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VSDVLVVGGGHNGLIAALRLARAGRRVTVVEQGAEPGGCVWTDRHPSGVLVERGAFEHGGVYPMAVELGL DDPALGDRAVRYREHPVLAGVAFGDGQRRVFYSDVAATVAALGADGPGYRHLVELADALFGMLDTFGTAP TLTQVAAALAALPGGDELFRTLLQPAETVLDAAVSDPHTRAAMALQAAHAQVPAWAPGSGLFALLLPASH RSPAVRPAGGSRALVDALVAALERAGATVRTGAAVVAMGSTESPAAARGRVELAGGAVLTADAVVSAIGL PRTAALLTDPAPAMRATARGLHSGHFNIAELTVTVVHDRAHALPLQDPDAVWYTLRAPADVRTGFAEVLA GRLPSSPWSMVGQVGQPDGITGGAVWMSSIVPLHRADGEWTPEREREAADRVIDQVGSVLGVDLRDGLVD VVVSGPLTWAARIGGDGNPNHLDNTLDQLLGWRPPGHADMRTELPWLFLAGAGQHPGGGLSGTSGSAAAA AVLGTRRRDRLDRRAVREVHALWSGLTAYRAMRRGPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3148 | - | - | 100% (527) | amine oxidase |
| M. vanbaalenii PYR-1 | Mvan_0988 | - | 1e-13 | 26.12% (536) | FAD dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1578 | - | 8e-13 | 26.37% (531) | phytoene dehydrogenase-related protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0921c | - | 3e-13 | 25.32% (545) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1847 | - | 3e-16 | 27.41% (518) | phytoene dehydrogenase-related protein |
| M. tuberculosis H37Rv | Rv0897c | - | 3e-13 | 25.32% (545) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4734 | - | 3e-25 | 28.79% (521) | dehydrogenase |
| M. marinum M | MMAR_1580 | - | 4e-20 | 27.73% (512) | dehydrogenase |
| M. avium 104 | MAV_3885 | - | 1e-19 | 29.85% (536) | phytoene dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5400 | - | 2e-22 | 26.74% (516) | dehydrogenase |
| M. thermoresistible (build 8) | TH_4571 | - | 4e-16 | 27.34% (523) | PUTATIVE dehydrogenase |
| M. ulcerans Agy99 | MUL_2934 | - | 2e-13 | 24.14% (526) | dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0921c|M.bovis_AF2122/97 ------------------MSDHDRDFDVVVVGGGHNGLVAAAYLARAGLR
Rv0897c|M.tuberculosis_H37Rv ------------------MSDHDRDFDVVVVGGGHNGLVAAAYLARAGLR
MMAR_1580|M.marinum_M --------------------MKGASQTAIVVGGGPNGLAAAITLAKAGLQ
TH_4571|M.thermoresistible__bu VAAERSGADHGHLVPVPRRAGGGGVTTATVVGSGPNGLAAAVTLAKAGVA
MAB_4734|M.abscessus_ATCC_1997 ------------------------MSTAVIVGGGPNGLTAAILLAQQGVH
MSMEG_5400|M.smegmatis_MC2_155 --------------------MSRDSADAVVIGAGHNGLVAAAMLADAGWD
Mflv_1847|M.gilvum_PYR-GCK -----------------MRSVPGAGDRVVVVGAGLAGLSAAMHLAGRGRQ
MAV_3885|M.avium_104 ---------------MSMRAIEGSADHVVVIGAGLAGLSAALHLAGRGRA
Mvan_3148|M.vanbaalenii_PYR-1 ------------------------MSDVLVVGGGHNGLIAALRLARAGRR
MUL_2934|M.ulcerans_Agy99 ----------------------MTDYDAIVVGAGHNGLTAAAVLQRAGLR
. ::*.* ** ** * *
Mb0921c|M.bovis_AF2122/97 VRLLERLAQTGGAAVSIQAFDGVEVALSRYSYLVSLLPSRIVADLGAP--
Rv0897c|M.tuberculosis_H37Rv VRLLERLAQTGGAAVSIQAFDGVEVALSRYSYLVSLLPSRIVADLGAP--
MMAR_1580|M.marinum_M VTVLEAAEEVGGGARSSEAIVLGLVHDHCSAIHPMAVGSEFLTGLDLDRH
TH_4571|M.thermoresistible__bu VTVLEAADEIGGGTRSFEAIVPGLLHDHCSAIHPMAVGSPFINEFGLDRH
MAB_4734|M.abscessus_ATCC_1997 VTVLEAADSVGGGVRSGAATGPGLIHDYCSAIHPMAVGSPVLAGLDLEKH
MSMEG_5400|M.smegmatis_MC2_155 VLVLEAQPEPGGAVKS-AELVPGYTSDLFSAFYPLSVASPALRALNLEDH
Mflv_1847|M.gilvum_PYR-GCK VTVVERDPHPGG--RMGRADVNGYRLDTGPTVLTMPDIIDETFAALGETT
MAV_3885|M.avium_104 VTVVEREAWPGG--RAGRRDIDGYRIDTGPTVLTMPDIIEDTFAAVGDSL
Mvan_3148|M.vanbaalenii_PYR-1 VTVVEQGAEPGGCVWTDRHPSGVLVERGAFEHGGVYPMAVELGLDDPALG
MUL_2934|M.ulcerans_Agy99 TLCMEANTYAGGMAATVELIDGFHFEIAGSVQFPTASQISKELGLDTLP-
. :* **
Mb0921c|M.bovis_AF2122/97 -VRLARRPFSSYTPAPATAGRSGLLIGPTGEPRAAHLAAIGAAPDAHGFA
Rv0897c|M.tuberculosis_H37Rv -VRLARRPFSSYTPAPATAGRSGLLIGPTGEPRAAHLAAIGAAPDAHGFA
MMAR_1580|M.marinum_M GLSWLLPDIDCVHP--LDDGSAGVLHRSVGQTADGLG------ADGRRWR
TH_4571|M.thermoresistible__bu GLRWRWPDIDCVHP--LDDGTAGVLRRSVDHTAAGLG------PDGRVWR
MAB_4734|M.abscessus_ATCC_1997 GLQWLWPEVDCAHP--LDDGSCGVLYRDVAATANGLG------RDGRRWR
MSMEG_5400|M.smegmatis_MC2_155 GLRWTHAPAVVGHPRSAADDDAPMIYRDIDRTAAELDRHH--SGDGRRWC
Mflv_1847|M.gilvum_PYR-GCK SDRVHLDPVLPAYRASFADGTSLDVHTDPGVMAAEIERFAG-PEEAAGYA
MAV_3885|M.avium_104 ARRLELCTLDPAYRAVFADGSSLDVHRDPDRMADAVAEFAG-REQATGYR
Mvan_3148|M.vanbaalenii_PYR-1 DRAVRYREHPVLAGVAFGDGQRRVFYSDVAATVAALG------ADGPGYR
MUL_2934|M.ulcerans_Agy99 ----TVAPEVMSTNIGESDEEAMIFYRDPLQLISHLGEKHG-SAAVTGMA
.
Mb0921c|M.bovis_AF2122/97 AFYRRCRLVTARLWPTLIEP--LRTREQARRDIVEYGGHEAAAAWQAMVD
Rv0897c|M.tuberculosis_H37Rv AFYRRCRLVTARLWPTLIEP--LRTREQARRDIVEYGGHEAAAAWQAMVD
MMAR_1580|M.marinum_M ALFDWTSQRFDMLAEDIMGP--LLSIPGHPITLARFG--------VPTVL
TH_4571|M.thermoresistible__bu ALFGRPVDRFDAVNDAVMGP--LLRVPKHPLTLARFG--------APTVL
MAB_4734|M.abscessus_ATCC_1997 ALFERPARNFDLLTADIMGP--LLRIPRHPLALTRFG--------VPTVL
MSMEG_5400|M.smegmatis_MC2_155 DLFEQWLKIKDGLISSLFTP--FPPVSGLMQLLRKLGTAEALRLAQQLVM
Mflv_1847|M.gilvum_PYR-GCK RMRQWLSKLYELEFNGFINANFDSPLSLLTPQLARLAAIGGFRRWEPMVR
MAV_3885|M.avium_104 RLRAWLTRLYRTEFDGFIAANFDSPLSLLTPRLAQLIAIGGFRNWDRMVK
Mvan_3148|M.vanbaalenii_PYR-1 HLVELADALFGMLDTFGTAP----TLTQVAAALAALP--GGDELFRTLLQ
MUL_2934|M.ulcerans_Agy99 ELIGWSQGPARALGRFEVRTPPRTLDEMYACATNQAERRAIHEMLFGSAM
: .
Mb0921c|M.bovis_AF2122/97 EPIGHAIAGAVANDLLRGVIATDALIGTFARMHEPS--LMQNICFLYHLV
Rv0897c|M.tuberculosis_H37Rv EPIGHAIAGAVANDLLRGVIATDALIGTFARMHEPS--LMQNICFLYHLV
MMAR_1580|M.marinum_M P------ASVLAR-LFRTDQGRALFGGVAAHAFRPLHYPMTSAIGLGIIT
TH_4571|M.thermoresistible__bu P------ASALAR-VFRTPAARALWGGVAAHAFRPLHLPMTSAIGVGIIT
MAB_4734|M.abscessus_ATCC_1997 P------AAATAQ-LFRTRQARALFGGIAAHAFRPLHYPMTSAIGLGIIT
MSMEG_5400|M.smegmatis_MC2_155 P------AGIMAEHLFDGEAARLLLLGNAMHADVPIDGVGSAVMGYLLIM
Mflv_1847|M.gilvum_PYR-GCK R-------FLSDERLLRVFTFQALYVGVPPRR--------ALAAYAVIAY
MAV_3885|M.avium_104 R-------YLSDPRLQRIFTFQSLYAGVAPRD--------ALAVYAVIAY
Mvan_3148|M.vanbaalenii_PYR-1 P------AETVLDAAVSDPHTRAAMALQAAHAQVPAWAP-GSGLFALLLP
MUL_2934|M.ulcerans_Agy99 DVIDRFLPDKEKHAVMRGILAFLAVNSTYRGPFTPG--SAACLAFALAVP
Mb0921c|M.bovis_AF2122/97 GGGTGVWHVPIGGMGSVTSALATAAARHGAEIVTG-------------AD
Rv0897c|M.tuberculosis_H37Rv GGGTGVWHVPIGGMGSVTSALATAAARHGAEIVTG-------------AD
MMAR_1580|M.marinum_M AGHRHGWPVAAGGSQSITNALVATLDELGGKIETG---------------
TH_4571|M.thermoresistible__bu AGHRHGWAVAEGGSRAITDAMAARLRELGGTIETG---------------
MAB_4734|M.abscessus_ATCC_1997 AGHRHGWPVAAGGSQSITDALSSLLAQFGGRIETG---------------
MSMEG_5400|M.smegmatis_MC2_155 MAQDGGWPVPVGGAGQLTAALVNRARSAGARIECDRRVDGIDVRGGRAVG
Mflv_1847|M.gilvum_PYR-GCK MDTVSGVYFPRGGMRALPDAMAAAAADAGVEFRYD---------------
MAV_3885|M.avium_104 MDTVSGVVFPRGGVRALPDALAAAASDAGVQFRYG---------------
Mvan_3148|M.vanbaalenii_PYR-1 ASHRSPAVRPAGGSRALVDALVAALERAGATVRTGAAVVAMG-----STE
MUL_2934|M.ulcerans_Agy99 DDSTAMMTKLRGGIGALTDHLRERFASAGGEIRFRSKVVEIVVDRGAVSG
** : : * .
Mb0921c|M.bovis_AF2122/97 VFALDPDGTVRYHSDGSDGAEHLVRGRFVLVGVTPAVLASLLGEPVAALA
Rv0897c|M.tuberculosis_H37Rv VFALDPDGTVRYHSDGSDGAEHLVRGRFVLVGVTPAVLASLLGEPVAALA
MMAR_1580|M.marinum_M VRVQTASQLPPADVTMFDLAPDAVAGILG--DRMPGRIARAYNKFRRGPG
TH_4571|M.thermoresistible__bu VRVRDIADLPPTTITVFDLAPEAVAEILG--DRLPPRVARAYRAFRRGPG
MAB_4734|M.abscessus_ATCC_1997 VHVTSFTQLPTADVTLFDLSPTQVADILR--DHLPTSVARGLSRFRYGPG
MSMEG_5400|M.smegmatis_MC2_155 VRVSDGTTVRVRRAVIADTSAPRLYRDLLPEHAVPAAVRRSFDRFVWDTP
Mflv_1847|M.gilvum_PYR-GCK ---APVSALERSGSRVTAVRTVTGERIPADAVVLTTELPDTYRLLGRTPR
MAV_3885|M.avium_104 ---TTVTALEKTGGRVGAVLTEQAGRISCDAVVLTTELPQTYALLGRTPR
Mvan_3148|M.vanbaalenii_PYR-1 SPAAARGRVELAGGAVLTADAVVSAIGLPRTAALLTDPAPAMRATARGLH
MUL_2934|M.ulcerans_Agy99 VRLPDGSVIG-TPVVVSNLAPDVTLAKLVGPEHVPADLLARLAGRDHRAS
Mb0921c|M.bovis_AF2122/97 PGAQVKVNMVVRRLPRLRDD-SVTPQQAFAGTFHVNETWSQLDAAYSQAA
Rv0897c|M.tuberculosis_H37Rv PGAQVKVNMVVRRLPRLRDD-SVTPQQAFAGTFHVNETWSQLDAAYSQAA
MMAR_1580|M.marinum_M ---AFKVDFAIEGAVPWTN-----PQARRAGTVHLGGPYAELAAAEREVH
TH_4571|M.thermoresistible__bu ---AFKVDFAVEGGVPWCN-----PDAHRAGTVHVGGTFEEIAATERDVN
MAB_4734|M.abscessus_ATCC_1997 ---AFKVDFAIEDGVPWTN-----PDAGRAGTVHLGGTFAEVASTERAVH
MSMEG_5400|M.smegmatis_MC2_155 ---VLKINYALDAPVPWRS-----KNLNDAGTVHVGADHDGLVRWMADLN
Mflv_1847|M.gilvum_PYR-GCK --RMVPLRPAPSAVVAHFGT-RAPAQDTDGSHHTILFGDAWERTFDEIID
MAV_3885|M.avium_104 --RALRLRHSPSAVVAHVG---CPAVASQTAHHTILFGDAWDHTFADIIG
Mvan_3148|M.vanbaalenii_PYR-1 SGHFNIAELTVTVVHDRAH---ALPLQDPDAVWYTLRAPADVRTGFAEVL
MUL_2934|M.ulcerans_Agy99 ---FVQIHFALDALPEFAPPYELLNEPGMQQSVGIFGTPEEQQQQWETCR
Mb0921c|M.bovis_AF2122/97 SGRLPDPLPCEAYCHSLTDPSILSARLRDAGAQTLTVFGLHTPHSVFGDT
Rv0897c|M.tuberculosis_H37Rv SGRLPDPLPCEAYCHSLTDPSILSARLRDAGAQTLTVFGLHTPHSVFGDT
MMAR_1580|M.marinum_M AGRMPQRP------FVLVGQQYLADPERSVGNIHPLWTYAHVPNGYTGDA
TH_4571|M.thermoresistible__bu AGRMPERP------FVLVAQQYVADPGRSVGDIHPVWSYAHVPHGYPGDA
MAB_4734|M.abscessus_ATCC_1997 AGRMPERP------FVLVGQQYLADPGRSNGNIHPLWTYAHVPHGFTGDA
MSMEG_5400|M.smegmatis_MC2_155 TRTLPQQP------FMLFGQMTTADPTRSPAGTESAWAYTHLPRGMADDA
Mflv_1847|M.gilvum_PYR-GCK QGRPMADP------SLLVTRPALGDPSVAPPGRDLLYVLAPAPNTDVGHR
MAV_3885|M.avium_104 AGQLMRDP------SLLVTRPTASDPTLAPRGRDLLYVLAPAPNLESGGI
Mvan_3148|M.vanbaalenii_PYR-1 AGRLPSSP------WSMVGQVGQPDGITGGAVWMSSIVPLHRADGEWTPE
MUL_2934|M.ulcerans_Agy99 RGIVPENP------SMGMQIPSVHDSGLAPPGKHAASAYAYAFPVEVDRD
Mb0921c|M.bovis_AF2122/97 EG-LAERLTAAVLASLNSVLAEPIQDVLWTDAQSKPCIETTTTLDLQRTL
Rv0897c|M.tuberculosis_H37Rv EG-LAERLTAAVLASLNSVLAEPIQDVLWTDAQSKPCIETTTTLDLQRTL
MMAR_1580|M.marinum_M T----AAIIAQIER-----FAPGFREHIVGQTVRSTTEMSRYNPNYVGGD
TH_4571|M.thermoresistible__bu T----EAVVAQIER-----FAPGFRDRIVGYRTESAEGMARFNANFTGGD
MAB_4734|M.abscessus_ATCC_1997 T----QALIDQIER-----FAPGFRDRIVATAVRSTTDMTVYNPNYVGGD
MSMEG_5400|M.smegmatis_MC2_155 S----ADRLSEIVDHVLEEHAPGFGDRVIGRVVQRPSDLEGADANLHTGA
Mflv_1847|M.gilvum_PYR-GCK D-------WDADQDGYTSHMLDTVRER-MPHLGDDAELLRVVTPRDWARQ
MAV_3885|M.avium_104 D-------WDSVGRGYVDDLIALVGQRLLPGLPGSATVLDVVTPADWARR
Mvan_3148|M.vanbaalenii_PYR-1 R-----------EREAADRVIDQVGSVLGVDLRDGLVDVVVSGPLTWAAR
MUL_2934|M.ulcerans_Agy99 QHGHLKRIMARRVIDKITRFAPNFKDIVIRYITFAPYHMQTMFGAPSGDF
. .
Mb0921c|M.bovis_AF2122/97 GMTGGNIFHGALSWPFADNDDPLDTPARQWGVATDHERIMLCGSGARRGG
Rv0897c|M.tuberculosis_H37Rv GMTGGNIFHGALSWPFADNDDPLDTPARQWGVATDHERIMLCGSGARRGG
MMAR_1580|M.marinum_M IMTG-AKDIRQLTFGPRVTLSPYRTGVPG---------TYICSAATPPGP
TH_4571|M.thermoresistible__bu ILTG-AKDIRQLTFGPRITLSPYATGAPG---------YYICSAATPPGP
MAB_4734|M.abscessus_ATCC_1997 IVTG-AKDIRQLVFGPRTTAHPYRLGIPG---------MYICSAATPPGP
MSMEG_5400|M.smegmatis_MC2_155 VNGGTSQLYQQLIFRPVPGFGTAETPVAN---------VFLGSAGAHPGG
Mflv_1847|M.gilvum_PYR-GCK GMASGTPFALSHTFAQTGPFRPANTIRGIDN-------AVLAGSSTVPGV
MAV_3885|M.avium_104 GMAAGSPFALAHTFAQTGPFRPANMVRGIDN-------AVLAGSSTVPGV
Mvan_3148|M.vanbaalenii_PYR-1 IGGDGNPNHLDNTLDQLLGWRPPGHADMRTELP----WLFLAGAGQHPGG
MUL_2934|M.ulcerans_Agy99 CHGLLHPDLMGPNRPGPGGFLDFPIPIDG---------LYLGGAGCHGGP
: .:. *
Mb0921c|M.bovis_AF2122/97 AVSG-IGGHNAAMAVLACLASRRKSP------------------------
Rv0897c|M.tuberculosis_H37Rv AVSG-IGGHNAAMAVLACLASRRKSP------------------------
MMAR_1580|M.marinum_M GAHG-MCGANAAKLALAELK------------------------------
TH_4571|M.thermoresistible__bu GAHG-MCGYHAAQTALRELAR-----------------------------
MAB_4734|M.abscessus_ATCC_1997 GAHG-MCGAHAAAEALRHLRASI---------------------------
MSMEG_5400|M.smegmatis_MC2_155 GVHG-VCGRNAAKAALANNGVLGWPRRKLSKAVLSLVTR-----------
Mflv_1847|M.gilvum_PYR-GCK GIPTAIVSGRLAADRVTGAGSRTQPRVVTQ--------------------
MAV_3885|M.avium_104 GVPTTLISGRLAADRITGVSKRTPARIDMKAGSP----------------
Mvan_3148|M.vanbaalenii_PYR-1 GLSG-TSGSAAAAAVLGTRRRDRLDRRAVREVHALWSGLTAYRAMRRGPR
MUL_2934|M.ulcerans_Agy99 GITF-IPGYNAAYQVLEDVATRQTSG------------------------
. . * :