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VTDRDITERLDPALRHLAGARTDLSPPVLGAVRDSLNQRRAETARSVDTVGVEIEQREVPVPAGHRVTVR IYRGGPPGSGVVLYCHSGAFVLGTLDTDHRQCIEMARRGRCTVLSVDYRLAPEHPYPAALDDAAAILDWG VGNAAELGIDAAAVALAGSSAGASLVAGLAQRSAAGGAPPVVFQLLHQPVLDDRPSPSKEEFTNTPGFDS QAVQWMWRHYGGGDPLPEDAVPARADELSELPATLITCSELDPLRDEAIDYALRLMWSGVNTELHVFSGT CHGFDSLVPDWEVSSQLFDIQGAALRRAFLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2244 | - | - | 100% (311) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0225 | - | 2e-36 | 39.60% (250) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2672 | - | 2e-32 | 40.00% (255) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1435c | lipI | 4e-39 | 38.31% (261) | lipase LipH |
| M. gilvum PYR-GCK | Mflv_4102 | - | 1e-151 | 82.74% (307) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1400c | lipI | 4e-39 | 38.31% (261) | lipase LipH |
| M. leprae Br4923 | MLBr_00314 | - | 9e-15 | 31.84% (223) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2655 | - | 2e-35 | 37.15% (253) | lipase/esterase (LipN) |
| M. marinum M | MMAR_0404 | lipW | 1e-100 | 57.10% (310) | esterase LipW |
| M. avium 104 | MAV_5118 | - | 1e-94 | 57.79% (308) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2568 | - | 1e-113 | 65.68% (303) | LipW protein |
| M. thermoresistible (build 8) | TH_2562 | - | 1e-104 | 61.59% (302) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_1054 | lipW | 7e-92 | 58.91% (275) | esterase LipW |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1435c|M.bovis_AF2122/97 ------------------------MPSLDNTADEKPAIDPILLKVLDAVP
Rv1400c|M.tuberculosis_H37Rv ------------------------MPSLDNTADEKPAIDPILLKVLDAVP
Mvan_2244|M.vanbaalenii_PYR-1 -----------------------MTD-RDITERLDPALRHLAGARTDLSP
Mflv_4102|M.gilvum_PYR-GCK -----------------------MT--RDIAERLDPQLRHLAAARTDLSP
MSMEG_2568|M.smegmatis_MC2_155 -----------------------MAHRSGWTERLDPALREFAGARTDLSP
TH_2562|M.thermoresistible__bu ------------------------VNPPEAGQRLAPELRHLWGTRTDLTA
MMAR_0404|M.marinum_M ------------------------MTQPEAVDRLDPLLRAVATARIDFTA
MUL_1054|M.ulcerans_Agy99 --------------------------------------------------
MAV_5118|M.avium_104 ------------------------MTALDGAERLDPALRAVATTRTDFSP
MAB_2655|M.abscessus_ATCC_1997 MTSITAEAPPRLTVSELIQRAAFTTLDRIPKVVLRQLIPPVVNADGDVMA
MLBr_00314|M.leprae_Br4923 -------------------MAISAGAPVEIVESGPSIAARLASLTSRLTI
Mb1435c|M.bovis_AF2122/97 FRLSIDD------------GIEAVRQRLRDLPRQPVHPELRVVDLAIDGP
Rv1400c|M.tuberculosis_H37Rv FRLSIDD------------GIEAVRQRLRDLPRQPVHPELRVVDLAIDGP
Mvan_2244|M.vanbaalenii_PYR-1 PVLGAVR------------DSLNQRRA-ETARSVDTVGVEIEQREVPVPA
Mflv_4102|M.gilvum_PYR-GCK PVLGAVR------------DSLNQRRA-ETARTADLIGVEVEQREVPVPA
MSMEG_2568|M.smegmatis_MC2_155 ETLAVVR------------ASIDRRRR-ESAQTLDTFGVAIAGGRAALGR
TH_2562|M.thermoresistible__bu DLLPTVR------------AVLDDRRR-ATAAAVDTGGVHIDDREIHCGT
MMAR_0404|M.marinum_M ESILTIR------------ESMNQRRREAAATETAAAGVAVADDVVTGEA
MUL_1054|M.ulcerans_Agy99 ---------------------MNQRRREAAATETAAAGVAVADDVATGEA
MAV_5118|M.avium_104 AAIELTR------------APFNERRR-LAAAQTDTAGVRIVDDDANG--
MAB_2655|M.abscessus_ATCC_1997 PEIALLMRFAAAAPDFSDCGVAEARAIIETDSRVFADTSETADADSGIVL
MLBr_00314|M.leprae_Br4923 RPILAVG-----------SYVPQLPWPFGLIDHAARVLLPVTNAARAEVN
Mb1435c|M.bovis_AF2122/97 AGPIGTRIYWPP-TCPDQAEAPVVLYFHGGGFVMGDLDTHDGTCRQHAVG
Rv1400c|M.tuberculosis_H37Rv AGPIGTRIYWPP-TCPDQAEAPVVLYFHGGGFVMGDLDTHDGTCRQHAVG
Mvan_2244|M.vanbaalenii_PYR-1 GHRVTVRIYRG-----GPPGSGVVLYCHSGAFVLGTLDTDHRQCIEMARR
Mflv_4102|M.gilvum_PYR-GCK GHTVTVRIYRG-----GPPQSPAVIYCHSGAFVLGNLDTDHRQCIEMARR
MSMEG_2568|M.smegmatis_MC2_155 -RSVPVRIYRG-----GPSPAPVVVYCHSGAFVLGNLDVDQRQCVELARR
TH_2562|M.thermoresistible__bu -GPIEIRIYRG-----RRGVAPAVLYCHAGAFVLGNLDTDHRQCVELARR
MMAR_0404|M.marinum_M GRPVPVRIYRA-----APTPAPVVVYCHAGGFALGNLDTDHRQCLELARR
MUL_1054|M.ulcerans_Agy99 GRPVPVRIYRA-----APTPAPVVVYCHAGGFALGNLDTDHRQCLERARR
MAV_5118|M.avium_104 ---VDVRIYRG-----GPEPAPAVIYCHAGGFALGNLDTDHRQCVELARR
MAB_2655|M.abscessus_ATCC_1997 PSGIRASLYRP-----KTQSNGLVLFLHGGGFVLGSRTAYDSPARLIAAH
MLBr_00314|M.leprae_Br4923 LSNTSAQLVRAAGVRPADGSGRIVLYLHGGAFLGCGANSHRRLVETLSKL
: *:: *.*.* :
Mb1435c|M.bovis_AF2122/97 ADAIVVSVDYRLAPEHPYPAAIEDAWAATRWVAEHGRQVGADLGRIAVAG
Rv1400c|M.tuberculosis_H37Rv ADAIVVSVDYRLAPEHPYPAAIEDAWAATRWVAEHGRQVGADLGRIAVAG
Mvan_2244|M.vanbaalenii_PYR-1 GRCTVLSVDYRLAPEHPYPAALDDAAAILDWGVGNAAELGIDAAAVALAG
Mflv_4102|M.gilvum_PYR-GCK GRCTVLSVDYRLAPEHPYPAAQDDVSAILDWAVRCSAELGIDATAVAVAG
MSMEG_2568|M.smegmatis_MC2_155 GQCTVVAMDYRLAPEHPYPAALDDAAMVLAWVAAQAGELDVDPDRIAVAG
TH_2562|M.thermoresistible__bu AECTVVSVDYRLAPEHPWPAAVDDATAVLSWLAGNATALDVDPARLAVAG
MMAR_0404|M.marinum_M ARCAVVSVDYRLAPEHPYPAALHDAIEVLTWVVGNATRLGFDARRLAVAG
MUL_1054|M.ulcerans_Agy99 ARCAVVSVDYRLAPEHPYPAALRDAIEVLTWVVGNATRLGFDARRLAVAG
MAV_5118|M.avium_104 GRCTVVSVDYRLAPEHPYPAALQDAGTVLRWVHAEAAALGVDPARLAVAG
MAB_2655|M.abscessus_ATCC_1997 AGVNVLSIEYRLAPEAPFPAALEDASEAWRFAVGHSSDWGIDPARIVLLG
MLBr_00314|M.leprae_Br4923 ADSPILVVNYRLLPKHSIGMALDDCHDGYQWLR----RLGYDPEQIVLAG
. :: ::*** *: . * * : . * :.: *
Mb1435c|M.bovis_AF2122/97 DSAGGTIAAVIAQRARDMGGPPIVFQLLWYPSTLWDQSLPSLAENADAPI
Rv1400c|M.tuberculosis_H37Rv DSAGGTIAAVIAQRARDMGGPPIVFQLLWYPSTLWDQSLPSLAENADAPI
Mvan_2244|M.vanbaalenii_PYR-1 SSAGASLVAGLAQRSAAGGAPPVVFQLLHQP-VLDDRPSPSKEEFTNTPG
Mflv_4102|M.gilvum_PYR-GCK SSAGAALAAGLARRSAAGDGPPVVFQMLHQP-VLDDRPSPSKDEFTTTPG
MSMEG_2568|M.smegmatis_MC2_155 SSAGGALAALLAQRSATGAAPPIVFQLLHQP-VLDDRPTRSKREFVDTPG
TH_2562|M.thermoresistible__bu SSAGGALAAGLAQRSGRNGLPQLVFQLLHQP-ALDDRVTPSKAEFCTTPG
MMAR_0404|M.marinum_M SSAGATLAAGLAHGAADGSLPPVIFQLLHQP-VLDDRPTASRSEFRATPA
MUL_1054|M.ulcerans_Agy99 SSAGATLAAGLAHGAADGSLPPVIFQLLHQP-VLDDRPTASRSEFRATPA
MAV_5118|M.avium_104 SSAGAALAACLAH--PDGSLPAVVFQLLHQP-VLDDRATGSKARFRTSPA
MAB_2655|M.abscessus_ATCC_1997 DSAGANLCAVLSNQLRDEEIR-PRMQVLMYPVVDAVGEYRSREEFADNPA
MLBr_00314|M.leprae_Br4923 DSAGGYLALALAQRLQDVGEEPAALVAISPLLQLAKKGKQAHPNAKTDAM
.***. : ::. : : : . .
Mb1435c|M.bovis_AF2122/97 LDVKAIAAFSRWYAGEIDL---HNPPAPMAPGRAENLADLPPAYIAVAGY
Rv1400c|M.tuberculosis_H37Rv LDVKAIAAFSRWYAGEIDL---HNPPAPMAPGRAENLADLPPAYIAVAGY
Mvan_2244|M.vanbaalenii_PYR-1 FDSQAVQWMWRHYGGGD------PLPEDAVPARADELSELPATLITCSEL
Mflv_4102|M.gilvum_PYR-GCK FDAEAVAWMWRHYGGDA------SLPDEAVPARIEEMSSLPAALITCSEL
MSMEG_2568|M.smegmatis_MC2_155 FDGPATVAMWRHWLAGR------AAPDGAVPARATEISDMPAAFISCSEL
TH_2562|M.thermoresistible__bu FDGPACDQMWRHYLAGA------APTAAAAPGRADDLTGAPPAFISCSEL
MMAR_0404|M.marinum_M FDGEAASLMWRHYLAGQ------TPSPESVPGRRGQLAGLPATLITCGEI
MUL_1054|M.ulcerans_Agy99 FDGEAASLMWRHYLAGQ------TPSPESVPGRRGQLAGLPATLITCGEI
MAV_5118|M.avium_104 FDGEAAELMWRYYLGPT------VGSAAAVPARRPELAGLPPALITCAEI
MAB_2655|M.abscessus_ATCC_1997 LSAKQIEWLSALYVPDAS----DRSDPRVSPMLADDLSGAPATLITVAGF
MLBr_00314|M.leprae_Br4923 FPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRTLIHVSGS
: : . * : * .
Mb1435c|M.bovis_AF2122/97 DPLRDDGIRYGELLAAAGVPVEVHNAQTLVHGYVGYAGVVPAATEATNRG
Rv1400c|M.tuberculosis_H37Rv DPLRDDGIRYGELLAAAGVPVEVHNAQTLVHGYVGYAGVVPAATEATNRG
Mvan_2244|M.vanbaalenii_PYR-1 DPLRDEAIDYALRLMWSGVNTELHVFSGTCHGFDSLVPDWEVSSQLFDIQ
Mflv_4102|M.gilvum_PYR-GCK DPLRDEALDYALRLLWAGVAAELHVFSGTCHGFDSLVPEWEISRQLFDIQ
MSMEG_2568|M.smegmatis_MC2_155 DPLRDEALDHARRLIDGGVSTELHVFAGTCHGFDSLLPEWEVSQELFTLQ
TH_2562|M.thermoresistible__bu DPLRDEALDYAARLLRCGVPTELHLFPGTCHGFDSLLPEWELSRQLFALQ
MMAR_0404|M.marinum_M DPFRDEVLDYAQRLLGAGVSTELHIFPRACHGFDSLLPEWTTSQRLFAMQ
MUL_1054|M.ulcerans_Agy99 DPFRDEVLDYAQRLLGAGVSTELHIFPRACHGFDSLLPEWTTSQRLFAMQ
MAV_5118|M.avium_104 DPFRDEAIDYARRLLDAGVCTELHVFARACHGFDSLLPDWPGSQRLFALQ
MAB_2655|M.abscessus_ATCC_1997 DPLRDEAIAYAKRLKDSGVSTRLLREGSLVHGYISMTQISQAARNAVQRV
MLBr_00314|M.leprae_Br4923 EVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEATLSLRQI
: : .: . * ** ..: * : . :
Mb1435c|M.bovis_AF2122/97 LVALRVVLHG---------
Rv1400c|M.tuberculosis_H37Rv LVALRVVLHG---------
Mvan_2244|M.vanbaalenii_PYR-1 GAALRRAFLG---------
Mflv_4102|M.gilvum_PYR-GCK GTALRRAFLR---------
MSMEG_2568|M.smegmatis_MC2_155 GAALRRALR----------
TH_2562|M.thermoresistible__bu AAAVRRAFTTAEYPAGQVN
MMAR_0404|M.marinum_M GHALADAFYPD--------
MUL_1054|M.ulcerans_Agy99 GHALADAFYPD--------
MAV_5118|M.avium_104 GEVLSAALHRGSTH-----
MAB_2655|M.abscessus_ATCC_1997 AAAINHAVR----------
MLBr_00314|M.leprae_Br4923 SQYIREATASKASRDRQSL
: .