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MRTLGGKTDRVVVVGAGLSGLSAALQLAGRGRQVTVLERGDHPGGRVGRADVNGYRLDTGPTVLTMPDII DDAFAAVGESLADRLPMDPVHPAYHAKFADGSALAVHTEADAMVSEIKRFAGRREADGYLRLREWLTKLY RTEFDGFIANNFDSPLSLLTPSLARLVALGGFRRWEPAVRRFLKDERLLRVFTFQSLYAGVPPQSALAVY AVIAYMDTVAGVYFPRGGMRALPDAMAAAASRAGVEFVYNATVSDLEFIGSRVTAVRTVDGGRVRADSVV LTTELPDTYRLIGRTPVRPLRLRPAPSAVVAHVGCRAVGPDADDAGHHTILFGDAWTQTFRDIIDDGRVM GDPSLLVTRPTATDPTLAPAGRDLLYVLAPAPNTDVGTLDWDAAGSGYVEQMLSAVRSRMPGVAEDAELL HVVTPADWRRQGMASGTPFALAHTFAQTGPFRPANTVRGIDNVVLAGSSTVPGVGVPTAILSGRLAADRI TGIPVRPRPSEVHR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1578 | - | - | 100% (504) | phytoene dehydrogenase-related protein |
| M. vanbaalenii PYR-1 | Mvan_3148 | - | 8e-13 | 26.37% (531) | amine oxidase |
| M. vanbaalenii PYR-1 | Mvan_5076 | - | 4e-08 | 22.99% (522) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 1e-05 | 38.27% (81) | flavin-containing monoamine oxidase |
| M. gilvum PYR-GCK | Mflv_1847 | - | 0.0 | 74.50% (502) | phytoene dehydrogenase-related protein |
| M. tuberculosis H37Rv | Rv3170 | aofH | 1e-05 | 38.27% (81) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | MLBr_00062 | gltD | 7e-05 | 57.14% (42) | glutamate synthase subunit beta |
| M. abscessus ATCC 19977 | MAB_2659 | - | 2e-05 | 44.23% (52) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_4806 | crtI | 0.0 | 68.81% (497) | phytoene dehydrogenase CrtI |
| M. avium 104 | MAV_3885 | - | 0.0 | 69.42% (497) | phytoene dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2347 | - | 0.0 | 67.27% (498) | phytoene dehydrogenase |
| M. thermoresistible (build 8) | TH_0076 | - | 0.0 | 72.76% (492) | phytoene dehydrogenase |
| M. ulcerans Agy99 | MUL_1423 | - | 5e-06 | 44.90% (49) | dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3195|M.bovis_AF2122/97 MTN------PPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDR--V
Rv3170|M.tuberculosis_H37Rv MTN------PPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDR--V
MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMGVSVLVIDARER--V
Mvan_1578|M.vanbaalenii_PYR-1 -----MRTLGGKTDRVVVVGAGLSGLSAALQLAGRGRQVTVLERGDH--P
Mflv_1847|M.gilvum_PYR-GCK -----MRSVPGAGDRVVVVGAGLAGLSAAMHLAGRGRQVTVVERDPH--P
TH_0076|M.thermoresistible__bu -----MRTVTGRPDHIVVVGAGLAGLSAALHLAGRGRSVTVVERGAH--P
MMAR_4806|M.marinum_M -----MRTIEGTADHVVVIGAGLAGLATALHLAGRGRSVTVVEREAW--P
MAV_3885|M.avium_104 ---MSMRAIEGSADHVVVIGAGLAGLSAALHLAGRGRAVTVVEREAW--P
MSMEG_2347|M.smegmatis_MC2_155 ----MSRAIPGPTDHVVVVGAGLSGLSAALHLAGRGRRVTVVEREPW--P
MUL_1423|M.ulcerans_Agy99 ----------------MVIGSGISGLTAAINLQRNGIRTLVVERREV--P
MLBr_00062|M.leprae_Br4923 ----------------MADPAGFLKYTQRELPRRRPVPLRLRDWKELYEE
: :*: : : :
Mb3195|M.bovis_AF2122/97 GGRSLTGRVAGVPADMGGSFIGP---TQDAVLALATELG-----IPTTPT
Rv3170|M.tuberculosis_H37Rv GGRSLTGRVAGVPADMGGSFIGP---TQDAVLALATELG-----IPTTPT
MAB_2659|M.abscessus_ATCC_1997 GGRSFTGEVAGVKVDLGATWVAK---RHTAIRDLMDRLG-----CSLTPQ
Mvan_1578|M.vanbaalenii_PYR-1 GGRVGRADVNGYRLDTGPTVLTMPDIIDDAFAAVGESLADRLPMDPVHPA
Mflv_1847|M.gilvum_PYR-GCK GGRMGRADVNGYRLDTGPTVLTMPDIIDETFAALGETTSDRVHLDPVLPA
TH_0076|M.thermoresistible__bu GGRMGRLDVHGYRLDTGPTVLTMPEILDETFAAVGSSVADRLDLKPVVPA
MMAR_4806|M.marinum_M GGRAGRLDIDGYRIDTGPTVLTMPDLIDEVFAAVGETISDRLELLPVDPA
MAV_3885|M.avium_104 GGRAGRRDIDGYRIDTGPTVLTMPDIIEDTFAAVGDSLARRLELCTLDPA
MSMEG_2347|M.smegmatis_MC2_155 GGRAGRIDTGGYRIDTGPTVLTMPDILDDVFAAVGESVGDRLQLLPVDPA
MUL_1423|M.ulcerans_Agy99 GGLCGTFTLDGYEFVTG-------------CNDFGGGLVRHLEELGVGTE
MLBr_00062|M.leprae_Br4923 FDKETLRNQASRCMDCGIPFCHNGCPLGNLIPEWNDLVRRGRWHDAVERL
. . *
Mb3195|M.bovis_AF2122/97 HR----DGRNVIQWRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGV
Rv3170|M.tuberculosis_H37Rv HR----DGRNVIQWRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGV
MAB_2659|M.abscessus_ATCC_1997 YD----EGVNLLWMAGKRKTWTGTLPTVDPVDLEDLGRITIEMGKLLETI
Mvan_1578|M.vanbaalenii_PYR-1 YHAKFADGSALAVHTEADAMVSEIKRFAGRREADGYLRLREWLTKLYRTE
Mflv_1847|M.gilvum_PYR-GCK YRASFADGTSLDVHTDPGVMAAEIERFAGPEEAAGYARMRQWLSKLYELE
TH_0076|M.thermoresistible__bu YRAEFADGSGLDVHTDPAAMADEITRFAGGAQAAGYLQLRNWLDLLYRTE
MMAR_4806|M.marinum_M YTAMFADGSSIDVHCDADRMVAAIENFAGPEQATGYLRLREWLTRLYRIE
MAV_3885|M.avium_104 YRAVFADGSSLDVHRDPDRMADAVAEFAGREQATGYRRLRAWLTRLYRTE
MSMEG_2347|M.smegmatis_MC2_155 YRAQFADGSALEVHSDADRMAAAIADLAGPSEAAGYRRLRDWLTRLYRIE
MUL_1423|M.ulcerans_Agy99 FR------------TPAARFHLGEHRIEMPPTLPTLATVARRLPALFSAF
MLBr_00062|M.leprae_Br4923 HATN----------NFPDVTGRLCPAPCESACVLGINQDPVTIKQIELEI
. : :
Mb3195|M.bovis_AF2122/97 P---VAAPWDARR-------ARELDDVSLGEWLRLVRATSSSRNLMAIMT
Rv3170|M.tuberculosis_H37Rv P---VAAPWDARR-------ARELDDVSLGEWLRLVRATSSSRNLMAIMT
MAB_2659|M.abscessus_ATCC_1997 N---VDAAWKSPN-------ADQLDSISFGEWLSQQQAVTSTNALMYIVT
Mvan_1578|M.vanbaalenii_PYR-1 FDGFIANNFDSPLSLLTPSLARLVALGGFRRWEPAVRRFLKDERLLRVFT
Mflv_1847|M.gilvum_PYR-GCK FNGFINANFDSPLSLLTPQLARLAAIGGFRRWEPMVRRFLSDERLLRVFT
TH_0076|M.thermoresistible__bu FDRFIAANFDSPLSLVSPHLAKLVALGGFRRWEKVMRRFITDERLLRVFT
MMAR_4806|M.marinum_M FAGFIGSNFDSPLSLLTPQLARLAAAGGFRNWDSMVKRHITDPRLRRVFT
MAV_3885|M.avium_104 FDGFIAANFDSPLSLLTPRLAQLIAIGGFRNWDRMVKRYLSDPRLQRIFT
MSMEG_2347|M.smegmatis_MC2_155 IDGFIGANFDSPLSLLTPQLAQLAAIGGFGKWDHMVRRHLRDPRLQRVFT
MUL_1423|M.ulcerans_Agy99 R---------------------TVRKGPGQTLGQLIDGAVQDRLLMAAAA
MLBr_00062|M.leprae_Br4923 IDKAFDEGWVQPLPPQQLTGKTVAVVGSGPAGLAAAQQLTRAGHRVTVFE
Mb3195|M.bovis_AF2122/97 R--VTWGCEP-DDVSMLHAARYVRAAGGLDR----LLDVKNGAQQDRVPG
Rv3170|M.tuberculosis_H37Rv R--VTWGCEP-DDVSMLHAARYVRAAGGLDR----LLDVKNGAQQDRVPG
MAB_2659|M.abscessus_ATCC_1997 R--VQWGCSP-LDVSLLHVLRYVQAVGGLDH----MLAVEHGQQEYRVTE
Mvan_1578|M.vanbaalenii_PYR-1 FQSLYAGVPPQSALAVYAVIAYMDTVAGVYFPRGGMRALPDAMAAAASRA
Mflv_1847|M.gilvum_PYR-GCK FQALYVGVPPRRALAAYAVIAYMDTVSGVYFPRGGMRALPDAMAAAAADA
TH_0076|M.thermoresistible__bu FQALYVGVPPQRALAVYAVIAYMDTVNGVYFPAGGVRAVPEALAAAARDA
MMAR_4806|M.marinum_M FQSLYAGVAPQDALAAYAVIAYMDTISGVFFPRGGVRALPDALAAAAACA
MAV_3885|M.avium_104 FQSLYAGVAPRDALAVYAVIAYMDTVSGVVFPRGGVRALPDALAAAASDA
MSMEG_2347|M.smegmatis_MC2_155 FQSLYAGVSPQRALAAYAVIAYMDTISGVFFPKGGVRAVPDALAAAGADA
MUL_1423|M.ulcerans_Agy99 IPAYALLRSPDDLTVEQVGQAYSKQLGYRYQKSYTPVGGPAAMIAAMVQR
MLBr_00062|M.leprae_Br4923 RDDRIGGLLRYGIPEFKMEKRFLERRLDQLRAEGTEFRSGVNVGVDITAD
:
Mb3195|M.bovis_AF2122/97 GTQQIAQAAAAQLGARVLLNAAVR--RIDRHGAGVTVTSDQGQAEAGFVI
Rv3170|M.tuberculosis_H37Rv GTQQIAQAAAAQLGARVLLNAAVR--RIDRHGAGVTVTSDQGQAEAGFVI
MAB_2659|M.abscessus_ATCC_1997 TTQEIAKRLAAQIGDQIVLNTRVR--QISQDDNGVTVSTDSGVINAKYAI
Mvan_1578|M.vanbaalenii_PYR-1 GVEFVYNATVSDLEFIGSRVTAVR--TVDGGRVRADSVVLTTELPDTYRL
Mflv_1847|M.gilvum_PYR-GCK GVEFRYDAPVSALERSGSRVTAVR--TVTGERIPADAVVLTTELPDTYRL
TH_0076|M.thermoresistible__bu GVEFCYRERVTGLERSGDRVTAVH--TDTGRRLAADVVVLTTELPDSYRL
MMAR_4806|M.marinum_M GVQFHYGSQVSELERDDARITAVR--TDRGERIACDAVVLTTELPTTYRL
MAV_3885|M.avium_104 GVQFRYGTTVTALEKTGGRVGAVL--TEQAGRISCDAVVLTTELPQTYAL
MSMEG_2347|M.smegmatis_MC2_155 GVRFHYGATVNCLERSADRVTAVH--TDTGERIPCDAVVLTTELPRTYEL
MUL_1423|M.ulcerans_Agy99 ---FEALGGELWLGCHSTQVERVG--AEKRVHTSDALVPARVVLSSAGRW
MLBr_00062|M.leprae_Br4923 QLCADFDAVVLAGGAATWRELPIPGRELDGVHQAMEFLPWVNRVQEGDDV
:
Mb3195|M.bovis_AF2122/97 VAIPPAHRVAIEFDPPLPPEYQQLAHHWPQ----GRLSKAYAAYSTPFWR
Rv3170|M.tuberculosis_H37Rv VAIPPAHRVAIEFDPPLPPEYQQLAHHWPQ----GRLSKAYAAYSTPFWR
MAB_2659|M.abscessus_ATCC_1997 VTAAPEHRAYIEYQPALPAKIEGLTTSFPM----GALSKAFVAYDKPFWR
Mvan_1578|M.vanbaalenii_PYR-1 IGRTPVRPLRLRPAPSAVVAHVGCRAVGPDADDAGHHTILFGDAWTQTFR
Mflv_1847|M.gilvum_PYR-GCK LGRTPRRMVPLRPAPSAVVAHFGTRAPAQDTDGS-HHTILFGDAWERTFD
TH_0076|M.thermoresistible__bu LGRRPRRPARLRPAPSAVVAHVGCRRAEP---APPHHTILFGSAWEQTFR
MMAR_4806|M.marinum_M LGRTPRRLRRLRAAPSAVVVHAGCRSASTASEPAAHHTILFGQAWEQTFT
MAV_3885|M.avium_104 LGRTPRRALRLRHSPSAVVAHVGCPAVASQ---TAHHTILFGDAWDHTFA
MSMEG_2347|M.smegmatis_MC2_155 LGRTPRRPRPWRASPSAVVVHVGCRRIDRP---VAHHNILFGDAWHDTFT
MUL_1423|M.ulcerans_Agy99 SEFPKTTKAGMEFAVLLFAVRKGFTYPRG------YHTIAWLQQDIGEEL
MLBr_00062|M.leprae_Br4923 LGDDGQPPITAKDKKVVIIGGGDTGADCLG----AVHRQGAIHVHQLEIM
.
Mb3195|M.bovis_AF2122/97 ASGYSGQALSDEAPVFIT---FDVSPHADGPGILMGFVDARGFDSLPIEE
Rv3170|M.tuberculosis_H37Rv ASGYSGQALSDEAPVFIT---FDVSPHADGPGILMGFVDARGFDSLPIEE
MAB_2659|M.abscessus_ATCC_1997 AEGLSGEALTDTAPVFIT---FDVSPSDDGPGILMVFCTARVYDGFGPEV
Mvan_1578|M.vanbaalenii_PYR-1 DIIDDGRVMGDPSLLVTRPTATDPTLAPAGRDLLYVLAPAPNTDVGTLDW
Mflv_1847|M.gilvum_PYR-GCK EIIDQGRPMADPSLLVTRPALGDPSVAPPGRDLLYVLAPAPNTDVGHRDW
TH_0076|M.thermoresistible__bu DIIDDGRLMRDPSLLVSRPTAGDASLAPDGRDLLYILAPAPNTAAGRIDW
MMAR_4806|M.marinum_M DIIRDGRLMRDPSLLVTRPTAGDPALAPPGRDLLYLLAPAPNLTAGRVDW
MAV_3885|M.avium_104 DIIGAGQLMRDPSLLVTRPTASDPTLAPRGRDLLYVLAPAPNLESGGIDW
MSMEG_2347|M.smegmatis_MC2_155 DIIDDGRLMRDPSLLVTRPTRGDPALAPAGRDLLYLLAPTPNLSSTAIDW
MUL_1423|M.ulcerans_Agy99 RKLDAGQPISRPSFHIFR----SDLPQPRDHYTINAFIPLPRGEGDPSAR
MLBr_00062|M.leprae_Br4923 PRPPDARAASTPWPTYPLMYRVSPAHEEGGERVFSVNTEEFVGKNGRVHA
.. . . :
Mb3195|M.bovis_AF2122/97 RR----------RDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTA
Rv3170|M.tuberculosis_H37Rv RR----------RDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTA
MAB_2659|M.abscessus_ATCC_1997 RR----------KLVLKQLVDLYGEQANTPIDYIDHCWGTEPFAAGGPHP
Mvan_1578|M.vanbaalenii_PYR-1 DAAGSGYVEQMLSAVRSR-MPGVAEDAELLHVVTPADWRRQGMASGTPFA
Mflv_1847|M.gilvum_PYR-GCK DADQDGYTSHMLDTVRER-MPHLGDDAELLRVVTPRDWARQGMASGTPFA
TH_0076|M.thermoresistible__bu DLLGDGYAEEMLNAVSAR-LPESTVDAEMLHVVNPADWERQGMAAGTPFA
MMAR_4806|M.marinum_M GSAGGSYAQSMIDTVASRLLPDLRDSVELLDVVTPLDWARQGMAAGTPFA
MAV_3885|M.avium_104 DSVGRGYVDDLIALVGQRLLPGLPGSATVLDVVTPADWARRGMAAGSPFA
MSMEG_2347|M.smegmatis_MC2_155 ETEGPAYAQRVVDTVAERLLPELRDDAQVLQVVTPADWARQGMVAGTPFA
MUL_1423|M.ulcerans_Agy99 RRQD---LSAHAVATIDKDLPGFKDALMYQRFLSPVEYASRLGLHSAPSS
MLBr_00062|M.leprae_Br4923 LKAH----EVTMQDGRFVKVENSVFELEADLVLLAMGFVGPEKPGLLTDL
: .
Mb3195|M.bovis_AF2122/97 AVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAAAEV
Rv3170|M.tuberculosis_H37Rv AVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAAAEV
MAB_2659|M.abscessus_ATCC_1997 AAPPFASVNYGEALREPHGRIHWAGTETAGEWVGTMNGAILMGLHTADQI
Mvan_1578|M.vanbaalenii_PYR-1 LAHTFAQTGPFRPANTVRGIDNVVLAGSSTVPGVGVPTAILSGRLAADRI
Mflv_1847|M.gilvum_PYR-GCK LSHTFAQTGPFRPANTIRGIDNAVLAGSSTVPGVGIPTAIVSGRLAADRV
TH_0076|M.thermoresistible__bu LAHTFSQTGPFRPGNMVRGVANAVLAGGSTVPGVGIPTALLSGRLAADRI
MMAR_4806|M.marinum_M LAHTFGQTGPFRPANTVRGIDNAVLAGSSTVPGVGVPTTLISGRLAADRI
MAV_3885|M.avium_104 LAHTFAQTGPFRPANMVRGIDNAVLAGSSTVPGVGVPTTLISGRLAADRI
MSMEG_2347|M.smegmatis_MC2_155 LAHTFSQTGPFRPGNTVRGVANAVLAGSSTVPGVGVPTALLSGRLAADRV
MUL_1423|M.ulcerans_Agy99 FVPP---TGFAGLPSYDAARDTYFIGTSVGPAGEHAGAACLSGKMAADLA
MLBr_00062|M.leprae_Br4923 GVKFTDRGNVARGADFDTSVPGVFVAGDMGRGQSLIVWAIAEGRAAAAAV
. : * :*
Mb3195|M.bovis_AF2122/97 AALL------------------------
Rv3170|M.tuberculosis_H37Rv AALL------------------------
MAB_2659|M.abscessus_ATCC_1997 AQQLGVTGEVSK----------------
Mvan_1578|M.vanbaalenii_PYR-1 TGIPVRPRPSEVHR--------------
Mflv_1847|M.gilvum_PYR-GCK TGAGSRTQPRVVTQ--------------
TH_0076|M.thermoresistible__bu TGAAR-----------------------
MMAR_4806|M.marinum_M TGNTTRSIRHLDLKAQLS----------
MAV_3885|M.avium_104 TGVSKRTPARIDMKAGSP----------
MSMEG_2347|M.smegmatis_MC2_155 TGTVRRTRTHHDINSVTAATADRKARMP
MUL_1423|M.ulcerans_Agy99 IKQLRR----------------------
MLBr_00062|M.leprae_Br4923 DRFLMGATALPAPVKPSSLPLQ------