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RSVPGAGDRVVVVGAGLAGLSAAMHLAGRGRQVTVVERDPHPGGRMGRADVNGYRLDTGPTVLTMPDIID ETFAALGETTSDRVHLDPVLPAYRASFADGTSLDVHTDPGVMAAEIERFAGPEEAAGYARMRQWLSKLYE LEFNGFINANFDSPLSLLTPQLARLAAIGGFRRWEPMVRRFLSDERLLRVFTFQALYVGVPPRRALAAYA VIAYMDTVSGVYFPRGGMRALPDAMAAAAADAGVEFRYDAPVSALERSGSRVTAVRTVTGERIPADAVVL TTELPDTYRLLGRTPRRMVPLRPAPSAVVAHFGTRAPAQDTDGSHHTILFGDAWERTFDEIIDQGRPMAD PSLLVTRPALGDPSVAPPGRDLLYVLAPAPNTDVGHRDWDADQDGYTSHMLDTVRERMPHLGDDAELLRV VTPRDWARQGMASGTPFALSHTFAQTGPFRPANTIRGIDNAVLAGSSTVPGVGIPTAIVSGRLAADRVTG AGSRTQPRVVTQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1847 | - | - | 100% (503) | phytoene dehydrogenase-related protein |
| M. gilvum PYR-GCK | Mflv_1677 | - | 2e-09 | 23.29% (395) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3592 | - | 2e-06 | 27.75% (227) | glutamate synthase, NADH/NADPH, small subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3859c | - | 5e-09 | 23.43% (495) | putative dehydrogenase |
| M. tuberculosis H37Rv | Rv3829c | - | 1e-08 | 23.23% (495) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2659 | - | 6e-06 | 43.33% (60) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_4806 | crtI | 0.0 | 69.28% (498) | phytoene dehydrogenase CrtI |
| M. avium 104 | MAV_3885 | - | 0.0 | 67.07% (501) | phytoene dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2347 | - | 0.0 | 69.01% (497) | phytoene dehydrogenase |
| M. thermoresistible (build 8) | TH_0076 | - | 0.0 | 70.93% (492) | phytoene dehydrogenase |
| M. ulcerans Agy99 | MUL_2934 | - | 2e-07 | 22.70% (511) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1578 | - | 0.0 | 74.50% (502) | phytoene dehydrogenase-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3859c|M.bovis_AF2122/97 ----------MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGG
Rv3829c|M.tuberculosis_H37Rv ----------MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGG
MUL_2934|M.ulcerans_Agy99 ----------MTDYDAIVVGAGHNGLTAAAVLQRAGLRTLCMEANTYAGG
Mflv_1847|M.gilvum_PYR-GCK -----MRSVPGAGDRVVVVGAGLAGLSAAMHLAGRGRQVTVVERDPHPGG
Mvan_1578|M.vanbaalenii_PYR-1 -----MRTLGGKTDRVVVVGAGLSGLSAALQLAGRGRQVTVLERGDHPGG
TH_0076|M.thermoresistible__bu -----MRTVTGRPDHIVVVGAGLAGLSAALHLAGRGRSVTVVERGAHPGG
MMAR_4806|M.marinum_M -----MRTIEGTADHVVVIGAGLAGLATALHLAGRGRSVTVVEREAWPGG
MSMEG_2347|M.smegmatis_MC2_155 ----MSRAIPGPTDHVVVVGAGLSGLSAALHLAGRGRRVTVVEREPWPGG
MAV_3885|M.avium_104 ---MSMRAIEGSADHVVVIGAGLAGLSAALHLAGRGRAVTVVEREAWPGG
MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMGVSVLVIDARERVGG
:::*** **::* * * . :: **
Mb3859c|M.bovis_AF2122/97 MASTVELFDGYRFDIAGS-VQFP--TSSAVSSELGLDSLPTVDLEVMSVA
Rv3829c|M.tuberculosis_H37Rv MASTVELFDGYRFEIAGS-VQFP--TSSAVSSELGLDSLPTVDLEVMSVA
MUL_2934|M.ulcerans_Agy99 MAATVELIDGFHFEIAGS-VQFP--TASQISKELGLDTLPTVAPEVMSTN
Mflv_1847|M.gilvum_PYR-GCK RMGRAD-VNGYRLDTGPT-VLTMPDIIDETFAALGETTSDRVHLDPVLPA
Mvan_1578|M.vanbaalenii_PYR-1 RVGRAD-VNGYRLDTGPT-VLTMPDIIDDAFAAVGESLADRLPMDPVHPA
TH_0076|M.thermoresistible__bu RMGRLD-VHGYRLDTGPT-VLTMPEILDETFAAVGSSVADRLDLKPVVPA
MMAR_4806|M.marinum_M RAGRLD-IDGYRIDTGPT-VLTMPDLIDEVFAAVGETISDRLELLPVDPA
MSMEG_2347|M.smegmatis_MC2_155 RAGRID-TGGYRIDTGPT-VLTMPDILDDVFAAVGESVGDRLQLLPVDPA
MAV_3885|M.avium_104 RAGRRD-IDGYRIDTGPT-VLTMPDIIEDTFAAVGDSLARRLELCTLDPA
MAB_2659|M.abscessus_ATCC_1997 RSFTGE-VAGVKVDLGATWVAKRHTAIRDLMDRLGCSLTPQYDEGVNLLW
: * :.: . : * :*
Mb3859c|M.bovis_AF2122/97 LRGVGDD--PVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRAL
Rv3829c|M.tuberculosis_H37Rv LRGVGDD--PVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRAL
MUL_2934|M.ulcerans_Agy99 IGESDEE--AMIFYRDPLQLISHLGEKHGSAAVTGMAELIGWSQGPARAL
Mflv_1847|M.gilvum_PYR-GCK YRASFADGTSLDVHTDPGVMAAEIERFAGPEEAAGYARMRQWLS---KLY
Mvan_1578|M.vanbaalenii_PYR-1 YHAKFADGSALAVHTEADAMVSEIKRFAGRREADGYLRLREWLT---KLY
TH_0076|M.thermoresistible__bu YRAEFADGSGLDVHTDPAAMADEITRFAGGAQAAGYLQLRNWLD---LLY
MMAR_4806|M.marinum_M YTAMFADGSSIDVHCDADRMVAAIENFAGPEQATGYLRLREWLT---RLY
MSMEG_2347|M.smegmatis_MC2_155 YRAQFADGSALEVHSDADRMAAAIADLAGPSEAAGYRRLRDWLT---RLY
MAV_3885|M.avium_104 YRAVFADGSSLDVHRDPDRMADAVAEFAGREQATGYRRLRAWLT---RLY
MAB_2659|M.abscessus_ATCC_1997 MAGKRKTWTGTLPTVDPVDLEDLGRITIEMGKLLETINVDAAWK---SPN
:. : :
Mb3859c|M.bovis_AF2122/97 GRFEAGTLPKSFDEMYACATNEFERSAIDDMLFGSVTDVLDRHFPDREKH
Rv3829c|M.tuberculosis_H37Rv GRFEAGTLPKSFDEMYACATNEFERSAIDDMLFGSVTDVLDRHFPDREKH
MUL_2934|M.ulcerans_Agy99 GRFEVRTPPRTLDEMYACATNQAERRAIHEMLFGSAMDVIDRFLPDKEKH
Mflv_1847|M.gilvum_PYR-GCK ELEFNGFINANFDSPLSLLTPQLARLAAIGG-FRRWEPMVRRFLSDER--
Mvan_1578|M.vanbaalenii_PYR-1 RTEFDGFIANNFDSPLSLLTPSLARLVALGG-FRRWEPAVRRFLKDER--
TH_0076|M.thermoresistible__bu RTEFDRFIAANFDSPLSLVSPHLAKLVALGG-FRRWEKVMRRFITDER--
MMAR_4806|M.marinum_M RIEFAGFIGSNFDSPLSLLTPQLARLAAAGG-FRNWDSMVKRHITDPR--
MSMEG_2347|M.smegmatis_MC2_155 RIEIDGFIGANFDSPLSLLTPQLAQLAAIGG-FGKWDHMVRRHLRDPR--
MAV_3885|M.avium_104 RTEFDGFIAANFDSPLSLLTPRLAQLIAIGG-FRNWDRMVKRYLSDPR--
MAB_2659|M.abscessus_ATCC_1997 ADQLDSISFGEWLSQQQAVTSTNALMYIVTRVQWGCSPLDVSLLHVLR--
. : : .
Mb3859c|M.bovis_AF2122/97 GALRGSMTVLAVNTLYRGPATPGSAAALAFGLGVPEGDFVRWKKLRGGIG
Rv3829c|M.tuberculosis_H37Rv GALRGSMTVLAVNTLYRGPATPGSAAALAFGLGVPEGDFVRWKKLRGGIG
MUL_2934|M.ulcerans_Agy99 AVMRGILAFLAVNSTYRGPFTPGSAACLAFALAVPDDSTAMMTKLRGGIG
Mflv_1847|M.gilvum_PYR-GCK -----LLRVFTFQALYVG--VPPRRALAAYAVIAYMDTVSGVYFPRGGMR
Mvan_1578|M.vanbaalenii_PYR-1 -----LLRVFTFQSLYAG--VPPQSALAVYAVIAYMDTVAGVYFPRGGMR
TH_0076|M.thermoresistible__bu -----LLRVFTFQALYVG--VPPQRALAVYAVIAYMDTVNGVYFPAGGVR
MMAR_4806|M.marinum_M -----LRRVFTFQSLYAG--VAPQDALAAYAVIAYMDTISGVFFPRGGVR
MSMEG_2347|M.smegmatis_MC2_155 -----LQRVFTFQSLYAG--VSPQRALAAYAVIAYMDTISGVFFPKGGVR
MAV_3885|M.avium_104 -----LQRIFTFQSLYAG--VAPRDALAVYAVIAYMDTVSGVVFPRGGVR
MAB_2659|M.abscessus_ATCC_1997 -------------------------YVQAVGGLDHMLAVEHGQQEYRVTE
. .
Mb3859c|M.bovis_AF2122/97 ALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGDTLTS
Rv3829c|M.tuberculosis_H37Rv ALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGDTLTS
MUL_2934|M.ulcerans_Agy99 ALTDHLRERFASAGGEIRFRSKVVEIVVDRG----AVSGVRLPDGSVIGT
Mflv_1847|M.gilvum_PYR-GCK ALPDAMAAAAADAGVEFRYDAPVSALERSGS----RVTAVRTVTGERIPA
Mvan_1578|M.vanbaalenii_PYR-1 ALPDAMAAAASRAGVEFVYNATVSDLEFIGS----RVTAVRTVDGGRVRA
TH_0076|M.thermoresistible__bu AVPEALAAAARDAGVEFCYRERVTGLERSGD----RVTAVHTDTGRRLAA
MMAR_4806|M.marinum_M ALPDALAAAAACAGVQFHYGSQVSELERDDA----RITAVRTDRGERIAC
MSMEG_2347|M.smegmatis_MC2_155 AVPDALAAAGADAGVRFHYGATVNCLERSAD----RVTAVHTDTGERIPC
MAV_3885|M.avium_104 ALPDALAAAASDAGVQFRYGTTVTALEKTGG----RVGAVLTEQAGRISC
MAB_2659|M.abscessus_ATCC_1997 TTQEIAKRLAAQIGDQIVLNTRVRQISQDDN-------GVTVSTDSGVIN
: * .. * : .* :
Mb3859c|M.bovis_AF2122/97 PIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHFALAQPP
Rv3829c|M.tuberculosis_H37Rv PIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHFALAQPP
MUL_2934|M.ulcerans_Agy99 PVVVSNLAPDVTLAKLVGPEHVPADLLARLAGRDHRASFVQIHFALDALP
Mflv_1847|M.gilvum_PYR-GCK DAVVLTTELPDTYRLLGRTPRRMVPLRP----------------APSAVV
Mvan_1578|M.vanbaalenii_PYR-1 DSVVLTTELPDTYRLIGRTPVRPLRLRP----------------APSAVV
TH_0076|M.thermoresistible__bu DVVVLTTELPDSYRLLGRRPRRPARLRP----------------APSAVV
MMAR_4806|M.marinum_M DAVVLTTELPTTYRLLGRTPRRLRRLRA----------------APSAVV
MSMEG_2347|M.smegmatis_MC2_155 DAVVLTTELPRTYELLGRTPRRPRPWRA----------------SPSAVV
MAV_3885|M.avium_104 DAVVLTTELPQTYALLGRTPRRALRLRH----------------SPSAVV
MAB_2659|M.abscessus_ATCC_1997 AKYAIVTAAPEHRAYIEYQPALPAKIEG----------------------
. :
Mb3859c|M.bovis_AF2122/97 AFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQIP
Rv3829c|M.tuberculosis_H37Rv AFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQIP
MUL_2934|M.ulcerans_Agy99 EFAPPYELLNEPGMQQSVGIFGTPEEQQQQWETCRRGIVPENPSMGMQIP
Mflv_1847|M.gilvum_PYR-GCK AHFGTRAPAQDTDGS-HHTILFGDAWERTFDEIIDQGRPMADPSLLVTRP
Mvan_1578|M.vanbaalenii_PYR-1 AHVGCRAVGPDADDAGHHTILFGDAWTQTFRDIIDDGRVMGDPSLLVTRP
TH_0076|M.thermoresistible__bu AHVGCRRAEP---APPHHTILFGSAWEQTFRDIIDDGRLMRDPSLLVSRP
MMAR_4806|M.marinum_M VHAGCRSASTASEPAAHHTILFGQAWEQTFTDIIRDGRLMRDPSLLVTRP
MSMEG_2347|M.smegmatis_MC2_155 VHVGCR---RIDRPVAHHNILFGDAWHDTFTDIIDDGRLMRDPSLLVTRP
MAV_3885|M.avium_104 AHVGCP---AVASQTAHHTILFGDAWDHTFADIIGAGQLMRDPSLLVTRP
MAB_2659|M.abscessus_ATCC_1997 --------LTTSFPMGALSKAFVAYDKPFWRAEGLSGEALTDTAPVFIT-
* :.: .
Mb3859c|M.bovis_AF2122/97 SLHDPSLAPAGKQAASAFAMWFPIEGG-SKYGGYGRAKVEMGQNVIDKIT
Rv3829c|M.tuberculosis_H37Rv SLHDPSLAPAGKQAASAFAMWFPIEGG-SKYGGYGRAKVEMGQNVIDKIT
MUL_2934|M.ulcerans_Agy99 SVHDSGLAPPGKHAASAYAYAFPVEVD-RDQ--HGHLKRIMARRVIDKIT
Mflv_1847|M.gilvum_PYR-GCK ALGDPSVAPPGRDLLYVLAPAPNTDVGHRDWDADQDGYTSHMLDTVRER-
Mvan_1578|M.vanbaalenii_PYR-1 TATDPTLAPAGRDLLYVLAPAPNTDVGTLDWDAAGSGYVEQMLSAVRSR-
TH_0076|M.thermoresistible__bu TAGDASLAPDGRDLLYILAPAPNTAAGRIDWDLLGDGYAEEMLNAVSAR-
MMAR_4806|M.marinum_M TAGDPALAPPGRDLLYLLAPAPNLTAGRVDWGSAGGSYAQSMIDTVASRL
MSMEG_2347|M.smegmatis_MC2_155 TRGDPALAPAGRDLLYLLAPTPNLSSTAIDWETEGPAYAQRVVDTVAERL
MAV_3885|M.avium_104 TASDPTLAPRGRDLLYVLAPAPNLESGGIDWDSVGRGYVDDLIALVGQRL
MAB_2659|M.abscessus_ATCC_1997 --FDVSPSDDGPGILMVFCTAR----------VYDGFGPEVRRKLVLKQL
* : * . :
Mb3859c|M.bovis_AF2122/97 RLAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHSDQIGPN---RP
Rv3829c|M.tuberculosis_H37Rv RLAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHSDQIGPN---RP
MUL_2934|M.ulcerans_Agy99 RFAPNFKDIVIRYITFAPYHMQTMFGAPSGDFCHGLLHPDLMGPN---RP
Mflv_1847|M.gilvum_PYR-GCK MPHLGDDAELLRVVTPRDWARQGMASGTPFALSHTFAQTGPFRPANTIRG
Mvan_1578|M.vanbaalenii_PYR-1 MPGVAEDAELLHVVTPADWRRQGMASGTPFALAHTFAQTGPFRPANTVRG
TH_0076|M.thermoresistible__bu LPESTVDAEMLHVVNPADWERQGMAAGTPFALAHTFSQTGPFRPGNMVRG
MMAR_4806|M.marinum_M LPDLRDSVELLDVVTPLDWARQGMAAGTPFALAHTFGQTGPFRPANTVRG
MSMEG_2347|M.smegmatis_MC2_155 LPELRDDAQVLQVVTPADWARQGMVAGTPFALAHTFSQTGPFRPGNTVRG
MAV_3885|M.avium_104 LPGLPGSATVLDVVTPADWARRGMAAGSPFALAHTFAQTGPFRPANMVRG
MAB_2659|M.abscessus_ATCC_1997 VDLYGEQANTPIDYIDHCWGTEPFAAGGPHPAAPPFASVN---YGEALRE
. : .. . : . *
Mb3859c|M.bovis_AF2122/97 GPKGFIGQPIPIAGLYLGSAGCHGGPGITFIPGYNAARQALADRRAANCC
Rv3829c|M.tuberculosis_H37Rv GPKGFIGQPIPIAGLYLGSAGCHGGPGITFIPGYNAARQALADRRAANCC
MUL_2934|M.ulcerans_Agy99 GPGGFLDFPIPIDGLYLGGAGCHGGPGITFIPGYNAAYQVLEDVATR---
Mflv_1847|M.gilvum_PYR-GCK IDNAVLAGSSTVPGVGIPTAIVSGRLAADRVTGAGSRTQPRVVTQ-----
Mvan_1578|M.vanbaalenii_PYR-1 IDNVVLAGSSTVPGVGVPTAILSGRLAADRITGIPVRPRPSEVHR-----
TH_0076|M.thermoresistible__bu VANAVLAGGSTVPGVGIPTALLSGRLAADRITGAAR--------------
MMAR_4806|M.marinum_M IDNAVLAGSSTVPGVGVPTTLISGRLAADRITGNTTRSIRHLDLKAQLS-
MSMEG_2347|M.smegmatis_MC2_155 VANAVLAGSSTVPGVGVPTALLSGRLAADRVTGTVRRTRTHHDINSVTAA
MAV_3885|M.avium_104 IDNAVLAGSSTVPGVGVPTTLISGRLAADRITGVSKRTPARIDMKAGSP-
MAB_2659|M.abscessus_ATCC_1997 PHGRIHWAGTETAGEWVGTMNGAILMGLHTADQIAQQLGVTGEVSK----
. * : .
Mb3859c|M.bovis_AF2122/97 VLSGR----
Rv3829c|M.tuberculosis_H37Rv VLSGR----
MUL_2934|M.ulcerans_Agy99 QTSG-----
Mflv_1847|M.gilvum_PYR-GCK ---------
Mvan_1578|M.vanbaalenii_PYR-1 ---------
TH_0076|M.thermoresistible__bu ---------
MMAR_4806|M.marinum_M ---------
MSMEG_2347|M.smegmatis_MC2_155 TADRKARMP
MAV_3885|M.avium_104 ---------
MAB_2659|M.abscessus_ATCC_1997 ---------