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TRDIAERLDPQLRHLAAARTDLSPPVLGAVRDSLNQRRAETARTADLIGVEVEQREVPVPAGHTVTVRIY RGGPPQSPAVIYCHSGAFVLGNLDTDHRQCIEMARRGRCTVLSVDYRLAPEHPYPAAQDDVSAILDWAVR CSAELGIDATAVAVAGSSAGAALAAGLARRSAAGDGPPVVFQMLHQPVLDDRPSPSKDEFTTTPGFDAEA VAWMWRHYGGDASLPDEAVPARIEEMSSLPAALITCSELDPLRDEALDYALRLLWAGVAAELHVFSGTCH GFDSLVPEWEISRQLFDIQGTALRRAFLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4102 | - | - | 100% (310) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0442 | - | 4e-37 | 38.26% (264) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_3735 | - | 1e-34 | 40.91% (242) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1435c | lipI | 5e-40 | 38.31% (261) | lipase LipH |
| M. tuberculosis H37Rv | Rv1400c | lipI | 5e-40 | 38.31% (261) | lipase LipH |
| M. leprae Br4923 | MLBr_00314 | - | 1e-13 | 29.63% (216) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2814 | - | 2e-34 | 38.43% (268) | lipase LipH |
| M. marinum M | MMAR_0404 | lipW | 3e-98 | 57.52% (306) | esterase LipW |
| M. avium 104 | MAV_5118 | - | 8e-95 | 57.98% (307) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2568 | - | 1e-109 | 62.79% (301) | LipW protein |
| M. thermoresistible (build 8) | TH_2562 | - | 1e-102 | 59.02% (305) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_1054 | lipW | 8e-91 | 59.27% (275) | esterase LipW |
| M. vanbaalenii PYR-1 | Mvan_2244 | - | 1e-151 | 82.74% (307) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1435c|M.bovis_AF2122/97 -MPSLDNTADEKPAIDPILLKVLDAVP-FRLSIDDGI-EAVRQRLRDLP-
Rv1400c|M.tuberculosis_H37Rv -MPSLDNTADEKPAIDPILLKVLDAVP-FRLSIDDGI-EAVRQRLRDLP-
MAB_2814|M.abscessus_ATCC_1997 ----MTATAG----IDPIIVKILEAVP-IQLVSPDGP-QASRDAYRAIAT
Mflv_4102|M.gilvum_PYR-GCK ----MT--RDIAERLDPQLRHLAAARTDLSPPVLGAV-RDSLNQRRA-ET
Mvan_2244|M.vanbaalenii_PYR-1 ----MTD-RDITERLDPALRHLAGARTDLSPPVLGAV-RDSLNQRRA-ET
MSMEG_2568|M.smegmatis_MC2_155 ----MAHRSGWTERLDPALREFAGARTDLSPETLAVV-RASIDRRRR-ES
TH_2562|M.thermoresistible__bu -----VNPPEAGQRLAPELRHLWGTRTDLTADLLPTV-RAVLDDRRR-AT
MMAR_0404|M.marinum_M -----MTQPEAVDRLDPLLRAVATARIDFTAESILTI-RESMNQRRREAA
MUL_1054|M.ulcerans_Agy99 -----------------------------------------MNQRRREAA
MAV_5118|M.avium_104 -----MTALDGAERLDPALRAVATTRTDFSPAAIELT-RAPFNERRR-LA
MLBr_00314|M.leprae_Br4923 MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILAVGSYVPQLPWPFGL
:
Mb1435c|M.bovis_AF2122/97 -RQPVHPELRVVDLAIDGPAG-PIGTRIYWPP-TCPDQAEAPVVLYFHGG
Rv1400c|M.tuberculosis_H37Rv -RQPVHPELRVVDLAIDGPAG-PIGTRIYWPP-TCPDQAEAPVVLYFHGG
MAB_2814|M.abscessus_ATCC_1997 ARPPWIEVANIEDRTIPGPAG-EIPVRIYSP----AEGGVRPVFVLIHGG
Mflv_4102|M.gilvum_PYR-GCK ARTADLIGVEVEQREVPVPAGHTVTVRIYRG-----GPPQSPAVIYCHSG
Mvan_2244|M.vanbaalenii_PYR-1 ARSVDTVGVEIEQREVPVPAGHRVTVRIYRG-----GPPGSGVVLYCHSG
MSMEG_2568|M.smegmatis_MC2_155 AQTLDTFGVAIAGGRAALGR-RSVPVRIYRG-----GPSPAPVVVYCHSG
TH_2562|M.thermoresistible__bu AAAVDTGGVHIDDREIHCGT-GPIEIRIYRG-----RRGVAPAVLYCHAG
MMAR_0404|M.marinum_M ATETAAAGVAVADDVVTGEAGRPVPVRIYRA-----APTPAPVVVYCHAG
MUL_1054|M.ulcerans_Agy99 ATETAAAGVAVADDVATGEAGRPVPVRIYRA-----APTPAPVVVYCHAG
MAV_5118|M.avium_104 AAQTDTAGVRIVDDDANG-----VDVRIYRG-----GPEPAPAVIYCHAG
MLBr_00314|M.leprae_Br4923 IDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGG
: :: .: *.*
Mb1435c|M.bovis_AF2122/97 GFVMGDLDTHDGTCRQHAVGADAIVVSVDYRLAPEHPYPAAIEDAWAATR
Rv1400c|M.tuberculosis_H37Rv GFVMGDLDTHDGTCRQHAVGADAIVVSVDYRLAPEHPYPAAIEDAWAATR
MAB_2814|M.abscessus_ATCC_1997 GWVIGDLDTHDAVARAAAVQADAVVVSVDYRLAPEHPYPAAVEDCWAALQ
Mflv_4102|M.gilvum_PYR-GCK AFVLGNLDTDHRQCIEMARRGRCTVLSVDYRLAPEHPYPAAQDDVSAILD
Mvan_2244|M.vanbaalenii_PYR-1 AFVLGTLDTDHRQCIEMARRGRCTVLSVDYRLAPEHPYPAALDDAAAILD
MSMEG_2568|M.smegmatis_MC2_155 AFVLGNLDVDQRQCVELARRGQCTVVAMDYRLAPEHPYPAALDDAAMVLA
TH_2562|M.thermoresistible__bu AFVLGNLDTDHRQCVELARRAECTVVSVDYRLAPEHPWPAAVDDATAVLS
MMAR_0404|M.marinum_M GFALGNLDTDHRQCLELARRARCAVVSVDYRLAPEHPYPAALHDAIEVLT
MUL_1054|M.ulcerans_Agy99 GFALGNLDTDHRQCLERARRARCAVVSVDYRLAPEHPYPAALRDAIEVLT
MAV_5118|M.avium_104 GFALGNLDTDHRQCVELARRGRCTVVSVDYRLAPEHPYPAALQDAGTVLR
MLBr_00314|M.leprae_Br4923 AFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQ
.: : . : . . :: ::*** *:*. * *
Mb1435c|M.bovis_AF2122/97 WVAEHGRQVGADLGRIAVAGDSAGGTIAAVIAQRARDMGGPPIVFQLLWY
Rv1400c|M.tuberculosis_H37Rv WVAEHGRQVGADLGRIAVAGDSAGGTIAAVIAQRARDMGGPPIVFQLLWY
MAB_2814|M.abscessus_ATCC_1997 WVHEHAAEIGGDPGRLAVGGDSAGGNLSAVMAQLARDNG-IDLAFQVLWY
Mflv_4102|M.gilvum_PYR-GCK WAVRCSAELGIDATAVAVAGSSAGAALAAGLARRSAAGDGPPVVFQMLHQ
Mvan_2244|M.vanbaalenii_PYR-1 WGVGNAAELGIDAAAVALAGSSAGASLVAGLAQRSAAGGAPPVVFQLLHQ
MSMEG_2568|M.smegmatis_MC2_155 WVAAQAGELDVDPDRIAVAGSSAGGALAALLAQRSATGAAPPIVFQLLHQ
TH_2562|M.thermoresistible__bu WLAGNATALDVDPARLAVAGSSAGGALAAGLAQRSGRNGLPQLVFQLLHQ
MMAR_0404|M.marinum_M WVVGNATRLGFDARRLAVAGSSAGATLAAGLAHGAADGSLPPVIFQLLHQ
MUL_1054|M.ulcerans_Agy99 WVVGNATRLGFDARRLAVAGSSAGATLAAGLAHGAADGSLPPVIFQLLHQ
MAV_5118|M.avium_104 WVHAEAAALGVDPARLAVAGSSAGAALAACLAH--PDGSLPAVVFQLLHQ
MLBr_00314|M.leprae_Br4923 WLR----RLGYDPEQIVLAGDSAGGYLALALAQRLQDVGEEPAALVAISP
* :. * :.:.*.***. : :*: : :
Mb1435c|M.bovis_AF2122/97 PSTLWDQSLPSLAENADAPILDVKAIAAFSRWYAGEIDL---HNPPAPMA
Rv1400c|M.tuberculosis_H37Rv PSTLWDQSLPSLAENADAPILDVKAIAAFSRWYAGEIDL---HNPPAPMA
MAB_2814|M.abscessus_ATCC_1997 PATTFDTTLPSMVENAEAPVLDFKTVGALSKWYLGDTNP---ATAGPTLV
Mflv_4102|M.gilvum_PYR-GCK P-VLDDRPSPSKDEFTTTPGFDAEAVAWMWRHYGGDA------SLPDEAV
Mvan_2244|M.vanbaalenii_PYR-1 P-VLDDRPSPSKEEFTNTPGFDSQAVQWMWRHYGGGD------PLPEDAV
MSMEG_2568|M.smegmatis_MC2_155 P-VLDDRPTRSKREFVDTPGFDGPATVAMWRHWLAGR------AAPDGAV
TH_2562|M.thermoresistible__bu P-ALDDRVTPSKAEFCTTPGFDGPACDQMWRHYLAGA------APTAAAA
MMAR_0404|M.marinum_M P-VLDDRPTASRSEFRATPAFDGEAASLMWRHYLAGQ------TPSPESV
MUL_1054|M.ulcerans_Agy99 P-VLDDRPTASRSEFRATPAFDGEAASLMWRHYLAGQ------TPSPESV
MAV_5118|M.avium_104 P-VLDDRATGSKARFRTSPAFDGEAAELMWRYYLGPT------VGSAAAV
MLBr_00314|M.leprae_Br4923 LLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELY
. : . . : : : : .
Mb1435c|M.bovis_AF2122/97 PGRAENLADLPPAYIAVAGYDPLRDDGIRYGELLAAAGVPVEVHNAQTLV
Rv1400c|M.tuberculosis_H37Rv PGRAENLADLPPAYIAVAGYDPLRDDGIRYGELLAAAGVPVEVHNAQTLV
MAB_2814|M.abscessus_ATCC_1997 PARAENFEGLAPAFIGTAQFDPLRDDGAKYAELLRDAGVPVQLHNAPTLI
Mflv_4102|M.gilvum_PYR-GCK PARIEEMSSLPAALITCSELDPLRDEALDYALRLLWAGVAAELHVFSGTC
Mvan_2244|M.vanbaalenii_PYR-1 PARADELSELPATLITCSELDPLRDEAIDYALRLMWSGVNTELHVFSGTC
MSMEG_2568|M.smegmatis_MC2_155 PARATEISDMPAAFISCSELDPLRDEALDHARRLIDGGVSTELHVFAGTC
TH_2562|M.thermoresistible__bu PGRADDLTGAPPAFISCSELDPLRDEALDYAARLLRCGVPTELHLFPGTC
MMAR_0404|M.marinum_M PGRRGQLAGLPATLITCGEIDPFRDEVLDYAQRLLGAGVSTELHIFPRAC
MUL_1054|M.ulcerans_Agy99 PGRRGQLAGLPATLITCGEIDPFRDEVLDYAQRLLGAGVSTELHIFPRAC
MAV_5118|M.avium_104 PARRPELAGLPPALITCAEIDPFRDEAIDYARRLLDAGVCTELHVFARAC
MLBr_00314|M.leprae_Br4923 EPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQV
. : * . : : .: . * ** .:::
Mb1435c|M.bovis_AF2122/97 HGYVGYAGVVPAATEATNRGLVALRVVLHG---------
Rv1400c|M.tuberculosis_H37Rv HGYVGYAGVVPAATEATNRGLVALRVVLHG---------
MAB_2814|M.abscessus_ATCC_1997 HGYLGYADIVPSATEERDLSLAALKQALHG---------
Mflv_4102|M.gilvum_PYR-GCK HGFDSLVPEWEISRQLFDIQGTALRRAFLR---------
Mvan_2244|M.vanbaalenii_PYR-1 HGFDSLVPDWEVSSQLFDIQGAALRRAFLG---------
MSMEG_2568|M.smegmatis_MC2_155 HGFDSLLPEWEVSQELFTLQGAALRRALR----------
TH_2562|M.thermoresistible__bu HGFDSLLPEWELSRQLFALQAAAVRRAFTTAEYPAGQVN
MMAR_0404|M.marinum_M HGFDSLLPEWTTSQRLFAMQGHALADAFYPD--------
MUL_1054|M.ulcerans_Agy99 HGFDSLLPEWTTSQRLFAMQGHALADAFYPD--------
MAV_5118|M.avium_104 HGFDSLLPDWPGSQRLFALQGEVLSAALHRGSTH-----
MLBr_00314|M.leprae_Br4923 HVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL
* : . : : .