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TALDGAERLDPALRAVATTRTDFSPAAIELTRAPFNERRRLAAAQTDTAGVRIVDDDANGVDVRIYRGGP EPAPAVIYCHAGGFALGNLDTDHRQCVELARRGRCTVVSVDYRLAPEHPYPAALQDAGTVLRWVHAEAAA LGVDPARLAVAGSSAGAALAACLAHPDGSLPAVVFQLLHQPVLDDRATGSKARFRTSPAFDGEAAELMWR YYLGPTVGSAAAVPARRPELAGLPPALITCAEIDPFRDEAIDYARRLLDAGVCTELHVFARACHGFDSLL PDWPGSQRLFALQGEVLSAALHRGSTH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5118 | - | - | 100% (308) | alpha/beta hydrolase domain-containing protein |
| M. avium 104 | MAV_1617 | - | 1e-67 | 47.19% (303) | alpha/beta hydrolase domain-containing protein |
| M. avium 104 | MAV_4954 | - | 2e-43 | 40.64% (283) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0223c | lipW | 6e-46 | 45.82% (251) | esterase LipW |
| M. gilvum PYR-GCK | Mflv_4102 | - | 9e-95 | 57.98% (307) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv0217c | lipW | 8e-46 | 45.82% (251) | esterase LipW |
| M. leprae Br4923 | MLBr_00314 | - | 1e-12 | 30.97% (226) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2814 | - | 3e-38 | 36.04% (308) | lipase LipH |
| M. marinum M | MMAR_0404 | lipW | 1e-112 | 66.56% (311) | esterase LipW |
| M. smegmatis MC2 155 | MSMEG_2568 | - | 1e-101 | 61.46% (301) | LipW protein |
| M. thermoresistible (build 8) | TH_2562 | - | 2e-97 | 59.22% (309) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_1054 | lipW | 1e-104 | 69.09% (275) | esterase LipW |
| M. vanbaalenii PYR-1 | Mvan_2244 | - | 2e-94 | 57.79% (308) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0223c|M.bovis_AF2122/97 --------MSGNEVHPDLRRIAVVTPRQLVGPRTLPVMRALIVVAGLRMS
Rv0217c|M.tuberculosis_H37Rv --------MSGNEVHPDLRRIAVVTPRQLVGPRTLPVMRALIVVAGLRMS
MMAR_0404|M.marinum_M ----MTQPEAVDRLDPLLR--AVATARIDFTAESILTIRESMNQRRREAA
MUL_1054|M.ulcerans_Agy99 -----------------------------------------MNQRRREAA
MAV_5118|M.avium_104 ----MTALDGAERLDPALR--AVATTRTDFSPAAIELTRAPFNERRR-LA
Mflv_4102|M.gilvum_PYR-GCK ---MT--RDIAERLDPQLR--HLAAARTDLSPPVLGAVRDSLNQRRA-ET
Mvan_2244|M.vanbaalenii_PYR-1 ---MTD-RDITERLDPALR--HLAGARTDLSPPVLGAVRDSLNQRRA-ET
MSMEG_2568|M.smegmatis_MC2_155 ---MAHRSGWTERLDPALR--EFAGARTDLSPETLAVVRASIDRRRR-ES
TH_2562|M.thermoresistible__bu ----VNPPEAGQRLAPELR--HLWGTRTDLTADLLPTVRAVLDDRRR-AT
MAB_2814|M.abscessus_ATCC_1997 -------MTATAGIDPIIVKILEAVPIQLVSPDGPQASRDAY---RAIAT
MLBr_00314|M.leprae_Br4923 MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILAVGSYVPQLPWPFGL
Mb0223c|M.bovis_AF2122/97 RTPPDIEVLTLESG---------VGVRLYRPA---GSNEPAPALLWIHAG
Rv0217c|M.tuberculosis_H37Rv RTPPDIEVLTLESG---------VGVRLYRPA---GSNEPAPALLWIHAG
MMAR_0404|M.marinum_M ATETAAAGVAVADDVVTGEAGRPVPVRIYR-----AAPTPAPVVVYCHAG
MUL_1054|M.ulcerans_Agy99 ATETAAAGVAVADDVATGEAGRPVPVRIYR-----AAPTPAPVVVYCHAG
MAV_5118|M.avium_104 AAQTDTAGVRIVDDDANG-----VDVRIYR-----GGPEPAPAVIYCHAG
Mflv_4102|M.gilvum_PYR-GCK ARTADLIGVEVEQREVPVPAGHTVTVRIYR-----GGPPQSPAVIYCHSG
Mvan_2244|M.vanbaalenii_PYR-1 ARSVDTVGVEIEQREVPVPAGHRVTVRIYR-----GGPPGSGVVLYCHSG
MSMEG_2568|M.smegmatis_MC2_155 AQTLDTFGVAIAGGRAALGR-RSVPVRIYR-----GGPSPAPVVVYCHSG
TH_2562|M.thermoresistible__bu AAAVDTGGVHIDDREIHCGT-GPIEIRIYR-----GRRGVAPAVLYCHAG
MAB_2814|M.abscessus_ATCC_1997 ARPPWIEVANIEDRTIPGPAG-EIPVRIYSP----AEGGVRPVFVLIHGG
MLBr_00314|M.leprae_Br4923 IDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGG
: :: .: *.*
Mb0223c|M.bovis_AF2122/97 GYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPENPYPAALGDCYSALT
Rv0217c|M.tuberculosis_H37Rv GYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPENPYPAALGDCYSALT
MMAR_0404|M.marinum_M GFALGNLDTDHRQCLELARRARCAVVSVDYRLAPEHPYPAALHDAIEVLT
MUL_1054|M.ulcerans_Agy99 GFALGNLDTDHRQCLERARRARCAVVSVDYRLAPEHPYPAALRDAIEVLT
MAV_5118|M.avium_104 GFALGNLDTDHRQCVELARRGRCTVVSVDYRLAPEHPYPAALQDAGTVLR
Mflv_4102|M.gilvum_PYR-GCK AFVLGNLDTDHRQCIEMARRGRCTVLSVDYRLAPEHPYPAAQDDVSAILD
Mvan_2244|M.vanbaalenii_PYR-1 AFVLGTLDTDHRQCIEMARRGRCTVLSVDYRLAPEHPYPAALDDAAAILD
MSMEG_2568|M.smegmatis_MC2_155 AFVLGNLDVDQRQCVELARRGQCTVVAMDYRLAPEHPYPAALDDAAMVLA
TH_2562|M.thermoresistible__bu AFVLGNLDTDHRQCVELARRAECTVVSVDYRLAPEHPWPAAVDDATAVLS
MAB_2814|M.abscessus_ATCC_1997 GWVIGDLDTHDAVARAAAVQADAVVVSVDYRLAPEHPYPAAVEDCWAALQ
MLBr_00314|M.leprae_Br4923 AFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQ
.: : . : : ::*** *::. * *
Mb0223c|M.bovis_AF2122/97 WLASLP---AVDPARVAIGGASAGGGLAAALALLARDRGG-ITPAFQLLV
Rv0217c|M.tuberculosis_H37Rv WLASLP---AVDPARVAIGGASAGGGLAAALALLARDRGG-ITPAFQLLV
MMAR_0404|M.marinum_M WVVGNATRLGFDARRLAVAGSSAGATLAAGLAHGAADGSL-PPVIFQLLH
MUL_1054|M.ulcerans_Agy99 WVVGNATRLGFDARRLAVAGSSAGATLAAGLAHGAADGSL-PPVIFQLLH
MAV_5118|M.avium_104 WVHAEAAALGVDPARLAVAGSSAGAALAACLAH--PDGSL-PAVVFQLLH
Mflv_4102|M.gilvum_PYR-GCK WAVRCSAELGIDATAVAVAGSSAGAALAAGLARRSAAGDG-PPVVFQMLH
Mvan_2244|M.vanbaalenii_PYR-1 WGVGNAAELGIDAAAVALAGSSAGASLVAGLAQRSAAGGA-PPVVFQLLH
MSMEG_2568|M.smegmatis_MC2_155 WVAAQAGELDVDPDRIAVAGSSAGGALAALLAQRSATGAA-PPIVFQLLH
TH_2562|M.thermoresistible__bu WLAGNATALDVDPARLAVAGSSAGGALAAGLAQRSGRNGL-PQLVFQLLH
MAB_2814|M.abscessus_ATCC_1997 WVHEHAAEIGGDPGRLAVGGDSAGGNLSAVMAQLARDNGI-DLAFQVLWY
MLBr_00314|M.leprae_Br4923 WLRRLG----YDPEQIVLAGDSAGGYLALALAQRLQDVGEEPAALVAISP
* *. :.:.* ***. * :* :
Mb0223c|M.bovis_AF2122/97 YPMLDDRTSIAPANPHYR-LWNGRANRFGWRAYLG-DADARVA---VPGR
Rv0217c|M.tuberculosis_H37Rv YPMLDDRPSIAPANPHYR-LWNGRANRFGWRAYLG-DADARVA---VPGR
MMAR_0404|M.marinum_M QPVLDDRPTASRSEFRATPAFDGEAASLMWRHYLAGQTPSPES---VPGR
MUL_1054|M.ulcerans_Agy99 QPVLDDRPTASRSEFRATPAFDGEAASLMWRHYLAGQTPSPES---VPGR
MAV_5118|M.avium_104 QPVLDDRATGSKARFRTSPAFDGEAAELMWRYYLGPTVGSAAA---VPAR
Mflv_4102|M.gilvum_PYR-GCK QPVLDDRPSPSKDEFTTTPGFDAEAVAWMWRHYGGDASLPDEA---VPAR
Mvan_2244|M.vanbaalenii_PYR-1 QPVLDDRPSPSKEEFTNTPGFDSQAVQWMWRHYGGGDPLPEDA---VPAR
MSMEG_2568|M.smegmatis_MC2_155 QPVLDDRPTRSKREFVDTPGFDGPATVAMWRHWLAGRAAPDGA---VPAR
TH_2562|M.thermoresistible__bu QPALDDRVTPSKAEFCTTPGFDGPACDQMWRHYLAGAAPTAAA---APGR
MAB_2814|M.abscessus_ATCC_1997 PATTFDTTLPSMVENAEAPVLDFKTVGALSKWYLGDTNPATAGPTLVPAR
MLBr_00314|M.leprae_Br4923 LLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDD--KPEE
. : . : : . * .
Mb0223c|M.bovis_AF2122/97 RDD-----LGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQVEVVEG
Rv0217c|M.tuberculosis_H37Rv RDD-----LGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQVEVVEG
MMAR_0404|M.marinum_M RGQ-----LAGLPATLITCGEIDPFRDEVLDYAQRLLGAGVSTELHIFPR
MUL_1054|M.ulcerans_Agy99 RGQ-----LAGLPATLITCGEIDPFRDEVLDYAQRLLGAGVSTELHIFPR
MAV_5118|M.avium_104 RPE-----LAGLPPALITCAEIDPFRDEAIDYARRLLDAGVCTELHVFAR
Mflv_4102|M.gilvum_PYR-GCK IEE-----MSSLPAALITCSELDPLRDEALDYALRLLWAGVAAELHVFSG
Mvan_2244|M.vanbaalenii_PYR-1 ADE-----LSELPATLITCSELDPLRDEAIDYALRLMWSGVNTELHVFSG
MSMEG_2568|M.smegmatis_MC2_155 ATE-----ISDMPAAFISCSELDPLRDEALDHARRLIDGGVSTELHVFAG
TH_2562|M.thermoresistible__bu ADD-----LTGAPPAFISCSELDPLRDEALDYAARLLRCGVPTELHLFPG
MAB_2814|M.abscessus_ATCC_1997 AEN-----FEGLAPAFIGTAQFDPLRDDGAKYAELLRDAGVPVQLHNAPT
MLBr_00314|M.leprae_Br4923 LYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPG
: . : * . : : .: * * ** ::.
Mb0223c|M.bovis_AF2122/97 AFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT-----
Rv0217c|M.tuberculosis_H37Rv AFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT-----
MMAR_0404|M.marinum_M ACHGFDSLLPEWTTSQRLFAMQGHALADAFYPD--------
MUL_1054|M.ulcerans_Agy99 ACHGFDSLLPEWTTSQRLFAMQGHALADAFYPD--------
MAV_5118|M.avium_104 ACHGFDSLLPDWPGSQRLFALQGEVLSAALHRGSTH-----
Mflv_4102|M.gilvum_PYR-GCK TCHGFDSLVPEWEISRQLFDIQGTALRRAFLR---------
Mvan_2244|M.vanbaalenii_PYR-1 TCHGFDSLVPDWEVSSQLFDIQGAALRRAFLG---------
MSMEG_2568|M.smegmatis_MC2_155 TCHGFDSLLPEWEVSQELFTLQGAALRRALR----------
TH_2562|M.thermoresistible__bu TCHGFDSLLPEWELSRQLFALQAAAVRRAFTTAEYPAGQVN
MAB_2814|M.abscessus_ATCC_1997 LIHGYLGYADIVPSATEERDLSLAALKQALHG---------
MLBr_00314|M.leprae_Br4923 QVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL
* : : : *