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VTRNTATETAWRQHEGFFTAGDGTRIGFSDTGNRKAPTTVLFLHGWTQNREAWDDVAGPLHERDPELRII ALDHRGHGKSDAAPEGTVNVRQLATDAADFINAQIPAGQIVIVGHSMGGMTMMGLGEYHPDLVAQRISGA VFVATSAGRLLHRLRVVPPVFQVVKAVILGVVAQGWFLQQGYLMRPIISTLVFGRDPRPYDVGRVWDQIR SGTPRSYKDAAESMVLHEDLTEGLSAYRGMPTAVLAGDRDFLTPAGDSRIIAAALQTNELRTYPGSGHML PNERSSEVVNEIVTVLEALGQPAAPVTRESAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4337 | - | - | 100% (312) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_3738c | - | 6e-23 | 28.17% (284) | putative hydrolase alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_2045 | - | 3e-10 | 37.65% (85) | putative hydrolase (alpha/beta fold) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3196c | hpx | 3e-18 | 30.11% (279) | non-Heme haloperoxidase Hpx |
| M. gilvum PYR-GCK | Mflv_4933 | - | 1e-26 | 28.62% (297) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3171c | hpx | 2e-18 | 30.11% (279) | non-Heme haloperoxidase Hpx |
| M. leprae Br4923 | MLBr_00376 | - | 5e-11 | 24.30% (284) | hypothetical protein MLBr_00376 |
| M. marinum M | MMAR_1120 | - | 2e-21 | 27.15% (291) | hydrolase |
| M. avium 104 | MAV_4371 | - | 1e-23 | 28.31% (272) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1576 | - | 2e-27 | 29.83% (295) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_1693 | - | 4e-27 | 30.36% (303) | alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_0880 | - | 2e-21 | 28.68% (272) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_1485 | - | 5e-25 | 29.25% (294) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1120|M.marinum_M --------------------------------------MSAEETRRRQ--
MUL_0880|M.ulcerans_Agy99 --------------------------------------MSAEETRRRQ--
MAV_4371|M.avium_104 --------------------------------------------------
MLBr_00376|M.leprae_Br4923 --------------------------------------MTDDEIRRRRNG
Mflv_4933|M.gilvum_PYR-GCK ----------------------------------------------MSRG
Mvan_1485|M.vanbaalenii_PYR-1 ----------------------------------------------MNGR
MSMEG_1576|M.smegmatis_MC2_155 --------------------------------------------------
TH_1693|M.thermoresistible__bu VTGSSGEAAPRPRRRRSWDEQIVRRATRSATRVADASDAEDTSKPRVVKY
Mb3196c|M.bovis_AF2122/97 --------------------------------------------------
Rv3171c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4337|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1120|M.marinum_M RAWLAGGAGLTAVATIVGASARRSLAERGSVCDDPYAGEDFERLDSDRAR
MUL_0880|M.ulcerans_Agy99 RAWLAGGAGLTAVATIVGASARRSLAERGSVCDDPYAGEDFERLDSDRAR
MAV_4371|M.avium_104 ---------MTAVATIVGASARRSMTQR-ATIEDPYADEDFNTFDGDRAL
MLBr_00376|M.leprae_Br4923 RPWLAGGTGLVPVATIVGALSLRSIFERDNACRDPYVDRDFEKLGDERRC
Mflv_4933|M.gilvum_PYR-GCK AGWLAGAAGVAAVGSAAGVSMARSLRRR-VTDEDPHRDEDFELLDADRSC
Mvan_1485|M.vanbaalenii_PYR-1 AGWLAGAAGVAAVGSAAGMSVARSLRRR-VTDDDPHRDEDFELLDADRGC
MSMEG_1576|M.smegmatis_MC2_155 ------MAGLAAVGTVAGVSIARSLTLR-VSKEDPYAGEDFELLDADRSS
TH_1693|M.thermoresistible__bu PKLTAGVAGLTAVGTVAGVSAARSLRRR-R-RIDPYEGEDFALLEADRAV
Mb3196c|M.bovis_AF2122/97 -------------------------------------------------M
Rv3171c|M.tuberculosis_H37Rv -------------------------------------------------M
MAB_4337|M.abscessus_ATCC_1997 ----------------------------------MTRNTATETAWRQHEG
MMAR_1120|M.marinum_M VVTTPDGVPLAVREAGPVDAPLTMVFAHGFCLRMGAFHFQRMRLGEQWGS
MUL_0880|M.ulcerans_Agy99 VVTTPDGVPLAVREAGPVDAPLTMVFAHGFCLRMGAFHFERMRLGEQWGS
MAV_4371|M.avium_104 VVTTPDGVPLAVREAGPPDAPLTMVFVHGFCLQMGAFHFQRTRLPEQLGP
MLBr_00376|M.leprae_Br4923 WVTISGGMALVVREEGAVKAPVAMVFAYGFYLRMDSFHFQRKRFGKRWGP
Mflv_4933|M.gilvum_PYR-GCK VVTTSDGVPLAVREVGPEDAPLTVVFAHGFCLRMGSFHFQRVRLTEHWGA
Mvan_1485|M.vanbaalenii_PYR-1 VVSTPDGVPLTVREVGPVDAPLTVVFAHGFSLRMGSFYFQRARLTEQWGD
MSMEG_1576|M.smegmatis_MC2_155 VITTDDGVPLAVREVGPKDAKLTVVFAHGFCLRMSAFHFQRARLAEQWGD
TH_1693|M.thermoresistible__bu VVTTPDGVPLVVREVGPITAPVTVVFAHGWCLRMGAFHFQRARLEQEWGD
Mb3196c|M.bovis_AF2122/97 TVRAADGTPLHTQVFGPPHG-YPIVLTHGFVCAIRAWAYQIADLAGDY--
Rv3171c|M.tuberculosis_H37Rv TVRAADGTPLHTQVFGPPHG-YPIVLTHGFVCAIRAWAYQIADLAGDY--
MAB_4337|M.abscessus_ATCC_1997 FFTAGDGTRIGFSDTGNRKAPTTVLFLHGWTQNREAWDDVAGPLHERD-P
. .* : * . .::: :*: :: :
MMAR_1120|M.marinum_M RVRMVFYDQRGHGQSGEADPQTYTLTQLGQDLETVLQA-TAPRGPIVLVG
MUL_0880|M.ulcerans_Agy99 RVRMVFYDQRGHGQSGEADPQTYTLTQLGQDLETVLQA-TAPRGPIVLVG
MAV_4371|M.avium_104 DVRMVFYDQRGHGRSGEAAPESYTLTQLGRDLQTVLQV-VAPRGLVVLVG
MLBr_00376|M.leprae_Br4923 QVRMVFYDHCGHVQSSEVALDTYTLTQLGQDLRTVLQT-VTPHGMIVLVG
Mflv_4933|M.gilvum_PYR-GCK QVRMVFFDQRGHGQSGDAPPETYTVEQLGRDLEAVLAV-MAPKGPVVLVG
Mvan_1485|M.vanbaalenii_PYR-1 QVRMVFYDQRGHGQSGDAPPETYTVEQLGQDLESVLAV-MAPRGPIVLVG
MSMEG_1576|M.smegmatis_MC2_155 QVRMVFYDQRGHGRSGEAPPDTYTVEQLGRDLESVLAV-TAPRGPVVLVG
TH_1693|M.thermoresistible__bu QVRMVFYDQRGHGQSGEAHTETYTVPQLGQDLETVLRV-VVPRGPIVLVG
Mb3196c|M.bovis_AF2122/97 --RVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAG
Rv3171c|M.tuberculosis_H37Rv --RVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAG
MAB_4337|M.abscessus_ATCC_1997 ELRIIALDHRGHGKSDAAPEGTVNVRQLATDAADFINA-QIPAGQIVIVG
*:: *: ** :*. : .: :*. * .: . * *:.*
MMAR_1120|M.marinum_M HSMGGMTVLSHARQFPQRYGRRIVGAAVISSAAEGVTRSPLGEFLKNPAL
MUL_0880|M.ulcerans_Agy99 HSMGGMTVLSHARQFPQRYGRRIVGAAVISSAAEGVTRSPLGEFLKNPAL
MAV_4371|M.avium_104 HSMGGMTVLSHARQFPEQYGRRIVGAALISSAAEGVSRSPLGEILKNPAL
MLBr_00376|M.leprae_Br4923 HSMEG--------------------------------------ILKSPAL
Mflv_4933|M.gilvum_PYR-GCK HSMGGMAVLSHARQYPQRYPTRVVGAALISSAAEGVARSPVGEILKNPAL
Mvan_1485|M.vanbaalenii_PYR-1 HSMGGMTVLSHARQYPQRYPTRIVGAALISSAAEGVARSPVGEILKNPAL
MSMEG_1576|M.smegmatis_MC2_155 HSMGGMTVLSHARQFPQRYPARIVGAALISSAAEGVDRSPLGEILRNPAL
TH_1693|M.thermoresistible__bu HSMGGMTVLSHARQFPRRYGRRIVGAAVISSAAEGLPRSPLGEILQNPAL
Mb3196c|M.bovis_AF2122/97 HSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELS
Rv3171c|M.tuberculosis_H37Rv HSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELS
MAB_4337|M.abscessus_ATCC_1997 HSMGGMTMMGLGEYHPDLVAQRISGAVFVATSAGRLLHRLRVVPPVFQVV
*** *
MMAR_1120|M.marinum_M EAVRFTARSAPKLMHRG--RTASRSLIGPILRAASYSDLEVSRSLDAFSQ
MUL_0880|M.ulcerans_Agy99 EAVRFTARSAPKLMHRG--RTASRSLIGPILRAASYSDLEVSRSLDAFSQ
MAV_4371|M.avium_104 EAVRVAARSAPKLMHRG--RNVSRSLIGPVLRAASFSDLQVSRSLDAFSQ
MLBr_00376|M.leprae_Br4923 EAVRLTSRSASKLMHRG--SIASQSLIGPILRAASYSDLRVSRGLDAFSQ
Mflv_4933|M.gilvum_PYR-GCK EAVRFTARYAPKLVHRG--RGAARSVIGPILRAASYGDEKISPSVVAFSE
Mvan_1485|M.vanbaalenii_PYR-1 EAVRFSARYAPKLVHRS--RGAARSVIGPILRAASYGDEKVSPSVVAFSE
MSMEG_1576|M.smegmatis_MC2_155 EAVRFSARYAPKLVHRT--RGAARSLIAPILQAGSFGDEQVSPSVAAFAA
TH_1693|M.thermoresistible__bu EAFRFAARYAPGLVHRT--RGAAWTVLRPILRAASFGSDRVSPSVMAFSE
Mb3196c|M.bovis_AF2122/97 PVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAAD-ADPSATRLVY
Rv3171c|M.tuberculosis_H37Rv PVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAAD-ADPSATRLVY
MAB_4337|M.abscessus_ATCC_1997 KAVILGVVAQGWFLQQG-------YLMRPIISTLVFGRDPRPYDVGRVWD
. . . : :: : . . .
MMAR_1120|M.marinum_M QMMNDTPIATLVGFLHALEVHDETAGLWTL-LRIPTLIACGDHDLMTPDE
MUL_0880|M.ulcerans_Agy99 QMMNDTPIATLGGFLHALEVHDETAGLWTL-LRIPTLIACGDHDLMTPDE
MAV_4371|M.avium_104 RMMNSTPIPTMVGFLDALEHHDETAGLWTL-LRVPTLIACGDHDLLTPDE
MLBr_00376|M.leprae_Br4923 RIMNDTLIAILVSFLHALELHEETAGLWPL-LRVPALIACGDHDLLTSDE
Mflv_4933|M.gilvum_PYR-GCK RMMHDTPIATLVEFLHALEVHDETAGLETL-RRVPTLVACGDRDLLTPKE
Mvan_1485|M.vanbaalenii_PYR-1 RMMHDTSVATLVEFLHALEVHDETAGLKTL-NKVETLVACGDRDLLTPVE
MSMEG_1576|M.smegmatis_MC2_155 DMMHGTPIPTLVEFLHALEVHDETAALDVL-AGVPTLIACGDRDLLTPVE
TH_1693|M.thermoresistible__bu SMIQNTPIATLVEFMHALEVHDETAALPVL-ARIPTLIACGSDDVLTPAV
Mb3196c|M.bovis_AF2122/97 ELFTQMSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRDRLTPIS
Rv3171c|M.tuberculosis_H37Rv ELFTQTSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRDRLTPIS
MAB_4337|M.abscessus_ATCC_1997 QIRSGTPRSYKDAAESMVLHEDLTEGLSAY-RGMPTAVLAGDRDFLTPAG
: . : . : * : : : * * :*.
MMAR_1120|M.marinum_M YSRKMAASLPQSELVIVGGASHLALLDKPDAINEGLVRLVDRALPGKLTL
MUL_0880|M.ulcerans_Agy99 YSRKMAASLPQSELVIVGGASHLALLDEPDAINGGLVRLVDRALPGKLTL
MAV_4371|M.avium_104 YSRKMAASLPQSELVIVAGASHLALLDKPEAINGGLVRLVRRATPSRAAL
MLBr_00376|M.leprae_Br4923 RSRGMAAVLPLLALVIVSGASRLALLDKPGAINDGLVRLVNRAVPGKAAL
Mflv_4933|M.gilvum_PYR-GCK YSQEMADVLAKSELVIVPGAGHLVQLECPEVINDALVRLVERATPSKLTA
Mvan_1485|M.vanbaalenii_PYR-1 YSREMADALAKSELVIAGGAGHLVQLERPEVINDALVRLVERATPSKLVA
MSMEG_1576|M.smegmatis_MC2_155 YSREMAERLPKSELVVVGGAGHLVQLEEPEVINDALIRLVERATPSKLVA
TH_1693|M.thermoresistible__bu HSKRMAAALPDSELLIVEGAGHLVQLEAPEVINDALVRLVQRATPSTLVA
Mb3196c|M.bovis_AF2122/97 QSRRIARTAPNVVGLVELPGGHCSMLERHQEVNSHLRALAESVTR---HV
Rv3171c|M.tuberculosis_H37Rv QSRRIARTAPNVVGLVELPGGHCSMLERHQEVNSHLRALAESVTR---HV
MAB_4337|M.abscessus_ATCC_1997 DSRIIAAALQTNELRTYPGSGHMLPNERSSEVVNEIVTVLEALGQPAAPV
*: :* ..: : : : :
MMAR_1120|M.marinum_M RYRRVGERLRDRWRRHG
MUL_0880|M.ulcerans_Agy99 RYRRVGERLRDRWRRHG
MAV_4371|M.avium_104 ALRRIGERL---WRRG-
MLBr_00376|M.leprae_Br4923 RYRRFKERL----QRHG
Mflv_4933|M.gilvum_PYR-GCK LTRRVTQRV----RSDD
Mvan_1485|M.vanbaalenii_PYR-1 LTRRVKERV----RSHG
MSMEG_1576|M.smegmatis_MC2_155 LARRVRNRV----RPHG
TH_1693|M.thermoresistible__bu LTRRIRDKV----RPHD
Mb3196c|M.bovis_AF2122/97 RDRRISS----------
Rv3171c|M.tuberculosis_H37Rv RDRRISS----------
MAB_4337|M.abscessus_ATCC_1997 TRESAG-----------
.