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VSTVSSEPTTVTFRGAEDLALVADEWNNPAEAASSGRDFDASRPSVLMLHGGGQNRFSWKKTGQTLASQG LHVVALDSRGHGDSDRSPDANYTVEALCADTLAVLRQIGRPTVLIGASMGGLTGILASRQAGPELVTRLI LVDVVPRYEKDGSARIREFMFSHVHGFESLEQAAEAVAAYLPHRTKPRSPEGLKKNLRHRHGRWYWHWDP AFLTKPNEDPFVRVEQLEQAAIELTIPILLIRGKLSDVVSEEAVQDFLTKVPNAEFVELPGAGHTAAGDD NDAFSEVVAQFVLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4609 | - | - | 100% (294) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_0315 | - | 1e-57 | 45.05% (273) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_1862 | - | 5e-57 | 37.92% (298) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1154c | bpoB | 1e-108 | 64.97% (294) | peroxidase BpoB |
| M. gilvum PYR-GCK | Mflv_2096 | - | 1e-143 | 84.35% (294) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1123c | bpoB | 1e-108 | 64.97% (294) | peroxidase BpoB |
| M. leprae Br4923 | MLBr_02297 | - | 2e-09 | 21.94% (278) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2045 | - | 8e-65 | 45.72% (304) | putative hydrolase (alpha/beta fold) |
| M. marinum M | MMAR_4337 | bpoB | 1e-119 | 70.75% (294) | peroxidase BpoB |
| M. avium 104 | MAV_1254 | - | 1e-115 | 71.13% (284) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_5209 | - | 1e-122 | 71.77% (294) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2112 | - | 1e-101 | 65.58% (276) | hydrolase, alpha/beta fold family protein |
| M. ulcerans Agy99 | MUL_0147 | bpoB | 1e-117 | 69.73% (294) | peroxidase BpoB |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1154c|M.bovis_AF2122/97 MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAAD--
Rv1123c|M.tuberculosis_H37Rv MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAAD--
MMAR_4337|M.marinum_M --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTAASG--
MUL_0147|M.ulcerans_Agy99 --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTAASG--
MAV_1254|M.avium_104 ------------------------MEFAGVDGITLVADEWNRGSDGAG--
Mvan_4609|M.vanbaalenii_PYR-1 --------------MSTVSSEPTTVTFRGAEDLALVADEWNNPAEAASSG
Mflv_2096|M.gilvum_PYR-GCK --------------MSIEHREPKTVTFRGADGLALVADEWNNPAQTEA--
MSMEG_5209|M.smegmatis_MC2_155 --------------MSTAQTESQTVAFRGVDDLTLVGDEWNKGAERAA--
TH_2112|M.thermoresistible__bu --------------LNSTHSKPQTVRFRGAQGLTLVADQWNRGSGPKD--
MAB_2045|M.abscessus_ATCC_1997 ----------MSAKRTGDSSAPVVERVPTADGLALAVDLYHCDAP-----
MLBr_02297|M.leprae_Br4923 MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAPSATA--
. . :. . .
Mb1154c|M.bovis_AF2122/97 ------RPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDR
Rv1123c|M.tuberculosis_H37Rv ------RPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDR
MMAR_4337|M.marinum_M ------RPTILMLHGGGQNRFSWKNTGQILADTGLHVIALDTRGHGDSDR
MUL_0147|M.ulcerans_Agy99 ------RPTILMLHGGCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDR
MAV_1254|M.avium_104 ------RPSILMLHGGGQNRFSWKNTGQTLADEGLHVVALDSRGHGDSDR
Mvan_4609|M.vanbaalenii_PYR-1 RDFDASRPSVLMLHGGGQNRFSWKKTGQTLASQGLHVVALDSRGHGDSDR
Mflv_2096|M.gilvum_PYR-GCK --FDRSRPSVLMMHGGGQNRFSWKKTGQILGEQGLHVVALDSRGHGDSDR
MSMEG_5209|M.smegmatis_MC2_155 -----DRPTVLLLHGGGQNRYSWKNTGQILADQGFHVIALDARGHGDSDR
TH_2112|M.thermoresistible__bu ------RPTILLLHGGGQNRFSWKNTGQILADKGWHVVALDSRGHGDSDR
MAB_2045|M.abscessus_ATCC_1997 ------RAVVLLLHGGGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSDW
MLBr_02297|M.leprae_Br4923 ------RPLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGYGGSDK
*. ::::** . :* : * . : * * ** *.**
Mb1154c|M.bovis_AF2122/97 APGADYAVETPTTDVLHV--VEAIGRRVVVVEASMGGLTGILVAERAGPQ
Rv1123c|M.tuberculosis_H37Rv APGADYAVETPTTDVLHV--VEAIGRRVVVVEASMGGLTGILVAERAGPQ
MMAR_4337|M.marinum_M APDADYAIETLTSDILHV--LDAIGRPVVLIGASMGGLTGILVADSAGPD
MUL_0147|M.ulcerans_Agy99 APDADYAIETLTSDIRHV--LDAIGRPVVLIGASMGGLTGILVADSAGPD
MAV_1254|M.avium_104 SPQADYQIETLTADVLRV--LDAIGRPVTIIGASMGGLTGILAAHRAGPA
Mvan_4609|M.vanbaalenii_PYR-1 SPDANYTVEALCADTLAV--LRQIGRPTVLIGASMGGLTGILASRQAGPE
Mflv_2096|M.gilvum_PYR-GCK SPDARYTVEALCEDTLRV--LEQIGRPTVLIGASMGGLTGILAARRAGPE
MSMEG_5209|M.smegmatis_MC2_155 SPSANYSVDAMCGDVLAV--LYQISRPVALIGASMGGLTGLLAAHEAGPE
TH_2112|M.thermoresistible__bu SPTADYQLDDLCADTLSV--VDQIGRPVSLIGASMGGLTGILVADRAGAD
MAB_2045|M.abscessus_ATCC_1997 DPDGRYDMDRLGSDLLAVRSYADSGRPVAAIGASLGGLTILGTHLLAPPD
MLBr_02297|M.leprae_Br4923 PPRG-YDGWTLAGDTAGL--IRALGHSSATLVGHAEGGLACWATALLHPR
* . * * : .: : . * . .
Mb1154c|M.bovis_AF2122/97 TVNGLVLVDVVPRYEKEGNARIRDFMLGNIDGFGSLEEAADAVAEYLPHR
Rv1123c|M.tuberculosis_H37Rv TVNGLVLVDVVPRYEKEGNARIRDFMLGNIDGFGSLEEAADAVAEYLPHR
MMAR_4337|M.marinum_M RVTGLVLVDVVPKYEKDGSARIRDFMFTNLHGFATLEEAADAVATYLPHR
MUL_0147|M.ulcerans_Agy99 RVTGLVLVDVVPKYEKDGSARIRDFMFTNLHGFATLEEAADAVATYLPHR
MAV_1254|M.avium_104 KVTRLVLVDVVPRFEKDGSARIRDFMISGLDGFDSLEQAADAVAAYLPYR
Mvan_4609|M.vanbaalenii_PYR-1 LVTRLILVDVVPRYEKDGSARIREFMFSHVHGFESLEQAAEAVAAYLPHR
Mflv_2096|M.gilvum_PYR-GCK VVTRLVLVDVVPRYEKGGSARIRDFMFSHVHGFDSLEQAADAVAEYLPHR
MSMEG_5209|M.smegmatis_MC2_155 RVTQLVLVDVVPNFEKSGSARIRDFMASNVDGFDTLEEAADAVAAYLPHR
TH_2112|M.thermoresistible__bu KVTELVLVDVVPRVEQAGTDRIRDFMMTNVAGFETLEEAADAVAAYLPHR
MAB_2045|M.abscessus_ATCC_1997 LWQAVVLVDVTPRMEMDGARRVVAFMSAHPEGFDSLESAADVIAAYNPHR
MLBr_02297|M.leprae_Br4923 LVRAIALINSP-----HPAALRRSMLTHRNQGYALLPTLLRYQLPIWPER
: *:: :: *: * * *
Mb1154c|M.bovis_AF2122/97 DKPRS-PEGLKRNLRLR-DGRWHWHWDPAMMT----APGHDPQLRTENFE
Rv1123c|M.tuberculosis_H37Rv DKPRS-PEGLKRNLRLR-DGRWHWHWDPAMMT----APGHDPQLRTENFE
MMAR_4337|M.marinum_M TKPRS-PEGLKKNLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFE
MUL_0147|M.ulcerans_Agy99 TKPRS-PEGLKKNLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFE
MAV_1254|M.avium_104 SKPRS-PEGLKKNLRLR-DGRWYWHWDPAFMT----KPGDDPELRTESFE
Mvan_4609|M.vanbaalenii_PYR-1 TKPRS-PEGLKKNLRHR-HGRWYWHWDPAFLT----KPNEDPFVRVEQLE
Mflv_2096|M.gilvum_PYR-GCK AKPRS-PEGLKKNLRRR-NGRWYWHWDPAFLT----KPSEDPFARVEQLE
MSMEG_5209|M.smegmatis_MC2_155 RRPRN-PEGLKKNLRLR-DGRWYWHWDPAFLG----KPHDDPFVRVERLE
TH_2112|M.thermoresistible__bu RRPRS-PEGLKKNLRHR-DGRWHWHWDPAFVT----RVG-EQFVDVDVLE
MAB_2045|M.abscessus_ATCC_1997 PRPEN-LDGLRKVLARREDGRWSWRWDPAFVTSNFQFLQGDPDEGAEYFE
MLBr_02297|M.leprae_Br4923 LLTRNNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALE
... :.: : * .:* * *. :*
Mb1154c|M.bovis_AF2122/97 RA-------------------AMGLTIPVLLIRGKLSDVVSSDGARDFLA
Rv1123c|M.tuberculosis_H37Rv RA-------------------AMGLTIPVLLIRGKLSDVVSSDGARDFLA
MMAR_4337|M.marinum_M RA-------------------AMNLTIPILLIRGKLSDVVSSEGVQDFLD
MUL_0147|M.ulcerans_Agy99 RA-------------------AMNLTIPILLIRGKLSDVVTSEGVQDFLD
MAV_1254|M.avium_104 QA-------------------AKNLSIPVLLIRGKLSDVVSPEGVRHFLA
Mvan_4609|M.vanbaalenii_PYR-1 QA-------------------AIELTIPILLIRGKLSDVVSEEAVQDFLT
Mflv_2096|M.gilvum_PYR-GCK QA-------------------ATELTVPILLIRGKLSDVVSEEAVQDFLA
MSMEG_5209|M.smegmatis_MC2_155 QA-------------------AVNLTVPILLIRGKLSDVVSPEGVAEFLE
TH_2112|M.thermoresistible__bu RA-------------------ALRLTVPILLVRGKLSDVVSAEGVEEFLA
MAB_2045|M.abscessus_ATCC_1997 MMSAFL------------LDGARQVSAPTLLVRGLLSDIVSEETVRHFLT
MLBr_02297|M.leprae_Br4923 YQRWAVRSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRR
: .: * * :** . : : .
Mb1154c|M.bovis_AF2122/97 KVPNAEFVELSNAGRTAAGDDNDAFTDVVVDFVRRLS-------------
Rv1123c|M.tuberculosis_H37Rv KVPNAEFVELSNAGRTAAGDDNDAFTDVVVDFVRRLS-------------
MMAR_4337|M.marinum_M KVPHAEFVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG----------
MUL_0147|M.ulcerans_Agy99 KVPHAEFVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG----------
MAV_1254|M.avium_104 TVPRAEFVELSNAGHTAAGDDNDAFSDAVVAFVKRR--------------
Mvan_4609|M.vanbaalenii_PYR-1 KVPNAEFVELPGAGHTAAGDDNDAFSEVVAQFVLR---------------
Mflv_2096|M.gilvum_PYR-GCK KVPGAEFAELSGAGHTAAGDDNDAFSEVVTRFVLR---------------
MSMEG_5209|M.smegmatis_MC2_155 KVPAAEFVELSDAGHTAAGDDNDAFTQVVVEFVNR---------------
TH_2112|M.thermoresistible__bu KVPSAEFVELSAAXXXATIPARGSPRRCVTSPVCRRRPPTSRPAPSPRSA
MAB_2045|M.abscessus_ATCC_1997 VVPHAQTVDVSGAGHMIAGDNNDAFSTAVVEFLDRTI-------------
MLBr_02297|M.leprae_Br4923 YAPHGRYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS--------
.* .. ..:. * :. : :
Mb1154c|M.bovis_AF2122/97 ----------------
Rv1123c|M.tuberculosis_H37Rv ----------------
MMAR_4337|M.marinum_M ----------------
MUL_0147|M.ulcerans_Agy99 ----------------
MAV_1254|M.avium_104 ----------------
Mvan_4609|M.vanbaalenii_PYR-1 ----------------
Mflv_2096|M.gilvum_PYR-GCK ----------------
MSMEG_5209|M.smegmatis_MC2_155 ----------------
TH_2112|M.thermoresistible__bu PRHGNVAGPGANAVRR
MAB_2045|M.abscessus_ATCC_1997 ----------------
MLBr_02297|M.leprae_Br4923 ----------------