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VVIGSGISGLTAAINLQRNGIRTLVVERREVPGGLCGTFTLDGYEFVTGCNDFGGGLVRHLEELGVGTEF RTPAARFHLGEHRIEMPPTLPTLATVARRLPALFSAFRTVRKGPGQTLGQLIDGAVQDRLLMAAAAIPAY ALLRSPDDLTVEQVGQAYSKQLGYRYQKSYTPVGGPAAMIAAMVQRFEALGGELWLGCHSTQVERVGAEK RVHTSDALVPARVVLSSAGRWSEFPKTTKAGMEFAVLLFAVRKGFTYPRGYHTIAWLQQDIGEELRKLDA GQPISRPSFHIFRSDLPQPRDHYTINAFIPLPRGEGDPSARRRQDLSAHAVATIDKDLPGFKDALMYQRF LSPVEYASRLGLHSAPSSFVPPTGFAGLPSYDAARDTYFIGTSVGPAGEHAGAACLSGKMAADLAIKQLR R
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1423 | - | - | 100% (421) | dehydrogenase |
| M. ulcerans Agy99 | MUL_2101 | - | 2e-28 | 40.57% (175) | hypothetical protein MUL_2101 |
| M. ulcerans Agy99 | MUL_2934 | - | 9e-06 | 48.94% (47) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3859c | - | 3e-06 | 48.94% (47) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1847 | - | 1e-05 | 44.90% (49) | phytoene dehydrogenase-related protein |
| M. tuberculosis H37Rv | Rv3829c | - | 3e-06 | 48.94% (47) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1172 | - | 0.0 | 99.52% (421) | dehydrogenase |
| M. avium 104 | MAV_3885 | - | 1e-06 | 48.98% (49) | phytoene dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2347 | - | 1e-06 | 48.98% (49) | phytoene dehydrogenase |
| M. thermoresistible (build 8) | TH_2567 | - | 1e-06 | 37.33% (75) | PUTATIVE - |
| M. vanbaalenii PYR-1 | Mvan_1578 | - | 6e-06 | 44.90% (49) | phytoene dehydrogenase-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3885|M.avium_104 MSMRAIEGSADHVVVIGAGLAGLSAALHLAGRGRAVTVVEREAWPGGRAG
MSMEG_2347|M.smegmatis_MC2_155 -MSRAIPGPTDHVVVVGAGLSGLSAALHLAGRGRRVTVVEREPWPGGRAG
Mflv_1847|M.gilvum_PYR-GCK --MRSVPGAGDRVVVVGAGLAGLSAAMHLAGRGRQVTVVERDPHPGGRMG
Mvan_1578|M.vanbaalenii_PYR-1 --MRTLGGKTDRVVVVGAGLSGLSAALQLAGRGRQVTVLERGDHPGGRVG
MUL_1423|M.ulcerans_Agy99 -------------MVIGSGISGLTAAINLQRNGIRTLVVERREVPGGLCG
MMAR_1172|M.marinum_M -MPRSGCPPQFDAVVIGSGISGLTAAINLQRNGIRTLVVERREVPGGLCG
Mb3859c|M.bovis_AF2122/97 -------MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMAS
Rv3829c|M.tuberculosis_H37Rv -------MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMAS
TH_2567|M.thermoresistible__bu ----MTTEQEFDAIVIGAGAGGLFTAARLAHQGFRTVVVERLDKVGGRAS
:*:*:* ** :* * * . :: ** .
MAV_3885|M.avium_104 RRD-IDGYRIDTGPTVLTMPDIIEDTFAAVGDSLARRLELCTLDPAYRAV
MSMEG_2347|M.smegmatis_MC2_155 RID-TGGYRIDTGPTVLTMPDILDDVFAAVGESVGDRLQLLPVDPAYRAQ
Mflv_1847|M.gilvum_PYR-GCK RAD-VNGYRLDTGPTVLTMPDIIDETFAALGETTSDRVHLDPVLPAYRAS
Mvan_1578|M.vanbaalenii_PYR-1 RAD-VNGYRLDTGPTVLTMPDIIDDAFAAVGESLADRLPMDPVHPAYHAK
MUL_1423|M.ulcerans_Agy99 TFT-LDGYEFVTGCNDFGG--GLVRHLEELGVG----TEFRTPAARFH-L
MMAR_1172|M.marinum_M TFT-LDGYEFVTGCNDFGG--GLVRHLEELGVG----TEFRTPAARFH-L
Mb3859c|M.bovis_AF2122/97 TVELFDGYRFDIAGSVQFP--TSSAVSSELGLDSLPTVDLEVMSVALRGV
Rv3829c|M.tuberculosis_H37Rv TVELFDGYRFEIAGSVQFP--TSSAVSSELGLDSLPTVDLEVMSVALRGV
TH_2567|M.thermoresistible__bu TDD-IDGFKVNNGAIVIETGGITQQTCEEVGAP-----------------
.*:.. . :*
MAV_3885|M.avium_104 FADGSSLDVHRDPDRMADAVAEFAGREQATGYRRLRAWLTRLYRTEFDGF
MSMEG_2347|M.smegmatis_MC2_155 FADGSALEVHSDADRMAAAIADLAGPSEAAGYRRLRDWLTRLYRIEIDGF
Mflv_1847|M.gilvum_PYR-GCK FADGTSLDVHTDPGVMAAEIERFAGPEEAAGYARMRQWLSKLYELEFNGF
Mvan_1578|M.vanbaalenii_PYR-1 FADGSALAVHTEADAMVSEIKRFAGRREADGYLRLREWLTKLYRTEFDGF
MUL_1423|M.ulcerans_Agy99 GEHR--IEMPPTLPTLATVARRLP-----ALFSAFRTVR-KGPGQTLGQL
MMAR_1172|M.marinum_M GEHR--IEMPPTLPTLATVARRLP-----ALFSAFRTVR-KGPGQTLGQL
Mb3859c|M.bovis_AF2122/97 GDDP--VVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWS-QAPTRALGRF
Rv3829c|M.tuberculosis_H37Rv GDDP--VVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWS-QAPTRALGRF
TH_2567|M.thermoresistible__bu ------FDIREPKPPILYRIGGKNVDVTGGGWGFLLGKLTRQGAKLVKGI
. : : : . :
MAV_3885|M.avium_104 IAANFDSPLSLLTPRLAQLIAIGGFRNWDRMVKRYLSDPRLQRIFTFQSL
MSMEG_2347|M.smegmatis_MC2_155 IGANFDSPLSLLTPQLAQLAAIGGFGKWDHMVRRHLRDPRLQRVFTFQSL
Mflv_1847|M.gilvum_PYR-GCK INANFDSPLSLLTPQLARLAAIGGFRRWEPMVRRFLSDERLLRVFTFQAL
Mvan_1578|M.vanbaalenii_PYR-1 IANNFDSPLSLLTPSLARLVALGGFRRWEPAVRRFLKDERLLRVFTFQSL
MUL_1423|M.ulcerans_Agy99 IDGAVQDRLLMAAAAIPAYALLRSPDDLTVEQVGQAYSKQLGYR------
MMAR_1172|M.marinum_M IDGAVQDRLLMAAAAIPAYALLRSPDDLTVEQVGQAYSKQLGYR------
Mb3859c|M.bovis_AF2122/97 EAGTLPKSFDEMYACATNEFERSAIDDMLFGSVTDVLDRHFPDREKHGAL
Rv3829c|M.tuberculosis_H37Rv EAGTLPKSFDEMYACATNEFERSAIDDMLFGSVTDVLDRHFPDREKHGAL
TH_2567|M.thermoresistible__bu GAARNDSGLPEDEISTAEWVAKYTKNEGVHGIFRNMCASVFAVGSEDLPA
. : . :
MAV_3885|M.avium_104 YAGVAPRDALAVYAVIAYMDTVSGVVFP--------------RGGVRALP
MSMEG_2347|M.smegmatis_MC2_155 YAGVSPQRALAAYAVIAYMDTISGVFFP--------------KGGVRAVP
Mflv_1847|M.gilvum_PYR-GCK YVGVPPRRALAAYAVIAYMDTVSGVYFP--------------RGGMRALP
Mvan_1578|M.vanbaalenii_PYR-1 YAGVPPQSALAVYAVIAYMDTVAGVYFP--------------RGGMRALP
MUL_1423|M.ulcerans_Agy99 ------------YQKSYTP-----------------------VGGPAAMI
MMAR_1172|M.marinum_M ------------YQKSYTP-----------------------VGGPAAMI
Mb3859c|M.bovis_AF2122/97 RGSMTVLAVNTLYRGPATPGSAAALAFGLGVPEGDFVRWKKLRGGIGALT
Rv3829c|M.tuberculosis_H37Rv RGSMTVLAVNTLYRGPATPGSAAALAFGLGVPEGDFVRWKKLRGGIGALT
TH_2567|M.thermoresistible__bu RVFLTYFTRKSAFKRFGFHP-----------------------EGTIGLW
: * .:
MAV_3885|M.avium_104 DALAAAASDAGVQFRYGTTVTALEKTGG----RVGAVLTEQAGR---ISC
MSMEG_2347|M.smegmatis_MC2_155 DALAAAGADAGVRFHYGATVNCLERSAD----RVTAVHTDTGER---IPC
Mflv_1847|M.gilvum_PYR-GCK DAMAAAAADAGVEFRYDAPVSALERSGS----RVTAVRTVTGER---IPA
Mvan_1578|M.vanbaalenii_PYR-1 DAMAAAASRAGVEFVYNATVSDLEFIGS----RVTAVRTVDGGR---VRA
MUL_1423|M.ulcerans_Agy99 AAMVQRFEALGGELWLGCHSTQVERVGAEKRVHTSDALVPARVV---LSS
MMAR_1172|M.marinum_M AAMVQRFEALGGELWLGCHSTQVERVGAEKRVHTSDALVPARVV---LSS
Mb3859c|M.bovis_AF2122/97 THLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGDT---LTS
Rv3829c|M.tuberculosis_H37Rv THLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGDT---LTS
TH_2567|M.thermoresistible__bu RGLAGAVERHGGQVWLSTPATKILTDGT----AVQGVVVERDGRQLTLTA
: * .. . : . . . : .
MAV_3885|M.avium_104 DAVVLTTELPQTYALLGRTPRRALRLRHSPSAVVAHVG------------
MSMEG_2347|M.smegmatis_MC2_155 DAVVLTTELPRTYELLGRTPRRPRPWRASPSAVVVHVG------------
Mflv_1847|M.gilvum_PYR-GCK DAVVLTTELPDTYRLLGRTPRRMVPLRPAPSAVVAHFG------------
Mvan_1578|M.vanbaalenii_PYR-1 DSVVLTTELPDTYRLIGRTPVRPLRLRPAPSAVVAHVG------------
MUL_1423|M.ulcerans_Agy99 AGRWSEFP--KTTKAGMEFAVLLFAVRKGFTYPRG---------------
MMAR_1172|M.marinum_M AGRWSEFP--KTTKAGMEFAVLLFAVRKGFTYPRG---------------
Mb3859c|M.bovis_AF2122/97 PIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHFALAQPP
Rv3829c|M.tuberculosis_H37Rv PIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHFALAQPP
TH_2567|M.thermoresistible__bu PVVVSDVGPAATVTLLGEENVPADYRKMVKKGDRPTS-------------
* :
MAV_3885|M.avium_104 ----CPAVAS---QTAHHTILFGDAWDHTFADIIGAGQLMRDPSLLVTRP
MSMEG_2347|M.smegmatis_MC2_155 ----CRRIDR---PVAHHNILFGDAWHDTFTDIIDDGRLMRDPSLLVTRP
Mflv_1847|M.gilvum_PYR-GCK ----TRAPAQDTDGS-HHTILFGDAWERTFDEIIDQGRPMADPSLLVTRP
Mvan_1578|M.vanbaalenii_PYR-1 ----CRAVGPDADDAGHHTILFGDAWTQTFRDIIDDGRVMGDPSLLVTRP
MUL_1423|M.ulcerans_Agy99 --------------------YHTIAWLQQDIGEELRKLDAGQPISRPSFH
MMAR_1172|M.marinum_M --------------------YHTIAWLQQDIGEELRKLDAGQPISRPSFH
Mb3859c|M.bovis_AF2122/97 AFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQIP
Rv3829c|M.tuberculosis_H37Rv AFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQIP
TH_2567|M.thermoresistible__bu ------------------MISVNFASRERLVDVPGMLSFAKSRRLAYIAN
.
MAV_3885|M.avium_104 TASDPTLAPRGRDLLYVLAPAPNLESGG-IDWDSVGRGYVDDLIALVGQR
MSMEG_2347|M.smegmatis_MC2_155 TRGDPALAPAGRDLLYLLAPTPNLSSTA-IDWETEGPAYAQRVVDTVAER
Mflv_1847|M.gilvum_PYR-GCK ALGDPSVAPPGRDLLYVLAPAPNTDVGH-RDWDADQDGYTSHMLDTVRER
Mvan_1578|M.vanbaalenii_PYR-1 TATDPTLAPAGRDLLYVLAPAPNTDVGT-LDWDAAGSGYVEQMLSAVRSR
MUL_1423|M.ulcerans_Agy99 IFRSDLPQPRDHYTINAFIPLPRGEGDP----SARRRQDLSAHAVATIDK
MMAR_1172|M.marinum_M IFRSDLPQPRDHYTINAFIPLPRGEGDP----SARRRQDLSAHAVATIDK
Mb3859c|M.bovis_AF2122/97 SLHDPSLAPAGKQAASAFAMWFPIEGGSKYGGYGRAKVEMGQNVIDKITR
Rv3829c|M.tuberculosis_H37Rv SLHDPSLAPAGKQAASAFAMWFPIEGGSKYGGYGRAKVEMGQNVIDKITR
TH_2567|M.thermoresistible__bu FTDTCPEMAPEGWNLYVGTAVPKPSIGD-----FDQAAETELLLQDLRDN
. . .
MAV_3885|M.avium_104 LLPGLPGSATVLDVVTPADWARRGMAAG--------SPFALAHTFAQTGP
MSMEG_2347|M.smegmatis_MC2_155 LLPELRDDAQVLQVVTPADWARQGMVAG--------TPFALAHTFSQTGP
Mflv_1847|M.gilvum_PYR-GCK -MPHLGDDAELLRVVTPRDWARQGMASG--------TPFALSHTFAQTGP
Mvan_1578|M.vanbaalenii_PYR-1 -MPGVAEDAELLHVVTPADWRRQGMASG--------TPFALAHTFAQTGP
MUL_1423|M.ulcerans_Agy99 DLPGFKDALMYQRFLSPVEYASRLGLHS--------APSSFVP----PTG
MMAR_1172|M.marinum_M DLPGFKDALIYQRFLSPVEYASRLGLHS--------APSPFVP----PTG
Mb3859c|M.bovis_AF2122/97 LAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHSDQIGPNRPGPKG
Rv3829c|M.tuberculosis_H37Rv LAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHSDQIGPNRPGPKG
TH_2567|M.thermoresistible__bu IDDFDNRARILNIAITRDDWPPQRAVAG----------FDLPHDTPFANL
.: . . : .
MAV_3885|M.avium_104 FRPANMVRGIDNAVLAGSSTVP------GVGVPTTLISGRLAADRITGVS
MSMEG_2347|M.smegmatis_MC2_155 FRPGNTVRGVANAVLAGSSTVP------GVGVPTALLSGRLAADRVTGTV
Mflv_1847|M.gilvum_PYR-GCK FRPANTIRGIDNAVLAGSSTVP------GVGIPTAIVSGRLAADRVTGAG
Mvan_1578|M.vanbaalenii_PYR-1 FRPANTVRGIDNVVLAGSSTVP------GVGVPTAILSGRLAADRITGIP
MUL_1423|M.ulcerans_Agy99 FAGLPSYDAARDTYFIGTSVGP-----AGEHAGAACLSGKMAADLAIKQL
MMAR_1172|M.marinum_M FAGLPSYDAARDTYFIGTSVGP-----AGEHAGAACLSGKMAADLAIKQL
Mb3859c|M.bovis_AF2122/97 FIGQPIPIAGLYLGSAGCHGGPGITFIPGYNAARQALADRRAANCCVLSG
Rv3829c|M.tuberculosis_H37Rv FIGQPIPIAGLYLGSAGCHGGPGITFIPGYNAARQALADRRAANCCVLSG
TH_2567|M.thermoresistible__bu WNVGDGVKEYANGGTTACAETA------KLVVDKILASHRPAASR-----
: . . : : **.
MAV_3885|M.avium_104 KRT----------PARIDMKAGSP
MSMEG_2347|M.smegmatis_MC2_155 RRTRTHHDINSVTAATADRKARMP
Mflv_1847|M.gilvum_PYR-GCK SRTQ---------PRVVTQ-----
Mvan_1578|M.vanbaalenii_PYR-1 VRPR---------PSEVHR-----
MUL_1423|M.ulcerans_Agy99 RR----------------------
MMAR_1172|M.marinum_M RR----------------------
Mb3859c|M.bovis_AF2122/97 R-----------------------
Rv3829c|M.tuberculosis_H37Rv R-----------------------
TH_2567|M.thermoresistible__bu ------------------------