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MTDPRLPLHGLSVVEVSSFVAAPLCGMTLSQLGAEVIRVDPIGGASDVQRWPLAADGTSIYWTGLNKGKR SATIDLRSAEGQRLVQRLIVEGDGVVVTNAAGLSWLSHDALAALRADVIHVQLLGRGDGSTGVDYTVNAG IGYPLVTGPAEHAGPINHVLPAWDVCCGLYAALSVVTAVHRREQSGAGARISLALEDVALATAANLGLLT EPQVVGTQRERLGNAIYGQYGQDFTSRDGARFMVVTLTGRHFRDLLDVTGTGAAVSALADALGVDFGSEG ERYRYRDVLSGLFATWFGDHTADEITAALSHTTVLFERYRTFAEVAAGPKVTANPLFSRLHQPGLGDYFA PGLPAAFDGTHPAGAPAPALGQDTAEVLARLGLTAADIERLADAKTIAC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1574 | - | - | 100% (399) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. avium 104 | MAV_4024 | - | 2e-26 | 28.19% (408) | caib/baif family protein |
| M. avium 104 | MAV_2651 | - | 3e-24 | 28.29% (403) | L-carnitine dehydratase/bile acid-inducible protein F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 3e-15 | 27.11% (284) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_4144 | - | 1e-139 | 61.21% (397) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 3e-15 | 27.11% (284) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 2e-27 | 28.01% (407) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_4031 | - | 0.0 | 81.66% (398) | acyl-CoA transferase/carnitine dehydratase |
| M. smegmatis MC2 155 | MSMEG_2468 | - | 1e-145 | 63.48% (397) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_4570 | - | 4e-31 | 30.40% (421) | PUTATIVE caib/baif family protein |
| M. ulcerans Agy99 | MUL_3896 | - | 0.0 | 81.41% (398) | acyl-CoA transferase/carnitine dehydratase |
| M. vanbaalenii PYR-1 | Mvan_2197 | - | 1e-141 | 62.47% (397) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4031|M.marinum_M --------------------------------------------------
MUL_3896|M.ulcerans_Agy99 --------------------------------------------------
MAV_1574|M.avium_104 --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4570|M.thermoresistible__bu VVRISDFGQHGPLHGRPTSPLTMQAASGWVNAREFGRTPVQAGARIPEYI
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4031|M.marinum_M --------------------------------------------------
MUL_3896|M.ulcerans_Agy99 --------------------------------------------------
MAV_1574|M.avium_104 --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4570|M.thermoresistible__bu AGGYAALGALTGLRVAATVEDRPVEVDVSTFEALLSTLPYPMLLAERLRS
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4031|M.marinum_M --------------------------------------------------
MUL_3896|M.ulcerans_Agy99 --------------------------------------------------
MAV_1574|M.avium_104 --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4570|M.thermoresistible__bu MGLPTNSRAAPMLGIVRAADGWIGINCLTGQHWLDVCAMVGLPEFGEHQL
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4031|M.marinum_M --------------------------------------------------
MUL_3896|M.ulcerans_Agy99 --------------------------------------------------
MAV_1574|M.avium_104 --------------------------------------------------
Mflv_4144|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2197|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2468|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4570|M.thermoresistible__bu AIMLGGPERDEFLAKVQPWLDGQSVADIVELSQALRIPAAPVNDGSSILT
Mb3300|M.bovis_AF2122/97 -------------------------------------------MPTSNPA
Rv3272|M.tuberculosis_H37Rv -------------------------------------------MPTSNPA
MMAR_4031|M.marinum_M ---------------------------------------------MPGPD
MUL_3896|M.ulcerans_Agy99 ---------------------------------------------MPGPD
MAV_1574|M.avium_104 ---------------------------------------------MTDPR
Mflv_4144|M.gilvum_PYR-GCK --------------------------------------MTEP---APDPA
Mvan_2197|M.vanbaalenii_PYR-1 --------------------------------------MTEP---APDPA
MSMEG_2468|M.smegmatis_MC2_155 --------------------------------------MAEPVAHTPDPT
MAB_4651c|M.abscessus_ATCC_199 ------------------------------------------------MT
TH_4570|M.thermoresistible__bu CPQYAERGFFVPGGGPGWEYRRPGAPFRLSGARPGSGGAAEPADAEGDPA
Mb3300|M.bovis_AF2122/97 KPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGGEAARQITSVLP
Rv3272|M.tuberculosis_H37Rv KPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGGEAARQITSVLP
MMAR_4031|M.marinum_M LPLSGISVVEVSSFVAAPLCGMTLSQLGAQVIRVDPIGGASDIRRWPLAA
MUL_3896|M.ulcerans_Agy99 LPLSGISVVEVSSFVAAPLCGMTLSQLGAQVIRVDPIGGASDIRRWPLAA
MAV_1574|M.avium_104 LPLHGLSVVEVSSFVAAPLCGMTLSQLGAEVIRVDPIGGASDVQRWPLAA
Mflv_4144|M.gilvum_PYR-GCK RPLAGVRVVEISSFVAVPLAGMTLAQLGAEVLRVDPVGGAADYRRWPLTE
Mvan_2197|M.vanbaalenii_PYR-1 RPLAGVRVVEISSFVAVPLAGMTLAQLGAEVLRVDPVGGAADYKRWPLTE
MSMEG_2468|M.smegmatis_MC2_155 RPLAGVRIIEISSFVAVPLAGMTLAQLGAEVVRVDPIGGAADYHRWPVTD
MAB_4651c|M.abscessus_ATCC_199 GALDGIRVLELGTLIAGPFAGRLLGDMGAEVLKIEPPGAPDPLRTWGQAE
TH_4570|M.thermoresistible__bu APFAGLKVFDLSTFWAGAYLTCYLGAFGADVVKVESIQRPDAHRYSGALL
.: *. :.:. * . * :**:*::::. :
Mb3300|M.bovis_AF2122/97 GRPP----LATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTADVVLEAF
Rv3272|M.tuberculosis_H37Rv GRPP----LATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTADVVLEAF
MMAR_4031|M.marinum_M SGT------SIYWTGLNKGKRSATIDLRSAAGQRLVQRLVLEGDGVVVTN
MUL_3896|M.ulcerans_Agy99 SGT------SIYWTGLNKGKRSATIDLRSAAGQRLVQRLVLEGDGVVVTN
MAV_1574|M.avium_104 DGT------SIYWTGLNKGKRSATIDLRSAEGQRLVQRLIVEGDGVVVTN
Mflv_4144|M.gilvum_PYR-GCK SGD------SIYWAGLNKGKKSLAVDMRSGQGQALVARLIADA-GVFITN
Mvan_2197|M.vanbaalenii_PYR-1 AGD------SIYWAGLNKGKRSLAVDMRSDTGQELVARLIADS-GVFITN
MSMEG_2468|M.smegmatis_MC2_155 GGD------SIYWAGLNKGKRSVAADMRSPEGQQVVQRLIAES-GVLITN
MAB_4651c|M.abscessus_ATCC_199 VDG-----HHVFWTVHARNKKAITLDLRTEAGRALFLDLVDKSDVIVENF
TH_4570|M.thermoresistible__bu RQGDDWYERGPLWQGTNLNKRDLTLDLNSGRGRELALRLAADADVVVENF
: .*: : *: : .: * . :.
Mb3300|M.bovis_AF2122/97 RPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDLVVAAEA
Rv3272|M.tuberculosis_H37Rv RPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDLVVAAEA
MMAR_4031|M.marinum_M AS----LPWLSHEVLAATRSDIIHLQLLGRRDGG-----TGVDYTVNAAT
MUL_3896|M.ulcerans_Agy99 AS----LPWLSHEVLAATRSDVIHLQLLGRRDGG-----TGVDYTVNAAT
MAV_1574|M.avium_104 AAG---LSWLSHDALAALRADVIHVQLLGRGDGS-----TGVDYTVNAGI
Mflv_4144|M.gilvum_PYR-GCK VAG---RQWHSYDALRTDRPDLIHAEVSGRHDGG-----TGVDYTVNAAI
Mvan_2197|M.vanbaalenii_PYR-1 VAG---RQWHSYDALRQIRPDLIHVEVSGRHDGG-----TGVDYTVNAAI
MSMEG_2468|M.smegmatis_MC2_155 AAG---RQWHSYEELAALRSDLIHVEVSGRADGG-----TGVDYTVNAAL
MAB_4651c|M.abscessus_ATCC_199 RPGTLERWGLGYDVLAQRNKGIILVRVSGYGQTGPDAHKAGYASVAEAAS
TH_4570|M.thermoresistible__bu SPRVVEQFGLDYDSLAAGNPDVIMVRMPGFGLAGPWRDYVGWALNIEQLA
. . : * . .:* .: . . *
Mb3300|M.bovis_AF2122/97 GMTTGMPTPEGK-PQIIPFQLVDNASGHVLAQAVLAALLHRERNGVADVV
Rv3272|M.tuberculosis_H37Rv GMTTGMPTPEGK-PQIIPFQLVDNASGHVLAQAVLAALLHRERNGVADVV
MMAR_4031|M.marinum_M GFPLVTGPADHAGPINHVLPAWDVSCGLYAALSVVAALRRRDQTGAGAQI
MUL_3896|M.ulcerans_Agy99 GFPLVTGPADHAGPINHVLPAWDVSCGLYAALVVVAALRRRDQTGAGAQI
MAV_1574|M.avium_104 GYPLVTGPAEHAGPINHVLPAWDVCCGLYAALSVVTAVHRREQSGAGARI
Mflv_4144|M.gilvum_PYR-GCK GFPLVTGPPELSTPVNHVLPAWDVTCGIYTALSVVTALRHRDATGHGQQI
Mvan_2197|M.vanbaalenii_PYR-1 GFPLVTGPPELTTPVNHVLPAWDVTCGIYAALSVVTALRHRDATGHGQQI
MSMEG_2468|M.smegmatis_MC2_155 GFPLVTGPAEVSTPVNHVLPAWDVSCGLYVALAVTAALRHRDATGEGARI
MAB_4651c|M.abscessus_ATCC_199 GLRHLNGFPGGP-PPRMALSIGDTLAGMFAAQGALAALYRRTVTGRGQVV
TH_4570|M.thermoresistible__bu GMSAVTGYPDGP--PCNLQGPADPIAGVHAGVALLAALHERRRTGGGQLI
* . * .* . :*: .* .* . :
Mb3300|M.bovis_AF2122/97 QVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKGVGFATQP-S
Rv3272|M.tuberculosis_H37Rv QVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKGVGFATQP-S
MMAR_4031|M.marinum_M SLALEDVALATAGNLGLLTEPQVNG---------TQRERLGNSIYGQY-G
MUL_3896|M.ulcerans_Agy99 SLALEDVALATAGNLGLLTEPQVNG---------TQRERLGNSIYGQY-G
MAV_1574|M.avium_104 SLALEDVALATAANLGLLTEPQVVG---------TQRERLGNAIYGQY-G
Mflv_4144|M.gilvum_PYR-GCK SIPLENVALATAGNLSLLTEAMING---------TSRQRIGNAVYGTY-G
Mvan_2197|M.vanbaalenii_PYR-1 SIPLENVALATAGNLSLLTEAMING---------TSRQRIGNAVYGTY-G
MSMEG_2468|M.smegmatis_MC2_155 SVPLENVALATAGNLGFLTEVMING---------TSRERLGNSLFGTY-G
MAB_4651c|M.abscessus_ATCC_199 DAALTESCLAVQEST--IPDYDVGR---------VVRGPSGTRLEGIAPS
TH_4570|M.thermoresistible__bu EVAQIEVGAAVTAEP--VIEYSMNG---------VIREREGNRHRSYAQG
. . : . . : : * .
Mb3300|M.bovis_AF2122/97 DAFRTADG-YIVISAYVPKHWQKLCYLIGRP---DLVE------DQRFAE
Rv3272|M.tuberculosis_H37Rv DAFRTADG-YIVISAYVPKHWQKLCYLIGRP---DLVE------DQRFAE
MMAR_4031|M.marinum_M QDFASRDGTSFMVITLTRRHFRDLVDVTGTG---PAVTALAEALGVDFDA
MUL_3896|M.ulcerans_Agy99 QDFASRDGTSFMVITLTRRHFRDLVDVTGTG---PAVTALAEALGVDFDA
MAV_1574|M.avium_104 QDFTSRDGARFMVVTLTGRHFRDLLDVTGTG---AAVSALADALGVDFGS
Mflv_4144|M.gilvum_PYR-GCK QNFTSSDGVSFMVVALTGRHFRDLNALTGTT---ESVAALSRSLDVDFSD
Mvan_2197|M.vanbaalenii_PYR-1 QNFTSSDGISYMVVALTGRHFRDLTALTGTT---EAVAVLADSLGADFSD
MSMEG_2468|M.smegmatis_MC2_155 QNFTSSDGVFFMLVALTGRHFRDLTEVTGTT---KAVAALGEALGADFTD
MAB_4651c|M.abscessus_ATCC_199 NIYQSADGSWVVIAANQDTVFRRLCEAMGRP---ELSS------DARFAN
TH_4570|M.thermoresistible__bu VYPCRDEDDWVAISVRDDTDWANLVAAMDLPGLAR---------DERFRT
:. : . : * . . *
Mb3300|M.bovis_AF2122/97 QRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDT
Rv3272|M.tuberculosis_H37Rv QRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDT
MMAR_4031|M.marinum_M EGDRYRYRSVLNGLFAAWFADHTAEQIGAALSATTVLFERYRTFAEVAAD
MUL_3896|M.ulcerans_Agy99 EGDRYRYRSVLNGLFAAWFADHRAEQIGAALSATTVLFERYRTFAEVAAD
MAV_1574|M.avium_104 EGERYRYRDVLSGLFATWFGDHTADEITAALSHTTVLFERYRTFAEVAAG
Mflv_4144|M.gilvum_PYR-GCK EGERYRHREALGGLYAEWFSAHTGAEISAALSETSVLWERYQTFAETAAD
Mvan_2197|M.vanbaalenii_PYR-1 EGERYRHREALSGLFAEWFTSHTGVEVAAALSATSVLWERYQTFGETAAA
MSMEG_2468|M.smegmatis_MC2_155 EGQRYTHRDALTGLFTLWFSEHTADEITEALSGTSVLWERYRTFAQTAGD
MAB_4651c|M.abscessus_ATCC_199 HVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPINTVADVVQD
TH_4570|M.thermoresistible__bu AAQRRRHHDEFDDVVSTWTRGRTAEQAVAAAIAHGVPAERILTGDRMYDL
* : : : : *
Mb3300|M.bovis_AF2122/97 PLFAESDLTLEVGR-GADTITVIR--TPARYASFRAVVTDPPP-TAGEHN
Rv3272|M.tuberculosis_H37Rv PLFAENDLTLEVGR-GADTITVIR--TPARYASFRAVVTDPPP-TAGEHN
MMAR_4031|M.marinum_M PKVTANPLFSQLSQPGVGDYLAPG--LPTAFDGCHPAGAPAPA-LGEHTA
MUL_3896|M.ulcerans_Agy99 PKVTANPLFSQLSQPGVGDYFAPG--LPTAFDGCHPAGAPAPA-LGEHTA
MAV_1574|M.avium_104 PKVTANPLFSRLHQPGLGDYFAPG--LPAAFDGTHPAGAPAPA-LGQDTA
Mflv_4144|M.gilvum_PYR-GCK ARVTDNPLFTELDQPRVGTHLAAG--LPVSIDGVYPRAVPAPA-LGDDTD
Mvan_2197|M.vanbaalenii_PYR-1 PRVTDNPLFTELDQPRVGRYLAAG--LPLSINGAYPAAVPAPA-LGDDTA
MSMEG_2468|M.smegmatis_MC2_155 RRVTDNPLFTPLDQPRIGRYLAPG--LPVSIGGVYPAAVAAPA-LGDDTA
MAB_4651c|M.abscessus_ATCC_199 PQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGPARPGQDND
TH_4570|M.thermoresistible__bu PQLDARGYYEEIEHPITGTHRYPG--WPFRISPGPARHHRTPPPTLGQHN
. . * *. .
Mb3300|M.bovis_AF2122/97 AVFLARP----------------------------
Rv3272|M.tuberculosis_H37Rv AVFLARP----------------------------
MMAR_4031|M.marinum_M DVLTEYLGLTTADIARLASAKTIGGPDGQQDKEYA
MUL_3896|M.ulcerans_Agy99 DVLTEYLGLTTADTARLASAKTIGGPDGQQDKEYA
MAV_1574|M.avium_104 EVLAR-LGLTAADIERLADAKTIAC----------
Mflv_4144|M.gilvum_PYR-GCK SVLGDWLSLDAARIDELRETGTVA-----------
Mvan_2197|M.vanbaalenii_PYR-1 AVLGDWLAMDRGRIDDLFGAGTVA-----------
MSMEG_2468|M.smegmatis_MC2_155 AVLAEHLGLSAEKIAELTESGTVATGSAQK-----
MAB_4651c|M.abscessus_ATCC_199 DVYVGLLGKSAQDIERLRAEGVL------------
TH_4570|M.thermoresistible__bu TEILRALGVTDDELGELADQRVIGRRLLHAD----