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PLPHTHTERVPDIEFHPELRRSARLLPKQVITPLTLPFIRAASRLMWRRNDSPADVEVLTLSSGVGVRLF RPSGVAPGRGPALLWIHGGGYVIGDAAQDDVLCRRFARELGATVASVNYRLAPEYPYPVPVEDCYSALHW LTQLPSVDPARVAIGGASAGGGLAAALALLTRDRGEIELAAQLLVYPMIDDRTVHRKGLDHPGHRLWNQS SNRFGWRAYLGDADPNEAVPARRDDLAGLPPAWIGVGTLDLFHDEDLAYAERLRVAGVQCEVMVVDGAFH GFDGIAPKADVSQSFFNSQCALLRTVFASAAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0225 | - | - | 100% (313) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2244 | - | 2e-36 | 39.60% (250) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2672 | - | 9e-35 | 37.26% (263) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0223c | lipW | 1e-106 | 66.22% (296) | esterase LipW |
| M. gilvum PYR-GCK | Mflv_0442 | - | 1e-143 | 81.94% (299) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv0217c | lipW | 1e-105 | 65.88% (296) | esterase LipW |
| M. leprae Br4923 | MLBr_00314 | - | 2e-19 | 30.10% (289) | putative esterase |
| M. abscessus ATCC 19977 | MAB_0826c | - | 6e-91 | 57.43% (296) | esterase LipW |
| M. marinum M | MMAR_2621 | - | 3e-80 | 53.61% (291) | esterase/lipase |
| M. avium 104 | MAV_4954 | - | 1e-111 | 65.46% (304) | alpha/beta hydrolase fold |
| M. smegmatis MC2 155 | MSMEG_0280 | - | 1e-116 | 69.31% (290) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_2573 | - | 1e-127 | 73.97% (292) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_3141 | - | 3e-50 | 48.39% (217) | esterase/lipase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0223c|M.bovis_AF2122/97 ----------------------MSGNEVHPDLRRIAVVTPRQLVGPRTLP
Rv0217c|M.tuberculosis_H37Rv ----------------------MSGNEVHPDLRRIAVVTPRQLVGPRTLP
MAV_4954|M.avium_104 --------------MAVGDTDPVPNNDVHPDLQRFARFAPRRLVGPRTLP
Mvan_0225|M.vanbaalenii_PYR-1 ------------MPLPHTHTERVPDIEFHPELRRSARLLPKQVITPLTLP
Mflv_0442|M.gilvum_PYR-GCK ----------------------MHGVDFHPELRRAARMLPRQVVTPVTLP
TH_2573|M.thermoresistible__bu ----------------VARSSKLP-LDFHPDLRRLARFIPRQAVSPVTLP
MSMEG_0280|M.smegmatis_MC2_155 -------------------MTATTPTRFHPDLERVARYIPRHMVNRATLP
MAB_0826c|M.abscessus_ATCC_199 ----------------------MSSPDIHPDLRLAARAFPRQVGLPRTLS
MMAR_2621|M.marinum_M -----------MQARSDGPPAFTKPDAIDPALRAISRILPRGYGLHRGLK
MUL_3141|M.ulcerans_Agy99 MRTPRCAIVWCMQARPDGPPAFTKPDAIDPALRAISRILPRGYGLHRGLK
MLBr_00314|M.leprae_Br4923 --------------MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILA
* : . *
Mb0223c|M.bovis_AF2122/97 VMRALIVVAGLRMSRTPPDIEVLTLE---------SGVGVRLYRPAGSNE
Rv0217c|M.tuberculosis_H37Rv VMRALIVVAGLRMSRTPPDIEVLTLE---------SGVGVRLYRPAGSNE
MAV_4954|M.avium_104 LMRVALAWRG-RLGKPVRDVEVITLG---------SGVGVRLFRPAGAAE
Mvan_0225|M.vanbaalenii_PYR-1 FIRAASRLMWRRNDSPA-DVEVLTLS---------SGVGVRLFRPSGVAP
Mflv_0442|M.gilvum_PYR-GCK LLRRASRLMWRRAPAP--DVEVLTLE---------SGVGVRLFRPAGATR
TH_2573|M.thermoresistible__bu LMRLATRPMTRR--APR-DIEVLTLS---------SGIGIRLFRPPGGGT
MSMEG_0280|M.smegmatis_MC2_155 VFQRLTRLMGRR--VPP-GCEVLTLP---------SGVGIRLFRPPASTT
MAB_0826c|M.abscessus_ATCC_199 ILRASIYLTDLL---PRHGVRRIAVN---------DNVTVRAHVPKNLEE
MMAR_2621|M.marinum_M LPRALMKLAGITG--RLRDVPVVAVN---------DAVSVRLHRPTGLPD
MUL_3141|M.ulcerans_Agy99 LPRALMKLAGITG--RLRDVPVVAVN---------DAVSVRSHRPAGLPD
MLBr_00314|M.leprae_Br4923 VGSYVPQLPWPFGLIDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRP
. :.: . : .
Mb0223c|M.bovis_AF2122/97 ---PAPALLWIHAGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPEN
Rv0217c|M.tuberculosis_H37Rv ---PAPALLWIHAGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPEN
MAV_4954|M.avium_104 ---TTPALLWIHGGGYVLGTAQQDDQLCSRFSRRLGITVASVDYRLAPEH
Mvan_0225|M.vanbaalenii_PYR-1 G--RGPALLWIHGGGYVIGDAAQDDVLCRRFARELGATVASVNYRLAPEY
Mflv_0442|M.gilvum_PYR-GCK ---PGPALLWIHGGGYILGDAAQDDVLCRRFAHELGATVASVDYRLAPEF
TH_2573|M.thermoresistible__bu ----GAAMLWIHGGGYVIGCAAQDDALCRRYARELDVTVAAVDYRLAPEN
MSMEG_0280|M.smegmatis_MC2_155 L--PGPALVWIHGGGYVLGSAAQDDAQCLQFARQAGVTVASVEYRLAPQN
MAB_0826c|M.abscessus_ATCC_199 ---PSAALLWIHGGGYVMGTARQDDFFCRKVMHETGIPVVSVDYRLAPEH
MMAR_2621|M.marinum_M ---PGPALLWIHGGGTVMGSAAQEDQYCRKLSHLAGVAVAAVDYRLAPEH
MUL_3141|M.ulcerans_Agy99 ---PGPALLWIHGGGTVMGSAAQEDQYCRKLSHLAGVAVAAVDYRLAPEH
MLBr_00314|M.leprae_Br4923 ADGSGRIVLYLHGGAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKH
::::*.*. : * .. . .: *:*** *:
Mb0223c|M.bovis_AF2122/97 PYPAALGDCYSALTWLASLPAVDPARVAIGGASAGGGLAAALALLARDRG
Rv0217c|M.tuberculosis_H37Rv PYPAALGDCYSALTWLASLPAVDPARVAIGGASAGGGLAAALALLARDRG
MAV_4954|M.avium_104 RYPVPLEDCYTALTWLAGLPSVDRYRIAIGGASAGGGLAAALALLARDRA
Mvan_0225|M.vanbaalenii_PYR-1 PYPVPVEDCYSALHWLTQLPSVDPARVAIGGASAGGGLAAALALLTRDRG
Mflv_0442|M.gilvum_PYR-GCK PYPAPVEDCYSALKWLSALPAVDPSRVAIGGASAGGGIAAALAFLARDRG
TH_2573|M.thermoresistible__bu PYPIPLEDCYAALLWLTRLPTVDPQRVVIAGGSAGGGLAAALALLARDRG
MSMEG_0280|M.smegmatis_MC2_155 PYPAGLEDCFAALRWLTALPSVDPARVAIGGASAGGGLAASLALLARDRG
MAB_0826c|M.abscessus_ATCC_199 PYPIPLEDCYAALRWLSVQGWIDPTRIAVGGASAGGGLAAALALLARDRG
MMAR_2621|M.marinum_M PYPTPVEDCYAALLWLRQQQWVDPSRIAVAGASAGGLFAATLVQLACDRG
MUL_3141|M.ulcerans_Agy99 PYPTPVEDCYAALLWLRQQQWVDPSRIAVAGASAGDLFAATLVQLACDRG
MLBr_00314|M.leprae_Br4923 SIGMALDDCHDGYQWLRRLG-YDPEQIVLAGDSAGGYLALALAQRLQDVG
: **. . ** * ::.:.* ***. :* :*. * .
Mb0223c|M.bovis_AF2122/97 GITPAFQLLVYPMLDDRTSIAP--ANPHYRLWNGRANRFGWRAYLG----
Rv0217c|M.tuberculosis_H37Rv GITPAFQLLVYPMLDDRPSIAP--ANPHYRLWNGRANRFGWRAYLG----
MAV_4954|M.avium_104 EVSPAFQLLTYPMLDDRSSDTA--PSPNYRLWDNRSNRFGWAAYLG----
Mvan_0225|M.vanbaalenii_PYR-1 EIELAAQLLVYPMIDDRTVHRKGLDHPGHRLWNQSSNRFGWRAYLG----
Mflv_0442|M.gilvum_PYR-GCK EIPLAAQLLVYPMIDDRTVLRTGLDNPGHRLWNQAANRFGWQAYLG----
TH_2573|M.thermoresistible__bu EVAPVAQLLVYPMLDDRTLHRTDLDHPGLRLWNQSSNRFGWSAYLG----
MSMEG_0280|M.smegmatis_MC2_155 -IDVAAQLLVYPMLDDRSSFVPSLDHPGQRLWNQGSNRFGWKAYLG----
MAB_0826c|M.abscessus_ATCC_199 EVAPAAQLLIYPMLDDRSSERTDIDGTNLRLWSGDSNRFGWDSYLG----
MMAR_2621|M.marinum_M DVEPVLQMLVYPMLDDRTGSGP--NGHKRIMWSERDNQQAWQLYLA----
MUL_3141|M.ulcerans_Agy99 DVEPVLQMLVYPMLDDRTGSGP--NGHKRIMWSERDNQQAWQLYLA----
MLBr_00314|M.leprae_Br4923 EEPAALVAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAK
. : : : :: .
Mb0223c|M.bovis_AF2122/97 ---DADARVAVPGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGV
Rv0217c|M.tuberculosis_H37Rv ---DADARVAVPGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGV
MAV_4954|M.avium_104 ---DADPHVAVPARRDDLSGLPPAWIGVGTHDLFHDEDLAYAERLRAAGV
Mvan_0225|M.vanbaalenii_PYR-1 ---DADPNEAVPARRDDLAGLPPAWIGVGTLDLFHDEDLAYAERLRVAGV
Mflv_0442|M.gilvum_PYR-GCK ---DADRDVAVPARRDDLAGLPPAWIGVGTLDLFHDEDLAYAERLRAAGV
TH_2573|M.thermoresistible__bu ---DADPEVAVPARQTDLAGLPPAWIGVGTYDLFHDEDLAYAERLRAAGV
MSMEG_0280|M.smegmatis_MC2_155 ---DADPDVAVPARREDLSGLPPAWVGVGTLDLFHDEDLAYAGRLHAAGV
MAB_0826c|M.abscessus_ATCC_199 ---DADRDIAVPGRRTDVAGLAPAWIGIGTADLFHDEDLAYAERLRTAGV
MMAR_2621|M.marinum_M ---GADPSTAAPARRADLSNLPPAWIGVGTLDLFHQECLDYAARLRDAGV
MUL_3141|M.ulcerans_Agy99 ---GADPSTAAPA-------------------------------------
MLBr_00314|M.leprae_Br4923 NKVDDKPEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGV
. .
Mb0223c|M.bovis_AF2122/97 PCQVEVVEGAFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT-----
Rv0217c|M.tuberculosis_H37Rv PCQVEVVEGAFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT-----
MAV_4954|M.avium_104 PCQVETIPGAFHGFDLILPKVQVSQRFFDSQCNSLRAALTPAG-------
Mvan_0225|M.vanbaalenii_PYR-1 QCEVMVVDGAFHGFDGIAPKADVSQSFFNSQCALLRTVFASAAP------
Mflv_0442|M.gilvum_PYR-GCK PCEVEVVKGAFHGFDGIAPKAEVSQSFFRSQCALLRGAFEPAAA------
TH_2573|M.thermoresistible__bu PCEVEVVPGAFHGFDAIAPRAGVSRQFFDSQCAMLRGLLRPEAA------
MSMEG_0280|M.smegmatis_MC2_155 PCEIDVVHGAFHGFDGVAPKAAVSRAFRNAQCAFLKRALT----------
MAB_0826c|M.abscessus_ATCC_199 PCELEVVPGAFHGFDKLVPWAGVSRDFVAKACRSLLGALS----------
MMAR_2621|M.marinum_M EVHEQIADGAFHAFDLLAPNAQVSLGFFASQCQFLRTHLHATVSDQPQAP
MUL_3141|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 PAEIRVWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL