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SFVIAAPDLVAMATEDLAGIGASLTAANAAAAVPTSGLLAAAGDEVSAAIAALFSSHGQQYQAMSAQAAA FHARFVQALAGAMGAYAAAEAANASPLQTLEQGLLGAINAPAAALSGRPFIGNGTNGAPGTGEAGGPGGW LLGNGGNGGSGAPGQTGGAGGAAGLLGHGGTGGAGGTGASGGKGGTGGWLWGSGGAGGAGGSGGGSGGAG GNALMFGIGGNGGAGGAASGVGNGGVGGAGGAGGALVAIGGAGGAGGAATTGTGGAGGAGSNALGLFLGL GGSGGQGGDSAMGSGGAGGAGGSGGAASPFGIDIGIGGAGGHGGAGTNGGAGGAGGAGGSSGTVFALDLS WGGAGGNGGAATTGTGGAGGTGGFAVAPDFIGFGAAYGGAGGLGGAATGAGGTGGTGGVGAGGFAALGVG VGGAGGAGGAATETGGIGGAGGLGVGLLGGAGGAGGPGGAASAGSGGHGGTGGDALGLIGAGIGGVGGVG GAATDTGGNGGAGGSGTGLLGGVGGAGGHGGGASVGTGGSGGAGGDGFGFVGAGGNGGNAGTGVGVNGAN GGNGGSATGALAAVGGAGAAGGDATSGTGGFGGAGGSARGLIFALGGAGAAGGDASTGVGGPGGPGGTGT ASSPFGIAIAIGGAGAQGGAGTSGATGGAGGDGVFEGIAVLGLGFGGAAGAGGAATGDGATGGAGGFGGA GAGIANFLGFSVLHGGAGGAGGTATGTGGNGGAGGGGGLSSPVILGIGIGGAGGDGGGALGVLGGMGGDG GDGGEAVAVGIAVGGAGGAGGAAPTGNGGAGGNGGDALGLVGVGGNGGNAGTGFGANTGGNGGDTTIVVN GMLAPSTLGYGGNGGNGVNGGAGGTGGKAGVFGAPGQNGLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0834c | PE_PGRS14 | - | 100% (882) | PE-PGRS FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3345c | PE_PGRS50 | 0.0 | 48.41% (977) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv3507 | PE_PGRS53 | 0.0 | 48.38% (1019) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0857c | PE_PGRS14 | 0.0 | 91.39% (883) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-145 | 46.65% (746) | triple helix repeat-containing collagen |
| M. leprae Br4923 | MLBr_01183 | - | 5e-14 | 40.62% (96) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 1e-49 | 30.40% (569) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_0492 | - | 0.0 | 55.26% (894) | PE-PGRS family protein |
| M. avium 104 | MAV_4827 | - | 4e-24 | 41.27% (189) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-130 | 40.38% (884) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 1e-41 | 39.61% (308) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 47.12% (1042) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-140 | 44.82% (772) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0834c|M.tuberculosis_H37Rv MSFVIAAPDLVAMATEDLAGIGASLTAANAAAAVPTSGLLAAAGDEVSAA
Mb0857c|M.bovis_AF2122/97 MSFVIAAPDLVAMATEDLAGIGASLTAANAAAAVPTSGLLAAAGDEVSAA
MMAR_0492|M.marinum_M MSGVIAALDTLTAAATDVAGLGAAINAANAAAAVSTTRLMAAAGDEVSAA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 -----MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAA
MUL_4367|M.ulcerans_Agy99 MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDEVSAA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAV
MAV_4827|M.avium_104 -------------------------MNIVLGVSMAPSSIQMVVLEGEYAD
Rv0834c|M.tuberculosis_H37Rv IAALFSSHGQQYQAMSAQAAAFHARFVQALAGAMGAYAAAEAANASPLQT
Mb0857c|M.bovis_AF2122/97 IAALFSSHGQQYQAMSAQAAAFHARFVQALAGAMGAYAAAEAANASPLQT
MMAR_0492|M.marinum_M IAALFSDHALQYQAVSAEAVAFHGRFVQALTGGVQMYAAAETANTASLQT
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------MMFLAPPGGPGPISAAIQLTSTGSEA
MSMEG_0868|M.smegmatis_MC2_155 LAPESPLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNT
MUL_4367|M.ulcerans_Agy99 IAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALNMWPLQE
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 MPVVAESVASNYGYQSQWVN--TGNPIHDLSGNLQNYYAAQPDGPS----
MAV_4827|M.avium_104 GATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAG---------
Rv0834c|M.tuberculosis_H37Rv LEQGLLGAIN----------------------------------------
Mb0857c|M.bovis_AF2122/97 LEQGLLGAIN----------------------------------------
MMAR_0492|M.marinum_M LGQDLLGMVN----------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------MVTFGGG
Mvan_1264|M.vanbaalenii_PYR-1 TEP--------------------------------------WYVVSFGGS
MSMEG_0868|M.smegmatis_MC2_155 TDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTT
MUL_4367|M.ulcerans_Agy99 LEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGILWGNGGNGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv0834c|M.tuberculosis_H37Rv ----------------------------------------------APAA
Mb0857c|M.bovis_AF2122/97 ----------------------------------------------APAA
MMAR_0492|M.marinum_M ----------------------------------------------APAA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ATPTP----------------------------------------TSLGA
Mvan_1264|M.vanbaalenii_PYR-1 GAPTP----------------------------------------NNLAA
MSMEG_0868|M.smegmatis_MC2_155 LIPNAPTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVAS
MUL_4367|M.ulcerans_Agy99 LGAAG-------------------------------ANGGAGGSAGLIGT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------------ILSP
MAV_4827|M.avium_104 -----------------------------------------------LQL
Rv0834c|M.tuberculosis_H37Rv ALSGRP---------------------------------------FIGNG
Mb0857c|M.bovis_AF2122/97 ALSGRP---------------------------------------FIGNG
MMAR_0492|M.marinum_M AVLGRP---------------------------------------LIGNG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AAVDLS------------------------GTSCG----------LICNG
Mvan_1264|M.vanbaalenii_PYR-1 SLVDLS------------------------GTSCG----------LICNG
MSMEG_0868|M.smegmatis_MC2_155 AVLDPTQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNG
MUL_4367|M.ulcerans_Agy99 GGVGGAG------------------GVGAAGMTGGSGGAGGGGGWLWGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SLLSPRD--------------------------------------NDFLS
MAV_4827|M.avium_104 SSIGVT----------------------------------------WTDQ
Rv0834c|M.tuberculosis_H37Rv TNG-APGTGEAGGPGGWLLGNGGNGG-SGAPGQTGGAGG-----------
Mb0857c|M.bovis_AF2122/97 TNG-APGTGEAGGPGGWLLGNGGNGG-SGAPGQTGGAGG-----------
MMAR_0492|M.marinum_M TNG-APGSGDAGGPGGLLFGNGGNGG-SGSAGMAGGAGG-----------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK QDG--TGQN-----GGILFGNGGSGWNSDVVGMDGGNGG-----------
Mvan_1264|M.vanbaalenii_PYR-1 QDG--TGQN-----GGILFGNGGSGWNSEIAGVSGGNGG-----------
MSMEG_0868|M.smegmatis_MC2_155 ING--TADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGG-----------
MUL_4367|M.ulcerans_Agy99 GSGGAAGAGGSGGSGGWLWGNAGQTAGAGVGGAGGAGGAGDAGDQGVSGV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 HNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFG-----------
MAV_4827|M.avium_104 LEAAALRDALAARRIDNVMLVSAFLAAAALAQNVGGAMG-----------
Rv0834c|M.tuberculosis_H37Rv ---AAGLLG-HGGTGGAGGTGASGGKGGTGG--WLWGSGGAGGAGGSGGG
Mb0857c|M.bovis_AF2122/97 ---AAGLLG-HGGTGGAGGTGASGGKGGTGG--WLWGSGGAGGAGGSGGG
MMAR_0492|M.marinum_M ---SAGLIG-NGGAGGAGGADAAGGPGGAGG--WLWGGGGAG--------
TH_3810|M.thermoresistible__bu -------------------VDGDGGSGGRTGLFSKLSRGGDGGDGGLG--
Mflv_5091|M.gilvum_PYR-GCK ---NGGLFGGNGGNGGNGLGGGNGGNGGNAGAFALFGNGGNGGNGGVGVV
Mvan_1264|M.vanbaalenii_PYR-1 ---NAGLFGGNGGNGGNGLGSGDGGNGGDAGLFSLFGRGGNGGNGGVGIA
MSMEG_0868|M.smegmatis_MC2_155 ---NAGLFG-NGGNGGVGWAGLDGGNGGSGG--LLMGIGGAGGAGGVGAD
MUL_4367|M.ulcerans_Agy99 APGEAGAVGFAGGAGGAGGAGGNGVGGGVNGAGGAGGAGGVGGGGGAGAS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------DLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVRDS
MAV_4827|M.avium_104 YERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMV
Rv0834c|M.tuberculosis_H37Rv SGGAGGNALMFGIGGNGGAGGAASGVGNGGVG-----GAGGAGGALVAIG
Mb0857c|M.bovis_AF2122/97 SGGAGGNALMFGIGGNGGAGGAASGVGNGGVG-----GAGGAGGALVAIG
MMAR_0492|M.marinum_M -----------------GLGGAASGAGNGGAG-----GAGGAGGAFIAIG
TH_3810|M.thermoresistible__bu -----------GNGGHGGGTGIIS--------------------LLSLAG
Mflv_5091|M.gilvum_PYR-GCK GATGAVG--APGVAGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAG
Mvan_1264|M.vanbaalenii_PYR-1 GATGAVG--APGVAGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAG
MSMEG_0868|M.smegmatis_MC2_155 GTSAHVDGGTGGTGGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAG
MUL_4367|M.ulcerans_Agy99 GVGAGVAGGDGGTGGAGGAAGVGGAAGTGGTGGAAGVAGTGGDGGDGGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQRNT
MAV_4827|M.avium_104 AGLEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEPETALARG
Rv0834c|M.tuberculosis_H37Rv GAGGAG-----------------GAATTGTGGAGGAGSNALGLFLGLGGS
Mb0857c|M.bovis_AF2122/97 GAGGAG-----------------GAATTGTGGAGGAGSNALGLFLGLGGS
MMAR_0492|M.marinum_M GVGGDG-----------------GAASSGTGGVGGAGGNADGLIVSLGGA
TH_3810|M.thermoresistible__bu NGGNGG---------------NGYRTTDNNALDGGHGG------------
Mflv_5091|M.gilvum_PYR-GCK AAGAAG--------------AVGSAGAAGEAGETGTWG--NAGLPGKAGD
Mvan_1264|M.vanbaalenii_PYR-1 AAGKAG--------------AVGSAGTAGSAGAPGVWG--NAGLPGAAGA
MSMEG_0868|M.smegmatis_MC2_155 NGGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGG
MUL_4367|M.ulcerans_Agy99 GAGSDAS------------LAGQAGFAGGSGGAGGVGGSAGAGGVNGSGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 TNINDS-----------------FNTDRSTNIGSGNTTNTEIGSHNQANI
MAV_4827|M.avium_104 AALAAAN----------APLFASSTAALAYAQDPGTGAVDQYSLPDYLYV
Rv0834c|M.tuberculosis_H37Rv GGQGG---------------------------------DSAMGSGGAGG-
Mb0857c|M.bovis_AF2122/97 GGQGG---------------------------------DSAMGSGGAGG-
MMAR_0492|M.marinum_M GGHGG---------------------------------DATTGIGGAGG-
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AGGAG----------------AVGAAGAAG------TVGTAGATGGTG--
Mvan_1264|M.vanbaalenii_PYR-1 AGGAG----------------AIGTAGVAG------AAGTAGATGGTG--
MSMEG_0868|M.smegmatis_MC2_155 GGGGGGGAILIGANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRV
MUL_4367|M.ulcerans_Agy99 DGGAG----------------AAGGAGGAS--ATVAGSGGVGGDGGAGG-
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GTSTS---------------------------------------------
MAV_4827|M.avium_104 PVDPE---------------------------------------------
Rv0834c|M.tuberculosis_H37Rv -------------AGGSGGAASPFGIDIGIG----------------GAG
Mb0857c|M.bovis_AF2122/97 -------------AGGSGGAASPFGIDIGIG----------------GAG
MMAR_0492|M.marinum_M -------------AGGMATARIPAGINFNVG----------------GAG
TH_3810|M.thermoresistible__bu -------------NGGNVGFFSLFNLGG--------------------AG
Mflv_5091|M.gilvum_PYR-GCK -------------TGANGGAGGVGGVGGTGAAG--------------AAG
Mvan_1264|M.vanbaalenii_PYR-1 -------------VGGNGGAGQAGGIGGTGAAG--------------AAG
MSMEG_0868|M.smegmatis_MC2_155 IAEGTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATG
MUL_4367|M.ulcerans_Agy99 ------------AAGGGVGAASLGGDGGHAGAG--------------GAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------AGGSAAVGGNAGLAGNAG----------------LAG
MAV_4827|M.avium_104 -------------PGDDELAYSAVGEED-------------------AES
Rv0834c|M.tuberculosis_H37Rv GHGGAG--TNGGAGGAGGAGGSSGTVFALDLSWGGAGGNGGAATTG----
Mb0857c|M.bovis_AF2122/97 GHGGAG--TNGGAGGAGGAGGSSGTVFALDLSWGGAGGNGGAATTG----
MMAR_0492|M.marinum_M GHGGAG--ATGGAGGGGGSAYSG--YVGIAFGQGGAGGIGGAASTG----
TH_3810|M.thermoresistible__bu GWGGSG--VDG---------------------VDVVGGNP----------
Mflv_5091|M.gilvum_PYR-GCK GAGGLG--ETGTTGGAGGVGGQ--GTAGGTGGVGGIGGAGSTGAVGGVGG
Mvan_1264|M.vanbaalenii_PYR-1 QAGTAG--ETGVTGGVGGIGGQ--GTEGGTGGVGGVGGVGATGGAGGVGG
MSMEG_0868|M.smegmatis_MC2_155 GRGGDG--IDGGTGGAGGMGEIYSGADGEATGISAGGDGGSATGADSLGG
MUL_4367|M.ulcerans_Agy99 GEGLSGGFNTGAAGGIGGAGGAG-GTGGDSGGVGGVNGDGGAGGGGGRGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NAGLAG-------------------NAGLAGNAGLAGNAGLAGNAG----
MAV_4827|M.avium_104 PTVVIEKLFLPEDSEPRRRPVLLVGSGLAVVGISAVLALEIALAIG----
Rv0834c|M.tuberculosis_H37Rv -----------------------------TGGAGGTGGFAVAPDFIGFG-
Mb0857c|M.bovis_AF2122/97 -----------------------------TGGAGGTGGFAVAPDFIGFG-
MMAR_0492|M.marinum_M -----------------------------MAGAGGSGGSCVAFDFVGFA-
TH_3810|M.thermoresistible__bu --------------------------------DGGTPG------------
Mflv_5091|M.gilvum_PYR-GCK KG----IQGGQG-------------LQGGKGGDGGAGGKGGDADSMGS--
Mvan_1264|M.vanbaalenii_PYR-1 KG----IQGGQG-------------LQGGQGGDGGTGGTGGDATSMGE--
MSMEG_0868|M.smegmatis_MC2_155 RGGTSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGA
MUL_4367|M.ulcerans_Agy99 DGGSSTSTSGVG-------------GAGGAGGNGGNAGFGVSAGGTGG--
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------------------LAGNAGLAG------------
MAV_4827|M.avium_104 -----------------------------IRTTGTVALQPTPNQHLIVP-
Rv0834c|M.tuberculosis_H37Rv -----------------AAYGGAGGLGGAATGAGGTG-------------
Mb0857c|M.bovis_AF2122/97 -----------------AAYGGAGGLGGAATGAGGTG-------------
MMAR_0492|M.marinum_M -----------------AAHGGAGGTGGAATGVGATA-------------
TH_3810|M.thermoresistible__bu ------------------AHGESHTPGVYTDRQ-----------------
Mflv_5091|M.gilvum_PYR-GCK ----------------AGATGGKGGNGGNGGRGGLFG-------------
Mvan_1264|M.vanbaalenii_PYR-1 ----------------AGATGGKGGNGGNGGRGSLFG-------------
MSMEG_0868|M.smegmatis_MC2_155 TGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSGHGG
MUL_4367|M.ulcerans_Agy99 ---------------SAGDGGAGGGAGGVDGVGGASG-------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------------NAGLAGNAGLAGNAGLAG-------------
MAV_4827|M.avium_104 -----------------TEQAPAPPPVQASAPQPKIS-------------
Rv0834c|M.tuberculosis_H37Rv ----GTGGVGAGG-------------------FAALGVGVGGAGGAGGAA
Mb0857c|M.bovis_AF2122/97 ----GTGGVGAGG-------------------FAALGVGVGGAGGAGGAA
MMAR_0492|M.marinum_M ----GAAGSGGLG-------------------VAIVGSGVGGVGGVGGAA
TH_3810|M.thermoresistible__bu --------------------------------------GEDGEDGTGTGI
Mflv_5091|M.gilvum_PYR-GCK --KGGNAGNGAD----------------------GGTGGAGGAGGTGG-T
Mvan_1264|M.vanbaalenii_PYR-1 --RGGNAGNGGN----------------------GGTGGNGGNGGTGG-T
MSMEG_0868|M.smegmatis_MC2_155 AAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGAT
MUL_4367|M.ulcerans_Agy99 --NGGAAGAGGAG---------------GSGIGAGIDGGAGGAGGTGGAA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------------------------NAGLAGNAGLAGNA
MAV_4827|M.avium_104 -----------------------------------VPEPVAAPKPLSPPV
Rv0834c|M.tuberculosis_H37Rv TETGGIGGAGGLGVGLLGGAGGAGGPGGAASAGSGGHGGTGGDALGLIGA
Mb0857c|M.bovis_AF2122/97 TETGGIGGAGGLGVGLLGGAGGAGGPGGAASAGSGGHGGTGGDALGLIGA
MMAR_0492|M.marinum_M TGAG-------------------------ATAAAGGAGGLG---LAAVGS
TH_3810|M.thermoresistible__bu GGRGGNGG---------------------SSSGTHPMAEDG--------E
Mflv_5091|M.gilvum_PYR-GCK GGAGGTGG----------------------TGGTGGIGGAGSTGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1 GGNGGTGG----------------------TGGTGGIGGAGSTGGTGGTG
MSMEG_0868|M.smegmatis_MC2_155 GGRGGDGAGASVWK-----ANGQHSTGQTDTGGNGGRGGDGGTFVNAGAN
MUL_4367|M.ulcerans_Agy99 GFPGGGGTTG-----------------AWGTGGAGGAGGAGGAGDHGGVG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GLAGNAG-----------------------LAGNAGLAGNAGLAGNAGLA
MAV_4827|M.avium_104 AAPLPAAP----------------------PPAAPPLPEAPPIPAAPPVV
Rv0834c|M.tuberculosis_H37Rv GIGGVGGVGGAATDTGGNGGAGGS-------GTGLLGGVGGAGGHGGGAS
Mb0857c|M.bovis_AF2122/97 GIGGVGGVGGAATDTGGNGGAGGS-------GTGLLGGVGGAGGHGGGAS
MMAR_0492|M.marinum_M GTGGAGGAGGVGAGTGGAGGAGAH-------GFGLLSGTAGAGGAGGAAS
TH_3810|M.thermoresistible__bu HVKALDGRPGLD---GGNGSHG---------GNGGHGGRGGFLGIGGSG-
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGTG-GTGGTGGTG---------GTGGKGGTGGTGGAGGTG-
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTG-GTGGTGGTG---------GTGGKGGTGGTGGDGGTG-
MSMEG_0868|M.smegmatis_MC2_155 GNGGAGGAGGVSEGEGGTGGHG---------GDGGRGGDGALGGNGGTGG
MUL_4367|M.ulcerans_Agy99 VNPGDSGTAGWAGGAGGAGGAGGSAAFNGVNGAGGAGGNGGAGGGGGAGA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGNAGLAGNAAVA-------GNAAVAGNAAVAGNAAVGG
MAV_4827|M.avium_104 PVPVVVPPVPVPVPVRIPVPDPVS--------PPQLLAPPRLSVPQPVQP
Rv0834c|M.tuberculosis_H37Rv -----VGTGGSGGAGGDGFG-----FVGAGGNGGNAGTG-----------
Mb0857c|M.bovis_AF2122/97 -----VGTGGSGGAGGDGFG-----FVGAGGNGGNAGTG-----------
MMAR_0492|M.marinum_M -----AGTGGAGGLGGTGFG-----LIAAGGDGGGAGTG-----------
TH_3810|M.thermoresistible__bu ------GWGGHGGNGGD-----------TDADGGNGGDG-----------
Mflv_5091|M.gilvum_PYR-GCK ---GDGGTGGTGGTGGTG---------GTGGTGGTGGAG-----------
Mvan_1264|M.vanbaalenii_PYR-1 ---GTGGTGGTGGTGGTG---------GTGGTGGTGGAG-----------
MSMEG_0868|M.smegmatis_MC2_155 VGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATG
MUL_4367|M.ulcerans_Agy99 SGIGAGVAGGDGGTGGTGGAAGTGGAAGTGGTGGAAGAAG---------S
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----VLNTGVSGAIGGSS-------HVGGAINESLGGSGS----------
MAV_4827|M.avium_104 P-VRVPQPPSPPQVGGTVPQ-------SPPQHQTPPGEG-----------
Rv0834c|M.tuberculosis_H37Rv --VGVNGANGG-----------------------------------NGGS
Mb0857c|M.bovis_AF2122/97 --VGVNGANGG-----------------------------------NGGS
MMAR_0492|M.marinum_M --VGSNGGDGG-----------------------------------GGGG
TH_3810|M.thermoresistible__bu ----GNGGSAG---------------------------------RGGTGG
Mflv_5091|M.gilvum_PYR-GCK DGTGGTGGTGG----TGGQGGQGGQGG-----------------TGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 DGLGGTGGTGG----TGGFGGQGGQGG-----------------TGGTGG
MSMEG_0868|M.smegmatis_MC2_155 TATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGG
MUL_4367|M.ulcerans_Agy99 AGDGGAGGAGG-AGDDGSAGVVSGDPG-----------------TAGKAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --VGGSTAVGG----------------------------------GAHTG
MAV_4827|M.avium_104 -----TPPKPD-----------------------------------GPGN
Rv0834c|M.tuberculosis_H37Rv ATGALAAVGGAGAA---------------------GGDATSGTGGFGGAG
Mb0857c|M.bovis_AF2122/97 ATGALAAVGGAGAA---------------------GGDATSGTGGFGGAG
MMAR_0492|M.marinum_M AHAVLAAIAGSGGQ---------------------GQAGTSGFGGFGGSG
TH_3810|M.thermoresistible__bu LRGVFGINGGNG------------------------RAGLGGRGXXXXGG
Mflv_5091|M.gilvum_PYR-GCK QGG-LGGGGGTG-----------------------GQGGTGGTGGQGGTG
Mvan_1264|M.vanbaalenii_PYR-1 QGG-LGGVGGTG-----------------------GTGGTGGTGGQGGTG
MSMEG_0868|M.smegmatis_MC2_155 NGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNG
MUL_4367|M.ulcerans_Agy99 GAGGAGGVGGNGVAG--------------------GVNGSGGAGGAGGAG
MLBr_01183|M.leprae_Br4923 ----MPLFLNAEP-----------------------QALTAAANTLEGLS
MAB_4284c|M.abscessus_ATCC_199 VGGGVSTGVGVG-----------------------SHVGGGISESLGGSG
MAV_4827|M.avium_104 YGGGHVPTPGAG-------------------------GSGGSGGGHVPTP
. .
Rv0834c|M.tuberculosis_H37Rv GSARGLIFALG------GAGAAGGDASTGV-GGPGGPGGTGTASSPFGIA
Mb0857c|M.bovis_AF2122/97 GSARGLIFALG------GAGAAGGDASTGV-GGPGGPGGTGTASSPFGIA
MMAR_0492|M.marinum_M GSAESLFFSIG------GAGGAGGDASTGG-GGLGGNGGVAVAHSPIGID
TH_3810|M.thermoresistible__bu GVGAAVRSG---------------NGVFSGGGGTPSAGFGVPTTIQFPAG
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTG--------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTG--------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPG
MSMEG_0868|M.smegmatis_MC2_155 GQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPG
MUL_4367|M.ulcerans_Agy99 GTGGAGASG-------VPASVDGGDGGAGGAGGAAGTGGSGGSAGNTGAG
MLBr_01183|M.leprae_Br4923 AATVASNAA--------------AAQLTTEIAPPAADDVSILLAHFFSGH
MAB_4284c|M.abscessus_ATCC_199 SVGGSTAVG---------------GGAHTGVGGGVSTGVGVGSHVGGGIS
MAV_4827|M.avium_104 GAGGSGGSG-------------GGHVPTPGTGGPGGTGGSGGGHVPTPGA
. . . . .
Rv0834c|M.tuberculosis_H37Rv IAIGGAGAQGGAGTSGATGGAGGDGVFEGIAVLGLGFGGAAGAGG-AATG
Mb0857c|M.bovis_AF2122/97 IAIGGAGAQGGAGTSGATGGAGGDGVFEGIAVLGLGFGGAAGAGG-AATG
MMAR_0492|M.marinum_M IGIGGAGGHGGSGTSGADGGAGGVSISEGIFAIDVNLGGAGGDGGTATTG
TH_3810|M.thermoresistible__bu SCTSRAVSREG------------------------IMPSSRAASA--RAG
Mflv_5091|M.gilvum_PYR-GCK GSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGA--SGG
Mvan_1264|M.vanbaalenii_PYR-1 GSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGA--SGG
MSMEG_0868|M.smegmatis_MC2_155 SATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTA--TAG
MUL_4367|M.ulcerans_Agy99 GAGGAGGAGGSAASTGVNGDGGAGG----AGGVGGLGGDSAATAG--GGG
MLBr_01183|M.leprae_Br4923 GRQYQAHASQG------------------------ATNHQDLIQS-----
MAB_4284c|M.abscessus_ATCC_199 ESLGGSGSVGGSTAVGGGAHTGVGG------GVNTGVGVGSHVGGGISES
MAV_4827|M.avium_104 GTPGGSGGGHLPFPGAGSTPGGSGG------GHLPTPGAGTPGGG-----
. . .
Rv0834c|M.tuberculosis_H37Rv DGATGGAGGFGGAG----AGIANFLGFSVLHGGAGGAGGTATGTGGNGGA
Mb0857c|M.bovis_AF2122/97 DGATGGAGGFGGAG----AGIANFLGFSVLHGGAGGAGGTATGTGGNGGA
MMAR_0492|M.marinum_M TAGSGGNGGFVEN--------FDFFGFGVAHGGDGGSGGAASGAGGIGGA
TH_3810|M.thermoresistible__bu ---------------------------AACASSTSRSRRSFCCSRA----
Mflv_5091|M.gilvum_PYR-GCK KGAQGATGAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSA
Mvan_1264|M.vanbaalenii_PYR-1 KGAQGATGAQGATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSA
MSMEG_0868|M.smegmatis_MC2_155 KGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGA
MUL_4367|M.ulcerans_Agy99 AGGDGGKGGAGGAG----VNGVGGGDGGKGGTGGAGGAGGAGSDGIIPSN
MLBr_01183|M.leprae_Br4923 ---------------------------LLTSSSAYAGTETANHDSL----
MAB_4284c|M.abscessus_ATCC_199 LGGSGSVGGSTAVG------------GGAHTSAINDALGGSGSVGGSTAV
MAV_4827|M.avium_104 -------------------------LGGFGGGHAPAPGGGLGGGGGHAPA
Rv0834c|M.tuberculosis_H37Rv GG--------GGGLSSPVILGIGIGGAGGDGGGALGVLGGMGGDGGDGGE
Mb0857c|M.bovis_AF2122/97 GG--------GGGLSSPVILGIGIG-------------------------
MMAR_0492|M.marinum_M GG--------NGGSGTTPLFGAYSGGAGGDGGAATG-TGGAGGNGGAGGA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK G-----------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-
Mvan_1264|M.vanbaalenii_PYR-1 G-----------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-
MSMEG_0868|M.smegmatis_MC2_155 GGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGS
MUL_4367|M.ulcerans_Agy99 GGLGGNGGNGGNGGQAFGDGVGGAGGIGGKGGNAAIGTIVINGGVGGAGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GG---------GAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAG-
MAV_4827|M.avium_104 PG------------------------------------------------
Rv0834c|M.tuberculosis_H37Rv AVAVGIAVGGAGGAGGAAPTG--NGGAGGNGGD----------ALGLVGV
Mb0857c|M.bovis_AF2122/97 -------------------------GAGGNGGD----------ALGLVGV
MMAR_0492|M.marinum_M ASGLGVGIGGAGGHGGAAPTG--NGGSGGAGAG----------GLGLIGA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -------AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGE
Mvan_1264|M.vanbaalenii_PYR-1 -------AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGE
MSMEG_0868|M.smegmatis_MC2_155 KIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNT
MUL_4367|M.ulcerans_Agy99 -----SGGLGGATEDGVGGVG-CAGGAGGNGGR----GDMLFTVGGSGGT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------TGFEAQ
MAV_4827|M.avium_104 --------------------------------------------------
Rv0834c|M.tuberculosis_H37Rv GGNGGNAGTGFGANTGGNGGDTTIVVNGMLAP-----STLGYGGNGGNGV
Mb0857c|M.bovis_AF2122/97 GGNGGNAGTGFGANTGGNGGDTTIVVNGMLAP-----STLGYGGN---GV
MMAR_0492|M.marinum_M GGNGGDAGAGVAAADGGDGGNAGLVINGTYEA-----SPYGNGGNGGNGV
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGDGGKGGAGAEGGAGGGGGAGGSGAGGAG-------GAGGSGGSG----
Mvan_1264|M.vanbaalenii_PYR-1 GGAGGAGGDGSEGGAGGSGGAGGSGTGGAG-------GAGGSGGSG----
MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNG----
MUL_4367|M.ulcerans_Agy99 GGDGGGGGSASGSGTGGSGGTGGVGGIGGDGKLGGFGGDGGDGGDGGFGV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GHAQGHASETAHTTLPGAEHH-----------------------------
MAV_4827|M.avium_104 GGLGGFGGGHSGGGLGGLGGGHK---------------------------
Rv0834c|M.tuberculosis_H37Rv NGGAGGTGGKAGVFG-APGQNGLP-----------
Mb0857c|M.bovis_AF2122/97 NGGAGGTGGKAGVFG-APGQNGLP-----------
MMAR_0492|M.marinum_M NGGSGGKGGSAGQVGGTPGQNGSP-----------
TH_3810|M.thermoresistible__bu -----------------------------------
Mflv_5091|M.gilvum_PYR-GCK --GSGGSGGSGGAAGDSDD----------------
Mvan_1264|M.vanbaalenii_PYR-1 --GSGGAGGSGGAAGDSD-----------------
MSMEG_0868|M.smegmatis_MC2_155 --GNGGADGTPGTAGTTGANNP-------------
MUL_4367|M.ulcerans_Agy99 IGGQGGGGGFGGLGGTGAGGAPSDKGINGEPGNPG
MLBr_01183|M.leprae_Br4923 -----------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------------------------
MAV_4827|M.avium_104 -----------------------------------