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TGYRIRASVVLAATLLVLVNGFAPWGQAAALRVDAILQVCTAAVAVVYGLWVARRVHGVSRTWRLLAVGA VAGLLVGELVWWERAGLLPLVGVIPYLLFLILGLASMLVLVGAGRGISVPADGSLRYTAVITVLDGLVAA AAFAILVFLVRYGAYSSSSWPHSSSPPIEIGYAVFQLVVVVVAAVVGMMYAADRPFRSNFLQLACGVVMA ISSDRVIAYFDSIGNEGAQIWAGVGLVLGPLLIAFSFRERTDATREPAETMRPMDWAQMTLPYAGFIGIT ILQAYHLLTGHTIGRGVVATTLVMVVLVAARQTVAMGTQRQLTRKLYEAQRGLAHQVHHDALTGLPNRLM FAQRLEAAVQHGDFVLIFVDLDDFKEVNDRFGHAAGDELLCAVGERLRRHVRSEDTLARIGGDEFAILID GVRDIPELIADRLRVALRDPFPVHGSSLRVRASMGLVRSGGAGGLQTPDDLLRQADISMYAGKRLGKDTA VVYQPSAGVRAEFPAALREAQGGVPDGFTLAYQPVVHLPDQTPAALEALARWTAPNGILIAPETFVAVAE ASGLGATLDAMVLRLACREVKDAGLDVDIHVNVGAARLGNPTFEEQVHRTFDECGMEPSRLVLEITETVP IVDLADAAAQIERFKALGIRIALDDFGAGYNSLTYLHALPVDIVKLDRSLAVGADPERDLALYRSVIGLC TDLGMDVVAEGIETQLQADTVHAAGCAFAQGHLFGKPVAISELTRGWHERSGQIGGGRGVNQPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4444 | - | - | 100% (765) | diguanylate cyclase/phosphodiesterase |
| M. gilvum PYR-GCK | Mflv_2740 | - | 0.0 | 53.12% (736) | diguanylate cyclase/phosphodiesterase |
| M. gilvum PYR-GCK | Mflv_2073 | - | 1e-68 | 28.84% (742) | diguanylate cyclase/phosphodiesterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 3e-64 | 36.79% (424) | hypothetical protein Mb1389c |
| M. tuberculosis H37Rv | Rv1354c | - | 3e-64 | 36.79% (424) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 1e-58 | 34.44% (421) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_1839 | - | 3e-13 | 34.81% (158) | diguanylate cyclase/phosphodiesterase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_3132 | - | 1e-57 | 33.18% (425) | GGDEF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 4e-60 | 34.19% (430) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 5e-64 | 36.05% (430) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1918 | - | 0.0 | 58.70% (741) | diguanylate cyclase/phosphodiesterase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4444|M.gilvum_PYR-GCK MTGYRIRASVVLAA--TLLVLVNGFAPWGQAAALRVDAILQVCTAAVAVV
Mvan_1918|M.vanbaalenii_PYR-1 MAAQRTRVRLLVAAGVPLLAVVNAMALWGDEVARRGEAILQVSTSLAAAA
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
MAV_3132|M.avium_104 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4444|M.gilvum_PYR-GCK YGLWVARRVHGVSRTWRLLAVGAVAGLLVGELVWWERAG-LLPLVGVIPY
Mvan_1918|M.vanbaalenii_PYR-1 CGVVVARRVGGAARWWRLLYVAALVSWVSGQILWWTGADEAAPALARAAY
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MLBr_01750|M.leprae_Br4923 --------------------------------------------------
MAV_3132|M.avium_104 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4444|M.gilvum_PYR-GCK LLFLILGLASMLVLVGAGRGISVPADGSLRYTAVITVLDGLVAAAAFAIL
Mvan_1918|M.vanbaalenii_PYR-1 LSLPVFALGAVVLLVRSSGGVTAPRDSPLRHPLVTNVLDGVVAGIAFLIL
MSMEG_2196|M.smegmatis_MC2_155 ---------------------------------MSESLDVLVTSVATQLM
TH_0811|M.thermoresistible__bu ---------------------------------VSTELDLLVTGVATKLM
MLBr_01750|M.leprae_Br4923 ---------------------------------MTRSLDELVTRVASKLM
MAV_3132|M.avium_104 ---------------------------------MSGTLDHLVTAAAAELM
Mb1389c|M.bovis_AF2122/97 ----------------------------MCNDTATPQLEELVTTVANQLM
Rv1354c|M.tuberculosis_H37Rv ----------------------------MCNDTATPQLEELVTTVANQLM
MAB_1839|M.abscessus_ATCC_1997 ----------MVTTYPGRNGFGSESNRCSTGAQVYGANNDILERVGLRRP
: :: .
Mflv_4444|M.gilvum_PYR-GCK VFLVRYGAYSSSSWPHSSSPPIEIGYAVFQLVVVVVAAVVGMMYAADRPF
Mvan_1918|M.vanbaalenii_PYR-1 VAMGGFGTHSTASLPRSGVPVVDVVFAVAELLLVAWAVVMAMLYEPGRPY
MSMEG_2196|M.smegmatis_MC2_155 AVEAATSVSVSQQVLAELVSFFDVDVSFLRHNDHRAHATRLVAEWPPRPV
TH_0811|M.thermoresistible__bu AADAATARDVSRRVLADLVRAFELDFSFLRHNDHEIRASKLIAEWPVREN
MLBr_01750|M.leprae_Br4923 AATAATAVTISEGVLAILVEHFGVDVSFLRHNNHDIHETKLIVEWPPRDY
MAV_3132|M.avium_104 AATAADAAQISERVLADLVSHFGVNFGFLRHNDHSIRATVLVAEWPPRN-
Mb1389c|M.bovis_AF2122/97 TVDAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLN
Rv1354c|M.tuberculosis_H37Rv TVDAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLN
MAB_1839|M.abscessus_ATCC_1997 VSRANAVFITAVGAAAILLAATGMSTIPLLCISLSIPAFLWGIRYARARA
. : : .
Mflv_4444|M.gilvum_PYR-GCK RSNFLQLACGVVMAISSDRVIAYFDSIGNEGAQIWAGVGLVLGPLLIAFS
Mvan_1918|M.vanbaalenii_PYR-1 RKNYLLLAGGLVMMAASDRVVAYFRSVGLEGGDLWGGIGLIIGPMVIAFA
MSMEG_2196|M.smegmatis_MC2_155 DAATDPIA--VVHFADADPVFAMAEHLKEP---------AVFRPEPLYDD
TH_0811|M.thermoresistible__bu VPDPDPIG--VVHFEGADPVFALAEHAKEI---------HIFRPEPATDE
MLBr_01750|M.leprae_Br4923 VPDPDPIG--VVYFADADPVFAMAEYLKEP---------AVLRPEPANAD
MAV_3132|M.avium_104 -VDPDPLG--VIYFADADSVFARVETMKEP---------DVLRPEPANAD
Mb1389c|M.bovis_AF2122/97 IPDPDPLR--LIYFADADPVFALCEHAKEP---------LVFRPEPATED
Rv1354c|M.tuberculosis_H37Rv IPDPDPLR--LIYFADADPVFALCEHAKEP---------LVFRPEPATED
MAB_1839|M.abscessus_ATCC_1997 VTYGESVA--YVLYCDVAILIGICVVTTTG---------VAFVKLAWLLA
: : :.. :
Mflv_4444|M.gilvum_PYR-GCK FRERTDATREPAETMRPMDWAQMTLPYAGFIGITILQAYHLLTGHTIGRG
Mvan_1918|M.vanbaalenii_PYR-1 MLETSESDDSGAG--RGIDWAQLVLPYLGFLGIAVMFGFHVLIGRQLNPF
MSMEG_2196|M.smegmatis_MC2_155 YQRTIEAGRHIPAT------SMACVPLLSGDVTTGVLGFVKFGDREWLPA
TH_0811|M.thermoresistible__bu FQRLIEESSGVPAS------TVAAVPLVSGEITTGVLGFVKYGDRQWHPD
MLBr_01750|M.leprae_Br4923 YQRRIEEGASVPAV------SLACVPLLSGEITTGVLGFVKYGDREWHDD
MAV_3132|M.avium_104 YQRNIEDGTGIPEV------SLAAVPLLSGDVTTGTLGFVKFGDREWLSE
Mb1389c|M.bovis_AF2122/97 YQRLIEEARGVPVT------SAAAVPLVSGEITTGLLGFIKFGDRKWHEA
Rv1354c|M.tuberculosis_H37Rv YQRLIEEARGVPVT------SAAAVPLVSGEITTGLLGFIKFGDRKWHEA
MAB_1839|M.abscessus_ATCC_1997 VSAYVSLVHGRVAV------AMQSLVTTAGTVLAVVGAVSRDEYSAAALA
. : : . : .
Mflv_4444|M.gilvum_PYR-GCK VVATTLVMVVLVAARQTVAMGTQRQLTRKLYEAQRGLAHQVHHDALTGLP
Mvan_1918|M.vanbaalenii_PYR-1 VVSLTVAMVALVTVRQILATRAQSLLTQRLYWAQRGLAYQVHHDALTGLP
MSMEG_2196|M.smegmatis_MC2_155 ELNALKAIASLFAQVQARIE------------AEERLRYLADHDHLTGLY
TH_0811|M.thermoresistible__bu ELNALKAIASLFAQVQARVE------------AEERLRYLAEHDDLTGLH
MLBr_01750|M.leprae_Br4923 ELRALQAIATLFAQLQARIV------------AEEQLRYLAEHDDLTGLL
MAV_3132|M.avium_104 ELNALQAIAALFAQLQARVV------------AEEQIHYLAEHDELTGLL
Mb1389c|M.bovis_AF2122/97 ELNALMTIATLFAQVQARVA------------AEARLRYLADHDDLTGLH
Rv1354c|M.tuberculosis_H37Rv ELNALMTIATLFAQVQARVA------------AEARLRYLADHDDLTGLH
MAB_1839|M.abscessus_ATCC_1997 AAVVTMLLANLFAGLVIYVG------KAQFSEHADGRDRLARHDVLTGLL
:. *.: . ** ****
Mflv_4444|M.gilvum_PYR-GCK NRLMFAQRLEAAVQHG---DFVLIFVDLDDFKEVNDRFGHAAGDELLCAV
Mvan_1918|M.vanbaalenii_PYR-1 NRILFARRLDEAMAHG---RFVLIFVDLDDFKEVNDRFGHAAGDELLRAV
MSMEG_2196|M.smegmatis_MC2_155 NRRALMAHLEARLAPGQPGPVAVMFFDLDRLKAINDYLGHTAGDAFISIL
TH_0811|M.thermoresistible__bu NRRALLAHLDARLAAGQPGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVL
MLBr_01750|M.leprae_Br4923 NRRALIAHLDERLADGQRGPVTLLFLGLDRLKAVNDYLGHNAGDRLIEVF
MAV_3132|M.avium_104 NRRALIAHLDKRLAPGQPGPVPVVFLAIDRFKVINGRLGQDAGDRFIDAF
Mb1389c|M.bovis_AF2122/97 NRRALLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVF
Rv1354c|M.tuberculosis_H37Rv NRRALLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVF
MAB_1839|M.abscessus_ATCC_1997 NRRGLQEAYEATVGVPG-MHVTVVVVDLNLFKQINDTFGHHVGDQVLQRT
** : : : . : . :: :* :*. :*: .** .:
Mflv_4444|M.gilvum_PYR-GCK GERLRRHVRSEDTLARIGGDEFAILIDG--VRDIPELIADRLRVALRDPF
Mvan_1918|M.vanbaalenii_PYR-1 GERLKRCVTAADTLARIGGDEFAVLIVA--EAEQLEVVAERLRIALRDPF
MSMEG_2196|M.smegmatis_MC2_155 AQRLQRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQSVLRERV
TH_0811|M.thermoresistible__bu AERLREGAGPDDLIARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQV
MLBr_01750|M.leprae_Br4923 ADRLREAAESLTVIARFGGDEFVVVPAESVSVDVAESFAHRLQTRLQKQV
MAV_3132|M.avium_104 AALLREATEIPSVIARFGGDEFGVVPAAPMDVEAAESFAHSLHERLHHPI
Mb1389c|M.bovis_AF2122/97 AQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHV
Rv1354c|M.tuberculosis_H37Rv AQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHV
MAB_1839|M.abscessus_ATCC_1997 AHRLRSVVGPDALLARLGGDEFGIVVVG----------------------
. : :**:***** ::
Mflv_4444|M.gilvum_PYR-GCK PVHGSSLRVRASMGLVRSGGAGGLQTPDDLLRQADISMYAGKRLGKDTAV
Mvan_1918|M.vanbaalenii_PYR-1 PVHGSSVRVKASMGLVRPEGDGMPQTSDDLLRQADISMYAGKRMGKDTAV
MSMEG_2196|M.smegmatis_MC2_155 TVDGEMLTRTVSIGIAQ--GIPGKDSTSDVLNRADHAVLTAKGSGGNRVA
TH_0811|M.thermoresistible__bu CVDGEMLTRTASIGVAQ--GTPGRDTTSDLLRRADQAVLTAKSAGGNQIT
MLBr_01750|M.leprae_Br4923 VIDGEILTRTVSIGVAT--GLPGRDTTSDLLRWADHAALSAKSDG-SKVV
MAV_3132|M.avium_104 AIDDEMLSRTVSIGVAA--GIPGDESTSDLLRRVDQATRSAKAAGGNNVA
Mb1389c|M.bovis_AF2122/97 AIGGEVLTRTVSIGVAS--GTPGQHTPSDLLRRADQAALAAKHAGGDSVA
Rv1354c|M.tuberculosis_H37Rv AIGGEVLTRTVSIGVAS--GTPGQHTPSDLLRRADQAALAAKHAGGDSVA
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4444|M.gilvum_PYR-GCK VYQPSAGVRAEFPAALREAQGGVPDG----FTLAYQPVVHLPDQTPAALE
Mvan_1918|M.vanbaalenii_PYR-1 VYQPASGVIVDFPTMLRTADGGAPPG----FRLVYQPVVRLPEGTPVAVE
MSMEG_2196|M.smegmatis_MC2_155 VFSDAMAMEIDFRNDIELHLQSVIEG--GALVLHYLPEIDMRTGEVLAAE
TH_0811|M.thermoresistible__bu VFTDDMSLEAEFRNDIELHLQSVIQD--EALLLHFLPEVDMRTGEILATE
MLBr_01750|M.leprae_Br4923 VLDHGISAQHTLRTEVELHLAGMIDT---DLVLHYLPEVDMSTGKVLGTE
MAV_3132|M.avium_104 TFRPEMSTIDTIRNDIELYLEGMIDGGSGALVLHYLPEFDMRTGEILGTE
Mb1389c|M.bovis_AF2122/97 IFTADMSVSGELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTE
Rv1354c|M.tuberculosis_H37Rv IFTADMSVSGELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTE
MAB_1839|M.abscessus_ATCC_1997 ----DAPPHIDYQRAVEEALNSASED------------------------
:.
Mflv_4444|M.gilvum_PYR-GCK ALARWTAPNGILIAPETFVAVAEASGLGATLDAMVLRLACREVK-----D
Mvan_1918|M.vanbaalenii_PYR-1 ALARWTAPNGIDISPETFVAVTEAAGMGADFDALVLDLACREVQ-----G
MSMEG_2196|M.smegmatis_MC2_155 ALVRWEHPTRGLLSPDSFIGVAESINLAGELGRWVLRTACAEFSRWRANG
TH_0811|M.thermoresistible__bu ALVRWHHPTRGLLAPDTFIGVAESVNLAGELGRWVMRTACGEFAKWRAEG
MLBr_01750|M.leprae_Br4923 ALVRWQHPTRGLLFPDSFIPVAESINLAGKLGRMVMHSACAEFSRWRSAG
MAV_3132|M.avium_104 ALTRWQHPTLGLLMPDSFIQVAESINLGAKLGRLVMRSACAQFGQWRSRG
Mb1389c|M.bovis_AF2122/97 ALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAG
Rv1354c|M.tuberculosis_H37Rv ALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAG
MAB_1839|M.abscessus_ATCC_1997 ------------------VPVSASVGVAAAILP-----------------
: *: : .:.. :
Mflv_4444|M.gilvum_PYR-GCK AGLDVDIHVNVGAARLGNPTFEEQVHRTFDECGMEPSRLVLEITETVPIV
Mvan_1918|M.vanbaalenii_PYR-1 RGLNLDIHVNIGAARLGNPGFEQQVSQVLARHRIPRNRLVLEITETEPIV
MSMEG_2196|M.smegmatis_MC2_155 VGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEITESVVVQ
TH_0811|M.thermoresistible__bu IGLDAVLRINVSPVQLVTDGFVASVADIIDEFGLDGSSVCLEITESVVVQ
MLBr_01750|M.leprae_Br4923 VGLDALLRINVSPVQLVAEGFVDNVAGTLDEFGLDGSMVCLEITENVVVQ
MAV_3132|M.avium_104 VGQGTVLRINVSPVQLVTAGIVDTVAATLDEFGLDPSTVCLEITESVVVQ
Mb1389c|M.bovis_AF2122/97 LGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQ
Rv1354c|M.tuberculosis_H37Rv LGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQ
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4444|M.gilvum_PYR-GCK DLADAAAQIERFKALGIRIALDDFGAGYNSLTYLHALPVDIVKLDRSLAV
Mvan_1918|M.vanbaalenii_PYR-1 DLDRAAAQIRRLGQLGVRVALDDFGAGFNSLTYLHCLPVHIVKLDRSLAV
MSMEG_2196|M.smegmatis_MC2_155 DIETTRTTLTGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDTLKIDRSFVA
TH_0811|M.thermoresistible__bu DIKTTRITLEGLNEVGVQVAIDDFGTGYSVLSHLKTLPVDTLKIDKGFVQ
MLBr_01750|M.leprae_Br4923 NIDATRKTLAGLKEVGVHLAIDDFGTGYSVLTHLKSLPVDTIKIDKSFVA
MAV_3132|M.avium_104 DIDATRQTLFGLKDIGVQIAIDDFGTGYSVLTYLKSLPVDSLKIDKGFVQ
Mb1389c|M.bovis_AF2122/97 DLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVR
Rv1354c|M.tuberculosis_H37Rv DLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVR
MAB_1839|M.abscessus_ATCC_1997 --ESDRTTIHTLGPIVTHLLVEADGAMYGAKKAG----------------
: : : :: :: *: :. .
Mflv_4444|M.gilvum_PYR-GCK GADP-ERDLALYRSVIGLCTDLGMDVVAEGIETQLQADTVHAAGCAFAQG
Mvan_1918|M.vanbaalenii_PYR-1 GGEP-ARDLSLYRSVIRLCDDLGLDVIAEGIELPAQSEMVHSAGGRLAQG
MSMEG_2196|M.smegmatis_MC2_155 ELGSNPGDLPIVRAVIALAGAFGLQLVAEGVETERAALTLLRHGCYRAQG
TH_0811|M.thermoresistible__bu DLGNSPGDLAIVRAIIALAEAFGLQLVAEGVETEAAALTLLRHGCHRAQG
MLBr_01750|M.leprae_Br4923 ELGSNASDLAIVRAIMALAKEFELEVVAEGVETAVAAQVLLELGCNRAQG
MAV_3132|M.avium_104 SLDTNPGDLAIVRSTLALADAFGLDVVAEGVETVAAAETLLSLGCHRAQG
Mb1389c|M.bovis_AF2122/97 QLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQG
Rv1354c|M.tuberculosis_H37Rv QLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQG
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4444|M.gilvum_PYR-GCK HLFGKPVAISEL---TRGWHERSGQIGGGRGVNQPS-----
Mvan_1918|M.vanbaalenii_PYR-1 HLFGRPVPIAELGDAVIGDREWGLSPAALPDLTQAD-----
MSMEG_2196|M.smegmatis_MC2_155 FLLSKPILGSEMQTLLAKGRVPVHFS--AAPRM--------
TH_0811|M.thermoresistible__bu FLLSRPIPSNEMRELLARGRIPMRFS--ATP----------
MLBr_01750|M.leprae_Br4923 FLLSRPVDGAAMESLLAKGVIPMALGTCQSPEPSEHQIHRS
MAV_3132|M.avium_104 FLLSRPLDSAGMEALLIKGAIPMRFSDGGAPE-NQHVV---
Mb1389c|M.bovis_AF2122/97 FLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
Rv1354c|M.tuberculosis_H37Rv FLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
MAB_1839|M.abscessus_ATCC_1997 -----------------------------------------