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MSYVFASPEVLNAAAAEVSTIGSSLQTANASAAAPTTALLSALGADEVSAAVTAMFGNHAQAYQAVSTQA AEFHDRFVAALTAGADAYSSAEASTAATLQSLPQDLLNVVNAPTQALLGRALIGNGANGADGTGQNGGDG GLLWGNGGNGGTGAAGQAGGNGGAAGLIGNGGAGGAGGAGATGGAGGTGGAGGWLTGAGGTGGAGGTGTS GGGGMGGAGGQAGWLSGAGGTGGAGGAGDNGSGGSGGSGGAGGLFNAGGAGGAGGTSLGNSGDAGGTGGA GGAGGIVAGVGGAGGAGGLSSSGDGGAGGTGGDGGFLLGQGAAGGAGGNGGAGATGISGPAGQTGGDGGA AGNGGNGGAGGKGGLLLGGGGRGGAGGLGGAGGAGGNGGIGAAATTPGATGGDGGNGGLGGTGGTGGNGG AGGQAGLFGAQGQQGAGGAGGNGGTGGIAGDGGTGGAGDATHLDGGKGGNGGNPGLGGTGGAGGTGASTG THGSAGATPTTVAGNGGKGGDGYTPTTPGADGGNGGAGGNGGLYGNGGNGGNGGNGTVGAAGVNPTPNPV LGQADPGTDGIDTTGIGGDGGPGSPGAFAGQQGGNGGEGGTGVDVGGGGGDGQTGGPGTLGGNGGNGGTA SMGGSGGGGGSGGDGGGGGGAGGNGAIGGFSGGNGGAGGNGGSGGGAGGNGGDGGNATDLMFANGGNGGN GGTGGEGTAGSGGGSGGNGGAGGAGGLYGNGGNGGTGGSGAAGGVGAMGGNGGNGGSGGTGTTAGADGNG GNGGTGGAGGNGGNGGTGGAAGSGGMFGQMGDAGDGGDAGTGGEGGDGGTGGSGAMSGQTGDQGAGGTPG TAGASG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5344 | - | - | 100% (846) | PE-PGRS family protein |
| M. marinum M | MMAR_3400 | - | 0.0 | 57.85% (873) | PE-PGRS family protein |
| M. marinum M | MMAR_5308 | - | 0.0 | 51.33% (1050) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1485c | PE_PGRS27 | 0.0 | 52.73% (935) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-176 | 47.79% (770) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv1450c | PE_PGRS27 | 0.0 | 50.35% (1009) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01556 | infB | 5e-11 | 37.40% (131) | translation initiation factor IF-2 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 2e-51 | 31.83% (600) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_4827 | - | 4e-24 | 42.77% (166) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-147 | 42.60% (885) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 2e-48 | 42.02% (326) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 46.69% (1028) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-174 | 47.94% (776) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1485c|M.bovis_AF2122/97 --------------------------------------------------
Rv1450c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5344|M.marinum_M --------------------------------------------------
MUL_4367|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1485c|M.bovis_AF2122/97 -----------------------------------------MSLVIVAPE
Rv1450c|M.tuberculosis_H37Rv -----------------------------------------MSLVIVAPE
MMAR_5344|M.marinum_M -----------------------------------------MSYVFASPE
MUL_4367|M.ulcerans_Agy99 -----------------------------------------MSFVSVGPG
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------------MSIID
MAV_4827|M.avium_104 -------------------------------------MNIVLGVSMAPSS
MLBr_01556|M.leprae_Br4923 ----------------------------------------MAGKARVHEL
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------MMFLAP
Mb1485c|M.bovis_AF2122/97 TVAAAALDVARIGSSIGVANSAAAGSTTSVLAAG-ADEVSAAIATLFGSH
Rv1450c|M.tuberculosis_H37Rv TVAAAALDVARIGSSIGAANAAAAGSTTSVLAAG-ADEVSAAIATLFGSH
MMAR_5344|M.marinum_M VLNAAAAEVSTIGSSLQTANASAAAPTTALLSALGADEVSAAVTAMFGNH
MUL_4367|M.ulcerans_Agy99 LLEAAARDLAGLGAGLREANLAAAGATVGVLPAA-GDEVSAAIAELFGGF
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 FILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAESVASN
MAV_4827|M.avium_104 IQMVVLEGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGTREGAA
MLBr_01556|M.leprae_Br4923 AKELGVTSKEVLARLNEQGEFVKSASSTVEAPVARRLRESFGGIKPAADK
Mflv_5091|M.gilvum_PYR-GCK -------------------------MVTFGGGATPTPTSLGAAAVDLSG-
Mvan_1264|M.vanbaalenii_PYR-1 PGGPGPISAAIQLTSTGSEATEPWYVVSFGGSGAPTPNNLAASLVDLSG-
Mb1485c|M.bovis_AF2122/97 AREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLEHNVLN-
Rv1450c|M.tuberculosis_H37Rv AREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLEHNVLN-
MMAR_5344|M.marinum_M AQAYQAVSTQAAEFHDRFVAALTAGADAYSSAEASTAATLQSLPQDLLN-
MUL_4367|M.ulcerans_Agy99 GREYQAMGARVALLHDDFVRALTAGGSAYGQAEALNMWPLQELEQQALG-
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 YGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSH
MAV_4827|M.avium_104 DAGLQLSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAALAQN-
MLBr_01556|M.leprae_Br4923 GAEQVATKAQAKRLGESLDQTLDRALDKAVAGNGATTAAPVQVDHSAAVV
Mflv_5091|M.gilvum_PYR-GCK ---------------------------TSCG---------LICNGQD---
Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------TSCG---------LICNGQD---
Mb1485c|M.bovis_AF2122/97 ---------------------------ALNAPTQALLGRPLIGDGAAGAP
Rv1450c|M.tuberculosis_H37Rv ---------------------------ALNAPTQALLGRPLIGDGAAGAP
MMAR_5344|M.marinum_M ---------------------------VVNAPTQALLGRALIGNGANGAD
MUL_4367|M.ulcerans_Agy99 ---------------------------VVNAPSMALFGRPSIGNGVDGVA
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGING-T
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 N---------------------DTDFASHNPIASGNQVMSPSGNVDSFNR
MAV_4827|M.avium_104 ------------------------------------VGGAMGYERTAVLL
MLBr_01556|M.leprae_Br4923 P-------------------------------IVAGEGPSTAHREELAPP
Mflv_5091|M.gilvum_PYR-GCK GTGQNGG---ILFGNGGSGWNSDVVGMDGGNGGNGGLFG--GNGGNGGNG
Mvan_1264|M.vanbaalenii_PYR-1 GTGQNGG---ILFGNGGSGWNSEIAGVSGGNGGNAGLFG--GNGGNGGNG
Mb1485c|M.bovis_AF2122/97 GTGQAGGAGGILWGNGGAGG-SGAPGQVGGAGGAAGLFGTGGAGGAGGAG
Rv1450c|M.tuberculosis_H37Rv GTGQAGGAGGILWGNGGAGG-SGAPGQVGGAGGAAGLFGTGGAGGAGGAG
MMAR_5344|M.marinum_M GTGQNGGDGGLLWGNGGNGG-TGAAGQAGGNGGAAGLIGNGGAGGAGGAG
MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGGVG
MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFGNGGNGGVGWAG
TH_3810|M.thermoresistible__bu ------------------------VDGDGGSGGRTGLFSKLSRGGDG---
MAB_4284c|M.abscessus_ATCC_199 GPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVR
MAV_4827|M.avium_104 VEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMVAGLEKLES
MLBr_01556|M.leprae_Br4923 AGQPSEQPGVPLPGQQGTPAAPHPGHPGMPTGPHPGPAPKPGGRPPRVGN
.
Mflv_5091|M.gilvum_PYR-GCK LGGGNGGN-----------------------GGNAGAFALFGNGG-NGGN
Mvan_1264|M.vanbaalenii_PYR-1 LGSGDGGN-----------------------GGDAGLFSLFGRGG-NGGN
Mb1485c|M.bovis_AF2122/97 AAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGVGG-TGGP
Rv1450c|M.tuberculosis_H37Rv AAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAGLFGVGG-TGGP
MMAR_5344|M.marinum_M ATGGAGG-----------------------TGGAGG--WLTGAGG-TGGA
MUL_4367|M.ulcerans_Agy99 AAGMTGGSG----------------------GAGGGGGWLWGAGG-SGGA
MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGGLLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTGGT
TH_3810|M.thermoresistible__bu -----------------------------------------GDGG-LGGN
MAB_4284c|M.abscessus_ATCC_199 DSNIINADHG---------------------SNVGVDQSQTRVGGDYTNV
MAV_4827|M.avium_104 LPGGLLLVGSG--------------------VDVAPLKQVLQTTTFLDVS
MLBr_01556|M.leprae_Br4923 NPFSSAQSVAR---------------------PIPRPPAPRPSASPSSMS
Mflv_5091|M.gilvum_PYR-GCK GGVGV-----------------VGATGAVGAPGVAGATGATG--------
Mvan_1264|M.vanbaalenii_PYR-1 GGVGI-----------------AGATGAVGAPGVAGATGATG--------
Mb1485c|M.bovis_AF2122/97 GGPGGPGGPGGPGGPGGVGG--TGGAGGLGGT-LYGAGGHGG--------
Rv1450c|M.tuberculosis_H37Rv GGPGG---------PGGVGG--TGGAGGLGGT-LYGAGGHGG--------
MMAR_5344|M.marinum_M GGTGT----------SGGGG--MGGAGGQAGW-LSGAGGTGG--------
MUL_4367|M.ulcerans_Agy99 AGAGG---------SGGSGGWLWGNAGQTAGAGVGGAGGAGG--------
MSMEG_0868|M.smegmatis_MC2_155 GGIGG---------TGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVL
TH_3810|M.thermoresistible__bu GGHGG-------------------GTGIISLLSLAGNGGNGG--------
MAB_4284c|M.abscessus_ATCC_199 SGHGS-----------------ADIDKSVTVVDDHSQRNTTN--------
MAV_4827|M.avium_104 VAEEP----------------ETALARGAALAAANAPLFASS--------
MLBr_01556|M.leprae_Br4923 PRPGG-----------------AVGGGGPRPPRTGVPRPGGG--------
.
Mflv_5091|M.gilvum_PYR-GCK -------VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------
Mvan_1264|M.vanbaalenii_PYR-1 -------VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------
Mb1485c|M.bovis_AF2122/97 -------AGG--PGPIGGVGGHGGVGGAAGLLG-VGGHGGAGGHGAAGIA
Rv1450c|M.tuberculosis_H37Rv -------AGG--PGPIGGVGGHGGVGGAAGLLG-VGGHGGAGGHGAEGVA
MMAR_5344|M.marinum_M -------AGG--AGDNG-SGGSGGSGGAGGLFN-AGGAGGAGGT------
MUL_4367|M.ulcerans_Agy99 -------AGD--AGDQGVSGVAPGEAGAVGFAGGAGGAGGAGGNGVGG--
MSMEG_0868|M.smegmatis_MC2_155 IAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGG-------
TH_3810|M.thermoresistible__bu -------NGYRTTDNNALDGGHGGNGGNVGFFS-----------------
MAB_4284c|M.abscessus_ATCC_199 ------INDSFNTDRSTNIGSGNTTNTEIGSHN-----------------
MAV_4827|M.avium_104 -------TAALAYAQDPGTGAVDQYSLPDYLYVPVDPEPGDD--------
MLBr_01556|M.leprae_Br4923 -------RPGAPVGGRSDAGGGNYRGGGVGALPGGGSGGFRG--------
.
Mflv_5091|M.gilvum_PYR-GCK ---------AVGSAGAAG-EAGETGTWGNAGLPGKAGDAGGAGAVGAAG-
Mvan_1264|M.vanbaalenii_PYR-1 ---------AVGSAGTAG-SAGAPGVWGNAGLPGAAGAAGGAGAIGTAG-
Mb1485c|M.bovis_AF2122/97 GAAGKGGIFPDGSNGGAGGDAGDGGTGGRGGWLAGAGGAGGDGGIGGTGG
Rv1450c|M.tuberculosis_H37Rv GAAG-EDLSPHGTSGGVGGDAGDGGTGGRGGWLAGAGGAGGAGGVGGTGG
MMAR_5344|M.marinum_M ---------SLGNSGDAG---GTGGAGGAGGIVAGVGGAGGAGGLSSSG-
MUL_4367|M.ulcerans_Agy99 ---------GVNGAGGAGGAGGVGGGGGAGASGVGAGVAGGDGGTGGAGG
MSMEG_0868|M.smegmatis_MC2_155 -------AILIGANGGTVDGHAIGGNGGNGGNGSTT-AAGGNGGTGGTG-
TH_3810|M.thermoresistible__bu --------------------------------LFNLGGAGGWGGSG----
MAB_4284c|M.abscessus_ATCC_199 ----------QANIGTSTSAGGSAAVGGNAGLAGNAGLAGNAGLAGNAG-
MAV_4827|M.avium_104 ----------ELAYSAVGEEDAESPTVVIEKLFLPEDSEPRRRPVLLVG-
MLBr_01556|M.leprae_Br4923 ----------RPGGGGHGGGGRPGQRGGAAGAFGRPGGAPRRGRKSKRQK
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1485c|M.bovis_AF2122/97 AGGAGFSRALIVAGDNGGDGGNGGMGGAGGAGGPGGAGGLISLLGGQGAG
Rv1450c|M.tuberculosis_H37Rv AGGAGFSRALIVAGDNGGD-------------------------------
MMAR_5344|M.marinum_M --------------------------------------------------
MUL_4367|M.ulcerans_Agy99 AAG-----------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 RQE-----------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------AAGTVGT
Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------VAGAAGT
Mb1485c|M.bovis_AF2122/97 GDGGDGGAGGVGGDRGAGANGNQAVNAGAGGAGGHGGDPGAGGAGGTGGA
Rv1450c|M.tuberculosis_H37Rv --------------------------------------PGAGGAGGTGGA
MMAR_5344|M.marinum_M ----------------------------------------DGGAGGTGGD
MUL_4367|M.ulcerans_Agy99 ----------------------------------------VGGAAGTGGT
MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------RVIAEGTGSTAE
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 -----------------------------------------YDSMQAPVV
Mflv_5091|M.gilvum_PYR-GCK AGATGGTGTGAN----GGAGGVGGVGG----TGAAGAA-GGAGGLGETGT
Mvan_1264|M.vanbaalenii_PYR-1 AGATGGTGVGGN----GGAGQAGGIGG----TGAAGAA-GQAGTAGETGV
Mb1485c|M.bovis_AF2122/97 GSTIGAHGAAGASPTSGGNGGAGGNGAHFSSGGKAGGN-GGAGGAGGLVG
Rv1450c|M.tuberculosis_H37Rv GSTIGAHGAAGASPTSGGNGGAGGNGAHFSSGGKAGGN-GGAGGAGGLVG
MMAR_5344|M.marinum_M GGFLLGQGAAGG---AGGNGGAGATGISGPAG-QTGGD-GGAAGNG---G
MUL_4367|M.ulcerans_Agy99 GGAAGVAGTGGD----GGDGGAGGAGSDASLAGQAGFA-GGSGGAGGVGG
MSMEG_0868|M.smegmatis_MC2_155 GTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 GGVRLPHGNGETIRLARGASLSDFAEKIDANPAALVQALFNLGEMVTATQ
Mflv_5091|M.gilvum_PYR-GCK TGGAGGVGG-------------QGTAGGTGGVG-------------GIGG
Mvan_1264|M.vanbaalenii_PYR-1 TGGVGGIGG-------------QGTEGGTGGVG-------------GVGG
Mb1485c|M.bovis_AF2122/97 NGGAGGAGGNGAPGAPPSGGDPNGGGGGAGGAGGKGGDGGAQAGDGGAGG
Rv1450c|M.tuberculosis_H37Rv NGGAGGAGGNGAPGAPPSGGDPNGGGGGAGGAGGKGGDGGAQAGDGGAGG
MMAR_5344|M.marinum_M NGGAGGKGG------------LLLGGGGRGGAG-------------GLGG
MUL_4367|M.ulcerans_Agy99 SAGAGGVNG-------------SGGDGGAGAAGGAGGASATVAGSGGVGG
MSMEG_0868|M.smegmatis_MC2_155 TGGAGGMGEIY-----------SGADGEATGISAGGDG-------GSATG
TH_3810|M.thermoresistible__bu -----------------------------------------------VDG
MAB_4284c|M.abscessus_ATCC_199 -----------------------------------------------LAG
MAV_4827|M.avium_104 ------------------------------------------------SG
MLBr_01556|M.leprae_Br4923 SVGDETLELLG---------------------------------SEMNYN
.
Mflv_5091|M.gilvum_PYR-GCK AGSTGAVGG-------------VGGKGIQGGQGLQGGKGGDGGAGGKGG-
Mvan_1264|M.vanbaalenii_PYR-1 VGATGGAGG-------------VGGKGIQGGQGLQGGQGGDGGTGGTGG-
Mb1485c|M.bovis_AF2122/97 AGGKGGNGGNGATGATGLNGLGAGADGTDGGKGGNGGAGGGGGAGGQGG-
Rv1450c|M.tuberculosis_H37Rv AGGKGGNGGNGATGATGLNGLGAGADGTDGGKGGNGGAGGGGGAGGQGG-
MMAR_5344|M.marinum_M AGGAGGNGGIGAAATT------PGATGGDGGNGGLGGTGGTGGNGGAGG-
MUL_4367|M.ulcerans_Agy99 DGGAGGAAGGGVGAASLGGDGGHAGAGGAGGEGLSGGFN-TGAAGGIGG-
MSMEG_0868|M.smegmatis_MC2_155 ADSLGGRGGTSWVQAG--YGPTTGGKASGTAKAGHGGKASDGGKGGNGGD
TH_3810|M.thermoresistible__bu VDVVGGNPD--------------------------------GGTPGAHG-
MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAG----------------------LAGNAGLAGNAGLAGNAG-
MAV_4827|M.avium_104 LAVVG----------------------ISAVLALEIALAIGIRTTGTVAL
MLBr_01556|M.leprae_Br4923 VQVVSPEDEDRELLEP-------FDLTYGEDQGDEDELQVRPPVVTVMGH
. .
Mflv_5091|M.gilvum_PYR-GCK ----DADSMGSAGATGGKGGNGGNGGR-GGLFGKGGNAGNGAD-------
Mvan_1264|M.vanbaalenii_PYR-1 ----DATSMGEAGATGGKGGNGGNGGR-GSLFGRGGNAGNGGN-------
Mb1485c|M.bovis_AF2122/97 ----KALAATHQDGSMGAGGAGGNGGA-GGMGGDGGNGAKGTFDNGGDGV
Rv1450c|M.tuberculosis_H37Rv ----KALAATHQDGSMGAGGAGGNGGA-GGMGGDGGNGAKGTFDNGGDGV
MMAR_5344|M.marinum_M ----QAGLFGAQ-GQQGAGGAGGNGGT-GGIAGDGGTGGAGDATHLD---
MUL_4367|M.ulcerans_Agy99 ----AGGAGGTGGDSGGVGGVNGDGGA-GGGGGRGGDGGSSTSTSGVGGA
MSMEG_0868|M.smegmatis_MC2_155 ALVMAAGATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDS
TH_3810|M.thermoresistible__bu ----ESHTPGVYTDRQGEDGEDGTGTG----------------------I
MAB_4284c|M.abscessus_ATCC_199 -----------LAGNAGLAGNAGLAGN-AGLAGNAGLAGN----------
MAV_4827|M.avium_104 QPTPNQHLIVPTEQAPAPPPVQASAPQPKISVPEPVAAPKPLSPPVAAPL
MLBr_01556|M.leprae_Br4923 VDHGKTRLLDTIRKANVREAEAGGITQHIGAYQVGVDLDGSERLITFIDT
.
Mflv_5091|M.gilvum_PYR-GCK GGTGGAGGAG-------GTGGTGGAGGTGGTGG-TGGIGGAGSTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGNGGNG-------GTGGTGGNGGTGGTGG-TGGIGGAGSTGGTGGT
Mb1485c|M.bovis_AF2122/97 GGNGGNGGSR-------GIGGAGGIGGAGSTAG-ADGARGATPTS--GGN
Rv1450c|M.tuberculosis_H37Rv GGNGGNGGSR-------GIGGAGGIGGAGSTAG-ADGARGATPTS--GGN
MMAR_5344|M.marinum_M GGKGGNGGNP-------GLGGTGGAGGTGASTG-THGSAGATPTTV-AGN
MUL_4367|M.ulcerans_Agy99 GGAGGNGGNAGFGVSAGGTGGSAGDGGAGGGAGGVDGVGGASGNGGAAGA
MSMEG_0868|M.smegmatis_MC2_155 SATSGHGGAA--------QGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAA
TH_3810|M.thermoresistible__bu GGRGGNGGSS---------SGTHPMAEDGEHVKALDGRP-----------
MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAG-------NAGLAGNAGLAGNAG-LAGNAGLAGNAGLAGN
MAV_4827|M.avium_104 PAAPPPAAPP--------LPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIP
MLBr_01556|M.leprae_Br4923 PGHEAFTAMR--------ARGAKATDIAILVVAADDGVMPQTVEAINHAQ
. .
Mflv_5091|M.gilvum_PYR-GCK GGTGGTGG----TGGTGGTGGTGG-----------TGGTGGKGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGG----TGGTGGTGGTGG-----------TGGTGGKGGTGGTGG
Mb1485c|M.bovis_AF2122/97 GGTGGNGANATVAGGAGGAGGKGG-----------NGGLVGNGGAGGKGG
Rv1450c|M.tuberculosis_H37Rv GGTGGNGANATVAGGAGGAGGKGG-----------NGGLVGNGGAGGKGG
MMAR_5344|M.marinum_M GGKGGDGYTPTTPGADGGNGGAGG-----------NGGLYGNGGNGGNGG
MUL_4367|M.ulcerans_Agy99 GGAGGSGIGAGIDGGAGGAGGTGG-----------AAGFPGGGGTTGAWG
MSMEG_0868|M.smegmatis_MC2_155 GGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGG
TH_3810|M.thermoresistible__bu GLDGGNGS----HGGNGGHGGRGG--------------FLGIGGSGGWGG
MAB_4284c|M.abscessus_ATCC_199 AGLAGNAAVAGNAAVAGNAAVAGN------------AAVGGVLNTGVSGA
MAV_4827|M.avium_104 VPDPVSPPQLLAPPRLSVPQPVQP--------------PVRVPQPPSPPQ
MLBr_01556|M.leprae_Br4923 AADVPIVVAVNKIDKEGADPAKIR-------------GQLTEYGLVAEDF
.
Mflv_5091|M.gilvum_PYR-GCK AGGTGGDGGTGGTG----------GTGGTGGTGG----TGGTGGAG----
Mvan_1264|M.vanbaalenii_PYR-1 DGGTGGTGGTGGTG----------GTGGTGGTGG----TGGTGGAG----
Mb1485c|M.bovis_AF2122/97 DGMAGVAGSSPTTAGESGTSGQNGGAGGAGGAGGRGGDFGGDGGTGGAGG
Rv1450c|M.tuberculosis_H37Rv DGMAGVAGSSPTTAGESGTSGQNGGAGGAGGAGGRGGDFGGDGGTG----
MMAR_5344|M.marinum_M NGTVGAAGVNPTPNPVLGQADP--GTDGIDTTG-----IGGDGGPG----
MUL_4367|M.ulcerans_Agy99 TGGAGGAGGAGGAGDHGGVGVNPGDSGTAGWAGG----AGGAGGAG----
MSMEG_0868|M.smegmatis_MC2_155 DGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGG----DGGRGGDG----
TH_3810|M.thermoresistible__bu HGGN-----------------------------------GGDTDAD----
MAB_4284c|M.abscessus_ATCC_199 IGGSSHVGGAINES------------------------LGGSGSVG----
MAV_4827|M.avium_104 VGGTVPQSPPQHQTP------------------------PGEGTPP----
MLBr_01556|M.leprae_Br4923 GGDTMFIDISAKVGTNIEALLEAVLLTADAALDLR--ANSGMEAQG----
* *
Mflv_5091|M.gilvum_PYR-GCK --------------------DGTGGTGGTG-GTGGQGGQGGQGGTG----
Mvan_1264|M.vanbaalenii_PYR-1 --------------------DGLGGTGGTG-GTGGFGGQGGQGGTG----
Mb1485c|M.bovis_AF2122/97 NGADGGAGGNGANGANATTPGAKGGDGGHG-GPGAQGGNGGQGGPGGLAG
Rv1450c|M.tuberculosis_H37Rv -----GAGGNGANGANATTPGAKGGDGGHG-GPGAQGGNGGQGGPGGLAG
MMAR_5344|M.marinum_M ------------------SPGAFAGQ---------QGGNGGEGGTG----
MUL_4367|M.ulcerans_Agy99 ------------------GSAAFNGVNGAG-GAGGNGGAGGGGGAGASG-
MSMEG_0868|M.smegmatis_MC2_155 ------------------ALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYV
TH_3810|M.thermoresistible__bu ------------------------------------GGNGGDGGNG----
MAB_4284c|M.abscessus_ATCC_199 -------------------------------GSTAVGGGAHTGVGGG---
MAV_4827|M.avium_104 ----------------------------------KPDGPGNYGGGHVP--
MLBr_01556|M.leprae_Br4923 ----------------------------VAIEAHLDRGRGPVATVLVQR-
* . .
Mflv_5091|M.gilvum_PYR-GCK ---------GTGGQGGLGGGG-----------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ---------GTGGQGGLGGVG-----------------------------
Mb1485c|M.bovis_AF2122/97 NLFGQNGIQGVGGSGGKGGAGGLAGDGGNGANGNFAFGDGNGGHGGNGGN
Rv1450c|M.tuberculosis_H37Rv NLFGQNGIQGVGGSGGKGGAGGLAGDGGNGANGNFAFGDGNGGHGGNGGN
MMAR_5344|M.marinum_M --------VDVGGGGGDGQTG-----------------------------
MUL_4367|M.ulcerans_Agy99 --------IGAGVAGGDGGTGGTGGAAGTG--------------------
MSMEG_0868|M.smegmatis_MC2_155 DP----SHTGAGGNGGNGGAGRIRVNNGTATG------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------------GTGGQ
Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------------------GTGGT
Mb1485c|M.bovis_AF2122/97 PGAGGQGGSGGAGSTPGAKGAHGFTPTSGGDGGDGGNGGHSQVVGGNGGD
Rv1450c|M.tuberculosis_H37Rv PGAGGQGGSGGAGSTPGAKGAHGFTPTSGGDGGDGGNGGNSQVVGGNGGD
MMAR_5344|M.marinum_M ---------------------------------------------GPGTL
MUL_4367|M.ulcerans_Agy99 ---------------------------------------------GAAGT
MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------------TATGGN
TH_3810|M.thermoresistible__bu ---------------------------------------------GSAGR
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------VSTGVG
MAV_4827|M.avium_104 ----------------------------------------------TPGA
MLBr_01556|M.leprae_Br4923 ---------------------------------------------GTLRI
Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGQGGT-GGTGGTGGT----------------------GGTGGA
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGQGGT-GGTGGTGGT----------------------GGTGGA
Mb1485c|M.bovis_AF2122/97 GGNGGNGGSAGT-GGNGGRGGDGAFGGMSANATNPGENGPNGNPGGNGGA
Rv1450c|M.tuberculosis_H37Rv GGNGGNGGSAGT-GGNGGRGGDGAFGGMSANATNPGENGPNGNPGGNGGA
MMAR_5344|M.marinum_M GGNGGNGGTASM-GGSGGGGGS----------------------GGDGGG
MUL_4367|M.ulcerans_Agy99 GGTGGAAGAAGS-AGDGGAGGAGGAGDDGSAGVVSGDPGTAGKAGGAGGA
MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGDADGHRGGKGGDGGEALIR-----ATVIGSNASGTATGGDGGN
TH_3810|M.thermoresistible__bu GGTGGLRGVFGINGGNGR--------------------------------
MAB_4284c|M.abscessus_ATCC_199 VGSHVGGGISESLGGSGSVGGS----------------------------
MAV_4827|M.avium_104 GGSGGSGGGHVPTPGAGGSGGS----------------------------
MLBr_01556|M.leprae_Br4923 GDSVVAGDAYGRVRRMVDEHGVDIEAALP---------------------
.. .
Mflv_5091|M.gilvum_PYR-GCK G------------GDGGLGGLGGFGG-------------------SGGTG
Mvan_1264|M.vanbaalenii_PYR-1 G------------GDGGLGGLGGFGG-------------------VGGTG
Mb1485c|M.bovis_AF2122/97 GGAGGAGLNGGNGGAGGNGGLGGFGGNGAAGANGVAVGAPGQPGGAGGHG
Rv1450c|M.tuberculosis_H37Rv GGAGGAGLNGGNGGAGGNGGLGGFGGNGAAGANGVAVGAPGQPGGAGGHG
MMAR_5344|M.marinum_M G-----------GGAGGNGAIGGFSG---------------------GNG
MUL_4367|M.ulcerans_Agy99 GGVGGNGVAGGVNGSGGAGGAGGAGGTGGAGASGVPASVDGGDGGAGGAG
MSMEG_0868|M.smegmatis_MC2_155 GGTLG-----ATNGTGGAATIVAYNVVQAN--------PQASGTATDGHG
TH_3810|M.thermoresistible__bu ----------------------------------------------AGLG
MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------------TAVG
MAV_4827|M.avium_104 ---------------------------------------------GGGHV
MLBr_01556|M.leprae_Br4923 ----------------------------------------SSPVQVIGFT
.
Mflv_5091|M.gilvum_PYR-GCK GQGGLGGPGGSTG---------GAGGAG-GQAGTAGK---------GGLF
Mvan_1264|M.vanbaalenii_PYR-1 GQGGQGGPGGSTG---------GAGGAG-GQAGVAGK---------GGLF
Mb1485c|M.bovis_AF2122/97 GAGGNGGAGGNGGQGVVSDGAGGAGGAG-GDGGAPGDGANGGNGQGAGAF
Rv1450c|M.tuberculosis_H37Rv GAGGNGGAGGNGGQGVVSDGAGGAGGAG-GDGGAPGDGANGGNGQGAGAF
MMAR_5344|M.marinum_M GAGGNGGSGG------------GAGGNG-GDGGNATD----------LMF
MUL_4367|M.ulcerans_Agy99 GAAGTGGSGGSAG----NTGAGGAGGAG-GAGGSAAS---------TGVN
MSMEG_0868|M.smegmatis_MC2_155 GSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDG------IDGGLG
TH_3810|M.thermoresistible__bu GRGXXX------------------XGGGVGAAVRSGN----------GVF
MAB_4284c|M.abscessus_ATCC_199 GGAHTGVGGG--------------VSTGVGVGSHVGG----------GIS
MAV_4827|M.avium_104 PTPGTGGPGG-------------TGGSGGGHVPTPGA----------GTP
MLBr_01556|M.leprae_Br4923 SVPGAGDNFLVVDEDRIARQIADRRSARKRNALAARSRKRISLEDLDSAL
.
Mflv_5091|M.gilvum_PYR-GCK GGSG------------------------------------SAGKAGATGA
Mvan_1264|M.vanbaalenii_PYR-1 GGSG------------------------------------SAGTAGVTGA
Mb1485c|M.bovis_AF2122/97 AGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGGH
Rv1450c|M.tuberculosis_H37Rv AGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDGGNGGHGGH
MMAR_5344|M.marinum_M ANGG------------------------------------NGGNGGTGGE
MUL_4367|M.ulcerans_Agy99 GDGGAGG---------------------------------AGGVGGLGGD
MSMEG_0868|M.smegmatis_MC2_155 GNGGDGVVNTTANAANPG----------------------SATGTATGGD
TH_3810|M.thermoresistible__bu SGGG---------------------------------------GTPSAGF
MAB_4284c|M.abscessus_ATCC_199 ESLG---------------------------------------GSGSVGG
MAV_4827|M.avium_104 GGSG-------------------------------------------GGH
MLBr_01556|M.leprae_Br4923 KETSQLN---------------------------------LILKGDNAGT
. *
Mflv_5091|M.gilvum_PYR-GCK AGASGGKGAQGATGA-----QGATGAQGATGATGAAGKAGATGAAGAAGA
Mvan_1264|M.vanbaalenii_PYR-1 SGASGGKGAQGATGA-----QGATGAQGATGATGASGAQGSAGSAGSAGV
Mb1485c|M.bovis_AF2122/97 GAASGGNGGPGGHGG-----NGGNGGTGANGGNGGIGGTGGAGSTGAKGV
Rv1450c|M.tuberculosis_H37Rv GAASGGNGGPGGHGG-----NGGNGGTGANGGNGGIGGTGGAGSTGAKGV
MMAR_5344|M.marinum_M GTAGSG----GGSGG-----NGGAGGAGGLYGNGGNGGTGGSGAAGGVGA
MUL_4367|M.ulcerans_Agy99 SAATAGGGGAGGDGG-----KGGAGGAGVNGVGGGDGGKGGTGGAGGAGG
MSMEG_0868|M.smegmatis_MC2_155 GGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAG
TH_3810|M.thermoresistible__bu GVPTTIQFPAGSCTS------RAVSREGIMPSSRAASARAGAACASSTSR
MAB_4284c|M.abscessus_ATCC_199 STAVGGGAHTGVGGG-----VNTGVGVGSHVGGGISESLGGSGSVGGSTA
MAV_4827|M.avium_104 LPFPGAGSTPGGSGG------GHLPTPGAGTPGGGLGGFGGGHAPAPGGG
MLBr_01556|M.leprae_Br4923 VEALEEALMGIQVDDEVALRVIDRGVGGITETNVNLASASDAIIIGFNVR
* . .
Mflv_5091|M.gilvum_PYR-GCK AGSAGTTGAQGSAGTNGANGANGSQGAAGKAGATGTTGATGAAGEDGDAG
Mvan_1264|M.vanbaalenii_PYR-1 AGSAGTTGAQGSAGTNGANGANGSQGAAGKAGATGTTGATGAAGDAGDPG
Mb1485c|M.bovis_AF2122/97 LGTNEGDGGDGGRGGNGGRGGNGGQGLTGAGGNGGTGGTPGNGGNGGNGA
Rv1450c|M.tuberculosis_H37Rv LGTNEGDGGDGGRGGNGGRGGNGGQGLTGAGGNGGTGGTPGNGGNGGNGA
MMAR_5344|M.marinum_M MGGNGGNGGSGGTGTTAGADGNGG--------NGGTGGAGGNGGNGGTGG
MUL_4367|M.ulcerans_Agy99 AGSDGIIPSNGGLGGNGGNGGNGGQ-----AFGDGVGGAGGIGGKGGNAA
MSMEG_0868|M.smegmatis_MC2_155 NGGNALVMAAGTTGVATGNTATGGDG-GAATTAGATGGAGGFSNIAAIHG
TH_3810|M.thermoresistible__bu SRRSFCCSRA----------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VG-----GGAHTSAINDALGGSGSVGGSTAVGGGAHTSAINESMNSSINA
MAV_4827|M.avium_104 LGGGGGHAPAPGGGLGG---------------------------------
MLBr_01556|M.leprae_Br4923 AEGKATELASREGVEIRYYLVIYQAIDDIEKALRGMLKPIYEENQLGRAE
Mflv_5091|M.gilvum_PYR-GCK SGGSGINGGAGGAGGAGGEGGEGGDGG------------KGGAGAEGGAG
Mvan_1264|M.vanbaalenii_PYR-1 SEAVDINGGAGGAGGAGGEGGEGGAGG------------AGGDGSEGGAG
Mb1485c|M.bovis_AF2122/97 SGDLVTSPGDGGGGGRGGDAGRGGDAGLGGSSGPGGTPGDWGTGGTGGTG
Rv1450c|M.tuberculosis_H37Rv SGDLVTSPGDGGGGGRGGDAGRGGDAGLGGSSGPGGTPGDWGTGGTGGTG
MMAR_5344|M.marinum_M ------AAGSGGMFGQMGDAGDGGDA---------------GTGGEGGDG
MUL_4367|M.ulcerans_Agy99 IGTIVINGGVGGAGGSGGLGGATEDG-------------VGGVGCAGGAG
MSMEG_0868|M.smegmatis_MC2_155 AITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAG--PVGSKIANSSAVA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SHSSSMNESFGSSMGSHGAAG-------------------TGFEAQGHAQ
MAV_4827|M.avium_104 ------FGGGHSGGGLGGLGGGHK--------------------------
MLBr_01556|M.leprae_Br4923 IRALFRSSKVGIIAGCIISSGVVRRNAKVR-------LLRDNIVVTDNLT
Mflv_5091|M.gilvum_PYR-GCK GGGGAGGSG--AGGAGG---------------AGGSGGS-----------
Mvan_1264|M.vanbaalenii_PYR-1 GSGGAGGSG--TGGAGG---------------AGGSGGS-----------
Mb1485c|M.bovis_AF2122/97 GTGGQGANGGLTGGRGGTGGNGG---------AGGTGGTGHNGSQPGMGG
Rv1450c|M.tuberculosis_H37Rv GTGGQGANGGLTGGRGGTGGNGGNGNTGGTGGAGGTGGTGHNGSQPGMGG
MMAR_5344|M.marinum_M GTGGSGAMSGQTGDQG----------------AGGTPGT-----------
MUL_4367|M.ulcerans_Agy99 GNGGRGDMLFTVGGSGG---------------TGGDGGGG----------
MSMEG_0868|M.smegmatis_MC2_155 GNGGDGGVNGTGGASGG---------------DGGNGGNTS---------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GHASETAHTTLPGAEHH---------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 VTSLRREKDDVTEVREG-------------------------------FE
Mflv_5091|M.gilvum_PYR-GCK -GGSGG--------SGGSGGAAGDSDD-----------------------
Mvan_1264|M.vanbaalenii_PYR-1 -GGSGG--------AGGSGGAAGDSD------------------------
Mb1485c|M.bovis_AF2122/97 NGGAGGFGGNGFAGVGGRGGMGGSGGTGGTGDAGPFGTGTGGTGGHGGQG
Rv1450c|M.tuberculosis_H37Rv NGGAGGFGGNGFAGVGGRGGMGGSGGTGGTGDAGPFGTGTGGTGGHGGQG
MMAR_5344|M.marinum_M -AGASG--------------------------------------------
MUL_4367|M.ulcerans_Agy99 -GSASGSGTGGSGGTGGVGGIGGDGKLG-------------GFGGDGGDG
MSMEG_0868|M.smegmatis_MC2_155 VWKSGGQTADGEHNTGGNGGNGGDGSEPGPGG--------NGAGGAGGNG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 CGMTLGYSDIKEGDVIESYELVEKQRA-----------------------
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------------
Mb1485c|M.bovis_AF2122/97 GGGGFSILLGLGGLGGLGSPGSIATGTAGGAGGGGGFGGLGGGEFV
Rv1450c|M.tuberculosis_H37Rv GGGGFSILLGLGGLGGLGSPGSIATGTAGGAGGGGGFGGLGGGEFV
MMAR_5344|M.marinum_M ----------------------------------------------
MUL_4367|M.ulcerans_Agy99 GDGGFGVIGGQGGGGGFGGLGGTGAGGAPSDKGINGEPGNPG----
MSMEG_0868|M.smegmatis_MC2_155 GTGG----TTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP---
TH_3810|M.thermoresistible__bu ----------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------------
MAV_4827|M.avium_104 ----------------------------------------------
MLBr_01556|M.leprae_Br4923 ----------------------------------------------