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MRLQYVGAVAVLSVGILTIPSIDVEPRTSVAIPPPDRSSDAVTPTGLIGRLLVPPVVPAGPPTPTPLALA DLEPHGSSVTTKVITVEDASGVRRQVTVSELRLDKEGRSASRVIAADTDEPARGGNSSAAEPATLVIPSD LDGDSVGRLAYLLGEVGGNIPIVALFVRNGSAEDPNAGLLIGNGGTGAAGVAGGTGGFLFGNGGAGGAGA DGGAAGLLGRGGDGGGATAENPLAGHGGRGGWIAGDGGDGGDGLSDAGVGLPGTGGRGGDAGLLGGKGGR GGAGGGASAQIGDTITGGAGGRGGNAGLLGTGGQGGAGGVARDTRANSGSETVIVEGGAGGQGGDGVLNA GVGGAGGAAYTSGDDKAGDLAVGGPGGAGGSAQASSSGRGGAGGDAVATEGDALGGTGGQGGTSTRAGDG GAGGIGGAGTSATGTGAGGTGGAGGSGATLGDGGRGGDAGYGEALDESGIAEGGTGGAGGLGGAFARGGD GGRGGAAIGGSQESVGGDGGRGGDGGFGGLGGDGGDGASPGGQGGEGGSPGGRPGGDNGGDG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_1569 | - | - | 100% (552) | hypothetical protein Mvan_1569 |
M. vanbaalenii PYR-1 | Mvan_3856 | - | 7e-77 | 46.63% (401) | hypothetical protein Mvan_3856 |
M. vanbaalenii PYR-1 | Mvan_3867 | - | 2e-75 | 42.26% (452) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0545 | PE_PGRS6a | 4e-81 | 48.56% (416) | hypothetical protein Mb0545 |
M. gilvum PYR-GCK | Mflv_5091 | - | 4e-79 | 44.44% (414) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv0834c | PE_PGRS14 | 8e-80 | 46.04% (454) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01556 | infB | 1e-08 | 45.68% (81) | translation initiation factor IF-2 |
M. abscessus ATCC 19977 | MAB_4284c | - | 1e-40 | 34.38% (381) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_5344 | - | 2e-83 | 47.09% (412) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 3e-19 | 43.31% (157) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-59 | 38.69% (473) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 2e-35 | 37.82% (312) | PUTATIVE - |
M. ulcerans Agy99 | MUL_0740 | - | 8e-77 | 46.15% (416) | PE-PGRS family protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Rv0834c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_0740|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5344|M.marinum_M -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES Mvan_1569|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Rv0834c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_0740|M.ulcerans_Agy99 -------------------------------------------------- MMAR_5344|M.marinum_M -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT Mvan_1569|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mb0545|M.bovis_AF2122/97 ------------MSNLLVTPELVAAAAADLAGIGSAIGAANAAAGAPTMA Rv0834c|M.tuberculosis_H37Rv ------------MSFVIAAPDLVAMATEDLAGIGASLTAANAAAAVPTSG MUL_0740|M.ulcerans_Agy99 ------------MSFVSVSPELVIDGAAALTQIGSSIDEANAAAGA-TRA MMAR_5344|M.marinum_M ------------MSYVFASPEVLNAAAAEVSTIGSSLQTANASAAAPTTA Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA Mvan_1569|M.vanbaalenii_PYR-1 -----------MRLQYVGAVAVLSVGILTIPSIDVEPRTSVAIPPPDRSS TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVS MAV_4827|M.avium_104 -------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVT MLBr_01556|M.leprae_Br4923 -----------MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASSTV Mb0545|M.bovis_AF2122/97 LLAAG-ADEVSAAVAAVFSSYAQQYQALSAAAAAFHDQFVRALAAGAGAY Rv0834c|M.tuberculosis_H37Rv LLAAA-GDEVSAAIAALFSSHGQQYQAMSAQAAAFHARFVQALAGAMGAY MUL_0740|M.ulcerans_Agy99 VLPPG-VDEVSVALAALFVAHGREYESLSAQVALFHRRFVQMLAAASGGY MMAR_5344|M.marinum_M LLSALGADEVSAAVTAMFGNHAQAYQAVSTQAAEFHDRFVAALTAGADAY Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP Mvan_1569|M.vanbaalenii_PYR-1 DAVTPTGLIGRLLVPPVVPAGPPTPTPLALADLEPHGSSVTTKVITVEDA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGP MAV_4827|M.avium_104 GADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRD MLBr_01556|M.leprae_Br4923 EAPVARRLRESFGGIKPAADKGAEQVATKAQAKRLGESLDQTLDRALDKA Mb0545|M.bovis_AF2122/97 A------------------------GAEAAN---------VEQQLLNAIN Rv0834c|M.tuberculosis_H37Rv A------------------------AAEAANASPLQ---TLEQGLLGAIN MUL_0740|M.ulcerans_Agy99 A------------------------EAEAANISAVAGLETVEQCVLDVIN MMAR_5344|M.marinum_M S------------------------SAEASTAATLQS---LPQDLLNVVN Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA Mvan_1569|M.vanbaalenii_PYR-1 S------------------------GVRRQVTVSELR---LDKEGRSASR TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 S-------------------------ILSPSLLSPRDNDFLSHNDTDFAS MAV_4827|M.avium_104 A-----------------------LAARRIDNVMLVSAFLAAAALAQNVG MLBr_01556|M.leprae_Br4923 VAG------------------------NGATTAAPVQVDHSAAVVPIVAG Mb0545|M.bovis_AF2122/97 APTLALLGRPLIGNGADGAAG-----TGQAGGAGG----LLYGNGGNGGS Rv0834c|M.tuberculosis_H37Rv APAAALSGRPFIGNGTNGAPG-----TGEAGGPGG----WLLGNGGNGGS MUL_0740|M.ulcerans_Agy99 APTQALFGWSLIGNGTDGAPG-----SGQAGGNGG----LLWGNGGNGGS MMAR_5344|M.marinum_M APTQALLGRALIGNGANGADG-----TGQNGGDGG----LLWGNGGNGGT Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGG----LFGGNGGNGGN MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAG----LFG-NGGNGGV Mvan_1569|M.vanbaalenii_PYR-1 VIAADTDEPARGGNSSAAEPATLVIPSDLDGDSVGRLAYLLGEVGGNIPI TH_3810|M.thermoresistible__bu --------------VDG---------DGGSGGRTG--LFSKLSRGGDGGD MAB_4284c|M.abscessus_ATCC_199 HNPIASGNQVMSPSGNVDSFNR----GPLLDLSFG---DLQFGNRDTTAI MAV_4827|M.avium_104 GAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQL MLBr_01556|M.leprae_Br4923 EGPSTAHREELAPPAGQPSEQPGVPLPGQQGTPAAP-------HPGHPGM Mb0545|M.bovis_AF2122/97 GAAGQAGGAGGAAG---LIGHGGTGGVGGT------GAAGG-AGGTGGWL Rv0834c|M.tuberculosis_H37Rv GAPGQTGGAGGAAG---LLGHGGTGGAGGT------GASGG-KGGTGGWL MUL_0740|M.ulcerans_Agy99 GGVGQAGGAGGSAG---LLGHGGAGGAGGVSGVSAVGATGG-AGGNGGWL MMAR_5344|M.marinum_M GAAGQAGGNGGAAG---LIGNGGAGGAGGAG---ATGGAGG-TGGAGGWL Mflv_5091|M.gilvum_PYR-GCK GLGGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGAT MSMEG_0868|M.smegmatis_MC2_155 GWAGLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTG Mvan_1569|M.vanbaalenii_PYR-1 VALFVRNGSAEDPNAGLLIGNGGTGAAGVAG-------------GTGGFL TH_3810|M.thermoresistible__bu GGLGGNGGHGGGTGIISLLSLAGNGGNGGNG------------YRTTDNN MAB_4284c|M.abscessus_ATCC_199 GDGAVAVGGSNSGP--IASGQGSTAVNGDVRDSNIINADHGSNVGVDQSQ MAV_4827|M.avium_104 SAMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEPETA MLBr_01556|M.leprae_Br4923 PTGPHPGPAPKPGGRPPRVGNNPFSSAQSVARPIPRPPAPRPSASPSSMS Mb0545|M.bovis_AF2122/97 FGNGGAG-------------------------GTGGAVTGVST------- Rv0834c|M.tuberculosis_H37Rv WGSGGAGGAGGSGGGSGGAGGNALMFGIGGNGGAGGAASGVGNGG----- MUL_0740|M.ulcerans_Agy99 YGNGGAGGLGGQG------------VLIGGNGGAGGAARFFGAGG----- MMAR_5344|M.marinum_M TGAGGTGGAGGTG-----------TSGGGGMGGAGGQAGWLSGAGG---- Mflv_5091|M.gilvum_PYR-GCK GATGVTSGVVGGNGE------DAVGYGATGAAGAAGAAGAAGAAG----- MSMEG_0868|M.smegmatis_MC2_155 GGTGGTGGIGGTGGG------LFGLLGHSGSTGAAGAAGNGGDGGNGGFG Mvan_1569|M.vanbaalenii_PYR-1 FGNGGAGGAGADG----------------------GAAGLLGRGG----- TH_3810|M.thermoresistible__bu ALDGGHGGNG-------------------------GNVGFFSLFN----- MAB_4284c|M.abscessus_ATCC_199 TRVGGDYTNVSGHG----------------SADIDKSVTVVDDHSQ---- MAV_4827|M.avium_104 LARGAALAAANAP------------------LFASSTAALAYAQD----- MLBr_01556|M.leprae_Br4923 PRPGGAVGGGGPRPP------------RTGVPRPGGGRPGAPVGGR---- * Mb0545|M.bovis_AF2122/97 ------------------TGGPGGHG------------GDAGLYG----- Rv0834c|M.tuberculosis_H37Rv ------------------VGGAGGAGGALVAIGGAGGAGGAATTG----- MUL_0740|M.ulcerans_Agy99 ------------------TGGAGGLGLGDTGGIGGIGGNAGALFG----- MMAR_5344|M.marinum_M ------------------TGGAGGAGDNGSGGSGGSG-GAGGLFN----- Mflv_5091|M.gilvum_PYR-GCK ---------AVG--SAGAAGEAGETGTWGNAGLPGKAGDAGGAG----AV MSMEG_0868|M.smegmatis_MC2_155 YVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILI Mvan_1569|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------RNTTNINDSFNTDRSTNIGSGNTTNTEIG----- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------SDAGGGNYRGGGVGALPGGGSGGFRG----- Mb0545|M.bovis_AF2122/97 -----------FGGAGGAG------------------------GFGQSGA Rv0834c|M.tuberculosis_H37Rv -----------TGGAGGAGSNALG----------------LFLGLGGSGG MUL_0740|M.ulcerans_Agy99 -----------PGGAGGPGGAG---------------------GNGGAGG MMAR_5344|M.marinum_M -----------AGGAGGAGGTSLGNSGDAGGTGGAGGAGGIVAGVGGAGG Mflv_5091|M.gilvum_PYR-GCK GAAG---AAGTVGTAGATGGTG-------------------TGANGGAGG MSMEG_0868|M.smegmatis_MC2_155 GANGGTVDGHAIGGNGGNGGNGSTT---------------AAGGNGGTGG Mvan_1569|M.vanbaalenii_PYR-1 ------------DGGGATAENP----------------------LAGHGG TH_3810|M.thermoresistible__bu -----------LGGAGGWGGSG----------------------VDGVDV MAB_4284c|M.abscessus_ATCC_199 -----------SHNQANIGTST---------------------SAGGSAA MAV_4827|M.avium_104 ------------PGTGAVDQYS----------------------LPDYLY MLBr_01556|M.leprae_Br4923 -----------RPGGGGHGGGGRPGQ--------------RGGAAGAFGR . Mb0545|M.bovis_AF2122/97 AGG--------------AGGAG------GAGG------------------ Rv0834c|M.tuberculosis_H37Rv QGGD---------SAMGSGGAG------GAGGSGGAASPFGID------- MUL_0740|M.ulcerans_Agy99 SGG----------ALADDGGDG------GAGG------------------ MMAR_5344|M.marinum_M AGGL---------SSSGDGGAG------GTGGDGGFLLGQG--------- Mflv_5091|M.gilvum_PYR-GCK VG-----GVGGTGAAGAAGGAG------GLGETGTTG------------- MSMEG_0868|M.smegmatis_MC2_155 TGRVIAEGTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSG Mvan_1569|M.vanbaalenii_PYR-1 RGG----------------------------------------------- TH_3810|M.thermoresistible__bu VGG---------------NPDG---------------------------- MAB_4284c|M.abscessus_ATCC_199 VGGN----------AGLAGNAG---------------------------- MAV_4827|M.avium_104 VPVD-----------PEPGDDE---------------------------- MLBr_01556|M.leprae_Br4923 PGGAPRRGRKSKRQKRQEYDSMQAP------------------------- Mb0545|M.bovis_AF2122/97 -WLYGDGGDGGAGGNG---------------------------------- Rv0834c|M.tuberculosis_H37Rv IGIGGAGGHGGAGTNGGAGGAGGAGGSSG--------------------- MUL_0740|M.ulcerans_Agy99 --AGGIGGNGGAGTTGLAG------------------------------- MMAR_5344|M.marinum_M -AAGGAGGNGGAGATGISGPAGQTGG------------------------ Mflv_5091|M.gilvum_PYR-GCK -GAGGVGGQGTAGGTGGVGGIG-----------------------GAGST MSMEG_0868|M.smegmatis_MC2_155 TATGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGGSATGADSL Mvan_1569|M.vanbaalenii_PYR-1 -WIAGDGGDGGDGLSDAG-------------------------------- TH_3810|M.thermoresistible__bu ---GTPGAHGESHTPGVYT------------------------------- MAB_4284c|M.abscessus_ATCC_199 -LAGNAGLAGNAGLAGNAGLAG---------------------------- MAV_4827|M.avium_104 LAYSAVGEEDAESPTVVIEKLFLPED------------------------ MLBr_01556|M.leprae_Br4923 -VVGGVRLPHGNGETIRLARGASLSDFAEKIDAN---------------- Mb0545|M.bovis_AF2122/97 ------------------------------GNESGTGVSGVGGVG----- Rv0834c|M.tuberculosis_H37Rv ---------------TVFALDLSWGGAGGNGGAATTGTGGAGGTGGFAVA MUL_0740|M.ulcerans_Agy99 ----------------------------HIGIDMNGGAGGVGGAGG---- MMAR_5344|M.marinum_M ----------------------------DGGAAGNGGNGGAGGKGGLLLG Mflv_5091|M.gilvum_PYR-GCK GAVGG-----------VGGKGIQGGQGLQGGKGGDGGAGGKGGDADSMGS MSMEG_0868|M.smegmatis_MC2_155 GGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAA Mvan_1569|M.vanbaalenii_PYR-1 -----------------------------VGLPGTGGRGGDAG------- TH_3810|M.thermoresistible__bu ------------------------------DRQGEDGEDGTG-------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------NAGLAGNAGLAGNAGLAG---- MAV_4827|M.avium_104 ----------------------------SEPRRRPVLLVGSG-------- MLBr_01556|M.leprae_Br4923 ------------------PAALVQALFNLGEMVTATQSVGDETLELLGSE * Mb0545|M.bovis_AF2122/97 -----------------------GAGGAGG-------------------- Rv0834c|M.tuberculosis_H37Rv PDFI------------GFGAAYGGAGGLGG-------------------- MUL_0740|M.ulcerans_Agy99 ---------------------NGGAGGTGG-------------------- MMAR_5344|M.marinum_M ------------------GGGRGGAGGLGG-------------------- Mflv_5091|M.gilvum_PYR-GCK ------------------AGATGGKGGNGGNGGRGGLFG----------- MSMEG_0868|M.smegmatis_MC2_155 GATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSGH Mvan_1569|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------NAGLAGNAG-------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 MNYNVQVVSPEDEDRELLEPFDLTYGEDQGDEDELQVRPP---------- Mb0545|M.bovis_AF2122/97 ---LLFGNGGDG-------------------------GVGGDGGDGSSTQ Rv0834c|M.tuberculosis_H37Rv ---AATGAGGTGGTGGVGAGGFAA----------LGVGVGGAGGAGGAAT MUL_0740|M.ulcerans_Agy99 ---DAGHAQAGG----------------------YSDGLQGAGGDGGHG- MMAR_5344|M.marinum_M ---AGGAGGNGGIGAAATTPGATG----------GDGGNGGLGGTGGTGG Mflv_5091|M.gilvum_PYR-GCK ----KGGNAGNG----------------------ADGGTGGAGGAGGTGG MSMEG_0868|M.smegmatis_MC2_155 GGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGG Mvan_1569|M.vanbaalenii_PYR-1 ----------------------------------LLGGKGGRGGAGGGAS TH_3810|M.thermoresistible__bu ------------------------------------TGIGGRGGNGGSSS MAB_4284c|M.abscessus_ATCC_199 ---LAGNAGLAG-----------------------NAGLAGNAGLAGNAG MAV_4827|M.avium_104 -----------------------------------LAVVGISAVLALEIA MLBr_01556|M.leprae_Br4923 -VVTVMGHVDHGKTRLLDTIRKAN-----------VREAEAGGITQHIGA . Mb0545|M.bovis_AF2122/97 DSGGDGGAG--------------------------GAGGAGG-----WLL Rv0834c|M.tuberculosis_H37Rv ETGGIGGAGG------------------LGVGLLGGAGGAGGPGGA-ASA MUL_0740|M.ulcerans_Agy99 GSGGVAGDGG------------------RGADAAAGSGLAGGDG---GRG MMAR_5344|M.marinum_M NGGAGGQAGL------------------FGAQGQQGAGGAGGNGGTGGIA Mflv_5091|M.gilvum_PYR-GCK -TGGAGGTGG-----------------TGGTGGIGGAGSTGGTGGTGGTG MSMEG_0868|M.smegmatis_MC2_155 ATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNG Mvan_1569|M.vanbaalenii_PYR-1 AQIGDTITGG--------------------------AGGRGGNAGLLGTG TH_3810|M.thermoresistible__bu GTHPMAEDGE---------------------HVKALDGRPGLDGGNGSHG MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGN---------------------AGLAGNAGLAGNAGLAGNA MAV_4827|M.avium_104 LAIGIRTTGT------------------VALQPTPNQHLIVPTEQAPAPP MLBr_01556|M.leprae_Br4923 YQVGVDLDGSERLITFIDTPG------HEAFTAMRARGAKATDIAILVVA * Mb0545|M.bovis_AF2122/97 GNGGAGGA-------GGAAS--IKVATGGLGGDGGDA------GLFGFGG Rv0834c|M.tuberculosis_H37Rv GSGGHGGT-------GGDALGLIGAGIGGVGGVGGAA------TDTGGNG MUL_0740|M.ulcerans_Agy99 GDPGAGGE-------GGAAGGGSVAGTAGLDGIGPNS------GGNGGNG MMAR_5344|M.marinum_M GDGGTGGAGDATHLDGGKGGNGGNPGLGGTGGAGGTG------ASTGTHG Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTG-GTGGTGGTGGTGGKGGTGGTGGAGGTG----GDGGTGGTG MSMEG_0868|M.smegmatis_MC2_155 GAGGAGGVSEGEGGTGGHGGDGGRGGDGALGGNGGTGGVGLGNGGKGGNG Mvan_1569|M.vanbaalenii_PYR-1 GQGGAGGVARDTRANSGSETVIVEGGAGGQGGDGVLN------AGVGGAG TH_3810|M.thermoresistible__bu GNGGHGGR-------GGFLGIGGSGGWGGHGGNGGDT------DADGGNG MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAG----NAGLAGNAAVAGNAAVAGNAAVAG----NAAVGGVL MAV_4827|M.avium_104 PVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAPPLPEAPPIPA MLBr_01556|M.leprae_Br4923 ADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEYGLV . . Mb0545|M.bovis_AF2122/97 DGGWGG----------RGVDARFGAAG------------GAAGAGGAGG- Rv0834c|M.tuberculosis_H37Rv GAGGSG----------TGLLGGVGGAGG----HGGGASVGTGGSGGAGGD MUL_0740|M.ulcerans_Agy99 GHGGSGA---------VGVEGGAGSAG------------GAGGRGGDGG- MMAR_5344|M.marinum_M SAGATP----------TTVAGNGGKGGD----GYTPTTPGADGGNGGAGG Mflv_5091|M.gilvum_PYR-GCK GTGGTG---------GTGGTGGTGGAG-----------DGTGGTGGTGG- MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGN Mvan_1569|M.vanbaalenii_PYR-1 GAAYTS---------------GDDKAGD----------LAVGGPGGAGG- TH_3810|M.thermoresistible__bu GDGGNG---------------------------------GSAGRGGTGG- MAB_4284c|M.abscessus_ATCC_199 NTGVSG------------AIGGSSHVGG-------AINESLGGSGSVGG- MAV_4827|M.avium_104 APPVVP----------VPVVVPPVPVPVP---------VRIPVPDPVSPP MLBr_01556|M.leprae_Br4923 AEDFGGDTMFIDISAKVGTNIEALLEAVLLTADAALDLRANSGMEAQGVA . Mb0545|M.bovis_AF2122/97 --WLYGDGGAGG------------------------------VGGVGGAV Rv0834c|M.tuberculosis_H37Rv GFGFVGAGGNGGNAGTG-----VGVNGANGGNGGSATGALAAVGGAGAAG MUL_0740|M.ulcerans_Agy99 ---AYGNGGVSGN------------------------------GGAGGAG MMAR_5344|M.marinum_M NGGLYGNGGNGGNGG----------NGTVGAAGVNPTPNPVLGQADPGTD Mflv_5091|M.gilvum_PYR-GCK ---TGGQGGQGGQGG-----------------TGGTGGQGG-LGGGGGTG MSMEG_0868|M.smegmatis_MC2_155 GDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTG Mvan_1569|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -STAVGGGAHTGVGG----------------------------GVSTGVG MAV_4827|M.avium_104 QLLAPPRLSVPQPVQPP--------------------------------- MLBr_01556|M.leprae_Br4923 IEAHLDRGRGPVATVLVQRG------------------------------ Mb0545|M.bovis_AF2122/97 F---------------------SLSSGDGGAGGAGGGG--GWLFGNG--- Rv0834c|M.tuberculosis_H37Rv G---------------------DATSGTGGFGGAGGSAR-GLIFALG--- MUL_0740|M.ulcerans_Agy99 --------------------------SPGAHGGTAGED--GFNAGDG--- MMAR_5344|M.marinum_M G---------------------IDTTGIGGDGGPGSPG--AFAGQQG--- Mflv_5091|M.gilvum_PYR-GCK -----------------------GQGGTGGTGGQGGTGGTGGTGGTG--- MSMEG_0868|M.smegmatis_MC2_155 GAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSA Mvan_1569|M.vanbaalenii_PYR-1 ----------------------SAQASSSGRGGAGGDAVATEGDALG--- TH_3810|M.thermoresistible__bu --------------------------LRGVFGINGGNG----RAGLG--- MAB_4284c|M.abscessus_ATCC_199 VG---------------------SHVGGGISESLGGSGSVGGSTAVG--- MAV_4827|M.avium_104 ----------------------VRVPQPPSPPQVGGTVPQSPPQHQTP-- MLBr_01556|M.leprae_Br4923 ----------------------TLRIGDSVVAGDAYGRVRRMVDEHG--- . Mb0545|M.bovis_AF2122/97 -----GDGGAG-------GGGGGRFGSGSG---------AGGDGAVGGAG Rv0834c|M.tuberculosis_H37Rv -----GAGAAGGDASTGVGGPGGPGGTGTASSPFGIAIAIGGAGAQGGAG MUL_0740|M.ulcerans_Agy99 -----GHGGAGG----AGGGGGAKGGVGGAG-------GSGGVGGQGGTG MMAR_5344|M.marinum_M -----GNGGEGGTG-VDVGGGGGDGQTGGPGTLGGNG-GNGGTASMGGSG Mflv_5091|M.gilvum_PYR-GCK -----GTGGAGGDG--GLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAG MSMEG_0868|M.smegmatis_MC2_155 VASGIGAGGNGGDG--IDGGLGGNGGDGVVNTTANAANPGSATGTATGGD Mvan_1569|M.vanbaalenii_PYR-1 -------------------GTGGQGGTSTRAG-------DGGAGGIGGAG TH_3810|M.thermoresistible__bu -------------------GRGXXXX-------------GGGVGAAVRSG MAB_4284c|M.abscessus_ATCC_199 -----------------GGAHTGVGGGVSTGVGVGSHVGGGISESLGGSG MAV_4827|M.avium_104 ------------------PGEGTPPKPDGPGNYGGGHVPTPGAGGSGGSG MLBr_01556|M.leprae_Br4923 ----VDIEAALPSSPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSAR . Mb0545|M.bovis_AF2122/97 GAGAWFGNG----GAG----------GVGGGGGRGTTAIGG--DGGAG-- Rv0834c|M.tuberculosis_H37Rv TSGATGGAG----GDGVFEGIAVLGLGFGGAAGAGGAATGDGATGGAGGF MUL_0740|M.ulcerans_Agy99 GDGATGLSG----KAG---------TGTDGESGGRGGHAGNGGNGGNGG- MMAR_5344|M.marinum_M GGGGSGGDGGGGGGAGGNGAIGGFSGGNGGAGGNGGSGGGAGGNGGDGG- Mflv_5091|M.gilvum_PYR-GCK G--QAGTAGKG--GLFG----GSGSAGKAGATGAAGASGGKGAQGATGAQ MSMEG_0868|M.smegmatis_MC2_155 GGKATGTASQG--GNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGV Mvan_1569|M.vanbaalenii_PYR-1 TSATGTGAG------------------GTGGAGGSGATLGDGGRGGDAG- TH_3810|M.thermoresistible__bu NGVFSGGGG-------------------TPSAGFGVPTTIQFPAGSCTS- MAB_4284c|M.abscessus_ATCC_199 SVGGSTAVG------------------GGAHTGVGGGVNTGVGVGSHVG- MAV_4827|M.avium_104 GGHVPTPGA-------------------GGSGGSGGGHVPTPGTGGPGG- MLBr_01556|M.leprae_Br4923 KRNALAARSRK-----------RISLEDLDSALKETSQLNLILKGDNAGT . . Mb0545|M.bovis_AF2122/97 -------------------GAGGAGGWLYGDGGAGGAGGGGGR------- Rv0834c|M.tuberculosis_H37Rv GGAGA-GIANFLGFSVLHGGAGGAGGTATGTGGNGGAGGGGGLSSPVILG MUL_0740|M.ulcerans_Agy99 -------------------RGGSAHASLVGKAGNGGFGGTGGNS------ MMAR_5344|M.marinum_M NATDL-MFANGGNGGNGGTGGEGTAGSGGGSGGNGGAGGAGGLYG----- Mflv_5091|M.gilvum_PYR-GCK GATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG--------- MSMEG_0868|M.smegmatis_MC2_155 AGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIH Mvan_1569|M.vanbaalenii_PYR-1 -------------------YGEALDESGIAEGGTGGAGGLGG-------- TH_3810|M.thermoresistible__bu ---------------------RAVSREGIMPSSRAASARAG--------- MAB_4284c|M.abscessus_ATCC_199 ---------------------GGISESLGGSGSVGGSTAVGGG------- MAV_4827|M.avium_104 --------------------TGGSGGGHVPTPGAGTPGGSGGG------- MLBr_01556|M.leprae_Br4923 VEALEEALMGIQVDDEVALRVIDRGVGGITETNVNLASASDAIIIG---- . Mb0545|M.bovis_AF2122/97 -----------------GGTGNDGGDGG---------------------- Rv0834c|M.tuberculosis_H37Rv IGIGGAGGDGGGALGVLGGMGGDGGDGGEAVAVGIAVGGAGGAGGAAPTG MUL_0740|M.ulcerans_Agy99 ----------------FGGVSGNGGNGG---------------------- MMAR_5344|M.marinum_M -NGGNGGTGGSGAAGGVGAMGGNGGNGG---------------------- Mflv_5091|M.gilvum_PYR-GCK --TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAG MSMEG_0868|M.smegmatis_MC2_155 GAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAG Mvan_1569|M.vanbaalenii_PYR-1 ----------------AFARGGDGGRGG---------------------- TH_3810|M.thermoresistible__bu -----------------AACASSTSRSR---------------------- MAB_4284c|M.abscessus_ATCC_199 ----------AHTSAINDALGGSGSVGG---------------------- MAV_4827|M.avium_104 ----------------HLPFPGAGSTPG---------------------- MLBr_01556|M.leprae_Br4923 -------FNVRAEGKATELASREGVEIRYYLVIYQAIDDIEKALRGMLKP Mb0545|M.bovis_AF2122/97 ---DGGRGGDAQ-LLGNGGDGG--------------------AGGAGG-- Rv0834c|M.tuberculosis_H37Rv NGGAGGNGGDALGLVGVGGNGGNA-----------GTGFGANTGGNGGDT MUL_0740|M.ulcerans_Agy99 ---DGGHALHGQ----PGGHGG--------------------QGGHGG-- MMAR_5344|M.marinum_M ---SGGTGTTAG-ADGNGGNGGTG-----------GAGGNGGNGGTGG-A Mflv_5091|M.gilvum_PYR-GCK EDGDAGSGGSG-INGGAGGAGG-----------------AGGEGGEGGDG MSMEG_0868|M.smegmatis_MC2_155 NGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDG Mvan_1569|M.vanbaalenii_PYR-1 ----AAIGGSQESVGGDGGRGG--------------------DGGFGG-- TH_3810|M.thermoresistible__bu ----RSFCCSRA-------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---STAVGGGAHTSAINESMNS------------------SINASHSS-- MAV_4827|M.avium_104 -----GSGGGHLPTPGAGTPGG-------------------GLGGFGG-- MLBr_01556|M.leprae_Br4923 IYEENQLGRAEIRALFRSSKVGIIAG------------CIISSGVVRRNA Mb0545|M.bovis_AF2122/97 -----------PAGFGASPGAGAAGGGG--GAGG--SLFGSPGTTGPHG- Rv0834c|M.tuberculosis_H37Rv TIVVNGMLAPSTLGYGGNGGNGVNGGAG--GTGGKAGVFGAPGQNGLP-- MUL_0740|M.ulcerans_Agy99 -----------VAHIDGSDYPGWPGLPG--DVGYQDGTGGGGGTGGAGGH MMAR_5344|M.marinum_M AGSGGMFGQMGDAGDGGDAGTGGEGGDG--GTGGSGAMSGQTGDQGAGGT Mflv_5091|M.gilvum_PYR-GCK GKGGAG--AEGGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGA MSMEG_0868|M.smegmatis_MC2_155 SEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGT Mvan_1569|M.vanbaalenii_PYR-1 ------------LGGDGGDGASPGGQGG---EGGSPGGRPGGDNGGDG-- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------SMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGA MAV_4827|M.avium_104 --------GHAPAPGGGLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLGGG MLBr_01556|M.leprae_Br4923 KVRLLRDNIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYSDIKEGDV Mb0545|M.bovis_AF2122/97 ------------ Rv0834c|M.tuberculosis_H37Rv ------------ MUL_0740|M.ulcerans_Agy99 AP---------- MMAR_5344|M.marinum_M PGTAGASG---- Mflv_5091|M.gilvum_PYR-GCK AGDSDD------ MSMEG_0868|M.smegmatis_MC2_155 TGANNP------ Mvan_1569|M.vanbaalenii_PYR-1 ------------ TH_3810|M.thermoresistible__bu ------------ MAB_4284c|M.abscessus_ATCC_199 EHH--------- MAV_4827|M.avium_104 HK---------- MLBr_01556|M.leprae_Br4923 IESYELVEKQRA