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M. ulcerans Agy99 MUL_3896 (-)

annotation: acyl-CoA transferase/carnitine dehydratase
coordinates: 4352728 - 4353957
length: 409

PGPDLPLSGISVVEVSSFVAAPLCGMTLSQLGAQVIRVDPIGGASDIRRWPLAASGTSIYWTGLNKGKRS
ATIDLRSAAGQRLVQRLVLEGDGVVVTNASLPWLSHEVLAATRSDVIHLQLLGRRDGGTGVDYTVNAATG
FPLVTGPADHAGPINHVLPAWDVSCGLYAALVVVAALRRRDQTGAGAQISLALEDVALATAGNLGLLTEP
QVNGTQRERLGNSIYGQYGQDFASRDGTSFMVITLTRRHFRDLVDVTGTGPAVTALAEALGVDFDAEGDR
YRYRSVLNGLFAAWFADHRAEQIGAALSATTVLFERYRTFAEVAADPKVTANPLFSQLSQPGVGDYFAPG
LPTAFDGCHPAGAPAPALGEHTADVLTEYLGLTTADTARLASAKTIGGPDGQQDKEYA*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. ulcerans Agy99 MUL_3896 - - 100% (409) acyl-CoA transferase/carnitine dehydratase
M. ulcerans Agy99 MUL_2446 - 2e-24 25.91% (413) hypothetical protein MUL_2446
M. ulcerans Agy99 MUL_0328 - 9e-22 26.78% (422) acyl-CoA transferase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1897 - 5e-17 24.40% (414) hypothetical protein Mb1897
M. gilvum PYR-GCK Mflv_4144 - 1e-137 59.95% (397) L-carnitine dehydratase/bile acid-inducible protein F
M. tuberculosis H37Rv Rv1866 - 5e-17 24.40% (414) hypothetical protein Rv1866
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_4651c - 4e-26 27.93% (401) putative L-carnitine dehydratase
M. marinum M MMAR_4031 - 0.0 98.78% (409) acyl-CoA transferase/carnitine dehydratase
M. avium 104 MAV_1574 - 0.0 81.41% (398) L-carnitine dehydratase/bile acid-inducible protein F
M. smegmatis MC2 155 MSMEG_2468 - 1e-144 61.63% (404) L-carnitine dehydratase/bile acid-inducible protein F
M. thermoresistible (build 8) TH_2496 - 5e-35 31.22% (410) PUTATIVE L-carnitine dehydratase/bile acid-inducible protein F
M. vanbaalenii PYR-1 Mvan_2197 - 1e-139 60.20% (397) L-carnitine dehydratase/bile acid-inducible protein F

CLUSTAL 2.0.9 multiple sequence alignment


MUL_3896|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4031|M.marinum_M               --------------------------------------------------
MAV_1574|M.avium_104                --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155      --------------------------------------------------
Mb1897|M.bovis_AF2122/97            MVTRLLADLGADVLKVQPPGGSPGRHVRPTLAGTSIGFAMHNANKRSAVL
Rv1866|M.tuberculosis_H37Rv         MVTRLLADLGADVLKVEPPGGSPGRHVRPTLAGTSIGFAMHNANKRSAVL
MAB_4651c|M.abscessus_ATCC_199      --------------------------------------------------
TH_2496|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MUL_3896|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4031|M.marinum_M               --------------------------------------------------
MAV_1574|M.avium_104                --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155      --------------------------------------------------
Mb1897|M.bovis_AF2122/97            NPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVAL
Rv1866|M.tuberculosis_H37Rv         NPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVAL
MAB_4651c|M.abscessus_ATCC_199      --------------------------------------------------
TH_2496|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MUL_3896|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4031|M.marinum_M               --------------------------------------------------
MAV_1574|M.avium_104                --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155      --------------------------------------------------
Mb1897|M.bovis_AF2122/97            SITDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATA
Rv1866|M.tuberculosis_H37Rv         SITDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATA
MAB_4651c|M.abscessus_ATCC_199      --------------------------------------------------
TH_2496|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MUL_3896|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4031|M.marinum_M               --------------------------------------------------
MAV_1574|M.avium_104                --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155      --------------------------------------------------
Mb1897|M.bovis_AF2122/97            AVQAAWAVLVAYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGI
Rv1866|M.tuberculosis_H37Rv         AVQAAWAVLVAYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGI
MAB_4651c|M.abscessus_ATCC_199      --------------------------------------------------
TH_2496|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MUL_3896|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4031|M.marinum_M               --------------------------------------------------
MAV_1574|M.avium_104                --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155      --------------------------------------------------
Mb1897|M.bovis_AF2122/97            RSTGRWRGRPKNQDAYPIYPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQ
Rv1866|M.tuberculosis_H37Rv         RSTGRWRGRPKNQDAYPIYPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQ
MAB_4651c|M.abscessus_ATCC_199      --------------------------------------------------
TH_2496|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MUL_3896|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4031|M.marinum_M               --------------------------------------------------
MAV_1574|M.avium_104                --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155      --------------------------------------------------
Mb1897|M.bovis_AF2122/97            DPKYDVIGARLAAWPQISVLVAKLCAEKTMKELVAAGQALGVPITAVLTP
Rv1866|M.tuberculosis_H37Rv         DPKYDVIGARLAAWPQISVLVAKLCAEKTMKELVAAGQALGVPITAVLTP
MAB_4651c|M.abscessus_ATCC_199      --------------------------------------------------
TH_2496|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MUL_3896|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4031|M.marinum_M               --------------------------------------------------
MAV_1574|M.avium_104                --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155      --------------------------------------------------
Mb1897|M.bovis_AF2122/97            SRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRAGFRTPAPAAG
Rv1866|M.tuberculosis_H37Rv         SRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRAGFRTPAPAAG
MAB_4651c|M.abscessus_ATCC_199      --------------------------------------------------
TH_2496|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MUL_3896|M.ulcerans_Agy99           -----------------MPGPDLPLSGISVVEVSSFVAAPLCGMTLSQLG
MMAR_4031|M.marinum_M               -----------------MPGPDLPLSGISVVEVSSFVAAPLCGMTLSQLG
MAV_1574|M.avium_104                -----------------MTDPRLPLHGLSVVEVSSFVAAPLCGMTLSQLG
Mflv_4144|M.gilvum_PYR-GCK          ----------MTEP---APDPARPLAGVRVVEISSFVAVPLAGMTLAQLG
Mvan_2197|M.vanbaalenii_PYR-1       ----------MTEP---APDPARPLAGVRVVEISSFVAVPLAGMTLAQLG
MSMEG_2468|M.smegmatis_MC2_155      ----------MAEPVAHTPDPTRPLAGVRIIEISSFVAVPLAGMTLAQLG
Mb1897|M.bovis_AF2122/97            QDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDLG
Rv1866|M.tuberculosis_H37Rv         QDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDLG
MAB_4651c|M.abscessus_ATCC_199      ------------------MTG--ALDGIRVLELGTLIAGPFAGRLLGDMG
TH_2496|M.thermoresistible__bu      -------------MAESEHADPAPLAGITVVALEQAVSAPMCTRVLADFG
                                                           .: *: :: :   ::       :.::*

MUL_3896|M.ulcerans_Agy99           AQVIRVDPIGGASDIRRWPLAASG-TSIYWTGLNKGKRSATIDLRSAAGQ
MMAR_4031|M.marinum_M               AQVIRVDPIGGASDIRRWPLAASG-TSIYWTGLNKGKRSATIDLRSAAGQ
MAV_1574|M.avium_104                AEVIRVDPIGGASDVQRWPLAADG-TSIYWTGLNKGKRSATIDLRSAEGQ
Mflv_4144|M.gilvum_PYR-GCK          AEVLRVDPVGGAADYRRWPLTESG-DSIYWAGLNKGKKSLAVDMRSGQGQ
Mvan_2197|M.vanbaalenii_PYR-1       AEVLRVDPVGGAADYKRWPLTEAG-DSIYWAGLNKGKRSLAVDMRSDTGQ
MSMEG_2468|M.smegmatis_MC2_155      AEVVRVDPIGGAADYHRWPVTDGG-DSIYWAGLNKGKRSVAADMRSPEGQ
Mb1897|M.bovis_AF2122/97            AEVIKVESADHPDGLRQTRVGDAMSESFAWTH--RNHLALGLDLRNSEGK
Rv1866|M.tuberculosis_H37Rv         AEVIKVESADHPDGLRQTRVGDAMSESFAWTH--RNHLALGLDLRNSEGK
MAB_4651c|M.abscessus_ATCC_199      AEVLKIEPPGAPDPLRTWGQAEVDGHHVFWTVHARNKKAITLDLRTEAGR
TH_2496|M.thermoresistible__bu      ARVIKVENPDGGDFARHYDDVVKG-QAAHFVWANRGKESVTLNLKSEAGM
                                    *.*::::  .     :             :.   :.: :   :::.  * 

MUL_3896|M.ulcerans_Agy99           RLVQRLVLEGDGVVVTNAS----LPWLSHEVLAATRSDVIHLQLLGRRDG
MMAR_4031|M.marinum_M               RLVQRLVLEGDGVVVTNAS----LPWLSHEVLAATRSDIIHLQLLGRRDG
MAV_1574|M.avium_104                RLVQRLIVEGDGVVVTNAAG---LSWLSHDALAALRADVIHVQLLGRGDG
Mflv_4144|M.gilvum_PYR-GCK          ALVARLIADA-GVFITNVAG---RQWHSYDALRTDRPDLIHAEVSGRHDG
Mvan_2197|M.vanbaalenii_PYR-1       ELVARLIADS-GVFITNVAG---RQWHSYDALRQIRPDLIHVEVSGRHDG
MSMEG_2468|M.smegmatis_MC2_155      QVVQRLIAES-GVLITNAAG---RQWHSYEELAALRSDLIHVEVSGRADG
Mb1897|M.bovis_AF2122/97            AIFGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNR
Rv1866|M.tuberculosis_H37Rv         AIFGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNR
MAB_4651c|M.abscessus_ATCC_199      ALFLDLVDKSDVIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQT
TH_2496|M.thermoresistible__bu      AVLHRLLDEADVLVSNLAPGALARMGLAADDLKTSHPRVLPVQIDGYGAG
                                     :.  *: ..  :. .  .        . : *   .  ::     .    

MUL_3896|M.ulcerans_Agy99           G-----TGVDYTVNAATGFPLVTGPADHAGPIN------HVLPAWDVSCG
MMAR_4031|M.marinum_M               G-----TGVDYTVNAATGFPLVTGPADHAGPIN------HVLPAWDVSCG
MAV_1574|M.avium_104                S-----TGVDYTVNAGIGYPLVTGPAEHAGPIN------HVLPAWDVCCG
Mflv_4144|M.gilvum_PYR-GCK          G-----TGVDYTVNAAIGFPLVTGPPELSTPVN------HVLPAWDVTCG
Mvan_2197|M.vanbaalenii_PYR-1       G-----TGVDYTVNAAIGFPLVTGPPELTTPVN------HVLPAWDVTCG
MSMEG_2468|M.smegmatis_MC2_155      G-----TGVDYTVNAALGFPLVTGPAEVSTPVN------HVLPAWDVSCG
Mb1897|M.bovis_AF2122/97            GPWSTRMGYGPLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVVG
Rv1866|M.tuberculosis_H37Rv         GPWSTRMGYGPLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVVG
MAB_4651c|M.abscessus_ATCC_199      GPDAHKAGYASVAEAASGLRHLNGFPGGPPPR-------MALSIGDTLAG
TH_2496|M.thermoresistible__bu      GPISHKRAYDLLIQAESGACAVTGYPGMPAKPG--------PPVADISTG
                                    .      .     .*  *   :                       *   *

MUL_3896|M.ulcerans_Agy99           LYAALVVVAALRRRDQ-----TGAGAQISLALEDVALATAGNLGLLTEPQ
MMAR_4031|M.marinum_M               LYAALSVVAALRRRDQ-----TGAGAQISLALEDVALATAGNLGLLTEPQ
MAV_1574|M.avium_104                LYAALSVVTAVHRREQ-----SGAGARISLALEDVALATAANLGLLTEPQ
Mflv_4144|M.gilvum_PYR-GCK          IYTALSVVTALRHRDA-----TGHGQQISIPLENVALATAGNLSLLTEAM
Mvan_2197|M.vanbaalenii_PYR-1       IYAALSVVTALRHRDA-----TGHGQQISIPLENVALATAGNLSLLTEAM
MSMEG_2468|M.smegmatis_MC2_155      LYVALAVTAALRHRDA-----TGEGARISVPLENVALATAGNLGFLTEVM
Mb1897|M.bovis_AF2122/97            RVGALLALAALIHRDR-----TGGGAHVHISQAEVVVNQLDTMFVAEAAR
Rv1866|M.tuberculosis_H37Rv         RVGALLALAALIHRDR-----TGGGAHVHISQAEVVVNQLDTMFVAEAAR
MAB_4651c|M.abscessus_ATCC_199      MFAAQGALAALYRRTV-----TGRGQVVDAALTESCLAVQESTIPDYDVG
TH_2496|M.thermoresistible__bu      LYAALSVMALLYGRDRRDRATPGPVPAVAVSLFDTMTDIMGYQLTYTQHS
                                       *  . : :  *       .*    :  .  :                

MUL_3896|M.ulcerans_Agy99           VNGTQRERLGNSIYGQYGQDFASRDGTSFMVITLTRRHFRDLVDVTGTGP
MMAR_4031|M.marinum_M               VNGTQRERLGNSIYGQYGQDFASRDGTSFMVITLTRRHFRDLVDVTGTGP
MAV_1574|M.avium_104                VVGTQRERLGNAIYGQYGQDFTSRDGARFMVVTLTGRHFRDLLDVTGTGA
Mflv_4144|M.gilvum_PYR-GCK          INGTSRQRIGNAVYGTYGQNFTSSDGVSFMVVALTGRHFRDLNALTGTTE
Mvan_2197|M.vanbaalenii_PYR-1       INGTSRQRIGNAVYGTYGQNFTSSDGISYMVVALTGRHFRDLTALTGTTE
MSMEG_2468|M.smegmatis_MC2_155      INGTSRERLGNSLFGTYGQNFTSSDGVFFMLVALTGRHFRDLTEVTGTTK
Mb1897|M.bovis_AF2122/97            --ATDVAEIHPDTS-VHAVYPCAGDDEWCVISIRSDDEWRRATSVFGQPE
Rv1866|M.tuberculosis_H37Rv         --ATDVAEIHPDTS-VHAVYPCAGDDEWCVISIRSDDEWRRATSVFGQPE
MAB_4651c|M.abscessus_ATCC_199      RVVRGPSGTRLEGI-APSNIYQSADGSWVVIAANQDTVFRRLCEAMGRPE
TH_2496|M.thermoresistible__bu      GVDQQPLGMSSPAVAPYGAFRTRDGQTVVLGTTNDREWQRLARDIIERPD
                                                     .      .    :         *          

MUL_3896|M.ulcerans_Agy99           AVTALAEALGVDFDAEGDRYRYRSVLNGLFAAWFADHRAEQIGAALSATT
MMAR_4031|M.marinum_M               AVTALAEALGVDFDAEGDRYRYRSVLNGLFAAWFADHTAEQIGAALSATT
MAV_1574|M.avium_104                AVSALADALGVDFGSEGERYRYRDVLSGLFATWFGDHTADEITAALSHTT
Mflv_4144|M.gilvum_PYR-GCK          SVAALSRSLDVDFSDEGERYRHREALGGLYAEWFSAHTGAEISAALSETS
Mvan_2197|M.vanbaalenii_PYR-1       AVAVLADSLGADFSDEGERYRHREALSGLFAEWFTSHTGVEVAAALSATS
MSMEG_2468|M.smegmatis_MC2_155      AVAALGEALGADFTDEGQRYTHRDALTGLFTLWFSEHTADEITEALSGTS
Mb1897|M.bovis_AF2122/97            LAN------DPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAG
Rv1866|M.tuberculosis_H37Rv         LAN------DPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAG
MAB_4651c|M.abscessus_ATCC_199      LSS------DARFANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAG
TH_2496|M.thermoresistible__bu      LAD------DPAYATNSDRVRHRDVLNEAIAAWCARHDLAHIQKTADDAG
                                             .  :     *   :. *    : *   :   .   . . : 

MUL_3896|M.ulcerans_Agy99           VLFERYRTFAEVAADPKVTANPLFSQLSQPGVGDYFAPGLPTAFDGCHPA
MMAR_4031|M.marinum_M               VLFERYRTFAEVAADPKVTANPLFSQLSQPGVGDYLAPGLPTAFDGCHPA
MAV_1574|M.avium_104                VLFERYRTFAEVAAGPKVTANPLFSRLHQPGLGDYFAPGLPAAFDGTHPA
Mflv_4144|M.gilvum_PYR-GCK          VLWERYQTFAETAADARVTDNPLFTELDQPRVGTHLAAGLPVSIDGVYPR
Mvan_2197|M.vanbaalenii_PYR-1       VLWERYQTFGETAAAPRVTDNPLFTELDQPRVGRYLAAGLPLSINGAYPA
MSMEG_2468|M.smegmatis_MC2_155      VLWERYRTFAQTAGDRRVTDNPLFTPLDQPRIGRYLAPGLPVSIGGVYPA
Mb1897|M.bovis_AF2122/97            VAAGPMNRPSDILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQ
Rv1866|M.tuberculosis_H37Rv         VAAGPMNRPSDILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQ
MAB_4651c|M.abscessus_ATCC_199      VIAGPINTVADVVQDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPG
TH_2496|M.thermoresistible__bu      IGNSRYNLPSEVVAHPHLSARDRWRPVDTPNGQITALRPPPVIEGFEQPM
                                    :     .  .:     ::  .                           * 

MUL_3896|M.ulcerans_Agy99           GAPAP---ALGEHTADVLTEYLGLTTADTARLASAKTIGGPDGQQDKEYA
MMAR_4031|M.marinum_M               GAPAP---ALGEHTADVLTEYLGLTTADIARLASAKTIGGPDGQQDKEYA
MAV_1574|M.avium_104                GAPAP---ALGQDTAEVLAR-LGLTAADIERLADAKTIAC----------
Mflv_4144|M.gilvum_PYR-GCK          AVPAP---ALGDDTDSVLGDWLSLDAARIDELRETGTVA-----------
Mvan_2197|M.vanbaalenii_PYR-1       AVPAP---ALGDDTAAVLGDWLAMDRGRIDDLFGAGTVA-----------
MSMEG_2468|M.smegmatis_MC2_155      AVAAP---ALGDDTAAVLAEHLGLSAEKIAELTESGTVATGSAQK-----
Mb1897|M.bovis_AF2122/97            APQRP-APLPGQDSVQICRKLLGMTADETERLINERVMFGPAVTA-----
Rv1866|M.tuberculosis_H37Rv         APQRP-APLPGQDSVQICRKLLGMTADETERLINERVMFGPAVTA-----
MAB_4651c|M.abscessus_ATCC_199      GVRNAGPARPGQDNDDVYVGLLGKSAQDIERLRAEGVL------------
TH_2496|M.thermoresistible__bu      GPVPG----LGQHTDAVLSGLLGMTDDEIAALREQGAIGPAYN-------
                                    .         *:..  :    *.        *    .:

species	id	gene	e-value	identity (len)	annotation
M. ulcerans Agy99	MUL_3896	-	-	100% (409)	acyl-CoA transferase/carnitine dehydratase
M. ulcerans Agy99	MUL_2446	-	2e-24	25.91% (413)	hypothetical protein MUL_2446
M. ulcerans Agy99	MUL_0328	-	9e-22	26.78% (422)	acyl-CoA transferase