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MTSITAEAPPRLTVSELIQRAAFTTLDRIPKVVLRQLIPPVVNADGDVMAPEIALLMRFAAAAPDFSDCG VAEARAIIETDSRVFADTSETADADSGIVLPSGIRASLYRPKTQSNGLVLFLHGGGFVLGSRTAYDSPAR LIAAHAGVNVLSIEYRLAPEAPFPAALEDASEAWRFAVGHSSDWGIDPARIVLLGDSAGANLCAVLSNQL RDEEIRPRMQVLMYPVVDAVGEYRSREEFADNPALSAKQIEWLSALYVPDASDRSDPRVSPMLADDLSGA PATLITVAGFDPLRDEAIAYAKRLKDSGVSTRLLREGSLVHGYISMTQISQAARNAVQRVAAAINHAVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2655 | - | - | 100% (349) | lipase/esterase (LipN) |
| M. abscessus ATCC 19977 | MAB_3270c | - | 5e-51 | 37.01% (335) | lipase/esterase LipN |
| M. abscessus ATCC 19977 | MAB_2039 | - | 4e-38 | 41.89% (222) | lipase LipH (carboxylesterase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2994c | lipN | 1e-45 | 37.42% (318) | lipase/esterase LipN |
| M. gilvum PYR-GCK | Mflv_4203 | - | 2e-46 | 35.26% (329) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv2970c | lipN | 1e-45 | 37.42% (318) | lipase/esterase LipN |
| M. leprae Br4923 | MLBr_00314 | - | 9e-17 | 26.92% (286) | putative esterase |
| M. marinum M | MMAR_1746 | lipN | 1e-43 | 35.92% (309) | lipase/esterase LipN |
| M. avium 104 | MAV_3814 | - | 8e-46 | 36.94% (333) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2409 | - | 3e-50 | 39.65% (285) | alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_1220 | lipN | 3e-45 | 47.21% (197) | PROBABLE LIPASE/ESTERASE LIPN |
| M. ulcerans Agy99 | MUL_1989 | lipN | 9e-44 | 35.92% (309) | lipase/esterase LipN |
| M. vanbaalenii PYR-1 | Mvan_2162 | - | 2e-48 | 43.21% (243) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2409|M.smegmatis_MC2_155 ---------------------------MLLAHATRLGLAAIPRMSDRRKH
TH_1220|M.thermoresistible__bu --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK MPASRATESHNNWTTPKGSPHAGGAVEKLTNTLAGVTLRALPRIPDPVKR
Mvan_2162|M.vanbaalenii_PYR-1 MTETVAAGES---VQPPVRRKVG-VSDVVANKVAGVTLRGMPRIPHPVKR
Mb2994c|M.bovis_AF2122/97 ---MTKSLPGVADLRLGANHPRM-WTRRVQGTVVNVGVKVLPWIPTPAKR
Rv2970c|M.tuberculosis_H37Rv ---MTKSLPGVADLRLGANHPRM-WTRRVQGTVVNVGVKVLPWIPTPAKR
MMAR_1746|M.marinum_M ---MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKR
MUL_1989|M.ulcerans_Agy99 ---MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKR
MAV_3814|M.avium_104 ---MTKPLTDTAPVDPGVQRGSMPLTNRIQGAVTSVGVKVIPWIPTAVRR
MAB_2655|M.abscessus_ATCC_1997 ---------------MTSITAEAPPRLTVSELIQRAAFTTLDRIPKVVLR
MLBr_00314|M.leprae_Br4923 -----------------------------MAISAGAPVEIVESGPSIAAR
MSMEG_2409|M.smegmatis_MC2_155 LLLGGRSVTVDGNTLDTTMQFMLTTQRLAGLPGLVADYDPEHGVAVSRAK
TH_1220|M.thermoresistible__bu --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK LLLGRRTITLDGNTLDTTLHLMLAGQRLMGIEGLVADDD----VTVARAQ
Mvan_2162|M.vanbaalenii_PYR-1 VLLGGRSITIDGNTLDTTLHLMLAGQQLLGLDGLVADDD----FVAARTQ
Mb2994c|M.bovis_AF2122/97 ILSAGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDD----IVASRAH
Rv2970c|M.tuberculosis_H37Rv ILSAGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDD----IVASRAH
MMAR_1746|M.marinum_M LITRGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDD----LAASRAH
MUL_1989|M.ulcerans_Agy99 LITRGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDD----LAASRAH
MAV_3814|M.avium_104 GLVRGRSVIIDGNTLDPTLQLMLSGLRAVGIDGLVVDDD----PELSRAQ
MAB_2655|M.abscessus_ATCC_1997 QLIP-PVVNADGDVMAPEIALLMR---FAAAAPDFSDCG----VAEARAI
MLBr_00314|M.leprae_Br4923 LASLTSRLTIR---------------PILAVGSYVPQLP------WPFGL
MSMEG_2409|M.smegmatis_MC2_155 LRETAAMMRMPIHVD-VSDISIPGPAGPLAARRYVPVERGSASALVLYFH
TH_1220|M.thermoresistible__bu --------------------------------------------------
Mflv_4203|M.gilvum_PYR-GCK LEVLAAAFKQHIPVAAVTNLTVPGAQGPLDARHYRTDEPD--AALLVFFH
Mvan_2162|M.vanbaalenii_PYR-1 LELLAASFKQRIPIAGVTDLTVSGAEGPVKARHYRTDEPG--APLLVFYH
Mb2994c|M.bovis_AF2122/97 MRAICEAMPGPQIHVDVTDLSIPGPAGEIPARHYRPSG-GGATPLLVFYH
Rv2970c|M.tuberculosis_H37Rv MRAICEAMPGPQIHVDVTDLSIPGPAGEIPARHYRPSG-GGATPLLVFYH
MMAR_1746|M.marinum_M MREAMLGFPGPQIHVDVEELTLPGPAGDISARHYRPPG-DAAAPLLVFYH
MUL_1989|M.ulcerans_Agy99 MREAMLGFPGPQIHVDVEELTLPGPAGDISARHYRPPG-DAAAPLLVFYH
MAV_3814|M.avium_104 MHESTVGFPGPQIHVDVAELALPGPAGDIPARHYRPAGGETQAPLLVFYH
MAB_2655|M.abscessus_ATCC_1997 IETDSRVFADTSETADADSGIVLPSG--IRASLYRPKTQS--NGLVLFLH
MLBr_00314|M.leprae_Br4923 IDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGS--GRIVLYLH
MSMEG_2409|M.smegmatis_MC2_155 GGGFVIGDLEVHDNLCRLICRDGDVQVVSVDYRLAPEHKAPAAAEDAYAA
TH_1220|M.thermoresistible__bu --------------------------VLSVDYRLAPEHKAPAAVEDAYAA
Mflv_4203|M.gilvum_PYR-GCK GGGHVIGSLDSHDDLCREICRAGRIHVLSVDYRLAPEHKAPAGAQDAYSA
Mvan_2162|M.vanbaalenii_PYR-1 GGGHVIGSIDSHDDLCREICRSGGVHVLSVDYRLAPEHPAPAAVEDSYAA
Mb2994c|M.bovis_AF2122/97 GGGWTLGDLDTHDALCRLTCRDADIQVLSIDYRLAPEHPAPAAVEDAYAA
Rv2970c|M.tuberculosis_H37Rv GGGWTLGDLDTHDALCRLTCRDADIQVLSIDYRLAPEHPAPAAVEDAYAA
MMAR_1746|M.marinum_M GGGWALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEDRAPAAIDDAFAA
MUL_1989|M.ulcerans_Agy99 GGGWALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEHRAPAAIDDAFAA
MAV_3814|M.avium_104 GGGWSIGDLDTHDSLCRLTCRDAGIHVLSIDYRLAPEHPAPAAIDDAYAA
MAB_2655|M.abscessus_ATCC_1997 GGGFVLGSRTAYDSPARLIAAHAGVNVLSIEYRLAPEAPFPAALEDASEA
MLBr_00314|M.leprae_Br4923 GGAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDG
:: ::*** *: . :*. .
MSMEG_2409|M.smegmatis_MC2_155 YQWALEHAG-GLGAS--RIVVAGDSAGGNLAAVVSQWARD----DELPLP
TH_1220|M.thermoresistible__bu YRWVLDHPG-DVGADPARIAVGGDSAGGNLAAVVAQRCRD----EGAPAP
Mflv_4203|M.gilvum_PYR-GCK YLWAREHAA-ELGADPERVAVGGDSAGGNLSAVLTQRARD----EGAPLP
Mvan_2162|M.vanbaalenii_PYR-1 YLWACEHAA-ELGADPQRVAVGGDSAGGNLAALVTLRARD----EKAPRP
Mb2994c|M.bovis_AF2122/97 FVWAHEHASDEFGALPGRVAVGGDSAGGNLSAVVCQLARDKARYEGGPTP
Rv2970c|M.tuberculosis_H37Rv FVWAHEHASDEFGALPGRVAVGGDSAGGNLSAVVCQLARDKARYEGGPTP
MMAR_1746|M.marinum_M FEWAHAHAA-ELGALPGRVAVGGDSAGGNLAAVVSQLARD----SGGPAP
MUL_1989|M.ulcerans_Agy99 FEWAHAHAA-ELGALPGRVAVGGDSAGGNLAAVVSQLARD----SGGPAP
MAV_3814|M.avium_104 FTWAHEHAG-ELGAIPGRVAVGGDSAGGNLAAVVSQLARD----AGGPAP
MAB_2655|M.abscessus_ATCC_1997 WRFAVGHSS-DWGIDPARIVLLGDSAGANLCAVLSNQLRD-----EEIRP
MLBr_00314|M.leprae_Br4923 YQWLR-----RLGYDPEQIVLAGDSAGGYLALALAQRLQD-----VGEEP
: : * ::.: *****. *. : :* *
MSMEG_2409|M.smegmatis_MC2_155 ALQVLLYPITDWVSETRSRTLFSDGYFLNR----QDMDWFAGHYLDGADV
TH_1220|M.thermoresistible__bu ALQLLLYPVTDLRGRYRSRTLFADGFFLTA----EDMDWFTAHYLDGSGV
Mflv_4203|M.gilvum_PYR-GCK ALQVLLYPATEVGIQTRSQTLFSDGFFLTK----RDMDWFMDHFLDGADV
Mvan_2162|M.vanbaalenii_PYR-1 ALQLLLYPVTHYDAETRSRTLFARGFFLTQ----HDIDWFRARYLGGAQL
Mb2994c|M.bovis_AF2122/97 VLQWLLYPRTDFTAQTRSMGLFGNGFLLTK----RDIDWFHTQYLRDSDV
Rv2970c|M.tuberculosis_H37Rv VLQWLLYPRTDFTAQTRSMGLFGNGFLLTK----RDIDWFHTQYLRDSDV
MMAR_1746|M.marinum_M IFQWLIYPRTDFAGRTRSASLFARGFLLTK----RDIDWFHSQYLKGSGI
MUL_1989|M.ulcerans_Agy99 IFQWLIYPRTDFAGRTRSASLFARGFLLTK----RDIDWFHSQYLKGSGI
MAV_3814|M.avium_104 VLQWLIYPRTDFTARTRSLSLFSRGFLLTK----RDIDWFESQYLRNSGL
MAB_2655|M.abscessus_ATCC_1997 RMQVLMYPVVDAVGEYRSREEFADNPALSA----KQIEWLSALYVP-DAS
MLBr_00314|M.leprae_Br4923 AALVAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKV
: * . . :. . : : :
MSMEG_2409|M.smegmatis_MC2_155 TPEDPAVSPLLAEDLSGLPPALVVTAGFDPLRDEGNRYAAAMRDAGVLVD
TH_1220|M.thermoresistible__bu DEKDPRVSPLLADDLSGLAPALVVTAGFDPLRDEGNEYAEAMRAAGVPVD
Mflv_4203|M.gilvum_PYR-GCK ADTDPRVSPLRTDDMSGLPPALVVTAGFDPLRDEGRLYAEALREAGTPVD
Mvan_2162|M.vanbaalenii_PYR-1 EGSDPRVSPLLAEDHSGLSPALVVTAGFDPLRDEGRHYADALRAAGTPVD
Mb2994c|M.bovis_AF2122/97 DPADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVD
Rv2970c|M.tuberculosis_H37Rv DPADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVD
MMAR_1746|M.marinum_M EPTDPRVSPLRAESLAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVD
MUL_1989|M.ulcerans_Agy99 EPTDPRVSPLRAESLAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVD
MAV_3814|M.avium_104 DRTDPRVSPALAESLAGLAPALIAVAGFDPLRDEGQSYAEALRAAGTPVD
MAB_2655|M.abscessus_ATCC_1997 DRSDPRVSPMLADDLSGAPATLITVAGFDPLRDEAIAYAKRLKDSGVSTR
MLBr_00314|M.leprae_Br4923 DDKPEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAE
: . .* . :*: .:* : * .:. * : *. .
MSMEG_2409|M.smegmatis_MC2_155 LREERSMIHAFANFFPLGGGGAAATTAMISALRAHLRHV--------
TH_1220|M.thermoresistible__bu LREYGSLIHAFANFFPLGGGSATATAEVISALRAHLSRV--------
Mflv_4203|M.gilvum_PYR-GCK YREYGTVVHGFANFFPLGGDSATAMADVISAIRAHLTRAG-------
Mvan_2162|M.vanbaalenii_PYR-1 YREYGSLVHGFANFFPLGGASATATGDVISAMRAHLTRAG-------
Mb2994c|M.bovis_AF2122/97 LRYLGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV--------
Rv2970c|M.tuberculosis_H37Rv LRYLGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV--------
MMAR_1746|M.marinum_M LRAMGSLTHGFLNLFPLGGGCAAATSELISALRAHLTRV--------
MUL_1989|M.ulcerans_Agy99 LRAMGSLTHGFLNLFPLGGGCAAATSELISALRAHLTRV--------
MAV_3814|M.avium_104 LRYLGSLTHGFANLFQLGGDSMVATSELISALRAHLSRV--------
MAB_2655|M.abscessus_ATCC_1997 LLREGSLVHGYISMTQISQAARNAVQRVAAAINHAVR----------
MLBr_00314|M.leprae_Br4923 IRVWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL
* : : . : :.