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MPTITTQDGVEIFYKDWGSGQPIVFSHGWPLSADDWDAQLMFFLGHGYRVVAHDRRGHGRSGQVDDGHDM DHYADDLAAVVEHLDLHDAVHVGHSTGGGEVVRYLARHGEDRAVKAALISAVPPLMVQTDTNPGGLPKSV FDDFQHQVATNRAGFYRAVPEGPFYGFNREGVEPVEGIIANWWRQGMQGGAKAHYDGIVAFSQTDFTEDL QKIRIPVLVMHGDDDQIVPYDDAGPLSAALLPNGILKTYNGFPHGMPTTHADVINADLLEFIRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3146 | - | - | 100% (274) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_2561 | - | 2e-43 | 40.31% (258) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_2937 | - | 6e-12 | 37.30% (126) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3203 | - | 5e-10 | 25.36% (276) | peroxidase |
| M. tuberculosis H37Rv | Rv3177 | - | 5e-10 | 25.36% (276) | peroxidase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-09 | 35.20% (125) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4551c | - | 4e-12 | 29.17% (264) | lysophospholipase |
| M. marinum M | MMAR_2050 | - | 2e-21 | 30.62% (258) | hypothetical protein MMAR_2050 |
| M. avium 104 | MAV_5175 | - | 3e-37 | 35.02% (257) | non-haem bromoperoxidase BPO-A2 |
| M. smegmatis MC2 155 | MSMEG_4707 | - | 2e-45 | 38.35% (266) | non-heme bromoperoxidase BPO-A2 |
| M. thermoresistible (build 8) | TH_3727 | - | 1e-134 | 79.56% (274) | PUTATIVE Chloride peroxidase |
| M. ulcerans Agy99 | MUL_3299 | - | 4e-18 | 43.40% (106) | hypothetical protein MUL_3299 |
| M. vanbaalenii PYR-1 | Mvan_1567 | - | 1e-127 | 75.46% (273) | chloride peroxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3146|M.gilvum_PYR-GCK ------MPTITTQDG-----------------------VEIFYKDWG---
TH_3727|M.thermoresistible__bu ------MATITTSDG-----------------------VEIFYRDWG---
Mvan_1567|M.vanbaalenii_PYR-1 ------MSIFTTTDG-----------------------TDIFYKDWG---
MAV_5175|M.avium_104 ------MPDVIAHHGLL-------------------KDTRLHVDDTGG--
MSMEG_4707|M.smegmatis_MC2_155 ------MAAITAYRGLL-------------------RSIELHVEDTGG--
MMAR_2050|M.marinum_M MRPTLAAAALAGASGLVGWGGARALARRIERNPDPFPRERLLAEPQGERV
MUL_3299|M.ulcerans_Agy99 MRPTLAAAALAGASGLVGWGGARALARRIERNPDPFPRERLLAEPQGERV
Mb3203|M.bovis_AF2122/97 -MPQRQAGDIGATYQDAPTKSIN------------VGGTRFVYRRLGAD-
Rv3177|M.tuberculosis_H37Rv -MPQRQAGDIGATYQDAPTKSIN------------VGGTRFVYRRLGAD-
MLBr_00862|M.leprae_Br4923 ------MPATQSIHKVPHQFVES------------PDGVRLAIYQSGQP-
MAB_4551c|M.abscessus_ATCC_199 -----MQRTFDGADD-----------------------VRIVYDTWTPAG
:
Mflv_3146|M.gilvum_PYR-GCK ----------------SGQPIVFSHGWPLSADDWDAQLMFFLGHGYRVVA
TH_3727|M.thermoresistible__bu ----------------SGQPIVFSHGWPLTADDWDPQMLFFLNAGYRVIA
Mvan_1567|M.vanbaalenii_PYR-1 ----------------SGQPIVFSHGWPLSSDDWDTQMLFFLQRGYRVIA
MAV_5175|M.avium_104 ----------------PGRPVLLMHPWPLSGQSWSAQVPVLHAAGYRVVT
MSMEG_4707|M.smegmatis_MC2_155 ----------------AGRPVVLVHGWPLTGESWGAQVEALTAAGHRVIT
MMAR_2050|M.marinum_M AITRPDGTVLHALVAGRGTPVILVHGYCASLTEWNFVWDELLARGLRVIA
MUL_3299|M.ulcerans_Agy99 AITRPDGTVLHALVAGRGTPVILVHGYCASLTEWNFVWDELLARGLRVIA
Mb3203|M.bovis_AF2122/97 ----------------AGVPVIFLHHLGAVLDNWDPRVVDGIAAKHPVVT
Rv3177|M.tuberculosis_H37Rv ----------------AGVPVIFLHHLGAVLDNWDPRVVDGIAAKHPVVT
MLBr_00862|M.leprae_Br4923 ----------------EGPAIVLVHGFPDSHVLWDG-VVPLLAKRFRIVR
MAB_4551c|M.abscessus_ATCC_199 ---------------TPRAVVVLSHGFGEHARRYDHVARRFNEAGYLVYA
::: * :. :
Mflv_3146|M.gilvum_PYR-GCK HDRRGHGRSGQVD--DGHDMDHYADDLAAVVEHLD----LHDAVHVGHST
TH_3727|M.thermoresistible__bu HDRRGHGRSSPVP--DGHDMDHYADDLAALVEHLG----LRDAVHVGHST
Mvan_1567|M.vanbaalenii_PYR-1 HDRRGHGRSTQTP--DGHDLDHYADDLAELTAHLD----LRDAIHVGHST
MAV_5175|M.avium_104 YDRRGFGRSDKPL--TGYSYSQLTQDLHTLVESLD----LRDLTLVGSSM
MSMEG_4707|M.smegmatis_MC2_155 YDRRGFGRSDTSL--VGYTYEALSDDLAAVLDELD----VRDATLVGFSM
MMAR_2050|M.marinum_M FDQRGHGRSTLGA--EGIGSEPMADDLAAVLQHFD----IRDGVLVGHSM
MUL_3299|M.ulcerans_Agy99 FDQRGHGRSTLGA--EGIGSEPMADDLAAVLQHFD----LRDGVLVGHSM
Mb3203|M.bovis_AF2122/97 FDNRGVG-ASEGQ--TPDTVTTMADDAIAFVRALG----FDQVDLLGFSL
Rv3177|M.tuberculosis_H37Rv FDNRGVG-ASEGQ--TPDTVTTMADDAIAFVRALG----FDQVDLLGFSL
MLBr_00862|M.leprae_Br4923 YDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP---DRPVHVLAHDW
MAB_4551c|M.abscessus_ATCC_199 LDHRGHGRSGGKR-VYLRDISEYTDDFGTLVDIAAREHPDLKRIVLGHSM
*.** * : ::* . :. .
Mflv_3146|M.gilvum_PYR-GCK GGGEVVRYLARHG-------------------------------------
TH_3727|M.thermoresistible__bu GGGVVVRYLARHG-------------------------------------
Mvan_1567|M.vanbaalenii_PYR-1 GGGEVVRYLGRHG-------------------------------------
MAV_5175|M.avium_104 GGGEVARYLSTYG-------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 GTGEVAAYCARKG-------------------------------------
MMAR_2050|M.marinum_M GGFVSIRALLDHGA------------------------------------
MUL_3299|M.ulcerans_Agy99 GGFVSIRALLDHGA------------------------------------
Mb3203|M.bovis_AF2122/97 GG-FVAQVIAQQE-------------------------------------
Rv3177|M.tuberculosis_H37Rv GG-FVAQVIAQQE-------------------------------------
MLBr_00862|M.leprae_Br4923 GSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFA
MAB_4551c|M.abscessus_ATCC_199 GGGIVFAYGVDHQD------------------------------------
*
Mflv_3146|M.gilvum_PYR-GCK -----------------EDRAVKAALISAVPPLMVQTDTNPGG-LPKSVF
TH_3727|M.thermoresistible__bu -----------------EERTAKAVLIAAVPPLMVRTDANPGG-LPKSVF
Mvan_1567|M.vanbaalenii_PYR-1 -----------------ESRVAKAALISAVPPLMVRTEDNPEG-TPKEVF
MAV_5175|M.avium_104 -----------------PERVRSVVFASSVTPYLLQTTDNPDGPLTMKDA
MSMEG_4707|M.smegmatis_MC2_155 -----------------TERLRSVVLAAPVTPYMLNTADNPEGPLSKTQA
MMAR_2050|M.marinum_M ----------------LAQRLRAVVLFATWAGRVLDGAPQNRLQIPLLER
MUL_3299|M.ulcerans_Agy99 ----------------LAQRLRAVVLFATWAGRVLDGAPQNRLQIPLLER
Mb3203|M.bovis_AF2122/97 -----------------PQLVRKIILAGTGPAGGVGIGKVTFGTIRESIK
Rv3177|M.tuberculosis_H37Rv -----------------PQLVRKIILAGTGPAGGVGIGKVTFGTIRESIK
MLBr_00862|M.leprae_Br4923 RAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHS
MAB_4551c|M.abscessus_ATCC_199 ---------------------RYDLMVLSGPAIAAQVGLPYVLTLVAPVV
.
Mflv_3146|M.gilvum_PYR-GCK DDFQHQVATNRAGFYRAVPEGPFYGFNREGVEPVEGIIANWWRQGMQGGA
TH_3727|M.thermoresistible__bu DDFQAQLAANRSEFYRALASGPFYGFNRDGVEPSEALIANWWRQGMMGDA
Mvan_1567|M.vanbaalenii_PYR-1 DDLQAQLAANRSVFYRSLPAGPFYGFNRPGVEPQEAIIENWWRQGMMGDA
MAV_5175|M.avium_104 ARATASFVKDQDAFYDHQMTEFFSANG--QLRVSPATRAEALRLCKQAGK
MSMEG_4707|M.smegmatis_MC2_155 AQMAAALTTNSDAFYREMMTGVFSADG--VLTISEDALQQVLDMCGQASK
MMAR_2050|M.marinum_M GILQRLLRSRT----IAVLFGAAQCGARPSPAMISVFLEWFHQHLDRHGP
MUL_3299|M.ulcerans_Agy99 GILQRLLRSRT----IAVLFGAAQCGARPSPAMISG-IPRVVPSTSRPAR
Mb3203|M.bovis_AF2122/97 ATLTFRDPKELRFFTRTDSG---KSAARQFVKRLKERKDNRDKSITVRAF
Rv3177|M.tuberculosis_H37Rv ATLTFRDPKELRFFTRTDSG---KSAARQFVKRLKERKDNRDKSITVRAF
MLBr_00862|M.leprae_Br4923 ATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVR
MAB_4551c|M.abscessus_ATCC_199 GRLAPGLPVQK------------LDVNAISHDPAIIAAYHADPLVHHGRV
Mflv_3146|M.gilvum_PYR-GCK KAHYDGIVAFSQTDFTEDLQKIRIP----VLVMHGDDDQIVPYDDAGPLS
TH_3727|M.thermoresistible__bu KAHYDGIVAFSQTDFTEDLTKITVP----VLVMHGDDDQVVPYANSGPLT
Mvan_1567|M.vanbaalenii_PYR-1 YSHYDGIVAFSQTDFTEDLKKITVP----VLVMHSEADQIVPYVASGPKS
MAV_5175|M.avium_104 EASLACMAAWANTDFRPDLTRVSVP----ALIIHGEGDESVPLAGSARRT
MSMEG_4707|M.smegmatis_MC2_155 NAALACMAAFSNTDFREDLPRVTVP----ALVIHGDADATTPLQNCGERT
MMAR_2050|M.marinum_M HLPIVRA--FSREDRYPRLAEISVP----AVVMVGSSDRTTPPSHSHRLA
MUL_3299|M.ulcerans_Agy99 TAPTHRAGVLARGSLSTAGRDLGAGGG--DGGLLGSHHPAQPLAPAGRRN
Mb3203|M.bovis_AF2122/97 RSQLKAIHAWGTQK-PSDLTSIGHP----VLIANGDDDTMVPTSNSLDLA
Rv3177|M.tuberculosis_H37Rv RSQLKAIHAWGTQK-PSDLTSIGHP----VLIANGDDDTMVPTSNSLDLA
MLBr_00862|M.leprae_Br4923 PYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPS
MAB_4551c|M.abscessus_ATCC_199 PAGIGRALLGVGKTMRQRAAGLKRP----VLTMHGSDDRLTAPEGSRWLS
. .
Mflv_3146|M.gilvum_PYR-GCK AALLPN----------GILKTYNGFPHGMPTTHADVINADLLEFIRS---
TH_3727|M.thermoresistible__bu AELLRN----------AKLKTYQGFPHGMMTTHAEVVNADILEFLRS---
Mvan_1567|M.vanbaalenii_PYR-1 AALLKN----------GVLKTYKDFPHGMPTTHADVVNADLLEFLKG---
MAV_5175|M.avium_104 HRAIPG----------SRLCVIADGPHGCHISHAQEFNAALLDFLAA---
MSMEG_4707|M.smegmatis_MC2_155 HAALPN----------SRLHVISGGPHGIPVSHTEEFNRVLLDFLAEDLA
MMAR_2050|M.marinum_M AGIPG-----------ARLVT--VPGAGHLLN--WEAVDELAEVVESFAA
MUL_3299|M.ulcerans_Agy99 PGCPAGHR--------ARRGTPAELGGGRRAGRSRRILCGAAVLMRGHAA
Mb3203|M.bovis_AF2122/97 DRLPDA-----------TLRIYPDAGHGGIFQHHAQFVDDALQFLES---
Rv3177|M.tuberculosis_H37Rv DRLPDA-----------TLRIYPDAGHGGIFQHHAQFVDDALQFLES---
MLBr_00862|M.leprae_Br4923 RALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALARRGAEVVVSDID
MAB_4551c|M.abscessus_ATCC_199 ESAPDA-----------TLKIWNGLYHEIFNEFEKELVLDEVVGWIDARL
Mflv_3146|M.gilvum_PYR-GCK --------------------------------------------------
TH_3727|M.thermoresistible__bu --------------------------------------------------
Mvan_1567|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 AAR-----------------------------------------------
MMAR_2050|M.marinum_M QR------------------------------------------------
MUL_3299|M.ulcerans_Agy99 GVWR----------------------------------------------
Mb3203|M.bovis_AF2122/97 --------------------------------------------------
Rv3177|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 EAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVN
MAB_4551c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3146|M.gilvum_PYR-GCK --------------------------------------------------
TH_3727|M.thermoresistible__bu --------------------------------------------------
Mvan_1567|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_3299|M.ulcerans_Agy99 --------------------------------------------------
Mb3203|M.bovis_AF2122/97 --------------------------------------------------
Rv3177|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 NAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIV
MAB_4551c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3146|M.gilvum_PYR-GCK --------------------------------------------------
TH_3727|M.thermoresistible__bu --------------------------------------------------
Mvan_1567|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_3299|M.ulcerans_Agy99 --------------------------------------------------
Mb3203|M.bovis_AF2122/97 --------------------------------------------------
Rv3177|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 NVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVI
MAB_4551c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3146|M.gilvum_PYR-GCK --------------------------------------------------
TH_3727|M.thermoresistible__bu --------------------------------------------------
Mvan_1567|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
MSMEG_4707|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_3299|M.ulcerans_Agy99 --------------------------------------------------
Mb3203|M.bovis_AF2122/97 --------------------------------------------------
Rv3177|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIK
MAB_4551c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3146|M.gilvum_PYR-GCK -----------------------------------
TH_3727|M.thermoresistible__bu -----------------------------------
Mvan_1567|M.vanbaalenii_PYR-1 -----------------------------------
MAV_5175|M.avium_104 -----------------------------------
MSMEG_4707|M.smegmatis_MC2_155 -----------------------------------
MMAR_2050|M.marinum_M -----------------------------------
MUL_3299|M.ulcerans_Agy99 -----------------------------------
Mb3203|M.bovis_AF2122/97 -----------------------------------
Rv3177|M.tuberculosis_H37Rv -----------------------------------
MLBr_00862|M.leprae_Br4923 KNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI
MAB_4551c|M.abscessus_ATCC_199 -----------------------------------