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MSSSPRAERTPAPVLRPPRTWSLRTRLILTQLLLLAVVCAGVGVATEFALQRFLMNQLDEQVIEAGRRSS MIFEFGPPPPPGMGMPPPPGVGMPPPPGVGMPVPPVGPPPRRGHHMMIRDEGPGPAFLNAPGQAILTVGA VVSDGRADDAGMIATDGSRTEISDVAARQLATVAVGGRPHTVDLDGLGRYRVVAFPSHMEGEAVVAGLPT TDVDDTLFWVAVIFGVVAVVALMAAGTAGAVIVRRQLAPLARVSEAAQQVADLELDRGEVRLPTPIVKVD PAAAQTEVGQLGSALNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRGYTELAQRKQAELPD DVAHAMSRVESETARMTQLVEDMLLLARLDTGRPLDRDSVDLTRLVVDAVSDAHVAAPDHVWELDLPDEP LTVCGDEARLHQVLANLLANAGIHTPAGTTVTTSLTATDTGDVLVRVVDDGPGIPARLQPDVFERFARGD TSRSRRGGSTGLGLAIVAAVVRAHHGTISLHSVPGRTEFAVVLPGDTQAVHSVGPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2267 | - | - | 100% (546) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_1582 | - | 4e-62 | 36.31% (526) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_1888 | - | 2e-30 | 29.35% (494) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3790c | - | 1e-145 | 58.06% (496) | putative two component sensor kinase |
| M. tuberculosis H37Rv | Rv3764c | - | 1e-143 | 57.66% (496) | two component sensor kinase |
| M. leprae Br4923 | MLBr_00175 | - | 8e-31 | 32.94% (337) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_2582 | - | 1e-144 | 57.53% (485) | putative two component sensor kinase |
| M. marinum M | MMAR_5316 | tcrY | 1e-154 | 57.76% (535) | two-component sensor kinase TcrY |
| M. avium 104 | MAV_0305 | - | 1e-152 | 56.87% (524) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_4989 | - | 0.0 | 67.05% (528) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2428 | - | 1e-33 | 29.27% (533) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. ulcerans Agy99 | MUL_4625 | trcS | 2e-71 | 39.58% (432) | two component sensor histidine kinase TrcS |
| M. vanbaalenii PYR-1 | Mvan_4428 | - | 0.0 | 78.33% (540) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3790c|M.bovis_AF2122/97 -------------------------------------------MGITAAT
Rv3764c|M.tuberculosis_H37Rv -------------------------------------------MGITAAT
MAV_0305|M.avium_104 ------------MADTRRV-----WSLRLRLLVGQIVVLALVCLGITAVT
MMAR_5316|M.marinum_M ------------MSSNRLVRRPGAWSLRLRLLVGQILVLAVVCVGITAAT
Mflv_2267|M.gilvum_PYR-GCK MSSSPRAERTPAPV----LRPPRTWSLRTRLILTQLLLLAVVCAGVGVAT
Mvan_4428|M.vanbaalenii_PYR-1 -------------M----FRSPRSWSLRSRLIVIQVLLLAAACAGIAVAT
MSMEG_4989|M.smegmatis_MC2_155 MFFVPRADAPRAAVGGTRWWSPRTWPLRARLVGTQVALLAVVCLSIGLAT
MAB_2582|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4625|M.ulcerans_Agy99 --------------------------MRWQLLLGVLAVVTIVLVAVGGVS
MLBr_00175|M.leprae_Br4923 -------------------------MVRFAW-------RRRASLRATSSL
TH_2428|M.thermoresistible__bu --------------------------MTFAQPYPPSPPQRQATSQPASSL
Mb3790c|M.bovis_AF2122/97 EMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRRETHNY-------
Rv3764c|M.tuberculosis_H37Rv EMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRHETHNY-------
MAV_0305|M.avium_104 ELALNHHLVKQLDGQLAGTSFRSALMYPE--PNHP-RHEHSPY-------
MMAR_5316|M.marinum_M ELALHHHLVAQLDGQLGGTSHRSALMYPE--SSHRFWRHQHRY-------
Mflv_2267|M.gilvum_PYR-GCK EFALQRFLMNQLDEQVIEAGRRSSMIFEFGPPPPPGMGMPPPPGVGMPPP
Mvan_4428|M.vanbaalenii_PYR-1 EFALQRFLMNQLDEQVVEAGRRSSVIFELGPPPPP--GMRPPP---MPPP
MSMEG_4989|M.smegmatis_MC2_155 EFALQRFLMHQLDEQLLEAGRRSAAIYELPPPPRGFLPLFPPG---MGPP
MAB_2582|M.abscessus_ATCC_1997 ---MNRFLNTQLDEQVRDAGNRSVVLFELGPPPPLSLPRPLAN----G--
MUL_4625|M.ulcerans_Agy99 VLSLRGYVTAMNDAEVVESMHAFSHAYARYRNGEHTSIHTGTP-------
MLBr_00175|M.leprae_Br4923 SLRWRVMLLAMSMVAMVVVLMAFAVYVVISAALYSDIDNQLQS-------
TH_2428|M.thermoresistible__bu SLRWRVMLLAMSMVAMVVVLMSIALYAVVSRALYNDIDNQLHS-------
. : :
Mb3790c|M.bovis_AF2122/97 -----------------------IRSGPGPRFLDAPGQPAGMVAAVVSDG
Rv3764c|M.tuberculosis_H37Rv -----------------------IRSGPGPRFLDAPGQPAGMVAAVVSDG
MAV_0305|M.avium_104 -----------------------PRPGPGPRFLDAPGQPAGMVAAVVSHG
MMAR_5316|M.marinum_M -----------------------WRPGPGPRFLDAPGQPAGMVGAVVRDG
Mflv_2267|M.gilvum_PYR-GCK PGVGMPVPPVGPPPRRGHHMMIRDE-GPGPAFLNAPGQAILTVGAVVSDG
Mvan_4428|M.vanbaalenii_PYR-1 G--AMVAP---PPPGQGHRIVIRDDQGPGPAFLNAPGQAIYTVGALVSAG
MSMEG_4989|M.smegmatis_MC2_155 G---------------RHLRVFDPEQGPGPGFLNAPGQAARTVGAVVSPD
MAB_2582|M.abscessus_ATCC_1997 ---------------------WRPTDGPGPAFLDAPGQSIGMVGAVAVNG
MUL_4625|M.ulcerans_Agy99 --------------------------PLSQALLEFTGQTPGNLIAVMRDG
MLBr_00175|M.leprae_Br4923 ---------------------RAQLLIASGSLAADPGKAIEGTAYSDVNA
TH_2428|M.thermoresistible__bu ---------------------RARLLIESGSLAADPGRAIEGTAYSDVNA
. : .*:.
Mb3790c|M.bovis_AF2122/97 TTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRVLAA
Rv3764c|M.tuberculosis_H37Rv TTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRVLAA
MAV_0305|M.avium_104 KTVDAGYLTSSGTRDALTSTAQTQLEQIAGSRAPVTVNLDGLGRYRVVAA
MMAR_5316|M.marinum_M KAIVAGYLTNSGDRAEISPTAQAQLAAVAGSQDPVTLNLDGLGRYRVVSA
Mflv_2267|M.gilvum_PYR-GCK RADDAGMIATDGSRTEISDVAARQLATVAVGGRPHTVDLDGLGRYRVVAF
Mvan_4428|M.vanbaalenii_PYR-1 QVEEAGVITADGSRAQVSATAAGQLAAVAVDERPHTVDLDGLGRYRVVAF
MSMEG_4989|M.smegmatis_MC2_155 GSVDAGVITSDGDRQEVSAAAARQLAAIPATREPQTIDLDGLGRYRLIGL
MAB_2582|M.abscessus_ATCC_1997 HVTEAARITADGSRERLSPQACREVEGLLQQS-TSTVDLDHAGLYRLVTM
MUL_4625|M.ulcerans_Agy99 VVIGSAVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLGSLGSYQVDSR
MLBr_00175|M.leprae_Br4923 MLVNPGHSIYTANQPGQTLPVGTAEKAVIRGELFMSQRTASDQRILAIHL
TH_2428|M.thermoresistible__bu MLVNPGRSIYTANQQGEALPLGEPERQVLSGELVMSLRTADQQRVLAIHL
.. . : .
Mb3790c|M.bovis_AF2122/97 PS-RNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAGIVIIK
Rv3764c|M.tuberculosis_H37Rv PS-RNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAGIVIIK
MAV_0305|M.avium_104 PS-RNGSDIIVTGLSMANIDATLIRMLVIFGIVTVIALAAATIAGVVIIR
MMAR_5316|M.marinum_M LS-RRGDELIVTGLSMSDVDATMIRMLIIFGIVTIVALVAATTAGAIIIR
Mflv_2267|M.gilvum_PYR-GCK PSHMEG-EAVVAGLPTTDVDDTLFWVAVIFGVVAVVALMAAGTAGAVIVR
Mvan_4428|M.vanbaalenii_PYR-1 PAHIPG-QVVVAGLPTGDVDDTLFWVAVIFGAVGAVALVAAGTAGIVIVR
MSMEG_4989|M.smegmatis_MC2_155 HPRHGGPQTIVTGLPNSVVDDTLLWVLGMFCVIAAVALIAAITAGTLLIR
MAB_2582|M.abscessus_ATCC_1997 P--TNGGAVIVTGLPAEGVGQTLSSVFGIICVVGAAALITAIGAGIVIIR
MUL_4625|M.ulcerans_Agy99 AA---GSDRLIVGVSLSIADRIITRKQITTSVLVATALVITAALTVWVVG
MLBr_00175|M.leprae_Br4923 PN----DSSLLISKSLRPTEAVMTKLRWVLLIVGSLGVAVAAVAGGMVTR
TH_2428|M.thermoresistible__bu SN----GSSLLISKSLAPTMEVLRRLGTVLLIVGGIGVAVAAIAGGMVAR
:: . . : : .: : :
Mb3790c|M.bovis_AF2122/97 RALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPD-ANPSTEVGQLGSA
Rv3764c|M.tuberculosis_H37Rv RALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPD-ANPSTEVGQLGSA
MAV_0305|M.avium_104 RALAPLRRVAQTAREVADLPLARGEVELPVRVRESD-ANPSTEVGQLGAA
MMAR_5316|M.marinum_M RALAPLRRVAQTATEVVDLPLDRGEVELPVRVSETD-ANPDTEVGQLGSA
Mflv_2267|M.gilvum_PYR-GCK RQLAPLARVSEAAQQVADLELDRGEVRLPTPIVKVDPAAAQTEVGQLGSA
Mvan_4428|M.vanbaalenii_PYR-1 RQLAPLARVSAAARQVADLELDRGEVNLPTPIVKVDPAAEHTEVGQLGTA
MSMEG_4989|M.smegmatis_MC2_155 RQFAPLARVSATAREVADLELERGEVRLPTPIVPVDPAVAHTEVGQLGTS
MAB_2582|M.abscessus_ATCC_1997 RQLDPLSQVATAAQEVAELELHRGEVNLPTPIIDVASNRTHTELGQLGAA
MUL_4625|M.ulcerans_Agy99 ITLRPLRRVAATAATVAAMPLAGDDHQISVRVRPED-TDPDNEVGIVGHT
MLBr_00175|M.leprae_Br4923 AGLRPVGRLTEAAERVARTDDLR-----PIPVFGSD-------------E
TH_2428|M.thermoresistible__bu AGLRPVSRLTEAAERVARTDDLR-----PIPVVGSD-------------E
: *: ::: :* *. . :
Mb3790c|M.bovis_AF2122/97 LNRMLDHIAAALSARQASETRVRQFVADASHELRTPLAAIRGYTELTQR-
Rv3764c|M.tuberculosis_H37Rv LNRMLDHIAAALSARQASETCVRQFVADASHELRTPLAAIRGYTELTQR-
MAV_0305|M.avium_104 LNRMLDHIADALSARQASETRVRQFVADASHELRTPLAAIRGYTELTQR-
MMAR_5316|M.marinum_M LNRMLDHIAAALSTRQASETRVRQFVADASHELRTPLAAIRGYTELAQR-
Mflv_2267|M.gilvum_PYR-GCK LNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRGYTELAQRK
Mvan_4428|M.vanbaalenii_PYR-1 LNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRGYTELAQRK
MSMEG_4989|M.smegmatis_MC2_155 LNRMLDRIASALSARHASETRVRQFVADASHELRTPLAAIRGYTELAQRK
MAB_2582|M.abscessus_ATCC_1997 LNRMLERIDDALSARHVSETRVRQFVADASHELRTPLAAISGYAELARRN
MUL_4625|M.ulcerans_Agy99 LNRLLDNVDSALQHRVASDLRMRQFITDASHELRTPLAAIQGYAELTRQD
MLBr_00175|M.leprae_Br4923 LARLTEAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLIAS
TH_2428|M.thermoresistible__bu LARLTEAFNMMLRALAESRERQARLVADAGHELRTPLTSLRTNVELLMAS
* *: : . * * ::::**.*******::: .**
Mb3790c|M.bovis_AF2122/97 IGDDPE-----AVAHAMSRVASETERITRLVEDLLLLARLDSGRPLERGP
Rv3764c|M.tuberculosis_H37Rv IGDDPE-----AVAHAMSRVASETERITRLVEDLLLLARLDSGRPLERGP
MAV_0305|M.avium_104 MGDDRE-----AVAQAMSRVASETERMTRLVEDLLLLARLDSGRPLEREP
MMAR_5316|M.marinum_M MGDDRA-----AVAHAMSRVGSETERITSLVEDLLLLARLDSGRPLEREP
Mflv_2267|M.gilvum_PYR-GCK QAELPD-----DVAHAMSRVESETARMTQLVEDMLLLARLDTGRPLDRDS
Mvan_4428|M.vanbaalenii_PYR-1 QAQLPE-----DVAHAMNRVESETERMTQLVEDMLLLARLDSGRPLDRET
MSMEG_4989|M.smegmatis_MC2_155 RGELPD-----DVAHAMSRVESETSRMTQLVEDMLLLARLDAGRPLERDR
MAB_2582|M.abscessus_ATCC_1997 HDALPT-----DVAHAMSRVQSEAARMTELVEDLLLLARLDSGRPLAQEP
MUL_4625|M.ulcerans_Agy99 SSDLPP-----TTEYALARIESEARRMASLVDELLLLSRLGEGEDLETEH
MLBr_00175|M.leprae_Br4923 MAPEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAG-QVVHEP
TH_2428|M.thermoresistible__bu QQPGAPGLPEEEMAGLRADVIAQIEELSTLVGDLVDLTRDDAG-GVIHEP
: :: .:: ** ::: *:* . * :
Mb3790c|M.bovis_AF2122/97 VDMSRLAVDAVSDAHVAGPDHQWALDLPPEPVVIPGDAARLHQVVTNLLA
Rv3764c|M.tuberculosis_H37Rv VDMSRLAVDAVSDAHVAGPDHQWALDLPPEPVVIPGDAARLHQVVTNLLA
MAV_0305|M.avium_104 VDLSRLAVDAVNDAHVAGPDHQWELDLPEEPVVITGDAARLHQVLTNLLA
MMAR_5316|M.marinum_M VDMSRLAVDAVSDAHVAGPDQQWELDLPAEPVVVTGDAARLHQVVANLLA
Mflv_2267|M.gilvum_PYR-GCK VDLTRLVVDAVSDAHVAAPDHVWELDLPDEPLTVCGDEARLHQVLANLLA
Mvan_4428|M.vanbaalenii_PYR-1 VDLTRLVVDAVSDAHVAGPDHAWELDLPDEPVTVQGDEARLHQVLANLLA
MSMEG_4989|M.smegmatis_MC2_155 VELSRLVVDTVSDAHVAGPQHKWSLDLPEDAVVIDGDEARLHQVMANLLA
MAB_2582|M.abscessus_ATCC_1997 VDLSRLVVDAASDAHIAASEHRWLLNLPEDPVIVCGDTPRLHQVVANLLS
MUL_4625|M.ulcerans_Agy99 LDLTDLVMNAVNDAAVAAPTHRWIKDLPDEPVWVNGDHARLHQLVSNLLT
MLBr_00175|M.leprae_Br4923 IDMSEVLYRSLERVRRRRND--IHFDVQAIGWQIYGDAAGLSRAVLNLMD
TH_2428|M.thermoresistible__bu VDIADVVDRSLERVRRRRND--IDFDIEVVPWQVYGDAAGLSRAVMNLLD
:::: : : . . :: : ** . * : : **:
Mb3790c|M.bovis_AF2122/97 NARVHTGPGTIVTTRLST-----GPTHVVLQVIDNGPGIPAALQSEVFER
Rv3764c|M.tuberculosis_H37Rv NARVHTGPGTIVTTRLST-----GPTHVVLQVIDNGPGIPAALQSEVFER
MAV_0305|M.avium_104 NARVHTGAGTVVTTRLST-----EPAHTVLQVIDNGPGIPAELQSEVFER
MMAR_5316|M.marinum_M NARIHTGPGAVVTTRLSS-----GPTHVVLEVIDNGPGIPEAMQSEIFER
Mflv_2267|M.gilvum_PYR-GCK NAGIHTPAGTTVTTSLTAT----DTGDVLVRVVDDGPGIPARLQPDVFER
Mvan_4428|M.vanbaalenii_PYR-1 NARIHTPAGTVVTTSLGVG----DGGSAVLTVLDDGPGIPDGLQPEVFER
MSMEG_4989|M.smegmatis_MC2_155 NARTHTPPGTSVTVALSAD----AEGWVTVAVTDDGPGIAPELLPDVFER
MAB_2582|M.abscessus_ATCC_1997 NCRIHTPPGTTVTVTLRS-----DGNSTYLTVADDGPGIPAGQQNEIFER
MUL_4625|M.ulcerans_Agy99 NAWVHTPPGVTVKTGITNYPDDPNGPYTELTVSNDGPDIDPEVLPHLFER
MLBr_00175|M.leprae_Br4923 NAAKWSPSGGRVVVTMRQF----DPSHVELVVSDYGPGIPPQERRLVFER
TH_2428|M.thermoresistible__bu NAAKWSPSGGRVGVRLTQV----DPVHAELVVSDHGPGIPPQERRLVFER
*. : .* * . : . : * : **.* :***
Mb3790c|M.bovis_AF2122/97 FARGDTSRSRQA--------GSTGLGLAIVSAVVKAHNGTITVSS-----
Rv3764c|M.tuberculosis_H37Rv FARGDTSRSRQA--------GSTGLGLAIVSAVVKAHNGTITVSS-----
MAV_0305|M.avium_104 FARGDSSRSRKG--------GSTGLGLAIVSAVVKAHNGTISVNS-----
MMAR_5316|M.marinum_M FARGDTSRSRKG--------GSTGLGLAIVAAVVKAHNGTITVNS-----
Mflv_2267|M.gilvum_PYR-GCK FARGDTSRSRRG--------GSTGLGLAIVAAVVRAHHGTISLHS-----
Mvan_4428|M.vanbaalenii_PYR-1 FARGDTSRSRRGDTSRSRGGGSTGLGLAIVAAVVRAHGGTIDVHS-----
MSMEG_4989|M.smegmatis_MC2_155 FARGDSSRSRRE--------GSTGLGLAIVAAVVKAHGGVIDVTS-----
MAB_2582|M.abscessus_ATCC_1997 FARGDTSRSRRA--------GSTGLGLAIAAAVIKAHHGEIRVNS-----
MUL_4625|M.ulcerans_Agy99 FVRSSKSRSSAP---------GHGLGLAIVNSIVKAHDGSVTAES-----
MLBr_00175|M.leprae_Br4923 FYRSTTARSLPG----------SGLGLAIVKQVVINHGGLLRVEDTAPGV
TH_2428|M.thermoresistible__bu FYRSTTARSMPG----------SGLGLAIVKQVVLKHGGTLRVEDTVPGG
* *. .:** ******. :: * * : .
Mb3790c|M.bovis_AF2122/97 SPGYTEFAVRLPLDGWQPLESSPR--------------------------
Rv3764c|M.tuberculosis_H37Rv SPGYTEFAVRLPLDGWQPLESSPR--------------------------
MAV_0305|M.avium_104 SPGHTEFTVRLPPNGWQPHASA----------------------------
MMAR_5316|M.marinum_M SPGRTEFVVRLPLDAWQRSGVPPG--------------------------
Mflv_2267|M.gilvum_PYR-GCK VPGRTEFAVVLPGDTQAVHSVGPR--------------------------
Mvan_4428|M.vanbaalenii_PYR-1 VPGRTEFVVTLPGDSQPGHSSGQSDA------------------------
MSMEG_4989|M.smegmatis_MC2_155 RPGETRFVVRLPG---AAHS------------------------------
MAB_2582|M.abscessus_ATCC_1997 VAGETVFTITLPTAGTQHGAFTEKLP------------------------
MUL_4625|M.ulcerans_Agy99 AAGQTVFRIRLPLIDAPLNASAPGRPRQPSDY------------------
MLBr_00175|M.leprae_Br4923 QPPGTSIYVLLPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQVSGKSAN
TH_2428|M.thermoresistible__bu QPPGTSIHVVLPGRPLSGVPPASQEPQPP-----QHAPGADPHAPTQTGN
. * : : **
Mb3790c|M.bovis_AF2122/97 ------------------
Rv3764c|M.tuberculosis_H37Rv ------------------
MAV_0305|M.avium_104 ------------------
MMAR_5316|M.marinum_M ------------------
Mflv_2267|M.gilvum_PYR-GCK ------------------
Mvan_4428|M.vanbaalenii_PYR-1 ------------------
MSMEG_4989|M.smegmatis_MC2_155 ------------------
MAB_2582|M.abscessus_ATCC_1997 ------------------
MUL_4625|M.ulcerans_Agy99 ------------------
MLBr_00175|M.leprae_Br4923 FRDSAHVISVDYQSARAR
TH_2428|M.thermoresistible__bu -DAVQSVFTAENK-----