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MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYP IHNPDRPPSRFYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYL TTVAIDLADVRSTVRSLVLLQVGIGSAVLVVLGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWH PRTEVGRLSLALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAA RDVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKRRITLEVLDG PGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALRVFERFYR ADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPVVPGPP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | - | 100% (485) | two component system response sensor kinase membrane associated PHOR |
| M. bovis AF2122 / 97 | Mb3790c | - | 5e-58 | 36.77% (427) | putative two component sensor kinase |
| M. bovis AF2122 / 97 | Mb1061c | trcS | 2e-46 | 33.67% (499) | two component sensor histidine kinase TRCS |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1582 | - | 0.0 | 72.28% (469) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0758 | phoR | 0.0 | 99.59% (485) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_00774 | mtrB | 2e-34 | 33.65% (312) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 1e-156 | 64.89% (470) | putative sensor histidine kinase PhoR |
| M. marinum M | MMAR_4941 | phoR | 0.0 | 73.67% (471) | two-component system response phosphate sensor kinase, PhoR |
| M. avium 104 | MAV_0703 | - | 0.0 | 76.45% (467) | sensor histidine kinase PhoR |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 0.0 | 71.00% (469) | sensor histidine kinase PhoR |
| M. thermoresistible (build 8) | TH_2452 | - | 4e-38 | 28.93% (484) | PUTATIVE putative sensor histidine kinase PhoR |
| M. ulcerans Agy99 | MUL_0464 | phoR | 0.0 | 73.46% (471) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_5174 | - | 0.0 | 71.09% (467) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1582|M.gilvum_PYR-GCK --------MSSASPDERSNLNNGDVAGRRRYLRRGVPLRVALVAATLLLV
Mvan_5174|M.vanbaalenii_PYR-1 --------MDGG---DGPTLNNGGVPGR---IRRGVPLRVGLVAAMLLLV
MSMEG_5870|M.smegmatis_MC2_155 --------MNRG--------------------RRGIPLRVGLVAAALVLV
Mb0781|M.bovis_AF2122/97 --------MARH-------------------LRGRLPLRVRLVAATLILV
Rv0758|M.tuberculosis_H37Rv --------MARH-------------------LRGRLPLRVRLVAATLILV
MMAR_4941|M.marinum_M --------MAER-------------------LPRAVPLRVGLVAATLALV
MUL_0464|M.ulcerans_Agy99 --------MAER-------------------LPRAVQLRVGLVAATLALV
MAV_0703|M.avium_104 -------MVVTR-------------------PRRGLPLRVGLVAATLALV
MAB_0674|M.abscessus_ATCC_1997 --MAWDTYCASRDERLREEQLALLVAVPG--VRRGVPLRVSLVVGTLVLV
MLBr_00774|M.leprae_Br4923 MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLS
TH_2452|M.thermoresistible__bu -MTSEPPSPSGR---------------PRWRRLLPSAARTRIIGWVLLLV
: :: : *
Mflv_1582|M.gilvum_PYR-GCK ACGLLASGIAVTTIMQHSLMN------RVDDTLLDASRGWAQVPRRLPTI
Mvan_5174|M.vanbaalenii_PYR-1 ACGLLASGIAVTTIMQHSLMN------RVDDTLLDASRGWAQVPRRVLTV
MSMEG_5870|M.smegmatis_MC2_155 ACGLLASGIAVTSIMRHTEVS------RIDQTLLDASRSWAQAPRRAPTT
Mb0781|M.bovis_AF2122/97 ATGLVASGIAVTSMLQHRLTS------RIDRVLLEEAQIWAQITLPLAPD
Rv0758|M.tuberculosis_H37Rv ATGLVASGIAVTSMLQHRLTS------RIDRVLLEEAQIWAQITLPLAPD
MMAR_4941|M.marinum_M LCGLLASGVAVTSILRHSLVS------RIDSTLLEASRTWAQASWRHSMP
MUL_0464|M.ulcerans_Agy99 LCGLLASGVAVTSILRHSLVS------RIDSTLLEASRTWAQASWRHSMP
MAV_0703|M.avium_104 ACGLAVSGIAVTSILRHSLVS------RIDSTLLDASRGWAQAPRRQSSS
MAB_0674|M.abscessus_ATCC_1997 ALGLVASGIAVTTTMQRTMMN------RADRELIDAANGWANRP--PPPP
MLBr_00774|M.leprae_Br4923 LAVILALGFVLTSQLTSRVLDVK---VRVAIEQIERARTTVTGIVNGEET
TH_2452|M.thermoresistible__bu MVALGVVTLTTWRLMVSSIDARMDEALHIEVDEFEELTASGLNPRTGAPF
: . .. : : ::
Mflv_1582|M.gilvum_PYR-GCK TVDDPNPARPPSDFYVRGID-----PDGHVWMLINDRE-AEPELPADNNV
Mvan_5174|M.vanbaalenii_PYR-1 PMEGPNPARPPSDFYVRAVD-----PDGHVWMEVNDRE-AEPALPEDNDV
MSMEG_5870|M.smegmatis_MC2_155 PLEGPNPARPPSNFYVRGFD-----EDGRTWIAVNDRE-AEPALPENNDV
Mb0781|M.bovis_AF2122/97 PYPIHNPDRPPSRFYVRVIS-----PDGQSYTALNDNT-AIPAVPANNDV
Rv0758|M.tuberculosis_H37Rv PYPGHNPDRPPSRFYVRVIS-----PDGQSYTALNDNT-AIPAVPANNDV
MMAR_4941|M.marinum_M SVEGPDPARPPSKFYVRSIS-----PDGRAMTAINDRN-AEPALPADNDV
MUL_0464|M.ulcerans_Agy99 SVEGPDPARPPSKFYVRSIS-----PDGRAMTAINDRN-AEPALPADNDV
MAV_0703|M.avium_104 AYEGPDPGRPPSKFYVRGVS-----TDGTPFTAINDRN-AEPALPADNDV
MAB_0674|M.abscessus_ATCC_1997 PAFETTRHRPPSLFFIRTTD-----DRGRVVIMLNDRARADPDLPFDNDV
MLBr_00774|M.leprae_Br4923 RSLDSSLQLARNTLTSKTDP-----TSGAGLVGAFDAVLIVPGDGPRTAT
TH_2452|M.thermoresistible__bu TGVAEVIREAIAYNLARPNEKFLGYVDGEYHTQSRQEPGFPEVLAGDDAF
. : * :
Mflv_1582|M.gilvum_PYR-GCK GPEPRTVGS--------VDHSDVQWRAMTVRGLRGELTTVAIDLS-----
Mvan_5174|M.vanbaalenii_PYR-1 GSEPVTVAS--------VDHSHVQWRAMTVRGLSGELTTVAIDLS-----
MSMEG_5870|M.smegmatis_MC2_155 GPVPVTVGS--------IDKSNVEWRAMTVRGPNGELTTVAIDLS-----
Mb0781|M.bovis_AF2122/97 GRHPTTLPS--------IGGSKTLWRAVSVRASDGYLTTVAIDLA-----
Rv0758|M.tuberculosis_H37Rv GRHPTTLPS--------IGGSKTLWRAVSVRASDGYLTTVAIDLA-----
MMAR_4941|M.marinum_M GSDPTTLPS--------VNGSNIEWRAVSVHGPQGGLTTVAIDLS-----
MUL_0464|M.ulcerans_Agy99 GSDPTTLPS--------VNGSNIEWRAVSVHGPQGGLTTVAIDLS-----
MAV_0703|M.avium_104 GPNPTTLPS--------VNGSDIQWRAVSVRGPHG-LTTVAIDLS-----
MAB_0674|M.abscessus_ATCC_1997 GGRPVTVRS--------SDGG-TEWRAVSRHDALGGYTTVARDIT-----
MLBr_00774|M.leprae_Br4923 TAGPVDQVPNSLRGFIKAGQAAYQYATVHTEGFSGPALIIGTPTSSQVTN
TH_2452|M.thermoresistible__bu TERVATVTEPVEGSYDHPEVGEVRYLAIPVTMAGDPAQGVIVAAYLG---
. : :: . :
Mflv_1582|M.gilvum_PYR-GCK ----------DVKSTMRSLVYTQVGIGAAVLLVLGIAGYAVVHRSLRPLS
Mvan_5174|M.vanbaalenii_PYR-1 ----------DVKSTVRSLVYTQAGFGVAVLVVLGIAGYAVVHRSLRPLS
MSMEG_5870|M.smegmatis_MC2_155 ----------EVQSSVRALVWSQVGIGAAVLLVLGVVGYVVVHRSLRPLV
Mb0781|M.bovis_AF2122/97 ----------DVRSTVRSLVLLQVGIGSAVLVVLGVAGYAVVRRSLRPLA
Rv0758|M.tuberculosis_H37Rv ----------DVRSTVRSLVLLQVGIGSAVLVVPGVAGYAVVRRSLRPLA
MMAR_4941|M.marinum_M ----------DVQHTVRSLVWLQIGIGAGVLVVVGLAGFAVVQRSLRPLS
MUL_0464|M.ulcerans_Agy99 ----------DVQHTVRSLVWLQIGIGAGVLVVVGLAGFAVVQRSLRPLS
MAV_0703|M.avium_104 ----------DVQHTVSSLVWLQIGIGVAVLAVVGIASFAVVQRSLRPLV
MAB_0674|M.abscessus_ATCC_1997 ----------DVRTTVRDLLWLQVAIGIAVLTVLGVAGYWLVHRSLRPLA
MLBr_00774|M.leprae_Br4923 LELYLIFPLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVPVR
TH_2452|M.thermoresistible__bu ---------DAERAAADDAARLMLLVGAATLFGAIGAAWLVAGRILRPLR
: : * * . : : : *:
Mflv_1582|M.gilvum_PYR-GCK EVEQTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQHAMALSES
Mvan_5174|M.vanbaalenii_PYR-1 EVEQTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQRAMASSEA
MSMEG_5870|M.smegmatis_MC2_155 EVERTAAAIAAGQLDRRVPERDPRTEVGRLSSALNGMLAQIQRAVAASEA
Mb0781|M.bovis_AF2122/97 EFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAES
Rv0758|M.tuberculosis_H37Rv EFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAES
MMAR_4941|M.marinum_M EVEQTAAAIASGQLDRRVPERDPRTEVGQLSLAMNGMLSQIQVALAASED
MUL_0464|M.ulcerans_Agy99 EVEQTAAAIASGQLDRRVPERDPRTEVGQLSLAMNGMLSQIQVALAASED
MAV_0703|M.avium_104 EVEQTAAAIAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQQALASSES
MAB_0674|M.abscessus_ATCC_1997 EVEATAADIAAGHLDRRVPERDPRTEVGRLSLALNGMLAQIQRAVADSEK
MLBr_00774|M.leprae_Br4923 SASRIAERFAEGHLSERMPVRG-EDDMARLAVSFNDMAESLSRQITQLEE
TH_2452|M.thermoresistible__bu DVADTARTITDTDLSRRIPSRGEGDEMDSLVRTINGMLDRIEAGVSAQR-
. * : .*..*:* :: * ::*.* :. :: .
Mflv_1582|M.gilvum_PYR-GCK SAEKARSSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVEMLMG
Mvan_5174|M.vanbaalenii_PYR-1 SAEQARTSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVEMLMS
MSMEG_5870|M.smegmatis_MC2_155 SAEQARSSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDIEMLMG
Mb0781|M.bovis_AF2122/97 SAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLS
Rv0758|M.tuberculosis_H37Rv SAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLS
MMAR_4941|M.marinum_M SAEKARSSEERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLS
MUL_0464|M.ulcerans_Agy99 SAEKARSSEERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLS
MAV_0703|M.avium_104 SAEKARGSEDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLS
MAB_0674|M.abscessus_ATCC_1997 SAKAARTSEERMRRFITDASHELRTPLTTIRGYAELYRQGAATDTELVLG
MLBr_00774|M.leprae_Br4923 FGNLQR-------RFTSDVSHELRTPLTTVRMAADLIYDHSS-DLDPTLR
TH_2452|M.thermoresistible__bu -------------RFIDDAGHELRTPITIVRGHLEVLDPDDPDDVRSTVA
:* *..******:* :* :: . * :
Mflv_1582|M.gilvum_PYR-GCK R----IKSESRRMGLLVEDLLLLARLDA-QRPLEHRRVDLLALASDTVHD
Mvan_5174|M.vanbaalenii_PYR-1 R----IESESRRMGLLVEDLLLLARLDA-QRPLDRHRVDLLTLATDAVHD
MSMEG_5870|M.smegmatis_MC2_155 R----IESESRRMGLLVEDLLLLARLDA-QRPLERRRVDLLALATDAVHD
Mb0781|M.bovis_AF2122/97 R----IESEASRMGLLVDDLLLLARLDA-HRPLELCRVDLLALASDAAHD
Rv0758|M.tuberculosis_H37Rv R----IESEASRMGLLVDDLLLLARLDA-HRPLELCRVDLLALASDAAHD
MMAR_4941|M.marinum_M R----IESEASRMGLLVDDLLTLARLDV-QRPLERNRVDLLVLAADAVHD
MUL_0464|M.ulcerans_Agy99 R----IESEASRMGLLVDDLLTLARLDV-QRPLERNRVDLLVLAADAVHD
MAV_0703|M.avium_104 R----IESEASRMGLLVDDLLLLARLDV-QRPLEHHRVDLLALASDAVHD
MAB_0674|M.abscessus_ATCC_1997 R----IEGESTRMGQLVEDLLLLARLDA-HRPMEQRLVDLLVLATDAVHD
MLBr_00774|M.leprae_Br4923 RSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMVNNALGN
TH_2452|M.thermoresistible__bu L----VDDELVRMNRMVTDLLLLARSEQ-PTFLTPEPTDIGALTRAIFDK
: .* *: :: *** ::* : : .*: .:. .
Mflv_1582|M.gilvum_PYR-GCK AQSIAPKRRIRMEVFDGPGTPEVLGDEARLRQVLSNLVANALQHTPESAG
Mvan_5174|M.vanbaalenii_PYR-1 AQSIAPKRSIKMEVFDGPGTPEVLGDEPRLRQVLSNLVANALQHTPETAA
MSMEG_5870|M.smegmatis_MC2_155 AQSIAPKRRVKMEVFDGPGTPEVLGDEARLRQVIGNLVANAVQHTPETAG
Mb0781|M.bovis_AF2122/97 ARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESAD
Rv0758|M.tuberculosis_H37Rv ARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESAD
MMAR_4941|M.marinum_M ARAIDRKRAITVEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTPDSAD
MUL_0464|M.ulcerans_Agy99 ARAIDRKRAITVEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTPDSAD
MAV_0703|M.avium_104 AQAMDPKRTITLEVLDGPGTPEVFGDEPRIRQVLGNLIANALQHTPESAD
MAB_0674|M.abscessus_ATCC_1997 AKATAPERDVELEVFDGPGTPEVIGDELRLRQVLGNLVSNALGHT--TAA
MLBr_00774|M.leprae_Br4923 VGHLAEEAGIELLVDMPVDEVIAEVDARRVERILRNLIANAIDHS-EHKP
TH_2452|M.thermoresistible__bu VVQLGDRD----YQLQSVAEVTAVLDAQRITQALIALADNACRYTRDGDW
. . . * *: : : * ** ::
Mflv_1582|M.gilvum_PYR-GCK VTVRVGTADDTAIVEVCDEGPGMTGEDAQRVFERFYRADSSRARASGGTG
Mvan_5174|M.vanbaalenii_PYR-1 VTVRVGTDGNDAVVEVCDEGPGMRPEDAQRVFERFYRTDTSRARASGGTG
MSMEG_5870|M.smegmatis_MC2_155 ITVRVGTDGDNAVLEVCDEGPGMSQEDARRVFERFYRADTSRTRASGGTG
Mb0781|M.bovis_AF2122/97 VTVRVGTEGDDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTG
Rv0758|M.tuberculosis_H37Rv VTVRVGTEGDDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTG
MMAR_4941|M.marinum_M VTVRVGTAGQNAVLEVADKGPGMPAEDAARVFERFYRTDSSRARASGGTG
MUL_0464|M.ulcerans_Agy99 VTVRVGTAGENAVLEVADKGPGMPAEDAARVFERFYRTDSSRARASGGTG
MAV_0703|M.avium_104 VTVRVGTDGDDAVLEVADRGPGMNEQDASRVFERFYRTDSSRARASGGTG
MAB_0674|M.abscessus_ATCC_1997 VRVRVGTEGDDAVLEVIDRGPGMTKTDAERVFERFYRADSSRTRSSGGTG
MLBr_00774|M.leprae_Br4923 VRIRMAADEDTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGGTG
TH_2452|M.thermoresistible__bu IAVGSGLYDGWLRFWVSDSGPGVSDADRDRIFERFARGSAGGQR-SDGAG
: : . . * * * *: : :*.** * ... * *.*:*
Mflv_1582|M.gilvum_PYR-GCK LGLSIVDSLVYAHGGRVSVTTAPGCGCRFTVRLPRVTDERLREEQATDER
Mvan_5174|M.vanbaalenii_PYR-1 LGLSIVDSLVYAHGGRVSVTTAPGQGSRFRVSLPRIADAGP---------
MSMEG_5870|M.smegmatis_MC2_155 LGLSIVDSLVYAHGGTVKVTTALGKGSRFTVSLPRIADLPARL-------
Mb0781|M.bovis_AF2122/97 LGLSIVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLS-------
Rv0758|M.tuberculosis_H37Rv LGLSIVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLS-------
MMAR_4941|M.marinum_M LGLSIVHSLVKAHGGDVTLTTAPGEGCCFRVTLPRVSEAAVEL-------
MUL_0464|M.ulcerans_Agy99 LGLSIVHSLVKAHGGDVTLTTAPGEGCCFRVTLPRVSEAAVEL-------
MAV_0703|M.avium_104 LGLSIVESLVRAHGGTVGVTTAPGQGCCFRVTLPRISDVPAVQ-------
MAB_0674|M.abscessus_ATCC_1997 LGLSIVDALTAAHGGTVTVHTAPGAGCRFEVRLPRADMTDDDADVDEPE-
MLBr_00774|M.leprae_Br4923 LGLAISIEDARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKP
TH_2452|M.thermoresistible__bu LGLSIVRAIAGAHGGHVDLDTVVGRGSTFTITIPAVLEAPWPAS------
***:* . * * : * *. * : :*
Mflv_1582|M.gilvum_PYR-GCK LREEQMPAPEHAGEESRGEQTDVPVSATAPTPP
Mvan_5174|M.vanbaalenii_PYR-1 ---------------DAGPDAEVPVSSAQLG--
MSMEG_5870|M.smegmatis_MC2_155 ---------------------------------
Mb0781|M.bovis_AF2122/97 ---------------------LTPVVPGPP---
Rv0758|M.tuberculosis_H37Rv ---------------------LTPVVPGPP---
MMAR_4941|M.marinum_M ---------------------TEPVS-------
MUL_0464|M.ulcerans_Agy99 ---------------------TEPVS-------
MAV_0703|M.avium_104 ---------------------AS----------
MAB_0674|M.abscessus_ATCC_1997 ---------SATPDAAASEPKIVRASRSESAQP
MLBr_00774|M.leprae_Br4923 ILQPSPQASTAGQQHGTQRQRLREHAERSR---
TH_2452|M.thermoresistible__bu ---------------------------------