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MSIFTTTDGTDIFYKDWGSGQPIVFSHGWPLSSDDWDTQMLFFLQRGYRVIAHDRRGHGRSTQTPDGHDL DHYADDLAELTAHLDLRDAIHVGHSTGGGEVVRYLGRHGESRVAKAALISAVPPLMVRTEDNPEGTPKEV FDDLQAQLAANRSVFYRSLPAGPFYGFNRPGVEPQEAIIENWWRQGMMGDAYSHYDGIVAFSQTDFTEDL KKITVPVLVMHSEADQIVPYVASGPKSAALLKNGVLKTYKDFPHGMPTTHADVVNADLLEFLKG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1567 | - | - | 100% (274) | chloride peroxidase |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 7e-10 | 34.65% (101) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_3112 | - | 3e-09 | 28.11% (217) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3196c | hpx | 4e-09 | 34.30% (172) | non-Heme haloperoxidase Hpx |
| M. gilvum PYR-GCK | Mflv_3146 | - | 1e-127 | 75.46% (273) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3171c | hpx | 4e-09 | 34.30% (172) | non-Heme haloperoxidase Hpx |
| M. leprae Br4923 | MLBr_02269 | - | 2e-08 | 26.30% (270) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4337 | - | 8e-11 | 25.17% (286) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_2050 | - | 4e-22 | 33.77% (231) | hypothetical protein MMAR_2050 |
| M. avium 104 | MAV_5175 | - | 2e-37 | 35.02% (257) | non-haem bromoperoxidase BPO-A2 |
| M. smegmatis MC2 155 | MSMEG_4707 | - | 2e-43 | 38.85% (260) | non-heme bromoperoxidase BPO-A2 |
| M. thermoresistible (build 8) | TH_3727 | - | 1e-129 | 77.29% (273) | PUTATIVE Chloride peroxidase |
| M. ulcerans Agy99 | MUL_3299 | - | 4e-18 | 44.76% (105) | hypothetical protein MUL_3299 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2050|M.marinum_M MRPTLAAAALAGASGLVGWGGARALARRIERNPDPFPRERLLAEPQGERV
MUL_3299|M.ulcerans_Agy99 MRPTLAAAALAGASGLVGWGGARALARRIERNPDPFPRERLLAEPQGERV
Mb3196c|M.bovis_AF2122/97 -------------------------------------------------M
Rv3171c|M.tuberculosis_H37Rv -------------------------------------------------M
Mflv_3146|M.gilvum_PYR-GCK ------------------------------------------------MP
TH_3727|M.thermoresistible__bu ------------------------------------------------MA
Mvan_1567|M.vanbaalenii_PYR-1 ------------------------------------------------MS
MAV_5175|M.avium_104 ------------------------------------------------MP
MSMEG_4707|M.smegmatis_MC2_155 ------------------------------------------------MA
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
MAB_4337|M.abscessus_ATCC_1997 ----------------------------------MTRNTATETAWRQHEG
MMAR_2050|M.marinum_M AITRPDG----TVLHALVAG---RGTPVILVHGYCASLTEWN-FVWDELL
MUL_3299|M.ulcerans_Agy99 AITRPDG----TVLHALVAG---RGTPVILVHGYCASLTEWN-FVWDELL
Mb3196c|M.bovis_AF2122/97 TVRAADG----TPLHTQVFGPP-HGYPIVLTHGFVCAIRAWA-YQIADLA
Rv3171c|M.tuberculosis_H37Rv TVRAADG----TPLHTQVFGPP-HGYPIVLTHGFVCAIRAWA-YQIADLA
Mflv_3146|M.gilvum_PYR-GCK TITTQDG----VEIFYKDWG---SGQPIVFSHGWPLSADDWD-AQLMFFL
TH_3727|M.thermoresistible__bu TITTSDG----VEIFYRDWG---SGQPIVFSHGWPLTADDWD-PQMLFFL
Mvan_1567|M.vanbaalenii_PYR-1 IFTTTDG----TDIFYKDWG---SGQPIVFSHGWPLSSDDWD-TQMLFFL
MAV_5175|M.avium_104 DVIAHHGLLKDTRLHVDDTGG--PGRPVLLMHPWPLSGQSWS-AQVPVLH
MSMEG_4707|M.smegmatis_MC2_155 AITAYRGLLRSIELHVEDTGG--AGRPVVLVHGWPLTGESWG-AQVEALT
MLBr_02269|M.leprae_Br4923 ----------MINLAYEDRG---TGEPVVFIAGRGGAGRTWQPHQVPAFL
MAB_4337|M.abscessus_ATCC_1997 FFTAGDG----TRIGFSDTGNRKAPTTVLFLHGWTQNREAWDDVAGPLHE
: * .::: *
MMAR_2050|M.marinum_M AR-GLRVIAFDQRGHGRSTLGAEGIGSE-PMADDLAAVLQHFDIR--DGV
MUL_3299|M.ulcerans_Agy99 AR-GLRVIAFDQRGHGRSTLGAEGIGSE-PMADDLAAVLQHFDLR--DGV
Mb3196c|M.bovis_AF2122/97 G--DYRVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAV
Rv3171c|M.tuberculosis_H37Rv G--DYRVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAV
Mflv_3146|M.gilvum_PYR-GCK GH-GYRVVAHDRRGHGRSGQVDDG-HDMDHYADDLAAVVEHLDLH--DAV
TH_3727|M.thermoresistible__bu NA-GYRVIAHDRRGHGRSSPVPDG-HDMDHYADDLAALVEHLGLR--DAV
Mvan_1567|M.vanbaalenii_PYR-1 QR-GYRVIAHDRRGHGRSTQTPDG-HDLDHYADDLAELTAHLDLR--DAI
MAV_5175|M.avium_104 AA-GYRVVTYDRRGFGRSDKPLTG-YSYSQLTQDLHTLVESLDLR--DLT
MSMEG_4707|M.smegmatis_MC2_155 AA-GHRVITYDRRGFGRSDTSLVG-YTYEALSDDLAAVLDELDVR--DAT
MLBr_02269|M.leprae_Br4923 AA-GYRVITFDNRGIG-ATENTEG-FTTQTMVADTAVLIESLGAVP--AR
MAB_4337|M.abscessus_ATCC_1997 RDPELRIIALDHRGHGKSDAAPEGTVNVRQLATDAADFINAQIPAG-QIV
*::: *.** * : * * .
MMAR_2050|M.marinum_M LVGHSMGGFVSIRALLDHG--ALAQRLRAVVLFATWAGRVLD---GAPQN
MUL_3299|M.ulcerans_Agy99 LVGHSMGGFVSIRALLDHG--ALAQRLRAVVLFATWAGRVLD---GAPQN
Mb3196c|M.bovis_AF2122/97 VAGHSMGG-ITIAAWSDRYRHKVRRRTDAVALINTTTGDLVR---KVKLL
Rv3171c|M.tuberculosis_H37Rv VAGHSMGG-ITIAAWSDRYRHKVRRRTDAVALINTTTGDLVR---KVKLL
Mflv_3146|M.gilvum_PYR-GCK HVGHSTGGGEVVRYLARHG----EDRAVKAALISAVPPLMVQ---TDTNP
TH_3727|M.thermoresistible__bu HVGHSTGGGVVVRYLARHG----EERTAKAVLIAAVPPLMVR---TDANP
Mvan_1567|M.vanbaalenii_PYR-1 HVGHSTGGGEVVRYLGRHG----ESRVAKAALISAVPPLMVR---TEDNP
MAV_5175|M.avium_104 LVGSSMGGGEVARYLSTYG----PERVRSVVFASSVTPYLLQ---TTDNP
MSMEG_4707|M.smegmatis_MC2_155 LVGFSMGTGEVAAYCARKG----TERLRSVVLAAPVTPYMLN---TADNP
MLBr_02269|M.leprae_Br4923 IVGVSMGSFIAQELMVARP-----ELVRAAVLMATRG--------RLDRT
MAB_4337|M.abscessus_ATCC_1997 IVGHSMGGMTMMGLGEYHP-DLVAQRISGAVFVATSAGRLLHRLRVVPPV
.* * * ..: .
MMAR_2050|M.marinum_M RLQIPLLERGILQR--LLRSRTIAVLFGAAQCGARPSPAMISVF------
MUL_3299|M.ulcerans_Agy99 RLQIPLLERGILQR--LLRSRTIAVLFGAAQCGARPSPAMISG-------
Mb3196c|M.bovis_AF2122/97 SVPRELSPVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAADADPS
Rv3171c|M.tuberculosis_H37Rv SVPRELSPVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAADADPS
Mflv_3146|M.gilvum_PYR-GCK GG-LPKSVFDDFQHQVATNRAGFYRAVPEGPFYGFNREGVEPVE------
TH_3727|M.thermoresistible__bu GG-LPKSVFDDFQAQLAANRSEFYRALASGPFYGFNRDGVEPSE------
Mvan_1567|M.vanbaalenii_PYR-1 EG-TPKEVFDDLQAQLAANRSVFYRSLPAGPFYGFNRPGVEPQE------
MAV_5175|M.avium_104 DGPLTMKDAARATASFVKDQDAFYDHQMTEFFSANG--QLRVSP------
MSMEG_4707|M.smegmatis_MC2_155 EGPLSKTQAAQMAAALTTNSDAFYREMMTGVFSADG--VLTISE------
MLBr_02269|M.leprae_Br4923 RQFFHAAEAEFHDSGIQLPSGYNAKVRLLENLSRKTLNDDVAVA------
MAB_4337|M.abscessus_ATCC_1997 FQVVKAVILGVVAQGWFLQQGYLMRPIISTLVFGRDPRPYDVGR------
MMAR_2050|M.marinum_M -LEWFHQHLDRHGPHLPIVRA--FSREDRYPRLAEISVP--AVVMVGSSD
MUL_3299|M.ulcerans_Agy99 -IPRVVPSTSRPARTAPTHRAGVLARGSLSTAGRDLGAGGGDGGLLGSHH
Mb3196c|M.bovis_AF2122/97 ATRLVYELFTQMSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRD
Rv3171c|M.tuberculosis_H37Rv ATRLVYELFTQTSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRD
Mflv_3146|M.gilvum_PYR-GCK -GIIANWWRQGMQGGAKAHYDGIVAFSQTDFTEDLQKIRIPVLVMHGDDD
TH_3727|M.thermoresistible__bu -ALIANWWRQGMMGDAKAHYDGIVAFSQTDFTEDLTKITVPVLVMHGDDD
Mvan_1567|M.vanbaalenii_PYR-1 -AIIENWWRQGMMGDAYSHYDGIVAFSQTDFTEDLKKITVPVLVMHSEAD
MAV_5175|M.avium_104 -ATRAEALRLCKQAGKEASLACMAAWANTDFRPDLTRVSVPALIIHGEGD
MSMEG_4707|M.smegmatis_MC2_155 -DALQQVLDMCGQASKNAALACMAAFSNTDFREDLPRVTVPALVIHGDAD
MLBr_02269|M.leprae_Br4923 --DWIAMFNMWPIKSTPGLRCQTDVAPQNNRLPAYRSIAAPVLVIGFAED
MAB_4337|M.abscessus_ATCC_1997 ---VWDQIRSGTPRSYKDAAESMVLHEDLT-EGLSAYRGMPTAVLAGDRD
: .
MMAR_2050|M.marinum_M RTTPPSHSHRLAAGIPG---ARLVT--VPGAGHLLN--WEAVDELAEVVE
MUL_3299|M.ulcerans_Agy99 PAQPLAPAGRRNPGCPAGHRARRGTPAELGGGRRAGRSRRILCGAAVLMR
Mb3196c|M.bovis_AF2122/97 RLTPISQSRRIARTAPNVVGLVELPGGHCSMLERHQEVNSHLRALAESVT
Rv3171c|M.tuberculosis_H37Rv RLTPISQSRRIARTAPNVVGLVELPGGHCSMLERHQEVNSHLRALAESVT
Mflv_3146|M.gilvum_PYR-GCK QIVPYDDAGPLSAALLPNGILKTYNGFPHGMP--TTHADVINADLLEFIR
TH_3727|M.thermoresistible__bu QVVPYANSGPLTAELLRNAKLKTYQGFPHGMM--TTHAEVVNADILEFLR
Mvan_1567|M.vanbaalenii_PYR-1 QIVPYVASGPKSAALLKNGVLKTYKDFPHGMP--TTHADVVNADLLEFLK
MAV_5175|M.avium_104 ESVPLAGSARRTHRAIPGSRLCVIADGPHGCH--ISHAQEFNAALLDFLA
MSMEG_4707|M.smegmatis_MC2_155 ATTPLQNCGERTHAALPNSRLHVISGGPHGIP--VSHTEEFNRVLLDFLA
MLBr_02269|M.leprae_Br4923 VVTPPSLGREVADVLPNGRYLQIPDAGHLGFFE---RPEAVNAAALQFFA
MAB_4337|M.abscessus_ATCC_1997 FLTPAGDSRIIAAALQTNELRTYPGSGHMLPNERSSEVVNEIVTVLEALG
* .
MMAR_2050|M.marinum_M SFAAQR------
MUL_3299|M.ulcerans_Agy99 GHAAGVWR----
Mb3196c|M.bovis_AF2122/97 RHVRDRRISS--
Rv3171c|M.tuberculosis_H37Rv RHVRDRRISS--
Mflv_3146|M.gilvum_PYR-GCK S-----------
TH_3727|M.thermoresistible__bu S-----------
Mvan_1567|M.vanbaalenii_PYR-1 G-----------
MAV_5175|M.avium_104 A-----------
MSMEG_4707|M.smegmatis_MC2_155 EDLAAAR-----
MLBr_02269|M.leprae_Br4923 GVKGEWP-----
MAB_4337|M.abscessus_ATCC_1997 QPAAPVTRESAG