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MNRFLNTQLDEQVRDAGNRSVVLFELGPPPPLSLPRPLANGWRPTDGPGPAFLDAPGQSIGMVGAVAVNG HVTEAARITADGSRERLSPQACREVEGLLQQSTSTVDLDHAGLYRLVTMPTNGGAVIVTGLPAEGVGQTL SSVFGIICVVGAAALITAIGAGIVIIRRQLDPLSQVATAAQEVAELELHRGEVNLPTPIIDVASNRTHTE LGQLGAALNRMLERIDDALSARHVSETRVRQFVADASHELRTPLAAISGYAELARRNHDALPTDVAHAMS RVQSEAARMTELVEDLLLLARLDSGRPLAQEPVDLSRLVVDAASDAHIAASEHRWLLNLPEDPVIVCGDT PRLHQVVANLLSNCRIHTPPGTTVTVTLRSDGNSTYLTVADDGPGIPAGQQNEIFERFARGDTSRSRRAG STGLGLAIAAAVIKAHHGEIRVNSVAGETVFTITLPTAGTQHGAFTEKLP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2582 | - | - | 100% (470) | putative two component sensor kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 3e-51 | 39.64% (333) | putative sensor histidine kinase PhoR |
| M. abscessus ATCC 19977 | MAB_1721 | - | 2e-34 | 31.51% (311) | putative histidine kinase sensor of two-component system |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3790c | - | 1e-125 | 54.58% (469) | putative two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_2267 | - | 1e-144 | 57.53% (485) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3764c | - | 1e-124 | 54.37% (469) | two component sensor kinase |
| M. leprae Br4923 | MLBr_00774 | mtrB | 1e-31 | 28.86% (343) | putative two-component system sensor kinase |
| M. marinum M | MMAR_5316 | tcrY | 1e-123 | 54.80% (458) | two-component sensor kinase TcrY |
| M. avium 104 | MAV_0305 | - | 1e-127 | 55.08% (463) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_4989 | - | 1e-140 | 57.75% (471) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2452 | - | 1e-34 | 31.40% (363) | PUTATIVE putative sensor histidine kinase PhoR |
| M. ulcerans Agy99 | MUL_4625 | trcS | 9e-69 | 38.98% (413) | two component sensor histidine kinase TrcS |
| M. vanbaalenii PYR-1 | Mvan_4428 | - | 1e-148 | 60.33% (484) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2267|M.gilvum_PYR-GCK ---MSSSPRAERTPAPV----LRPPRTWSLRTRLILTQLLLLAVVCAGVG
Mvan_4428|M.vanbaalenii_PYR-1 ----------------M----FRSPRSWSLRSRLIVIQVLLLAAACAGIA
MSMEG_4989|M.smegmatis_MC2_155 ---MFFVPRADAPRAAVGGTRWWSPRTWPLRARLVGTQVALLAVVCLSIG
MAB_2582|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3790c|M.bovis_AF2122/97 ----------------------------------------------MGIT
Rv3764c|M.tuberculosis_H37Rv ----------------------------------------------MGIT
MAV_0305|M.avium_104 ---------------MADTRRV-----WSLRLRLLVGQIVVLALVCLGIT
MMAR_5316|M.marinum_M ---------------MSSNRLVRRPGAWSLRLRLLVGQILVLAVVCVGIT
MUL_4625|M.ulcerans_Agy99 -----------------------------MRWQLLLGVLAVVTIVLVAVG
TH_2452|M.thermoresistible__bu --------MTSEPPSPSGRPRWRRLLPSAARTRIIGWVLLLVMVALGVVT
MLBr_00774|M.leprae_Br4923 MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLS
Mflv_2267|M.gilvum_PYR-GCK VATEFALQRFLMNQLDEQVIEAGRRSSMIFEFGPPPPPGMGMPPPPGVGM
Mvan_4428|M.vanbaalenii_PYR-1 VATEFALQRFLMNQLDEQVVEAGRRSSVIFELGPPPPP--GMRPPP---M
MSMEG_4989|M.smegmatis_MC2_155 LATEFALQRFLMHQLDEQLLEAGRRSAAIYELPPPPRGFLPLFPPG---M
MAB_2582|M.abscessus_ATCC_1997 ------MNRFLNTQLDEQVRDAGNRSVVLFELGPPPPLSLPRPLAN----
Mb3790c|M.bovis_AF2122/97 AATEMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRRETHNYI---
Rv3764c|M.tuberculosis_H37Rv AATEMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRHETHNYI---
MAV_0305|M.avium_104 AVTELALNHHLVKQLDGQLAGTSFRSALMYPE--PNHP-RHEHSPYP---
MMAR_5316|M.marinum_M AATELALHHHLVAQLDGQLGGTSHRSALMYPE--SSHRFWRHQHRYW---
MUL_4625|M.ulcerans_Agy99 GVSVLSLRGYVTAMNDAEVVESMHAFSHAYARYRNGEHTSIHTGTPP---
TH_2452|M.thermoresistible__bu LTTWRLMVSSIDARMDEALHIEVDEFEELTASGLNPRTGAPFTGVAEV--
MLBr_00774|M.leprae_Br4923 LAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETR--
: : :
Mflv_2267|M.gilvum_PYR-GCK PPPPGVGMPVPPVGPPPRRGHHMMIRDE-GPGPAFLNAPGQAILTVGAVV
Mvan_4428|M.vanbaalenii_PYR-1 PPPG--AMVAP---PPPGQGHRIVIRDDQGPGPAFLNAPGQAIYTVGALV
MSMEG_4989|M.smegmatis_MC2_155 GPPG---------------RHLRVFDPEQGPGPGFLNAPGQAARTVGAVV
MAB_2582|M.abscessus_ATCC_1997 G-----------------------WRPTDGPGPAFLDAPGQSIGMVGAVA
Mb3790c|M.bovis_AF2122/97 ---------------------------RSGPGPRFLDAPGQPAGMVAAVV
Rv3764c|M.tuberculosis_H37Rv ---------------------------RSGPGPRFLDAPGQPAGMVAAVV
MAV_0305|M.avium_104 ---------------------------RPGPGPRFLDAPGQPAGMVAAVV
MMAR_5316|M.marinum_M ---------------------------RPGPGPRFLDAPGQPAGMVGAVV
MUL_4625|M.ulcerans_Agy99 ------------------------------LSQALLEFTGQTPGNLIAVM
TH_2452|M.thermoresistible__bu --------------------------IREAIAYNLARPNEKFLGYVDGEY
MLBr_00774|M.leprae_Br4923 -----------------------------SLDSSLQLARNTLTSKTDPTS
:
Mflv_2267|M.gilvum_PYR-GCK SDGRADDAGMIATDGSRTEISDVAARQLATVAVGGRPHTVDLDGLGRYRV
Mvan_4428|M.vanbaalenii_PYR-1 SAGQVEEAGVITADGSRAQVSATAAGQLAAVAVDERPHTVDLDGLGRYRV
MSMEG_4989|M.smegmatis_MC2_155 SPDGSVDAGVITSDGDRQEVSAAAARQLAAIPATREPQTIDLDGLGRYRL
MAB_2582|M.abscessus_ATCC_1997 VNGHVTEAARITADGSRERLSPQACREVEGLLQQSTS-TVDLDHAGLYRL
Mb3790c|M.bovis_AF2122/97 SDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRV
Rv3764c|M.tuberculosis_H37Rv SDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRV
MAV_0305|M.avium_104 SHGKTVDAGYLTSSGTRDALTSTAQTQLEQIAGSRAPVTVNLDGLGRYRV
MMAR_5316|M.marinum_M RDGKAIVAGYLTNSGDRAEISPTAQAQLAAVAGSQDPVTLNLDGLGRYRV
MUL_4625|M.ulcerans_Agy99 RDGVVIGSAVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLGSLGSYQV
TH_2452|M.thermoresistible__bu HTQSRQEPGFPEVLAGDDAFTERVATVTEPVEG--SYDHPEVGEVRYLAI
MLBr_00774|M.leprae_Br4923 GAGLVGAFDAVLIVPGDGPRTATTAGPVDQVPNSLRGFIKAGQAAYQYAT
.
Mflv_2267|M.gilvum_PYR-GCK VAFPSHMEG-EAVVAGLPTTDVDDTLFWVAVIFGVVAVVALMAAGTAG-A
Mvan_4428|M.vanbaalenii_PYR-1 VAFPAHIPG-QVVVAGLPTGDVDDTLFWVAVIFGAVGAVALVAAGTAG-I
MSMEG_4989|M.smegmatis_MC2_155 IGLHPRHGGPQTIVTGLPNSVVDDTLLWVLGMFCVIAAVALIAAITAG-T
MAB_2582|M.abscessus_ATCC_1997 VTMP--TNGGAVIVTGLPAEGVGQTLSSVFGIICVVGAAALITAIGAG-I
Mb3790c|M.bovis_AF2122/97 LAAPS-RNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAG-I
Rv3764c|M.tuberculosis_H37Rv LAAPS-RNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAG-I
MAV_0305|M.avium_104 VAAPS-RNGSDIIVTGLSMANIDATLIRMLVIFGIVTVIALAAATIAG-V
MMAR_5316|M.marinum_M VSALS-RRGDELIVTGLSMSDVDATMIRMLIIFGIVTIVALVAATTAG-A
MUL_4625|M.ulcerans_Agy99 DSRAA---GSDRLIVGVSLSIADRIITRKQITTSVLVATALVITAALT-V
TH_2452|M.thermoresistible__bu PVTMAGDPAQGVIVAAYLGDAERAAADDAARLMLLVGAATLFGAIGAA-W
MLBr_00774|M.leprae_Br4923 VHTEGFSGPALIIGTPTSSQVTNLELYLIFPLKNEQATVTLVRGTMATGG
: . :*
Mflv_2267|M.gilvum_PYR-GCK VIVRRQLAPLARVSEAAQQVADLELDRGEVRLPTPIVKVDP-AAAQTEVG
Mvan_4428|M.vanbaalenii_PYR-1 VIVRRQLAPLARVSAAARQVADLELDRGEVNLPTPIVKVDP-AAEHTEVG
MSMEG_4989|M.smegmatis_MC2_155 LLIRRQFAPLARVSATAREVADLELERGEVRLPTPIVPVDP-AVAHTEVG
MAB_2582|M.abscessus_ATCC_1997 VIIRRQLDPLSQVATAAQEVAELELHRGEVNLPTPIIDVAS-NRTHTELG
Mb3790c|M.bovis_AF2122/97 VIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPD--ANPSTEVG
Rv3764c|M.tuberculosis_H37Rv VIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPD--ANPSTEVG
MAV_0305|M.avium_104 VIIRRALAPLRRVAQTAREVADLPLARGEVELPVRVRESD--ANPSTEVG
MMAR_5316|M.marinum_M IIIRRALAPLRRVAQTATEVVDLPLDRGEVELPVRVSETD--ANPDTEVG
MUL_4625|M.ulcerans_Agy99 WVVGITLRPLRRVAATAATVAAMPLAGDDHQISVRVRPED--TDPDNEVG
TH_2452|M.thermoresistible__bu LVAGRILRPLRDVADTARTITDTDLSR---RIPS--------RGEGDEMD
MLBr_00774|M.leprae_Br4923 MVLLVLLSGIALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRGEDDMA
: : : : : .:. ::
Mflv_2267|M.gilvum_PYR-GCK QLGSALNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRGYTE
Mvan_4428|M.vanbaalenii_PYR-1 QLGTALNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRGYTE
MSMEG_4989|M.smegmatis_MC2_155 QLGTSLNRMLDRIASALSARHASETRVRQFVADASHELRTPLAAIRGYTE
MAB_2582|M.abscessus_ATCC_1997 QLGAALNRMLERIDDALSARHVSETRVRQFVADASHELRTPLAAISGYAE
Mb3790c|M.bovis_AF2122/97 QLGSALNRMLDHIAAALSARQASETRVRQFVADASHELRTPLAAIRGYTE
Rv3764c|M.tuberculosis_H37Rv QLGSALNRMLDHIAAALSARQASETCVRQFVADASHELRTPLAAIRGYTE
MAV_0305|M.avium_104 QLGAALNRMLDHIADALSARQASETRVRQFVADASHELRTPLAAIRGYTE
MMAR_5316|M.marinum_M QLGSALNRMLDHIAAALSTRQASETRVRQFVADASHELRTPLAAIRGYTE
MUL_4625|M.ulcerans_Agy99 IVGHTLNRLLDNVDSALQHRVASDLRMRQFITDASHELRTPLAAIQGYAE
TH_2452|M.thermoresistible__bu SLVRTINGMLDRIEAGVSA-------QRRFIDDAGHELRTPITIVRGHLE
MLBr_00774|M.leprae_Br4923 RLAVSFNDMAESLSRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAAD
: ::* : : : : *:* *..******:: : :
Mflv_2267|M.gilvum_PYR-GCK LAQRKQAELPDDVAHAMSRVESETARMTQLVEDMLLLARLDTGR-PLDRD
Mvan_4428|M.vanbaalenii_PYR-1 LAQRKQAQLPEDVAHAMNRVESETERMTQLVEDMLLLARLDSGR-PLDRE
MSMEG_4989|M.smegmatis_MC2_155 LAQRKRGELPDDVAHAMSRVESETSRMTQLVEDMLLLARLDAGR-PLERD
MAB_2582|M.abscessus_ATCC_1997 LARRNHDALPTDVAHAMSRVQSEAARMTELVEDLLLLARLDSGR-PLAQE
Mb3790c|M.bovis_AF2122/97 LTQR-IGDDPEAVAHAMSRVASETERITRLVEDLLLLARLDSGR-PLERG
Rv3764c|M.tuberculosis_H37Rv LTQR-IGDDPEAVAHAMSRVASETERITRLVEDLLLLARLDSGR-PLERG
MAV_0305|M.avium_104 LTQR-MGDDREAVAQAMSRVASETERMTRLVEDLLLLARLDSGR-PLERE
MMAR_5316|M.marinum_M LAQR-MGDDRAAVAHAMSRVGSETERITSLVEDLLLLARLDSGR-PLERE
MUL_4625|M.ulcerans_Agy99 LTRQDSSDLPPTTEYALARIESEARRMASLVDELLLLSRLGEGE-DLETE
TH_2452|M.thermoresistible__bu VLDP---DDPDDVRSTVALVDDELVRMNRMVTDLLLLARSEQPT-FLTPE
MLBr_00774|M.leprae_Br4923 LIYDHSSDLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVE
: : : .* *: :: ::* ::* *
Mflv_2267|M.gilvum_PYR-GCK SVDLTRLVVDAVSDAHVAAPDH--VWELDLPDEPLTVCGDEARLHQVLAN
Mvan_4428|M.vanbaalenii_PYR-1 TVDLTRLVVDAVSDAHVAGPDH--AWELDLPDEPVTVQGDEARLHQVLAN
MSMEG_4989|M.smegmatis_MC2_155 RVELSRLVVDTVSDAHVAGPQH--KWSLDLPEDAVVIDGDEARLHQVMAN
MAB_2582|M.abscessus_ATCC_1997 PVDLSRLVVDAASDAHIAASEH--RWLLNLPEDPVIVCGDTPRLHQVVAN
Mb3790c|M.bovis_AF2122/97 PVDMSRLAVDAVSDAHVAGPDH--QWALDLPPEPVVIPGDAARLHQVVTN
Rv3764c|M.tuberculosis_H37Rv PVDMSRLAVDAVSDAHVAGPDH--QWALDLPPEPVVIPGDAARLHQVVTN
MAV_0305|M.avium_104 PVDLSRLAVDAVNDAHVAGPDH--QWELDLPEEPVVITGDAARLHQVLTN
MMAR_5316|M.marinum_M PVDMSRLAVDAVSDAHVAGPDQ--QWELDLPAEPVVVTGDAARLHQVVAN
MUL_4625|M.ulcerans_Agy99 HLDLTDLVMNAVNDAAVAAPTH--RWIKDLPDEPVWVNGDHARLHQLVSN
TH_2452|M.thermoresistible__bu PTDIG-ALTRAIFDKVVQLGDR--DYQLQSVAEVTAVL-DAQRITQALIA
MLBr_00774|M.leprae_Br4923 AVDLRVMVNNALGNVGHLAEEAGIELLVDMPVDEVIAEVDARRVERILRN
:: : : : : * *: : :
Mflv_2267|M.gilvum_PYR-GCK LLANAGIHTPAGTTVTTSLTAT----DTGDVLVRVVDDGPGIPARLQPDV
Mvan_4428|M.vanbaalenii_PYR-1 LLANARIHTPAGTVVTTSLGVG----DGGSAVLTVLDDGPGIPDGLQPEV
MSMEG_4989|M.smegmatis_MC2_155 LLANARTHTPPGTSVTVALSAD----AEGWVTVAVTDDGPGIAPELLPDV
MAB_2582|M.abscessus_ATCC_1997 LLSNCRIHTPPGTTVTVTLRS-----DGNSTYLTVADDGPGIPAGQQNEI
Mb3790c|M.bovis_AF2122/97 LLANARVHTGPGTIVTTRLST-----GPTHVVLQVIDNGPGIPAALQSEV
Rv3764c|M.tuberculosis_H37Rv LLANARVHTGPGTIVTTRLST-----GPTHVVLQVIDNGPGIPAALQSEV
MAV_0305|M.avium_104 LLANARVHTGAGTVVTTRLST-----EPAHTVLQVIDNGPGIPAELQSEV
MMAR_5316|M.marinum_M LLANARIHTGPGAVVTTRLSS-----GPTHVVLEVIDNGPGIPEAMQSEI
MUL_4625|M.ulcerans_Agy99 LLTNAWVHTPPGVTVKTGITNYPDDPNGPYTELTVSNDGPDIDPEVLPHL
TH_2452|M.thermoresistible__bu LADNACRYTRDGDWIAVGSGLY-----DGWLRFWVSDSGPGVSDADRDRI
MLBr_00774|M.leprae_Br4923 LIANAIDHSEHKPVRIRMAAD------EDTVAVTVRDYGIGLRPGEEKLV
* *. :: . * : * .: :
Mflv_2267|M.gilvum_PYR-GCK FERFARGDTSRSRRG--------GSTGLGLAIVAAVVRAHHGTISLHSVP
Mvan_4428|M.vanbaalenii_PYR-1 FERFARGDTSRSRRGDTSRSRGGGSTGLGLAIVAAVVRAHGGTIDVHSVP
MSMEG_4989|M.smegmatis_MC2_155 FERFARGDSSRSRRE--------GSTGLGLAIVAAVVKAHGGVIDVTSRP
MAB_2582|M.abscessus_ATCC_1997 FERFARGDTSRSRRA--------GSTGLGLAIAAAVIKAHHGEIRVNSVA
Mb3790c|M.bovis_AF2122/97 FERFARGDTSRSRQA--------GSTGLGLAIVSAVVKAHNGTITVSSSP
Rv3764c|M.tuberculosis_H37Rv FERFARGDTSRSRQA--------GSTGLGLAIVSAVVKAHNGTITVSSSP
MAV_0305|M.avium_104 FERFARGDSSRSRKG--------GSTGLGLAIVSAVVKAHNGTISVNSSP
MMAR_5316|M.marinum_M FERFARGDTSRSRKG--------GSTGLGLAIVAAVVKAHNGTITVNSSP
MUL_4625|M.ulcerans_Agy99 FERFVRSSKSRSSAP---------GHGLGLAIVNSIVKAHDGSVTAESAA
TH_2452|M.thermoresistible__bu FERFARGSAGGQRSD---------GAGLGLSIVRAIAGAHGGHVDLDTVV
MLBr_00774|M.leprae_Br4923 FSRFWRSDPSRVRRS--------GGTGLGLAISIEDARLHQGRLEAWGEP
*.** *.. . . ****:* * * :
Mflv_2267|M.gilvum_PYR-GCK GR-TEFAVVLPGDTQAVHSVGPR---------------------------
Mvan_4428|M.vanbaalenii_PYR-1 GR-TEFVVTLPGDSQPGHSSGQSDA-------------------------
MSMEG_4989|M.smegmatis_MC2_155 GE-TRFVVRLPG---AAHS-------------------------------
MAB_2582|M.abscessus_ATCC_1997 GE-TVFTITLPTAGTQHGAFTEKLP-------------------------
Mb3790c|M.bovis_AF2122/97 GY-TEFAVRLPLDGWQPLESSPR---------------------------
Rv3764c|M.tuberculosis_H37Rv GY-TEFAVRLPLDGWQPLESSPR---------------------------
MAV_0305|M.avium_104 GH-TEFTVRLPPNGWQPHASA-----------------------------
MMAR_5316|M.marinum_M GR-TEFVVRLPLDAWQRSGVPPG---------------------------
MUL_4625|M.ulcerans_Agy99 GQ-TVFRIRLPLIDAPLNASAPGRPRQPSDY-------------------
TH_2452|M.thermoresistible__bu GRGSTFTITIPAVLEAPWPAS-----------------------------
MLBr_00774|M.leprae_Br4923 GQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHGTQRQRLR
* : * : :*
Mflv_2267|M.gilvum_PYR-GCK -------
Mvan_4428|M.vanbaalenii_PYR-1 -------
MSMEG_4989|M.smegmatis_MC2_155 -------
MAB_2582|M.abscessus_ATCC_1997 -------
Mb3790c|M.bovis_AF2122/97 -------
Rv3764c|M.tuberculosis_H37Rv -------
MAV_0305|M.avium_104 -------
MMAR_5316|M.marinum_M -------
MUL_4625|M.ulcerans_Agy99 -------
TH_2452|M.thermoresistible__bu -------
MLBr_00774|M.leprae_Br4923 EHAERSR