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MTEPAPDPARPLAGVRVVEISSFVAVPLAGMTLAQLGAEVLRVDPVGGAADYKRWPLTEAGDSIYWAGLN KGKRSLAVDMRSDTGQELVARLIADSGVFITNVAGRQWHSYDALRQIRPDLIHVEVSGRHDGGTGVDYTV NAAIGFPLVTGPPELTTPVNHVLPAWDVTCGIYAALSVVTALRHRDATGHGQQISIPLENVALATAGNLS LLTEAMINGTSRQRIGNAVYGTYGQNFTSSDGISYMVVALTGRHFRDLTALTGTTEAVAVLADSLGADFS DEGERYRHREALSGLFAEWFTSHTGVEVAAALSATSVLWERYQTFGETAAAPRVTDNPLFTELDQPRVGR YLAAGLPLSINGAYPAAVPAPALGDDTAAVLGDWLAMDRGRIDDLFGAGTVA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2197 | - | - | 100% (402) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. vanbaalenii PYR-1 | Mvan_4258 | - | 3e-28 | 29.84% (382) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. vanbaalenii PYR-1 | Mvan_1979 | - | 2e-27 | 26.92% (390) | L-carnitine dehydratase/bile acid-inducible protein F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 2e-19 | 27.51% (378) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_4144 | - | 0.0 | 88.06% (402) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 3e-19 | 27.51% (378) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 3e-27 | 27.14% (350) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_4031 | - | 1e-141 | 61.21% (397) | acyl-CoA transferase/carnitine dehydratase |
| M. avium 104 | MAV_1574 | - | 1e-141 | 62.47% (397) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_2468 | - | 1e-178 | 73.83% (405) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_3339 | - | 5e-30 | 27.54% (403) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_3896 | - | 1e-139 | 60.20% (397) | acyl-CoA transferase/carnitine dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2197|M.vanbaalenii_PYR-1 --MTEP---APDPARPLAGVRVVEISSFVAVPLAGMTLAQLGAEVLRVDP
Mflv_4144|M.gilvum_PYR-GCK --MTEP---APDPARPLAGVRVVEISSFVAVPLAGMTLAQLGAEVLRVDP
MSMEG_2468|M.smegmatis_MC2_155 --MAEPVAHTPDPTRPLAGVRIIEISSFVAVPLAGMTLAQLGAEVVRVDP
MMAR_4031|M.marinum_M ---------MPGPDLPLSGISVVEVSSFVAAPLCGMTLSQLGAQVIRVDP
MUL_3896|M.ulcerans_Agy99 ---------MPGPDLPLSGISVVEVSSFVAAPLCGMTLSQLGAQVIRVDP
MAV_1574|M.avium_104 ---------MTDPRLPLHGLSVVEVSSFVAAPLCGMTLSQLGAEVIRVDP
Mb3300|M.bovis_AF2122/97 -------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEA
Rv3272|M.tuberculosis_H37Rv -------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEA
MAB_4651c|M.abscessus_ATCC_199 ------------MTGALDGIRVLELGTLIAGPFAGRLLGDMGAEVLKIEP
TH_3339|M.thermoresistible__bu MTTEVETTATQPTTGPLHGIRVVEMGSLLAGPIVGQMMGDLGADVVKIED
.* *. :::. :* *: * : ::**:*::::
Mvan_2197|M.vanbaalenii_PYR-1 VGGAADYKRWPLTEAGDS---IYWAGLNKGKRSLAVDMRSDTGQELVARL
Mflv_4144|M.gilvum_PYR-GCK VGGAADYRRWPLTESGDS---IYWAGLNKGKKSLAVDMRSGQGQALVARL
MSMEG_2468|M.smegmatis_MC2_155 IGGAADYHRWPVTDGGDS---IYWAGLNKGKRSVAADMRSPEGQQVVQRL
MMAR_4031|M.marinum_M IGGASDIRRWPLAASGTS---IYWTGLNKGKRSATIDLRSAAGQRLVQRL
MUL_3896|M.ulcerans_Agy99 IGGASDIRRWPLAASGTS---IYWTGLNKGKRSATIDLRSAAGQRLVQRL
MAV_1574|M.avium_104 IGGASDVQRWPLAADGTS---IYWTGLNKGKRSATIDLRSAEGQRLVQRL
Mb3300|M.bovis_AF2122/97 PG-GEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRL
Rv3272|M.tuberculosis_H37Rv PG-GEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRL
MAB_4651c|M.abscessus_ATCC_199 PGAPDPLRTWGQAEVDGH--HVFWTVHARNKKAITLDLRTEAGRALFLDL
TH_3339|M.thermoresistible__bu PGKGDPLRQWGQNRPKGQ--SLWFSIVGRNKRSVTINLREPRGQELVRQL
* : :: :.*:: : :: .: . *
Mvan_2197|M.vanbaalenii_PYR-1 IADS-GVFITNVAG---RQWHSYDALRQIRPDLIHVEVSGRHDGG-----
Mflv_4144|M.gilvum_PYR-GCK IADA-GVFITNVAG---RQWHSYDALRTDRPDLIHAEVSGRHDGG-----
MSMEG_2468|M.smegmatis_MC2_155 IAES-GVLITNAAG---RQWHSYEELAALRSDLIHVEVSGRADGG-----
MMAR_4031|M.marinum_M VLEGDGVVVTNAS----LPWLSHEVLAATRSDIIHLQLLGRRDGG-----
MUL_3896|M.ulcerans_Agy99 VLEGDGVVVTNAS----LPWLSHEVLAATRSDVIHLQLLGRRDGG-----
MAV_1574|M.avium_104 IVEGDGVVVTNAAG---LSWLSHDALAALRADVIHVQLLGRGDGS-----
Mb3300|M.bovis_AF2122/97 ADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSR
Rv3272|M.tuberculosis_H37Rv ADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSR
MAB_4651c|M.abscessus_ATCC_199 VDKSDVIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQTGPDAHK
TH_3339|M.thermoresistible__bu VAEADVLVENFRPGTMERWGLGYSDLAEINPRLVIVRVSGFGQDGPYASR
. :. . . . * . :: .: . .
Mvan_2197|M.vanbaalenii_PYR-1 TGVDYTVNAAIGFPLVTGPPELTTPVNHVLPAWDVTCGIYAALSVVTALR
Mflv_4144|M.gilvum_PYR-GCK TGVDYTVNAAIGFPLVTGPPELSTPVNHVLPAWDVTCGIYTALSVVTALR
MSMEG_2468|M.smegmatis_MC2_155 TGVDYTVNAALGFPLVTGPAEVSTPVNHVLPAWDVSCGLYVALAVTAALR
MMAR_4031|M.marinum_M TGVDYTVNAATGFPLVTGPADHAGPINHVLPAWDVSCGLYAALSVVAALR
MUL_3896|M.ulcerans_Agy99 TGVDYTVNAATGFPLVTGPADHAGPINHVLPAWDVSCGLYAALVVVAALR
MAV_1574|M.avium_104 TGVDYTVNAGIGYPLVTGPAEHAGPINHVLPAWDVCCGLYAALSVVTAVH
Mb3300|M.bovis_AF2122/97 PGIDLVVAAEAGMTTGMPTPEGK-PQIIPFQLVDNASGHVLAQAVLAALL
Rv3272|M.tuberculosis_H37Rv PGIDLVVAAEAGMTTGMPTPEGK-PQIIPFQLVDNASGHVLAQAVLAALL
MAB_4651c|M.abscessus_ATCC_199 AGYASVAEAASGLRHLNGFPGGP-PPRMALSIGDTLAGMFAAQGALAALY
TH_3339|M.thermoresistible__bu PGYGAIGEAMGGLRYVVGDPSTP-PSRVGISIGDTLAALFATIGALAALR
.* * * . * : * .. : . :*:
Mvan_2197|M.vanbaalenii_PYR-1 HRDATGHGQQISIPLENVALATAGNLSLLTEAMINGTSRQRIGNAVYGTY
Mflv_4144|M.gilvum_PYR-GCK HRDATGHGQQISIPLENVALATAGNLSLLTEAMINGTSRQRIGNAVYGTY
MSMEG_2468|M.smegmatis_MC2_155 HRDATGEGARISVPLENVALATAGNLGFLTEVMINGTSRERLGNSLFGTY
MMAR_4031|M.marinum_M RRDQTGAGAQISLALEDVALATAGNLGLLTEPQVNGTQRERLGNSIYGQY
MUL_3896|M.ulcerans_Agy99 RRDQTGAGAQISLALEDVALATAGNLGLLTEPQVNGTQRERLGNSIYGQY
MAV_1574|M.avium_104 RREQSGAGARISLALEDVALATAANLGLLTEPQVVGTQRERLGNAIYGQY
Mb3300|M.bovis_AF2122/97 HRERNGVADVVQVAMYDVAVGLQANQ--LMMHLNRAASDQPKPEPAPKAK
Rv3272|M.tuberculosis_H37Rv HRERNGVADVVQVAMYDVAVGLQANQ--LMMHLNRAASDQPKPEPAPKAK
MAB_4651c|M.abscessus_ATCC_199 RRTVTGRGQVVDAALTESCLAVQEST--IPDYDVGRVVRGPSGTRLEGIA
TH_3339|M.thermoresistible__bu EREISGRGQMVDSAIYEAVLGVMESL--VPEWTVSGYQRERTGAILPKIA
.* .* . :. .: : :. . :
Mvan_2197|M.vanbaalenii_PYR-1 G-----------QNFTSSDGISYMVVALTGRHFRDLTALTGTTEAVAVLA
Mflv_4144|M.gilvum_PYR-GCK G-----------QNFTSSDGVSFMVVALTGRHFRDLNALTGTTESVAALS
MSMEG_2468|M.smegmatis_MC2_155 G-----------QNFTSSDGVFFMLVALTGRHFRDLTEVTGTTKAVAALG
MMAR_4031|M.marinum_M G-----------QDFASRDGTSFMVITLTRRHFRDLVDVTGTGPAVTALA
MUL_3896|M.ulcerans_Agy99 G-----------QDFASRDGTSFMVITLTRRHFRDLVDVTGTGPAVTALA
MAV_1574|M.avium_104 G-----------QDFTSRDGARFMVVTLTGRHFRDLLDVTGTGAAVSALA
Mb3300|M.bovis_AF2122/97 RRKGVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIGRPDLVE---
Rv3272|M.tuberculosis_H37Rv RRKGVGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIGRPDLVE---
MAB_4651c|M.abscessus_ATCC_199 ----------PSNIYQSADGSWVVIAANQDTVFRRLCEAMGRPELSS---
TH_3339|M.thermoresistible__bu ----------PSNVYPTSDDTWILIAANQDTVFRRLAEAMGRPELAE---
: : : *. :: : :: * *
Mvan_2197|M.vanbaalenii_PYR-1 DSLGADFSDEGERYRHREALSGLFAEWFTSHTGVEVAAALSATSVLWERY
Mflv_4144|M.gilvum_PYR-GCK RSLDVDFSDEGERYRHREALGGLYAEWFSAHTGAEISAALSETSVLWERY
MSMEG_2468|M.smegmatis_MC2_155 EALGADFTDEGQRYTHRDALTGLFTLWFSEHTADEITEALSGTSVLWERY
MMAR_4031|M.marinum_M EALGVDFDAEGDRYRYRSVLNGLFAAWFADHTAEQIGAALSATTVLFERY
MUL_3896|M.ulcerans_Agy99 EALGVDFDAEGDRYRYRSVLNGLFAAWFADHRAEQIGAALSATTVLFERY
MAV_1574|M.avium_104 DALGVDFGSEGERYRYRDVLSGLFATWFGDHTADEITAALSHTTVLFERY
Mb3300|M.bovis_AF2122/97 ---DQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLA
Rv3272|M.tuberculosis_H37Rv ---DQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLA
MAB_4651c|M.abscessus_ATCC_199 ---DARFANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPI
TH_3339|M.thermoresistible__bu ---DERYATHVARGEHQAELDEIVAEFTRRHTAAEVEALMHKHNVPVGKI
. : . * * : : : :
Mvan_2197|M.vanbaalenii_PYR-1 QTFGETAAAPRVTDNPLFTELDQPRVGRYLAAGLPLSINGAYPAAVP---
Mflv_4144|M.gilvum_PYR-GCK QTFAETAADARVTDNPLFTELDQPRVGTHLAAGLPVSIDGVYPRAVP---
MSMEG_2468|M.smegmatis_MC2_155 RTFAQTAGDRRVTDNPLFTPLDQPRIGRYLAPGLPVSIGGVYPAAVA---
MMAR_4031|M.marinum_M RTFAEVAADPKVTANPLFSQLSQPGVGDYLAPGLPTAFDGCHPAGAP---
MUL_3896|M.ulcerans_Agy99 RTFAEVAADPKVTANPLFSQLSQPGVGDYFAPGLPTAFDGCHPAGAP---
MAV_1574|M.avium_104 RTFAEVAAGPKVTANPLFSRLHQPGLGDYFAPGLPAAFDGTHPAGAP---
Mb3300|M.bovis_AF2122/97 HTWKQVVDTPLFAESDLTLEVG---RGADTITVIRTPARYASFRAVVTDP
Rv3272|M.tuberculosis_H37Rv HTWKQVVDTPLFAENDLTLEVG---RGADTITVIRTPARYASFRAVVTDP
MAB_4651c|M.abscessus_ATCC_199 NTVADVVQDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAG
TH_3339|M.thermoresistible__bu YRPKEMLADPQFRARESITSVDHPVLG-EIQMQNVFPRLSRTRGSIRWPG
: . * . .
Mvan_2197|M.vanbaalenii_PYR-1 APALGDDTAAVLGDWLAMDRGRIDDLFGAGTVA-----------
Mflv_4144|M.gilvum_PYR-GCK APALGDDTDSVLGDWLSLDAARIDELRETGTVA-----------
MSMEG_2468|M.smegmatis_MC2_155 APALGDDTAAVLAEHLGLSAEKIAELTESGTVATGSAQK-----
MMAR_4031|M.marinum_M APALGEHTADVLTEYLGLTTADIARLASAKTIGGPDGQQDKEYA
MUL_3896|M.ulcerans_Agy99 APALGEHTADVLTEYLGLTTADTARLASAKTIGGPDGQQDKEYA
MAV_1574|M.avium_104 APALGQDTAEVLAR-LGLTAADIERLADAKTIAC----------
Mb3300|M.bovis_AF2122/97 PPTAGEHNAVFLARP-----------------------------
Rv3272|M.tuberculosis_H37Rv PPTAGEHNAVFLARP-----------------------------
MAB_4651c|M.abscessus_ATCC_199 PARPGQDNDDVYVGLLGKSAQDIERLRAEGVL------------
TH_3339|M.thermoresistible__bu PG-LGEHTDEVLR-QLGLSDEELQKLHDAGVV------------
. *:.. .