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FRSPRSWSLRSRLIVIQVLLLAAACAGIAVATEFALQRFLMNQLDEQVVEAGRRSSVIFELGPPPPPGMR PPPMPPPGAMVAPPPPGQGHRIVIRDDQGPGPAFLNAPGQAIYTVGALVSAGQVEEAGVITADGSRAQVS ATAAGQLAAVAVDERPHTVDLDGLGRYRVVAFPAHIPGQVVVAGLPTGDVDDTLFWVAVIFGAVGAVALV AAGTAGIVIVRRQLAPLARVSAAARQVADLELDRGEVNLPTPIVKVDPAAEHTEVGQLGTALNRMLDRIA GALSARHASETRVRQFVADASHELRTPLAAIRGYTELAQRKQAQLPEDVAHAMNRVESETERMTQLVEDM LLLARLDSGRPLDRETVDLTRLVVDAVSDAHVAGPDHAWELDLPDEPVTVQGDEARLHQVLANLLANARI HTPAGTVVTTSLGVGDGGSAVLTVLDDGPGIPDGLQPEVFERFARGDTSRSRRGDTSRSRGGGSTGLGLA IVAAVVRAHGGTIDVHSVPGRTEFVVTLPGDSQPGHSSGQSDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4428 | - | - | 100% (534) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_2295 | - | 5e-92 | 41.76% (534) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_5174 | - | 2e-67 | 36.41% (541) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3790c | - | 1e-147 | 59.24% (503) | putative two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_2267 | - | 0.0 | 78.33% (540) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3764c | - | 1e-146 | 59.05% (503) | two component sensor kinase |
| M. leprae Br4923 | MLBr_00175 | - | 3e-31 | 28.07% (545) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_2582 | - | 1e-148 | 60.33% (484) | putative two component sensor kinase |
| M. marinum M | MMAR_5316 | tcrY | 1e-154 | 59.05% (525) | two-component sensor kinase TcrY |
| M. avium 104 | MAV_0305 | - | 1e-153 | 58.40% (524) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_4989 | - | 0.0 | 68.21% (519) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2452 | - | 2e-37 | 33.78% (370) | PUTATIVE putative sensor histidine kinase PhoR |
| M. ulcerans Agy99 | MUL_4625 | trcS | 2e-69 | 38.64% (440) | two component sensor histidine kinase TrcS |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3790c|M.bovis_AF2122/97 -------------------------------------------MGITAAT
Rv3764c|M.tuberculosis_H37Rv -------------------------------------------MGITAAT
MAV_0305|M.avium_104 ------------MADTRRV-----WSLRLRLLVGQIVVLALVCLGITAVT
MMAR_5316|M.marinum_M ------------MSSNRLVRRPGAWSLRLRLLVGQILVLAVVCVGITAAT
Mvan_4428|M.vanbaalenii_PYR-1 -------------M----FRSPRSWSLRSRLIVIQVLLLAAACAGIAVAT
Mflv_2267|M.gilvum_PYR-GCK MSSSPRAERTPAPV----LRPPRTWSLRTRLILTQLLLLAVVCAGVGVAT
MSMEG_4989|M.smegmatis_MC2_155 MFFVPRADAPRAAVGGTRWWSPRTWPLRARLVGTQVALLAVVCLSIGLAT
MAB_2582|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4625|M.ulcerans_Agy99 --------------------------MRWQLLLGVLAVVTIVLVAVGGVS
TH_2452|M.thermoresistible__bu -----MTSEPPSPSGRPRWRRLLPSAARTRIIGWVLLLVMVALGVVTLTT
MLBr_00175|M.leprae_Br4923 -------MVRFAWRRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAV
Mb3790c|M.bovis_AF2122/97 EMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRRETHNY-------
Rv3764c|M.tuberculosis_H37Rv EMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRHETHNY-------
MAV_0305|M.avium_104 ELALNHHLVKQLDGQLAGTSFRSALMYPE--PNHP-RHEHSPY-------
MMAR_5316|M.marinum_M ELALHHHLVAQLDGQLGGTSHRSALMYPE--SSHRFWRHQHRY-------
Mvan_4428|M.vanbaalenii_PYR-1 EFALQRFLMNQLDEQVVEAGRRSSVIFELGPPPPP--GMRPPP---MPPP
Mflv_2267|M.gilvum_PYR-GCK EFALQRFLMNQLDEQVIEAGRRSSMIFEFGPPPPPGMGMPPPPGVGMPPP
MSMEG_4989|M.smegmatis_MC2_155 EFALQRFLMHQLDEQLLEAGRRSAAIYELPPPPRGFLPLFPPG---MGPP
MAB_2582|M.abscessus_ATCC_1997 ---MNRFLNTQLDEQVRDAGNRSVVLFELGPPPPLSLPRPLAN----G--
MUL_4625|M.ulcerans_Agy99 VLSLRGYVTAMNDAEVVESMHAFSHAYARYRNGEHTSIHTGTP-------
TH_2452|M.thermoresistible__bu WRLMVSSIDARMDEALHIEVDEFEELTASGLNPRTGAPFTGVA-------
MLBr_00175|M.leprae_Br4923 YVVISAALYSDIDNQLQSR---AQLLIASG--------------------
: : * :
Mb3790c|M.bovis_AF2122/97 -----------------------IRSGPGPRFLDAPGQPAGMVAAVVSDG
Rv3764c|M.tuberculosis_H37Rv -----------------------IRSGPGPRFLDAPGQPAGMVAAVVSDG
MAV_0305|M.avium_104 -----------------------PRPGPGPRFLDAPGQPAGMVAAVVSHG
MMAR_5316|M.marinum_M -----------------------WRPGPGPRFLDAPGQPAGMVGAVVRDG
Mvan_4428|M.vanbaalenii_PYR-1 G--AMVAP---PPPGQGHRIVIRDDQGPGPAFLNAPGQAIYTVGALVSAG
Mflv_2267|M.gilvum_PYR-GCK PGVGMPVPPVGPPPRRGHHMMIRDE-GPGPAFLNAPGQAILTVGAVVSDG
MSMEG_4989|M.smegmatis_MC2_155 G---------------RHLRVFDPEQGPGPGFLNAPGQAARTVGAVVSPD
MAB_2582|M.abscessus_ATCC_1997 ---------------------WRPTDGPGPAFLDAPGQSIGMVGAVAVNG
MUL_4625|M.ulcerans_Agy99 --------------------------PLSQALLEFTGQTPGNLIAVMRDG
TH_2452|M.thermoresistible__bu ---------------------EVIREAIAYNLARPNEKFLGYVDGEYHTQ
MLBr_00175|M.leprae_Br4923 ------------------------------SLAADPGKAIEGTAYSDVNA
: :
Mb3790c|M.bovis_AF2122/97 TTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRVLAA
Rv3764c|M.tuberculosis_H37Rv TTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRVLAA
MAV_0305|M.avium_104 KTVDAGYLTSSGTRDALTSTAQTQLEQIAGSRAPVTVNLDGLGRYRVVAA
MMAR_5316|M.marinum_M KAIVAGYLTNSGDRAEISPTAQAQLAAVAGSQDPVTLNLDGLGRYRVVSA
Mvan_4428|M.vanbaalenii_PYR-1 QVEEAGVITADGSRAQVSATAAGQLAAVAVDERPHTVDLDGLGRYRVVAF
Mflv_2267|M.gilvum_PYR-GCK RADDAGMIATDGSRTEISDVAARQLATVAVGGRPHTVDLDGLGRYRVVAF
MSMEG_4989|M.smegmatis_MC2_155 GSVDAGVITSDGDRQEVSAAAARQLAAIPATREPQTIDLDGLGRYRLIGL
MAB_2582|M.abscessus_ATCC_1997 HVTEAARITADGSRERLSPQACREVEGLLQQS-TSTVDLDHAGLYRLVTM
MUL_4625|M.ulcerans_Agy99 VVIGSAVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLGSLGSYQVDSR
TH_2452|M.thermoresistible__bu SRQEPGFPEVLAGDDAFTERVATVTEPVEGSYDHPEVGEVRYLAIPVTMA
MLBr_00175|M.leprae_Br4923 MLVNPGHSIYTANQPGQTLPVGTAEKAVIRGELFMSQRTASDQRILAIHL
.. . .
Mb3790c|M.bovis_AF2122/97 PS-RNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAGIVIIK
Rv3764c|M.tuberculosis_H37Rv PS-RNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAGIVIIK
MAV_0305|M.avium_104 PS-RNGSDIIVTGLSMANIDATLIRMLVIFGIVTVIALAAATIAGVVIIR
MMAR_5316|M.marinum_M LS-RRGDELIVTGLSMSDVDATMIRMLIIFGIVTIVALVAATTAGAIIIR
Mvan_4428|M.vanbaalenii_PYR-1 PAHIPG-QVVVAGLPTGDVDDTLFWVAVIFGAVGAVALVAAGTAGIVIVR
Mflv_2267|M.gilvum_PYR-GCK PSHMEG-EAVVAGLPTTDVDDTLFWVAVIFGVVAVVALMAAGTAGAVIVR
MSMEG_4989|M.smegmatis_MC2_155 HPRHGGPQTIVTGLPNSVVDDTLLWVLGMFCVIAAVALIAAITAGTLLIR
MAB_2582|M.abscessus_ATCC_1997 P--TNGGAVIVTGLPAEGVGQTLSSVFGIICVVGAAALITAIGAGIVIIR
MUL_4625|M.ulcerans_Agy99 AA---GSDRLIVGVSLSIADRIITRKQITTSVLVATALVITAALTVWVVG
TH_2452|M.thermoresistible__bu GDPAQG--VIVAAYLGDAERAAADDAARLMLLVGAATLFGAIGAAWLVAG
MLBr_00175|M.leprae_Br4923 PN----DSSLLISKSLRPTEAVMTKLRWVLLIVGSLGVAVAAVAGGMVTR
:: . : : : :
Mb3790c|M.bovis_AF2122/97 RALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPD-ANPSTEVGQLGSA
Rv3764c|M.tuberculosis_H37Rv RALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPD-ANPSTEVGQLGSA
MAV_0305|M.avium_104 RALAPLRRVAQTAREVADLPLARGEVELPVRVRESD-ANPSTEVGQLGAA
MMAR_5316|M.marinum_M RALAPLRRVAQTATEVVDLPLDRGEVELPVRVSETD-ANPDTEVGQLGSA
Mvan_4428|M.vanbaalenii_PYR-1 RQLAPLARVSAAARQVADLELDRGEVNLPTPIVKVDPAAEHTEVGQLGTA
Mflv_2267|M.gilvum_PYR-GCK RQLAPLARVSEAAQQVADLELDRGEVRLPTPIVKVDPAAAQTEVGQLGSA
MSMEG_4989|M.smegmatis_MC2_155 RQFAPLARVSATAREVADLELERGEVRLPTPIVPVDPAVAHTEVGQLGTS
MAB_2582|M.abscessus_ATCC_1997 RQLDPLSQVATAAQEVAELELHRGEVNLPTPIIDVASNRTHTELGQLGAA
MUL_4625|M.ulcerans_Agy99 ITLRPLRRVAATAATVAAMPLAGDDHQISVRVRPED-TDPDNEVGIVGHT
TH_2452|M.thermoresistible__bu RILRPLRDVADTARTITDTDLSR---RIPS-------RGEGDEMDSLVRT
MLBr_00175|M.leprae_Br4923 AGLRPVGRLTEAAERVARTDDLR-----PIPVFGSD------ELARLTEA
: *: :: :* :. . *: : :
Mb3790c|M.bovis_AF2122/97 LNRMLDHIAAALSARQASETRVRQFVADASHELRTPLAAIRGYTELTQR-
Rv3764c|M.tuberculosis_H37Rv LNRMLDHIAAALSARQASETCVRQFVADASHELRTPLAAIRGYTELTQR-
MAV_0305|M.avium_104 LNRMLDHIADALSARQASETRVRQFVADASHELRTPLAAIRGYTELTQR-
MMAR_5316|M.marinum_M LNRMLDHIAAALSTRQASETRVRQFVADASHELRTPLAAIRGYTELAQR-
Mvan_4428|M.vanbaalenii_PYR-1 LNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRGYTELAQRK
Mflv_2267|M.gilvum_PYR-GCK LNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRGYTELAQRK
MSMEG_4989|M.smegmatis_MC2_155 LNRMLDRIASALSARHASETRVRQFVADASHELRTPLAAIRGYTELAQRK
MAB_2582|M.abscessus_ATCC_1997 LNRMLERIDDALSARHVSETRVRQFVADASHELRTPLAAISGYAELARRN
MUL_4625|M.ulcerans_Agy99 LNRLLDNVDSALQHRVASDLRMRQFITDASHELRTPLAAIQGYAELTRQD
TH_2452|M.thermoresistible__bu INGMLDRIEAGVSA-------QRRFIDDAGHELRTPITIVRGHLEVLDP-
MLBr_00175|M.leprae_Br4923 FNLMLRALAE-------SRERQARLVTDAGHELRTPLTSLRTNVELLIAS
:* :* : ::: **.******:: : *:
Mb3790c|M.bovis_AF2122/97 IGDDPE-----AVAHAMSRVASETERITRLVEDLLLLARLDSGRPLERGP
Rv3764c|M.tuberculosis_H37Rv IGDDPE-----AVAHAMSRVASETERITRLVEDLLLLARLDSGRPLERGP
MAV_0305|M.avium_104 MGDDRE-----AVAQAMSRVASETERMTRLVEDLLLLARLDSGRPLEREP
MMAR_5316|M.marinum_M MGDDRA-----AVAHAMSRVGSETERITSLVEDLLLLARLDSGRPLEREP
Mvan_4428|M.vanbaalenii_PYR-1 QAQLPE-----DVAHAMNRVESETERMTQLVEDMLLLARLDSGRPLDRET
Mflv_2267|M.gilvum_PYR-GCK QAELPD-----DVAHAMSRVESETARMTQLVEDMLLLARLDTGRPLDRDS
MSMEG_4989|M.smegmatis_MC2_155 RGELPD-----DVAHAMSRVESETSRMTQLVEDMLLLARLDAGRPLERDR
MAB_2582|M.abscessus_ATCC_1997 HDALPT-----DVAHAMSRVQSEAARMTELVEDLLLLARLDSGRPLAQEP
MUL_4625|M.ulcerans_Agy99 SSDLPP-----TTEYALARIESEARRMASLVDELLLLSRLGEGEDLETEH
TH_2452|M.thermoresistible__bu --DDPD-----DVRSTVALVDDELVRMNRMVTDLLLLARSEQPTFLTPEP
MLBr_00175|M.leprae_Br4923 MAPEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAG-QVVHEP
: : .: :* ::: *:* :
Mb3790c|M.bovis_AF2122/97 VDMSRLAVDAVSDAHVAGPDHQWALDLPPEPVVIPGDAARLHQVVTNLLA
Rv3764c|M.tuberculosis_H37Rv VDMSRLAVDAVSDAHVAGPDHQWALDLPPEPVVIPGDAARLHQVVTNLLA
MAV_0305|M.avium_104 VDLSRLAVDAVNDAHVAGPDHQWELDLPEEPVVITGDAARLHQVLTNLLA
MMAR_5316|M.marinum_M VDMSRLAVDAVSDAHVAGPDQQWELDLPAEPVVVTGDAARLHQVVANLLA
Mvan_4428|M.vanbaalenii_PYR-1 VDLTRLVVDAVSDAHVAGPDHAWELDLPDEPVTVQGDEARLHQVLANLLA
Mflv_2267|M.gilvum_PYR-GCK VDLTRLVVDAVSDAHVAAPDHVWELDLPDEPLTVCGDEARLHQVLANLLA
MSMEG_4989|M.smegmatis_MC2_155 VELSRLVVDTVSDAHVAGPQHKWSLDLPEDAVVIDGDEARLHQVMANLLA
MAB_2582|M.abscessus_ATCC_1997 VDLSRLVVDAASDAHIAASEHRWLLNLPEDPVIVCGDTPRLHQVVANLLS
MUL_4625|M.ulcerans_Agy99 LDLTDLVMNAVNDAAVAAPTHRWIKDLPDEPVWVNGDHARLHQLVSNLLT
TH_2452|M.thermoresistible__bu TDIG-ALTRAIFDKVVQLGDRDYQLQSVAEVTAVL-DAQRITQALIALAD
MLBr_00175|M.leprae_Br4923 IDMSEVLYRSLERVRRRRNDIHFDVQAIG--WQIYGDAAGLSRAVLNLMD
:: : : : : * : : : *
Mb3790c|M.bovis_AF2122/97 NARVHTGPGTIVTTRLST-----GPTHVVLQVIDNGPGIPAALQSEVFER
Rv3764c|M.tuberculosis_H37Rv NARVHTGPGTIVTTRLST-----GPTHVVLQVIDNGPGIPAALQSEVFER
MAV_0305|M.avium_104 NARVHTGAGTVVTTRLST-----EPAHTVLQVIDNGPGIPAELQSEVFER
MMAR_5316|M.marinum_M NARIHTGPGAVVTTRLSS-----GPTHVVLEVIDNGPGIPEAMQSEIFER
Mvan_4428|M.vanbaalenii_PYR-1 NARIHTPAGTVVTTSLGVG----DGGSAVLTVLDDGPGIPDGLQPEVFER
Mflv_2267|M.gilvum_PYR-GCK NAGIHTPAGTTVTTSLTAT----DTGDVLVRVVDDGPGIPARLQPDVFER
MSMEG_4989|M.smegmatis_MC2_155 NARTHTPPGTSVTVALSAD----AEGWVTVAVTDDGPGIAPELLPDVFER
MAB_2582|M.abscessus_ATCC_1997 NCRIHTPPGTTVTVTLRS-----DGNSTYLTVADDGPGIPAGQQNEIFER
MUL_4625|M.ulcerans_Agy99 NAWVHTPPGVTVKTGITNYPDDPNGPYTELTVSNDGPDIDPEVLPHLFER
TH_2452|M.thermoresistible__bu NACRYTRDGDWIAVGSGLY-----DGWLRFWVSDSGPGVSDADRDRIFER
MLBr_00175|M.leprae_Br4923 NAAKWSPSGGRVVVTMRQF----DPSHVELVVSDYGPGIPPQERRLVFER
*. : * : . . * : **.: :***
Mb3790c|M.bovis_AF2122/97 FARGDTSRSRQA--------GSTGLGLAIVSAVVKAHNGTITVSSSPGY-
Rv3764c|M.tuberculosis_H37Rv FARGDTSRSRQA--------GSTGLGLAIVSAVVKAHNGTITVSSSPGY-
MAV_0305|M.avium_104 FARGDSSRSRKG--------GSTGLGLAIVSAVVKAHNGTISVNSSPGH-
MMAR_5316|M.marinum_M FARGDTSRSRKG--------GSTGLGLAIVAAVVKAHNGTITVNSSPGR-
Mvan_4428|M.vanbaalenii_PYR-1 FARGDTSRSRRGDTSRSRGGGSTGLGLAIVAAVVRAHGGTIDVHSVPGR-
Mflv_2267|M.gilvum_PYR-GCK FARGDTSRSRRG--------GSTGLGLAIVAAVVRAHHGTISLHSVPGR-
MSMEG_4989|M.smegmatis_MC2_155 FARGDSSRSRRE--------GSTGLGLAIVAAVVKAHGGVIDVTSRPGE-
MAB_2582|M.abscessus_ATCC_1997 FARGDTSRSRRA--------GSTGLGLAIAAAVIKAHHGEIRVNSVAGE-
MUL_4625|M.ulcerans_Agy99 FVRSSKSRSSAP---------GHGLGLAIVNSIVKAHDGSVTAESAAGQ-
TH_2452|M.thermoresistible__bu FARGSAGGQRSD---------GAGLGLSIVRAIAGAHGGHVDLDTVVGRG
MLBr_00175|M.leprae_Br4923 FYRSTTARSLPG----------SGLGLAIVKQVVINHGGLLRVEDTAPGV
* *. . . ****:*. : * * :
Mb3790c|M.bovis_AF2122/97 ----TEFAVRLPLDGWQPLESSPR--------------------------
Rv3764c|M.tuberculosis_H37Rv ----TEFAVRLPLDGWQPLESSPR--------------------------
MAV_0305|M.avium_104 ----TEFTVRLPPNGWQPHASA----------------------------
MMAR_5316|M.marinum_M ----TEFVVRLPLDAWQRSGVPPG--------------------------
Mvan_4428|M.vanbaalenii_PYR-1 ----TEFVVTLPGDSQPGHSSGQSDA------------------------
Mflv_2267|M.gilvum_PYR-GCK ----TEFAVVLPGDTQAVHSVGPR--------------------------
MSMEG_4989|M.smegmatis_MC2_155 ----TRFVVRLPG---AAHS------------------------------
MAB_2582|M.abscessus_ATCC_1997 ----TVFTITLPTAGTQHGAFTEKLP------------------------
MUL_4625|M.ulcerans_Agy99 ----TVFRIRLPLIDAPLNASAPGRPRQPSDY------------------
TH_2452|M.thermoresistible__bu ----STFTITIPAVLEAPWPAS----------------------------
MLBr_00175|M.leprae_Br4923 QPPGTSIYVLLPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQVSGKSAN
: : : :*
Mb3790c|M.bovis_AF2122/97 ------------------
Rv3764c|M.tuberculosis_H37Rv ------------------
MAV_0305|M.avium_104 ------------------
MMAR_5316|M.marinum_M ------------------
Mvan_4428|M.vanbaalenii_PYR-1 ------------------
Mflv_2267|M.gilvum_PYR-GCK ------------------
MSMEG_4989|M.smegmatis_MC2_155 ------------------
MAB_2582|M.abscessus_ATCC_1997 ------------------
MUL_4625|M.ulcerans_Agy99 ------------------
TH_2452|M.thermoresistible__bu ------------------
MLBr_00175|M.leprae_Br4923 FRDSAHVISVDYQSARAR