A
Mflv_2267|M.gilvum_PYR-GCK VAFPSHMEG-EAVVAGLPTTDVDDTLFWVAVIFGVVAVVALMAAGTAG-A
Mvan_4428|M.vanbaalenii_PYR-1 VAFPAHIPG-QVVVAGLPTGDVDDTLFWVAVIFGAVGAVALVAAGTAG-I
MSMEG_4989|M.smegmatis_MC2_155 IGLHPRHGGPQTIVTGLPNSVVDDTLLWVLGMFCVIAAVALIAAITAG-T
MAB_2582|M.abscessus_ATCC_1997 VTMP--TNGGAVIVTGLPAEGVGQTLSSVFGIICVVGAAALITAIGAG-I
MUL_4625|M.ulcerans_Agy99 DSRAA---GSDRLIVGVSLSIADRIITRKQITTSVLVATALVITAALT-V
TH_2452|M.thermoresistible__bu PVTMAGDPAQGVIVAAYLGDAERAAADDAARLMLLVGAATLFGAIGAA-W
MLBr_00774|M.leprae_Br4923 VHTEGFSGPALIIGTPTSSQVTNLELYLIFPLKNEQATVTLVRGTMATGG
: . :*
Mb3790c|M.bovis_AF2122/97 VIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPD--ANPSTEVG
Rv3764c|M.tuberculosis_H37Rv VIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPD--ANPSTEVG
MAV_0305|M.avium_104 VIIRRALAPLRRVAQTAREVADLPLARGEVELPVRVRESD--ANPSTEVG
MMAR_5316|M.marinum_M IIIRRALAPLRRVAQTATEVVDLPLDRGEVELPVRVSETD--ANPDTEVG
Mflv_2267|M.gilvum_PYR-GCK VIVRRQLAPLARVSEAAQQVADLELDRGEVRLPTPIVKVDP-AAAQTEVG
Mvan_4428|M.vanbaalenii_PYR-1 VIVRRQLAPLARVSAAARQVADLELDRGEVNLPTPIVKVDP-AAEHTEVG
MSMEG_4989|M.smegmatis_MC2_155 LLIRRQFAPLARVSATAREVADLELERGEVRLPTPIVPVDP-AVAHTEVG
MAB_2582|M.abscessus_ATCC_1997 VIIRRQLDPLSQVATAAQEVAELELHRGEVNLPTPIIDVAS-NRTHTELG
MUL_4625|M.ulcerans_Agy99 WVVGITLRPLRRVAATAATVAAMPLAGDDHQISVRVRPED--TDPDNEVG
TH_2452|M.thermoresistible__bu LVAGRILRPLRDVADTARTITDTDLSR---RIPS--------RGEGDEMD
MLBr_00774|M.leprae_Br4923 MVLLVLLSGIALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRGEDDMA
: : : : : .:. ::
Mb3790c|M.bovis_AF2122/97 QLGSALNRMLDHIAAALSARQASETRVRQFVADASHELRTPLAAIRGYTE
Rv3764c|M.tuberculosis_H37Rv QLGSALNRMLDHIAAALSARQASETCVRQFVADASHELRTPLAAIRGYTE
MAV_0305|M.avium_104 QLGAALNRMLDHIADALSARQASETRVRQFVADASHELRTPLAAIRGYTE
MMAR_5316|M.marinum_M QLGSALNRMLDHIAAALSTRQASETRVRQFVADASHELRTPLAAIRGYTE
Mflv_2267|M.gilvum_PYR-GCK QLGSALNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRGYTE
Mvan_4428|M.vanbaalenii_PYR-1 QLGTALNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRGYTE
MSMEG_4989|M.smegmatis_MC2_155 QLGTSLNRMLDRIASALSARHASETRVRQFVADASHELRTPLAAIRGYTE
MAB_2582|M.abscessus_ATCC_1997 QLGAALNRMLERIDDALSARHVSETRVRQFVADASHELRTPLAAISGYAE
MUL_4625|M.ulcerans_Agy99 IVGHTLNRLLDNVDSALQHRVASDLRMRQFITDASHELRTPLAAIQGYAE
TH_2452|M.thermoresistible__bu SLVRTINGMLDRIEAGVSA-------QRRFIDDAGHELRTPITIVRGHLE
MLBr_00774|M.leprae_Br4923 RLAVSFNDMAESLSRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAAD
: ::* : : : : *:* *..******:: : :
Mb3790c|M.bovis_AF2122/97 LTQR-IGDDPEAVAHAMSRVASETERITRLVEDLLLLARLDSGR-PLERG
Rv3764c|M.tuberculosis_H37Rv LTQR-IGDDPEAVAHAMSRVASETERITRLVEDLLLLARLDSGR-PLERG
MAV_0305|M.avium_104 LTQR-MGDDREAVAQAMSRVASETERMTRLVEDLLLLARLDSGR-PLERE
MMAR_5316|M.marinum_M LAQR-MGDDRAAVAHAMSRVGSETERITSLVEDLLLLARLDSGR-PLERE
Mflv_2267|M.gilvum_PYR-GCK LAQRKQAELPDDVAHAMSRVESETARMTQLVEDMLLLARLDTGR-PLDRD
Mvan_4428|M.vanbaalenii_PYR-1 LAQRKQAQLPEDVAHAMNRVESETERMTQLVEDMLLLARLDSGR-PLDRE
MSMEG_4989|M.smegmatis_MC2_155 LAQRKRGELPDDVAHAMSRVESETSRMTQLVEDMLLLARLDAGR-PLERD
MAB_2582|M.abscessus_ATCC_1997 LARRNHDALPTDVAHAMSRVQSEAARMTELVEDLLLLARLDSGR-PLAQE
MUL_4625|M.ulcerans_Agy99 LTRQDSSDLPPTTEYALARIESEARRMASLVDELLLLSRLGEGE-DLETE
TH_2452|M.thermoresistible__bu VLDP---DDPDDVRSTVALVDDELVRMNRMVTDLLLLARSEQPT-FLTPE
MLBr_00774|M.leprae_Br4923 LIYDHSSDLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVE
: : : .* *: :: ::* ::* *
Mb3790c|M.bovis_AF2122/97 PVDMSRLAVDAVSDAHVAGPDH--QWALDLPPEPVVIPGDAARLHQVVTN
Rv3764c|M.tuberculosis_H37Rv PVDMSRLAVDAVSDAHVAGPDH--QWALDLPPEPVVIPGDAARLHQVVTN
MAV_0305|M.avium_104 PVDLSRLAVDAVNDAHVAGPDH--QWELDLPEEPVVITGDAARLHQVLTN
MMAR_5316|M.marinum_M PVDMSRLAVDAVSDAHVAGPDQ--QWELDLPAEPVVVTGDAARLHQVVAN
Mflv_2267|M.gilvum_PYR-GCK SVDLTRLVVDAVSDAHVAAPDH--VWELDLPDEPLTVCGDEARLHQVLAN
Mvan_4428|M.vanbaalenii_PYR-1 TVDLTRLVVDAVSDAHVAGPDH--AWELDLPDEPVTVQGDEARLHQVLAN
MSMEG_4989|M.smegmatis_MC2_155 RVELSRLVVDTVSDAHVAGPQH--KWSLDLPEDAVVIDGDEARLHQVMAN
MAB_2582|M.abscessus_ATCC_1997 PVDLSRLVVDAASDAHIAASEH--RWLLNLPEDPVIVCGDTPRLHQVVAN
MUL_4625|M.ulcerans_Agy99 HLDLTDLVMNAVNDAAVAAPTH--RWIKDLPDEPVWVNGDHARLHQLVSN
TH_2452|M.thermoresistible__bu PTDIG-ALTRAIFDKVVQLGDR--DYQLQSVAEVTAVL-DAQRITQALIA
MLBr_00774|M.leprae_Br4923 AVDLRVMVNNALGNVGHLAEEAGIELLVDMPVDEVIAEVDARRVERILRN
:: : : : : * *: : :
Mb3790c|M.bovis_AF2122/97 LLANARVHTGPGTIVTTRLST-----GPTHVVLQVIDNGPGIPAALQSEV
Rv3764c|M.tuberculosis_H37Rv LLANARVHTGPGTIVTTRLST-----GPTHVVLQVIDNGPGIPAALQSEV
MAV_0305|M.avium_104 LLANARVHTGAGTVVTTRLST-----EPAHTVLQVIDNGPGIPAELQSEV
MMAR_5316|M.marinum_M LLANARIHTGPGAVVTTRLSS-----GPTHVVLEVIDNGPGIPEAMQSEI
Mflv_2267|M.gilvum_PYR-GCK LLANAGIHTPAGTTVTTSLTAT----DTGDVLVRVVDDGPGIPARLQPDV
Mvan_4428|M.vanbaalenii_PYR-1 LLANARIHTPAGTVVTTSLGVG----DGGSAVLTVLDDGPGIPDGLQPEV
MSMEG_4989|M.smegmatis_MC2_155 LLANARTHTPPGTSVTVALSAD----AEGWVTVAVTDDGPGIAPELLPDV
MAB_2582|M.abscessus_ATCC_1997 LLSNCRIHTPPGTTVTVTLRS-----DGNSTYLTVADDGPGIPAGQQNEI
MUL_4625|M.ulcerans_Agy99 LLTNAWVHTPPGVTVKTGITNYPDDPNGPYTELTVSNDGPDIDPEVLPHL
TH_2452|M.thermoresistible__bu LADNACRYTRDGDWIAVGSGLY-----DGWLRFWVSDSGPGVSDADRDRI
MLBr_00774|M.leprae_Br4923 LIANAIDHSEHKPVRIRMAAD------EDTVAVTVRDYGIGLRPGEEKLV
* *. :: . * : * .: :
Mb3790c|M.bovis_AF2122/97 FERFARGDTSRSRQA--------GSTGLGLAIVSAVVKAHNGTITVSSSP
Rv3764c|M.tuberculosis_H37Rv FERFARGDTSRSRQA--------GSTGLGLAIVSAVVKAHNGTITVSSSP
MAV_0305|M.avium_104 FERFARGDSSRSRKG--------GSTGLGLAIVSAVVKAHNGTISVNSSP
MMAR_5316|M.marinum_M FERFARGDTSRSRKG--------GSTGLGLAIVAAVVKAHNGTITVNSSP
Mflv_2267|M.gilvum_PYR-GCK FERFARGDTSRSRRG--------GSTGLGLAIVAAVVRAHHGTISLHSVP
Mvan_4428|M.vanbaalenii_PYR-1 FERFARGDTSRSRRGDTSRSRGGGSTGLGLAIVAAVVRAHGGTIDVHSVP
MSMEG_4989|M.smegmatis_MC2_155 FERFARGDSSRSRRE--------GSTGLGLAIVAAVVKAHGGVIDVTSRP
MAB_2582|M.abscessus_ATCC_1997 FERFARGDTSRSRRA--------GSTGLGLAIAAAVIKAHHGEIRVNSVA
MUL_4625|M.ulcerans_Agy99 FERFVRSSKSRSSAP---------GHGLGLAIVNSIVKAHDGSVTAESAA
TH_2452|M.thermoresistible__bu FERFARGSAGGQRSD---------GAGLGLSIVRAIAGAHGGHVDLDTVV
MLBr_00774|M.leprae_Br4923 FSRFWRSDPSRVRRS--------GGTGLGLAISIEDARLHQGRLEAWGEP
*.** *.. . . ****:* * * :
Mb3790c|M.bovis_AF2122/97 GY-TEFAVRLPLDGWQPLESSPR---------------------------
Rv3764c|M.tuberculosis_H37Rv GY-TEFAVRLPLDGWQPLESSPR---------------------------
MAV_0305|M.avium_104 GH-TEFTVRLPPNGWQPHASA-----------------------------
MMAR_5316|M.marinum_M GR-TEFVVRLPLDAWQRSGVPPG---------------------------
Mflv_2267|M.gilvum_PYR-GCK GR-TEFAVVLPGDTQAVHSVGPR---------------------------
Mvan_4428|M.vanbaalenii_PYR-1 GR-TEFVVTLPGDSQPGHSSGQSDA-------------------------
MSMEG_4989|M.smegmatis_MC2_155 GE-TRFVVRLPG---AAHS-------------------------------
MAB_2582|M.abscessus_ATCC_1997 GE-TVFTITLPTAGTQHGAFTEKLP-------------------------
MUL_4625|M.ulcerans_Agy99 GQ-TVFRIRLPLIDAPLNASAPGRPRQPSDY-------------------
TH_2452|M.thermoresistible__bu GRGSTFTITIPAVLEAPWPAS-----------------------------
MLBr_00774|M.leprae_Br4923 GQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHGTQRQRLR
* : * : :*
Mb3790c|M.bovis_AF2122/97 -------
Rv3764c|M.tuberculosis_H37Rv -------
MAV_0305|M.avium_104 -------
MMAR_5316|M.marinum_M -------
Mflv_2267|M.gilvum_PYR-GCK -------
Mvan_4428|M.vanbaalenii_PYR-1 -------
MSMEG_4989|M.smegmatis_MC2_155 -------
MAB_2582|M.abscessus_ATCC_1997 -------
MUL_4625|M.ulcerans_Agy99 -------
TH_2452|M.thermoresistible__bu -------
MLBr_00774|M.leprae_Br4923 EHAERSR