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VSMRAIEGSADHVVVIGAGLAGLSAALHLAGRGRAVTVVEREAWPGGRAGRRDIDGYRIDTGPTVLTMPD IIEDTFAAVGDSLARRLELCTLDPAYRAVFADGSSLDVHRDPDRMADAVAEFAGREQATGYRRLRAWLTR LYRTEFDGFIAANFDSPLSLLTPRLAQLIAIGGFRNWDRMVKRYLSDPRLQRIFTFQSLYAGVAPRDALA VYAVIAYMDTVSGVVFPRGGVRALPDALAAAASDAGVQFRYGTTVTALEKTGGRVGAVLTEQAGRISCDA VVLTTELPQTYALLGRTPRRALRLRHSPSAVVAHVGCPAVASQTAHHTILFGDAWDHTFADIIGAGQLMR DPSLLVTRPTASDPTLAPRGRDLLYVLAPAPNLESGGIDWDSVGRGYVDDLIALVGQRLLPGLPGSATVL DVVTPADWARRGMAAGSPFALAHTFAQTGPFRPANMVRGIDNAVLAGSSTVPGVGVPTTLISGRLAADRI TGVSKRTPARIDMKAGSP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3885 | - | - | 100% (508) | phytoene dehydrogenase |
| M. avium 104 | MAV_5090 | - | 1e-12 | 25.67% (522) | putative dehydrogenase |
| M. avium 104 | MAV_0198 | - | 6e-11 | 24.12% (485) | FAD dependent oxidoreductase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3859c | - | 5e-11 | 24.23% (487) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1847 | - | 0.0 | 67.07% (501) | phytoene dehydrogenase-related protein |
| M. tuberculosis H37Rv | Rv3829c | - | 2e-10 | 24.02% (487) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2659 | - | 4e-07 | 34.41% (93) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_4806 | crtI | 0.0 | 73.72% (506) | phytoene dehydrogenase CrtI |
| M. smegmatis MC2 155 | MSMEG_2347 | - | 0.0 | 71.12% (502) | phytoene dehydrogenase |
| M. thermoresistible (build 8) | TH_0076 | - | 0.0 | 67.14% (493) | phytoene dehydrogenase |
| M. ulcerans Agy99 | MUL_1423 | - | 1e-06 | 48.98% (49) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1578 | - | 0.0 | 69.42% (497) | phytoene dehydrogenase-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3859c|M.bovis_AF2122/97 ----------MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGG
Rv3829c|M.tuberculosis_H37Rv ----------MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGG
MAV_3885|M.avium_104 ---MSMRAIEGSADHVVVIGAGLAGLSAALHLAGRGRAVTVVEREAWPGG
MMAR_4806|M.marinum_M -----MRTIEGTADHVVVIGAGLAGLATALHLAGRGRSVTVVEREAWPGG
MSMEG_2347|M.smegmatis_MC2_155 ----MSRAIPGPTDHVVVVGAGLSGLSAALHLAGRGRRVTVVEREPWPGG
Mflv_1847|M.gilvum_PYR-GCK -----MRSVPGAGDRVVVVGAGLAGLSAAMHLAGRGRQVTVVERDPHPGG
Mvan_1578|M.vanbaalenii_PYR-1 -----MRTLGGKTDRVVVVGAGLSGLSAALQLAGRGRQVTVLERGDHPGG
TH_0076|M.thermoresistible__bu -----MRTVTGRPDHIVVVGAGLAGLSAALHLAGRGRSVTVVERGAHPGG
MUL_1423|M.ulcerans_Agy99 ----------------MVIGSGISGLTAAINLQRNGIRTLVVERREVPGG
MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMGVSVLVIDARERVGG
:::*:* **::* * * . :: **
Mb3859c|M.bovis_AF2122/97 MASTVELFDGYRFDIAGSVQFP---TSSAVSSELGLDSLPTVDLEVMSVA
Rv3829c|M.tuberculosis_H37Rv MASTVELFDGYRFEIAGSVQFP---TSSAVSSELGLDSLPTVDLEVMSVA
MAV_3885|M.avium_104 RAGRRD-IDGYRIDTGPTVLTMPD-IIEDTFAAVGDSLARRLELCTLDPA
MMAR_4806|M.marinum_M RAGRLD-IDGYRIDTGPTVLTMPD-LIDEVFAAVGETISDRLELLPVDPA
MSMEG_2347|M.smegmatis_MC2_155 RAGRID-TGGYRIDTGPTVLTMPD-ILDDVFAAVGESVGDRLQLLPVDPA
Mflv_1847|M.gilvum_PYR-GCK RMGRAD-VNGYRLDTGPTVLTMPD-IIDETFAALGETTSDRVHLDPVLPA
Mvan_1578|M.vanbaalenii_PYR-1 RVGRAD-VNGYRLDTGPTVLTMPD-IIDDAFAAVGESLADRLPMDPVHPA
TH_0076|M.thermoresistible__bu RMGRLD-VHGYRLDTGPTVLTMPE-ILDETFAAVGSSVADRLDLKPVVPA
MUL_1423|M.ulcerans_Agy99 LCGTFT-LDGYEFVTG--------------CNDFGGGLVRHLEELGVGTE
MAB_2659|M.abscessus_ATCC_1997 RSFTGE-VAGVKVDLGATWVAKRHTAIRDLMDRLGCSLTPQYDEGVNLLW
* .. . .*
Mb3859c|M.bovis_AF2122/97 LRGVGDD--PVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRAL
Rv3829c|M.tuberculosis_H37Rv LRGVGDD--PVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRAL
MAV_3885|M.avium_104 YRAVFADGSSLDVHRDPDRMADAVAEFAGREQATGYRRLRAW---LTRLY
MMAR_4806|M.marinum_M YTAMFADGSSIDVHCDADRMVAAIENFAGPEQATGYLRLREW---LTRLY
MSMEG_2347|M.smegmatis_MC2_155 YRAQFADGSALEVHSDADRMAAAIADLAGPSEAAGYRRLRDW---LTRLY
Mflv_1847|M.gilvum_PYR-GCK YRASFADGTSLDVHTDPGVMAAEIERFAGPEEAAGYARMRQW---LSKLY
Mvan_1578|M.vanbaalenii_PYR-1 YHAKFADGSALAVHTEADAMVSEIKRFAGRREADGYLRLREW---LTKLY
TH_0076|M.thermoresistible__bu YRAEFADGSGLDVHTDPAAMADEITRFAGGAQAAGYLQLRNW---LDLLY
MUL_1423|M.ulcerans_Agy99 FRTPAARFHLGEHRIEMPPTLPTLATVARR-LPALFSAFRTVR----KGP
MAB_2659|M.abscessus_ATCC_1997 MAGKRKTWTGTLPTVDPVDLEDLGRITIEMGKLLETINVDAAWK---SPN
: .
Mb3859c|M.bovis_AF2122/97 GRFEAGTLPKSFDEMYACATNEFERSAIDDMLFGSVTDVLDRHFPDREKH
Rv3829c|M.tuberculosis_H37Rv GRFEAGTLPKSFDEMYACATNEFERSAIDDMLFGSVTDVLDRHFPDREKH
MAV_3885|M.avium_104 RTEFDGFIAANFDSPLSLLTPRLAQLIAIGG-FRNWDRMVKRYLSDPR--
MMAR_4806|M.marinum_M RIEFAGFIGSNFDSPLSLLTPQLARLAAAGG-FRNWDSMVKRHITDPR--
MSMEG_2347|M.smegmatis_MC2_155 RIEIDGFIGANFDSPLSLLTPQLAQLAAIGG-FGKWDHMVRRHLRDPR--
Mflv_1847|M.gilvum_PYR-GCK ELEFNGFINANFDSPLSLLTPQLARLAAIGG-FRRWEPMVRRFLSDER--
Mvan_1578|M.vanbaalenii_PYR-1 RTEFDGFIANNFDSPLSLLTPSLARLVALGG-FRRWEPAVRRFLKDER--
TH_0076|M.thermoresistible__bu RTEFDRFIAANFDSPLSLVSPHLAKLVALGG-FRRWEKVMRRFITDER--
MUL_1423|M.ulcerans_Agy99 GQTLGQLIDGAVQDRLLMAAAAIPAYALLRS-------------PD----
MAB_2659|M.abscessus_ATCC_1997 ADQLDSISFGEWLSQQQAVTSTNALMYIVTR-------------------
. :
Mb3859c|M.bovis_AF2122/97 GALRGSMTVLAVNTLYRGPATPGSAAALAFGLGVPEGDFVRWKKLRGGIG
Rv3829c|M.tuberculosis_H37Rv GALRGSMTVLAVNTLYRGPATPGSAAALAFGLGVPEGDFVRWKKLRGGIG
MAV_3885|M.avium_104 -----LQRIFTFQSLYAGVAPRDALAVYAVIAYMDTVSGVVFP--RGGVR
MMAR_4806|M.marinum_M -----LRRVFTFQSLYAGVAPQDALAAYAVIAYMDTISGVFFP--RGGVR
MSMEG_2347|M.smegmatis_MC2_155 -----LQRVFTFQSLYAGVSPQRALAAYAVIAYMDTISGVFFP--KGGVR
Mflv_1847|M.gilvum_PYR-GCK -----LLRVFTFQALYVGVPPRRALAAYAVIAYMDTVSGVYFP--RGGMR
Mvan_1578|M.vanbaalenii_PYR-1 -----LLRVFTFQSLYAGVPPQSALAVYAVIAYMDTVAGVYFP--RGGMR
TH_0076|M.thermoresistible__bu -----LLRVFTFQALYVGVPPQRALAVYAVIAYMDTVNGVYFP--AGGVR
MUL_1423|M.ulcerans_Agy99 ----------DLTVEQVGQAYSKQLGYRYQKSYTP----------VGGPA
MAB_2659|M.abscessus_ATCC_1997 ---------VQWGCSPLDVSLLHVLRYVQAVGGLDHMLAVEHGQQEYRVT
. .
Mb3859c|M.bovis_AF2122/97 ALTTHLSQ-LLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGDTLT
Rv3829c|M.tuberculosis_H37Rv ALTTHLSQ-LLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGDTLT
MAV_3885|M.avium_104 ALPDALAA-AASDAGVQFRYGTTVTALEK----TGGRVGAVLTEQAGRIS
MMAR_4806|M.marinum_M ALPDALAA-AAACAGVQFHYGSQVSELER----DDARITAVRTDRGERIA
MSMEG_2347|M.smegmatis_MC2_155 AVPDALAA-AGADAGVRFHYGATVNCLER----SADRVTAVHTDTGERIP
Mflv_1847|M.gilvum_PYR-GCK ALPDAMAA-AAADAGVEFRYDAPVSALER----SGSRVTAVRTVTGERIP
Mvan_1578|M.vanbaalenii_PYR-1 ALPDAMAA-AASRAGVEFVYNATVSDLEF----IGSRVTAVRTVDGGRVR
TH_0076|M.thermoresistible__bu AVPEALAA-AARDAGVEFCYRERVTGLER----SGDRVTAVHTDTGRRLA
MUL_1423|M.ulcerans_Agy99 AMIAAMVQ-RFEALGGELWLGCHSTQVER-------VGAEKRVHTSDALV
MAB_2659|M.abscessus_ATCC_1997 ETTQEIAKRLAAQIGDQIVLNTRVRQISQ-----DDNGVTVSTDSG----
: * .. : . .
Mb3859c|M.bovis_AF2122/97 SPIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRG-SYLQMHFALAQ
Rv3829c|M.tuberculosis_H37Rv SPIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRG-SYLQMHFALAQ
MAV_3885|M.avium_104 -----------------CDAVVLTTELPQTYALLGRTPRRALRLRHSPSA
MMAR_4806|M.marinum_M -----------------CDAVVLTTELPTTYRLLGRTPRRLRRLRAAPSA
MSMEG_2347|M.smegmatis_MC2_155 -----------------CDAVVLTTELPRTYELLGRTPRRPRPWRASPSA
Mflv_1847|M.gilvum_PYR-GCK -----------------ADAVVLTTELPDTYRLLGRTPRRMVPLRPAPSA
Mvan_1578|M.vanbaalenii_PYR-1 -----------------ADSVVLTTELPDTYRLIGRTPVRPLRLRPAPSA
TH_0076|M.thermoresistible__bu -----------------ADVVVLTTELPDSYRLLGRRPRRPARLRPAPSA
MUL_1423|M.ulcerans_Agy99 P----------------ARVVLSSAGRWSEFPKTTKAGMEFAVLLFAVRK
MAB_2659|M.abscessus_ATCC_1997 -------------------------VINAKYAIVTAAPEHRAYIEYQPAL
:
Mb3859c|M.bovis_AF2122/97 PPAFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQ
Rv3829c|M.tuberculosis_H37Rv PPAFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQ
MAV_3885|M.avium_104 VVAHVGCPAVASQ---TAHHTILFGDAWDHTFADIIGAGQLMRDPSLLVT
MMAR_4806|M.marinum_M VVVHAGCRSASTASEPAAHHTILFGQAWEQTFTDIIRDGRLMRDPSLLVT
MSMEG_2347|M.smegmatis_MC2_155 VVVHVGCRRIDRP---VAHHNILFGDAWHDTFTDIIDDGRLMRDPSLLVT
Mflv_1847|M.gilvum_PYR-GCK VVAHFGTRAPAQDTDGS-HHTILFGDAWERTFDEIIDQGRPMADPSLLVT
Mvan_1578|M.vanbaalenii_PYR-1 VVAHVGCRAVGPDADDAGHHTILFGDAWTQTFRDIIDDGRVMGDPSLLVT
TH_0076|M.thermoresistible__bu VVAHVGCRRAEP---APPHHTILFGSAWEQTFRDIIDDGRLMRDPSLLVS
MUL_1423|M.ulcerans_Agy99 GFTYP-----------RGYHTIAWLQQDIGEELRKLDAGQPISRPSFHIF
MAB_2659|M.abscessus_ATCC_1997 PAKIEG---------LTTSFPMGALSKAFVAYDKPFWRAEGLSGEALTDT
: . :.
Mb3859c|M.bovis_AF2122/97 IPSLHDPSLAPAGKQAASAFAMWFPIE-GGSKYGGYGRAKVEMGQNVIDK
Rv3829c|M.tuberculosis_H37Rv IPSLHDPSLAPAGKQAASAFAMWFPIE-GGSKYGGYGRAKVEMGQNVIDK
MAV_3885|M.avium_104 RPTASDPTLAPRGRDLLYVLAPAPNLESGGIDWDSVGRGYVDDLIALVGQ
MMAR_4806|M.marinum_M RPTAGDPALAPPGRDLLYLLAPAPNLTAGRVDWGSAGGSYAQSMIDTVAS
MSMEG_2347|M.smegmatis_MC2_155 RPTRGDPALAPAGRDLLYLLAPTPNLSSTAIDWETEGPAYAQRVVDTVAE
Mflv_1847|M.gilvum_PYR-GCK RPALGDPSVAPPGRDLLYVLAPAPNTDVGHRDWDADQDGYTSHMLDTVRE
Mvan_1578|M.vanbaalenii_PYR-1 RPTATDPTLAPAGRDLLYVLAPAPNTDVGTLDWDAAGSGYVEQMLSAVRS
TH_0076|M.thermoresistible__bu RPTAGDASLAPDGRDLLYILAPAPNTAAGRIDWDLLGDGYAEEMLNAVSA
MUL_1423|M.ulcerans_Agy99 RSDLPQP-------RDHYTINAFIPLPRGEGDPSARRRQDLSAHAVATID
MAB_2659|M.abscessus_ATCC_1997 APVFITFDVSPSDDGPGILMVFCTARVYDGFGPEVRRKLVLKQLVDLYGE
. : .
Mb3859c|M.bovis_AF2122/97 ITRLAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHSDQIGPN---
Rv3829c|M.tuberculosis_H37Rv ITRLAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHSDQIGPN---
MAV_3885|M.avium_104 RLLPGLPGSATVLDVVTPADWARRGMAAGSPFALAHTFAQTGPFRPANMV
MMAR_4806|M.marinum_M RLLPDLRDSVELLDVVTPLDWARQGMAAGTPFALAHTFGQTGPFRPANTV
MSMEG_2347|M.smegmatis_MC2_155 RLLPELRDDAQVLQVVTPADWARQGMVAGTPFALAHTFSQTGPFRPGNTV
Mflv_1847|M.gilvum_PYR-GCK R-MPHLGDDAELLRVVTPRDWARQGMASGTPFALSHTFAQTGPFRPANTI
Mvan_1578|M.vanbaalenii_PYR-1 R-MPGVAEDAELLHVVTPADWRRQGMASGTPFALAHTFAQTGPFRPANTV
TH_0076|M.thermoresistible__bu R-LPESTVDAEMLHVVNPADWERQGMAAGTPFALAHTFSQTGPFRPGNMV
MUL_1423|M.ulcerans_Agy99 KDLPGFKDALMYQRFLSPVEYASRLGLHSAPSSFVPPTGFAG---LPSYD
MAB_2659|M.abscessus_ATCC_1997 QANTPIDY--------IDHCWGTEPFAAGGPHPAAPPFASVNYGEALREP
. . .
Mb3859c|M.bovis_AF2122/97 RPGPKGFIGQPIPIAGLYLGSAGCHGGPGITFIPGYNAARQALADRRAAN
Rv3829c|M.tuberculosis_H37Rv RPGPKGFIGQPIPIAGLYLGSAGCHGGPGITFIPGYNAARQALADRRAAN
MAV_3885|M.avium_104 RGIDNAVLAGSSTVPGVGVPTTLISGRLAADRITGVSKRTPARIDMKAGS
MMAR_4806|M.marinum_M RGIDNAVLAGSSTVPGVGVPTTLISGRLAADRITGNTTRSIRHLDLKAQL
MSMEG_2347|M.smegmatis_MC2_155 RGVANAVLAGSSTVPGVGVPTALLSGRLAADRVTGTVRRTRTHHDINSVT
Mflv_1847|M.gilvum_PYR-GCK RGIDNAVLAGSSTVPGVGIPTAIVSGRLAADRVTGAGSRTQPRVVTQ---
Mvan_1578|M.vanbaalenii_PYR-1 RGIDNVVLAGSSTVPGVGVPTAILSGRLAADRITGIPVRPRPSEVHR---
TH_0076|M.thermoresistible__bu RGVANAVLAGGSTVPGVGIPTALLSGRLAADRITGAAR------------
MUL_1423|M.ulcerans_Agy99 AARDTYFIGTSVGPAGEHAGAACLSGKMAADLAIKQLRR-----------
MAB_2659|M.abscessus_ATCC_1997 HGRIHWAGTETAGEWVGTMNGAILMGLHTADQIAQQLGVTGEVSK-----
: *
Mb3859c|M.bovis_AF2122/97 CCVLSGR----
Rv3829c|M.tuberculosis_H37Rv CCVLSGR----
MAV_3885|M.avium_104 P----------
MMAR_4806|M.marinum_M S----------
MSMEG_2347|M.smegmatis_MC2_155 AATADRKARMP
Mflv_1847|M.gilvum_PYR-GCK -----------
Mvan_1578|M.vanbaalenii_PYR-1 -----------
TH_0076|M.thermoresistible__bu -----------
MUL_1423|M.ulcerans_Agy99 -----------
MAB_2659|M.abscessus_ATCC_1997 -----------