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TDTIDSLLRDQAAAHGARDAVVDPAERISYAELNRSTGELGAAFVASGIGKGMRVALLMPNGVAWARIAL ALMRFGAVVVPLSTLLTARELSAQLQTASVQHLIAVEEFRGHRYHLDATPPALRSVRTPEQVFALRGHPA AAEVAEAMSRGVRPADPLTVVFTSGSSGAPKGVRHSHGNAIGAVRSGLAARCVDADTRLYLPMPFFWIGG LGGGLLSALTAGATLITEPVPQPDSTLRLLADERVTLFRGWPDQAEALARHLPASGVELTELRAGSLDAL LPPRLRSRPGARARLFGMTESFGPYCGYPADTDMPETAWGSCGKPFDGMQVRIVGADTGEPAPTGAIGMI QIRGRHVMRGICRRSREEVFTSDGWYATGDLGHLDADGFLYYHGRCDDMFKVRGATVYPSEVEQALRSLD GVSAAFVTNVAGPEGDRVGAAVVCDAPATAERLRSAAREVLSSFKVPTVWLLLDSQDGVPRGATGKVDVT RLRALLEQS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1980 | - | - | 100% (500) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_1981 | - | 1e-69 | 36.40% (489) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_2960 | - | 6e-59 | 33.46% (535) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3591 | fadD3 | 2e-47 | 33.13% (501) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4364 | - | 0.0 | 76.80% (500) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3561 | fadD3 | 4e-47 | 33.13% (501) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 8e-25 | 26.98% (530) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_0596c | - | 3e-45 | 28.82% (517) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_4027 | - | 0.0 | 64.75% (505) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_1577 | - | 0.0 | 65.27% (501) | AMP-binding enzyme, putative |
| M. smegmatis MC2 155 | MSMEG_2215 | - | 1e-176 | 62.98% (497) | AMP-binding enzyme |
| M. thermoresistible (build 8) | TH_4352 | - | 1e-124 | 73.58% (299) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 4e-46 | 32.60% (500) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3591|M.bovis_AF2122/97 -----------------MINDLR----TVPAALDRLVRQLPDHTALIAED
Rv3561|M.tuberculosis_H37Rv -----------------MINDLR----TVPAALDRLVRQLPDHTALIAED
MUL_4126|M.ulcerans_Agy99 -----------------MTSDPR----TVPTALDRLVRRLPNHDALVTDE
MAB_0596c|M.abscessus_ATCC_199 -----------------MESAQQTPGLTIPAALDQAAARFGERDALYADG
Mvan_1980|M.vanbaalenii_PYR-1 -----------------MTD-------TIDSLLRDQAAAHGARDAVVDPA
Mflv_4364|M.gilvum_PYR-GCK -----------------MTD-------TVDALLRAQAERHPDTEAVVDPA
MMAR_4027|M.marinum_M -----------------MPD-------TIDHLVRSQAARHGAKPMVIDQA
MAV_1577|M.avium_104 -----------------MPEAST---PTIDRLVRSRAAEFGGKPMVIDPG
TH_4352|M.thermoresistible__bu --------------------------------------------------
MSMEG_2215|M.smegmatis_MC2_155 -----------------MTEH-----LTVGALIRHHAADTPDKPMVVDPK
MLBr_02661|M.leprae_Br4923 MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPSAPALVVTD
Mb3591|M.bovis_AF2122/97 R--RFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLAIH
Rv3561|M.tuberculosis_H37Rv R--RFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLAIH
MUL_4126|M.ulcerans_Agy99 R--SFTVSELNDEVYRAAAALIELGVKPAARVGIWSPNTWHWVVACLAIH
MAB_0596c|M.abscessus_ATCC_199 S--WLSFSELRARARRFAAALIALGVEHGQRLAIWSPNSWHWPIACLGGQ
Mvan_1980|M.vanbaalenii_PYR-1 E--RISYAELNRSTGELGAAFVASGIGKGMRVALLMPNGVAWARIALALM
Mflv_4364|M.gilvum_PYR-GCK E--RITYRELDAATRELGAAFVASGITKGTRVGLLMPNGVEWARTALALM
MMAR_4027|M.marinum_M S--RLSYRELDSSTSDLAAAFIQAGAGKGTRVGLIMPNGVRWVQIAIALT
MAV_1577|M.avium_104 Y--RITYDQLDTATRELAAVFVQAGVGKGTRVGLIMPNNTRWVLIAIALT
TH_4352|M.thermoresistible__bu --------------------------------------------------
MSMEG_2215|M.smegmatis_MC2_155 E--RIAYGDLDEKTRAMASGLVAAGVGKGSRVGLLMPNGTDWVLTALAVT
MLBr_02661|M.leprae_Br4923 NRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAASNIEFVVGLLAAS
Mb3591|M.bovis_AF2122/97 HAGAAVVPLNTRYTATEATDILDRAGAPV-LFAAGLFLGADRAAGLDRAA
Rv3561|M.tuberculosis_H37Rv HAGAAVVPLNTRYTATEATDILDRAGAPV-LFAAGLFLGADRAAGLDRAA
MUL_4126|M.ulcerans_Agy99 HVGAAMVPLNTRYTADEAADILARTEAPV-LFAMGHFLGSDRVAGLDRKA
MAB_0596c|M.abscessus_ATCC_199 YAGAAVVPMNTRYTVDEATDILQRSHARV-LVSVGKFLGTDRIEQLDTSS
Mvan_1980|M.vanbaalenii_PYR-1 RFGAVVVPLSTLLTARELSAQLQTASVQH-LIAVEEFRGHRY--HLDAT-
Mflv_4364|M.gilvum_PYR-GCK RIGAVLVPLSTLLTPPELDAQLRTASVQH-LIAVEEFRGHRYLDRLDAD-
MMAR_4027|M.marinum_M RIGAVLVPLSTLLRPRELASQLRSAAVQF-LISVPEFRGHRYLDAVESVP
MAV_1577|M.avium_104 RIGAVLVPLSTLLRAGELVAQLRVAAVQF-LVSVDEFRGHRYLDDVAAV-
TH_4352|M.thermoresistible__bu --------------------------------------------------
MSMEG_2215|M.smegmatis_MC2_155 RIGAILVPLSTMLTPTELEAQLRTASVQF-LIAVDEFRGRGYPVAPERL-
MLBr_02661|M.leprae_Br4923 RAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALEGVSDQRAATMRY
Mb3591|M.bovis_AF2122/97 LPALRHVVRVPVEA-DDGTWDEFIATGAG-ALDAVAARAAAVAPQDVSDI
Rv3561|M.tuberculosis_H37Rv LPALRHVVRVPVEA-DDGTWDEFIATGAG-ALDAVAARAAAVAPQDVSDI
MUL_4126|M.ulcerans_Agy99 LPALRHIVRIPIEE-PDGTWDEFIETGT--DTGAVTARAAAVSPDDVSDI
MAB_0596c|M.abscessus_ATCC_199 LPDLRHIVRVAVEDGDESGWDAFVAHGDGVSDGDIDTRKAAVSSEDISDI
Mvan_1980|M.vanbaalenii_PYR-1 ---PPALRSVRTPE------QVFALRGHPAAAEVAEAMSRGVRPADPLTV
Mflv_4364|M.gilvum_PYR-GCK ---LPALSTVWTTD------QITGLRPGPGTAAVSDAMSRGVRAADPMAI
MMAR_4027|M.marinum_M RAELPALQRVWADD------QVSSSNAGARALRMVEPIAETVTAADTLVI
MAV_1577|M.avium_104 RSELPALQQVWPTE------QLDAAAAGARAGQIVDAMTQTVTPADPLVI
TH_4352|M.thermoresistible__bu --------------------------------------------------
MSMEG_2215|M.smegmatis_MC2_155 ----PALRQMWTAE------QALTMTGEPAS---ADALAARVRPSDPMVI
MLBr_02661|M.leprae_Br4923 WPIAVSYGSVTGAS----EGSLLVHLDDTAALHPVTSTPDGLR-HDDAMI
Mb3591|M.bovis_AF2122/97 LFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFG
Rv3561|M.tuberculosis_H37Rv LFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFG
MUL_4126|M.ulcerans_Agy99 LFTSGTTGRSKGVLCAHRQSLSASASWAANGKITADDRHLCINPFFHNFG
MAB_0596c|M.abscessus_ATCC_199 LFTSGTTGRSKGVLCMHRQPLAASLAWATYGEFTENDRYLCVNPFFHNFG
Mvan_1980|M.vanbaalenii_PYR-1 VFTSGSSGAPKGVRHSHGNAIGAVRSGLAARCVDADTRLYLPMPFFWIGG
Mflv_4364|M.gilvum_PYR-GCK LFTSGSSGPPKGVIHSHGNAIGAVRSGLDARCIDDRTRLYLPMPFFWVGG
MMAR_4027|M.marinum_M MFTSGSTGAPKGVLHSHGSALGAVRSGLTARRITSATRLYLPMPFFWVGG
MAV_1577|M.avium_104 MFTSGSSGTPKGVWHSHGSALGAVQSGLAARCIDADSRLYLPMPFFWVGG
TH_4352|M.thermoresistible__bu --------------------------------------LYLPMPFFWVGG
MSMEG_2215|M.smegmatis_MC2_155 LFTSGSSGPPKGVIHSHGNAVRAVASGLAARCVTADTRLYLPMPFFWVGG
MLBr_02661|M.leprae_Br4923 MFTGGTTGLPKMVPWTDGNIAGSVHAIITAYQLGPQDATVVVMPLYHGHG
*:: *
Mb3591|M.bovis_AF2122/97 YKAGILACLQTG--ATLIPHVTFDPLHALRAIERHRITVLPGPPTIYQSL
Rv3561|M.tuberculosis_H37Rv YKAGILACLQTG--ATLIPHVTFDPLHALRAIERHRITVLPGPPTIYQSL
MUL_4126|M.ulcerans_Agy99 YKAGILACLQTG--ATLFPHLTFDPLRTLQAIERHRITVLPGPPTIYQTL
MAB_0596c|M.abscessus_ATCC_199 YKAGILACLQTG--AALMPQLTFDPEKAMAAVQEHKITVLPGAPTIFQML
Mvan_1980|M.vanbaalenii_PYR-1 LGGGLLSALTAG--ATLITEPVPQPDSTLRLLADERVTLFRGWPDQAEAL
Mflv_4364|M.gilvum_PYR-GCK FGGGLLSALVAG--ATLVTEAVPQPDSTLRLLTAERVTLFRGWPDQAEAL
MMAR_4027|M.marinum_M FGGGILSALLAG--ATLVTEARPFPENTLRLLEAERVTMFRGWPDQAEAL
MAV_1577|M.avium_104 FGSGILSALLAG--ATLVTEEIPRPETTLRLLESERVTLFRGWPDQAETL
TH_4352|M.thermoresistible__bu FGGGVLSALVAG--ATLVTEEKPQPHTTLRLLERERVTLFRGWPDQAEAL
MSMEG_2215|M.smegmatis_MC2_155 FGAGIVTALVAG--ATLVTEPIPSPQSTLDLLHRERVTLFRGWPDQAEAL
MLBr_02661|M.leprae_Br4923 LIAALLSTLASGGVVLLPARARFSARTFWDDIDAVAATWYTAAPAIHRIL
..::: * :* . * .. . : * . * . *
Mb3591|M.bovis_AF2122/97 LDHPARKDFDLSSLRFAVTGAATVPVVLVERMQS-ELDIDIVLTAYGLTE
Rv3561|M.tuberculosis_H37Rv LDHPARKDFDLSSLRFAVTGAATVPVVLVERMQS-ELDIDIVLTAYGLTE
MUL_4126|M.ulcerans_Agy99 LDHPARDDYDLSSLRFAVTGAATVPVVLVERMQS-ELDIDIVLTAYGLTE
MAB_0596c|M.abscessus_ATCC_199 LDHPARKNYDLTSLRYSVTGAAVVPVVLIERMQS-ELDFDLVLTAYGLTE
Mvan_1980|M.vanbaalenii_PYR-1 ARHLPASGVELTELRAGSLDALLPPRLRSR--------PGARARLFGMTE
Mflv_4364|M.gilvum_PYR-GCK ARHLPASGVELN-LRPGSLEALLPPNLRAR--------PGARANLFGMTE
MMAR_4027|M.marinum_M ARHPSSVDVDLSALQPGSLPALLPPERRAQ--------PGARARLFGMTE
MAV_1577|M.avium_104 ARHAGTVGADLSALRPGSLQALLPPEQRAR--------PGARATLFGMTE
TH_4352|M.thermoresistible__bu ARHRESVGADLSSLRPGSLEALLPPDQRAD--------RGARANLFGMTE
MSMEG_2215|M.smegmatis_MC2_155 ARHASST--DLSALRPGSLEALLPHELRAQ--------PGARASLFGMTE
MLBr_02661|M.leprae_Br4923 LELASTQSFRSKRAKLRFIRSCSAPLTQETAQALREEFLAPVICAFGMTE
. : : :*:**
Mb3591|M.bovis_AF2122/97 ANGMGTMCRP----EDDAVTVAT-TCGRPFADFELRIADD----------
Rv3561|M.tuberculosis_H37Rv ANGMGTMCRP----EDDAVTVAT-TCGRPFADFELRIADD----------
MUL_4126|M.ulcerans_Agy99 ANGMGTMCRA----DDDALTVAT-TCGRPFADFELRIGPDT---------
MAB_0596c|M.abscessus_ATCC_199 TQGFATICRS----DDDAVTVAT-TCGRPMLGYELRIDGAEK-----PGD
Mvan_1980|M.vanbaalenii_PYR-1 SFGPYCGYPA----DTDMPETAWGSCGKPFDGMQVRIVGADTGEPAPTGA
Mflv_4364|M.gilvum_PYR-GCK SFGPYCGHPA----DTDMPETAWGSCGTPFDGMQVRITDPGTGEELPAGA
MMAR_4027|M.marinum_M AFGPYCGYRA----DTDMPPTAWGSCGKPFPGMEIRIVDPETGTRVPAET
MAV_1577|M.avium_104 AFGPYSGYPA----DTDMPVSARGSCGKPFDGMEVRIVDPDTGAPVGAGT
TH_4352|M.thermoresistible__bu SFGPYCGYRA----DTDMPRSAWGSCGKPFPGMEVRIVDPDSGAPVPAGT
MSMEG_2215|M.smegmatis_MC2_155 SFGPYCGYPA----DADMPRSAWGSCGRPFDSMDVRIVDTTTGTPLRVDE
MLBr_02661|M.leprae_Br4923 ATHQVTTTNIKWFGQGENPTVTNGLVGQSTG-VQIRIVGSD-GQPLPPDT
: : : : * . ::**
Mb3591|M.bovis_AF2122/97 -GEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLRIND
Rv3561|M.tuberculosis_H37Rv -GEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLRITD
MUL_4126|M.ulcerans_Agy99 -GEVLLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIGVLDEAGNLRITD
MAB_0596c|M.abscessus_ATCC_199 EGEVLLRSANVMKGYLDDPKATAEAIDDDGWLHTGDIGKLDARGNLTITD
Mvan_1980|M.vanbaalenii_PYR-1 IGMIQIRGRHVMRGICR--RSREEVFTSDGWYATGDLGHLDADGFLYYHG
Mflv_4364|M.gilvum_PYR-GCK TGMIQIRGPHLMRGICR--RTREDVFTPDGFYPTGDLGHLDSDGFLFYHG
MMAR_4027|M.marinum_M IGQIQIRGPHTLRGLCR--RSREEVFTADGYYCSGDLGHLDANGYLFYHG
MAV_1577|M.avium_104 AGIIQIRGPHTLRGMCG--RSREELFTVDGFYPTGDLGHLDDAGFLFYHG
TH_4352|M.thermoresistible__bu VGEIQLRGPHLMRGICR--RSREEVFTPDGFYPTGDLGRLDADGFLFYHG
MSMEG_2215|M.smegmatis_MC2_155 VGEIQIRGPHILRGICR--RGREEVFTRDGYYPTGDLGRLDSDGFLFYHG
MLBr_02661|M.leprae_Br4923 VGEVWLRGSTVVRGYLGDPAITAANFT-HGWLRTGDLGSLSVTGDLRIRG
* : :*. : * : .*: :**:* :. * * .
Mb3591|M.bovis_AF2122/97 RLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVV
Rv3561|M.tuberculosis_H37Rv RLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVV
MUL_4126|M.ulcerans_Agy99 RLKDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHRLGEVGRAFIV
MAB_0596c|M.abscessus_ATCC_199 RLKDMYICGGFNVYPAEIEQVLMRLDGVADVAVIGVPDARLGEVGKAYIV
Mvan_1980|M.vanbaalenii_PYR-1 RCDDMFKVRGATVYPSEVEQALRSLDGVSAAFVTNVA-GPEGDRVGAAVV
Mflv_4364|M.gilvum_PYR-GCK RCDDMFKVRGATVYPAEVEQALRTVDGVRAASVTNLP-GPEGNRVGAAVV
MMAR_4027|M.marinum_M RSDDMFKVSGATVYPVEVETALRTIDGVSNAFVTNVA-GAQGQRVAAAVV
MAV_1577|M.avium_104 RADDMFKVSGATVYPSEVERALRTIDGVDGAVVTNVP-GATGDRVGAAVV
TH_4352|M.thermoresistible__bu RRDDMFKVSGATVYPGEVADALRSIDGVRAAYVTDVADGRGGDRVGAAVV
MSMEG_2215|M.smegmatis_MC2_155 RSDDMFKVSGATVYPGEAQHALRGIAGVRAAYVVNVP-DHQRNRVGAVVV
MLBr_02661|M.leprae_Br4923 RIKELINRSGEKISPERVEGVLASHHNVMEVAVFGDPDKVYGETVTAVIV
* .:: * .: * . .* .* . * . . : * :*
Mb3591|M.bovis_AF2122/97 ARPGTGLDEASVIAYTREHLANFKTPRSVRFVD---VLPRNAAGKVSKPQ
Rv3561|M.tuberculosis_H37Rv ARPGTGLDEASVIAYTREHLANFKTPRSVRFVD---VLPRNAAGKVSKPQ
MUL_4126|M.ulcerans_Agy99 ARPGFNLDEKSVIDYTREHLANFKAPRSVRFVD---TLPRNAGGKVVKPQ
MAB_0596c|M.abscessus_ATCC_199 LKPGATLNADSVIEYSAKHVANFKKPRFVDFLD---ELPRNLGGKVVKPT
Mvan_1980|M.vanbaalenii_PYR-1 CD--APATAERLRSAAREVLSSFKVPTVWLLLDSQDGVPRGATGKVDVTR
Mflv_4364|M.gilvum_PYR-GCK CD--ASLTVDVLRRAAREVLSSFKVPSVWALLPDEAAIPRGATGKVDTAR
MMAR_4027|M.marinum_M CST-PALTSEDLRTSAGQVLSAFKVPTVWLLLADDANIPRGPTGKVDLQR
MAV_1577|M.avium_104 CR---ELTAAQLRAAARNLLSSFKVPSVWLVLRSDDDLPRGVTGKVDVRR
TH_4352|M.thermoresistible__bu GT---VTDVGQLRREARKLLSSFKVPTVWLLLDSDDAVPRRATGKVDVNR
MSMEG_2215|M.smegmatis_MC2_155 TD---GMSARDLCAAAREVLSPFKVPSVWALLDDEAAVPIGATGKVDNNG
MLBr_02661|M.leprae_Br4923 PREVIAPTPSELAVFCRDRLAAFEVPTRFQEAS---ALPHTAKGSLDRRA
: . :: *: * :* *.:
Mb3591|M.bovis_AF2122/97 LRELG-------------
Rv3561|M.tuberculosis_H37Rv LRELG-------------
MUL_4126|M.ulcerans_Agy99 LRELA-------------
MAB_0596c|M.abscessus_ATCC_199 LRAMHGEQRRAQKESS--
Mvan_1980|M.vanbaalenii_PYR-1 LRALLEQS----------
Mflv_4364|M.gilvum_PYR-GCK LRELLQD-----------
MMAR_4027|M.marinum_M LRDMLANTA---------
MAV_1577|M.avium_104 LRELLADADRRQETRVQG
TH_4352|M.thermoresistible__bu LRDLLATHPDRVVT----
MSMEG_2215|M.smegmatis_MC2_155 LRAMLAERGER-------
MLBr_02661|M.leprae_Br4923 VAEQFAHRG---------
: