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TVRAADGTPLHTQVFGPPHGYPIVLTHGFVCAIRAWAYQIADLAGDYRVIAFDHRGHGRSGVPRRGAYSL NHLAADLDSVLDATLAPRERAVVAGHSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSV PRELSPVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAADADPSATRLVYELFTQTSAAGRGGCAK MLVEEVGSAHLNLDGLTVPTLVIGGVRDRLTPISQSRRIARTAPNVVGLVELPGGHCSMLERHQEVNSHL RALAESVTRHVRDRRISS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3171c | hpx | - | 100% (299) | POSSIBLE NON-HEME HALOPEROXIDASE HPX |
| M. tuberculosis H37Rv | Rv1938 | ephB | 7e-12 | 40.71% (113) | epoxide hydrolase EphB |
| M. tuberculosis H37Rv | Rv2214c | ephD | 4e-11 | 29.47% (190) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3196c | hpx | 1e-170 | 99.67% (299) | non-Heme haloperoxidase Hpx |
| M. gilvum PYR-GCK | Mflv_4502 | - | 1e-95 | 58.56% (292) | alpha/beta hydrolase fold |
| M. leprae Br4923 | MLBr_00862 | ephD | 4e-10 | 33.03% (109) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3738c | - | 1e-21 | 29.41% (306) | putative hydrolase alpha/beta fold |
| M. marinum M | MMAR_1388 | hpx | 1e-131 | 76.25% (299) | non-heme haloperoxidase Hpx |
| M. avium 104 | MAV_4061 | - | 1e-121 | 72.24% (299) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_2036 | - | 1e-93 | 59.23% (287) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_0684 | hpx | 1e-91 | 59.79% (286) | POSSIBLE NON-HEME HALOPEROXIDASE HPX |
| M. ulcerans Agy99 | MUL_2488 | hpx | 1e-131 | 76.25% (299) | non-heme haloperoxidase Hpx |
| M. vanbaalenii PYR-1 | Mvan_1865 | - | 1e-98 | 60.76% (288) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3171c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3196c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1388|M.marinum_M ------------------------MSARKATDGKAHTKAPAALPDVLPPS
MUL_2488|M.ulcerans_Agy99 ------------------------MSARKATDGKAHTKASAALPDVLPPS
MAV_4061|M.avium_104 ------------------------MRAR-----------TDPFPDRLPPS
Mflv_4502|M.gilvum_PYR-GCK ---------------------------MARSSSTRSRRAGSGPAVELPRG
Mvan_1865|M.vanbaalenii_PYR-1 ---------------------------MAPGTSTRSRSRGFAPAQALPPG
TH_0684|M.thermoresistible__bu -------------------------------------------VEQMPPG
MSMEG_2036|M.smegmatis_MC2_155 -----------------------------------------MTLPQLPPG
MAB_3738c|M.abscessus_ATCC_199 MSNKSNAWLAGVAGLGAVVAVAGVGTARSIGRRRFDDPYRGENFDLLQTD
MLBr_00862|M.leprae_Br4923 ----------------------------------------MPATQSIHKV
Rv3171c|M.tuberculosis_H37Rv --MTVRAADGTPLHTQVFGPPHG-YPIVLTHGFVCAIRAWAYQIADLAG-
Mb3196c|M.bovis_AF2122/97 --MTVRAADGTPLHTQVFGPPHG-YPIVLTHGFVCAIRAWAYQIADLAG-
MMAR_1388|M.marinum_M RSLTVRAADGTALHTQVFGPADG-YPIVLTHGFVCSIRAWAYQIADLAT-
MUL_2488|M.ulcerans_Agy99 RSLTVRAADGTALHTQVFGPADG-YPIVLTHGFVCSIRAWAYQIADLAT-
MAV_4061|M.avium_104 RTVTVRAVDGTRLHAQVFGPPDG-YPIVLTHGITCAIRAWAYQIDDLAR-
Mflv_4502|M.gilvum_PYR-GCK RVVDVRSRDGVRLHAEVFGPEDG-YPIVLAHGITCAIPVWAHQIADLSR-
Mvan_1865|M.vanbaalenii_PYR-1 RIVDVRSKDGVRLHAEVFGPEDG-YPIVLAHGITCSLRVWAYQIAELAR-
TH_0684|M.thermoresistible__bu RVVSVTAPDGVRLHAEVFGPADA-PPIVLAHGITCAIRVWAHQIAELAD-
MSMEG_2036|M.smegmatis_MC2_155 RTFEVRAVDGVRLHAQTFGPEDG-YPIVFAHGITCAIEVWAHQIADLAG-
MAB_3738c|M.abscessus_ATCC_199 RGSIVTTDDGVPLAVREVGPSNAPLTVVFVHGFCLQMASFHFQRRELASR
MLBr_00862|M.leprae_Br4923 PHQFVESPDGVRLAIYQSGQPEG-PAIVLVHGFPDSHVLWDGVVPLLAK-
* : **. * * .. .:*:.**: : *:
Rv3171c|M.tuberculosis_H37Rv ---DYRVIAFDHRGHGRSGVP-RRGAYSLNHLAADLDSVLDATLAPRERA
Mb3196c|M.bovis_AF2122/97 ---DYRVIAFDHRGHGRSGVP-RRGAYSLNHLAADLDSVLDATLAPRERA
MMAR_1388|M.marinum_M ---DYRVIAFDHRGHGRSGIP-RRGGYTLEHLASDLDSVLDATLAPHERA
MUL_2488|M.ulcerans_Agy99 ---DYRVIAFDHRGHGRSGIP-RRGGYTLEHLASDLDSVLDATLAPHERA
MAV_4061|M.avium_104 ---DYRVIAYDHRGHGRSGVP-KATGYSLKHLAADLDSVLEATLAPHERA
Mflv_4502|M.gilvum_PYR-GCK ---DHRVIAYDHRGHGRSGVPPRRGGYSLDYLASDLDAVLEATMAPGERA
Mvan_1865|M.vanbaalenii_PYR-1 ---DHRVIAFDHRGHGRSAIPPRRGGYSLDYLAGDLDAVLEATLAPGERA
TH_0684|M.thermoresistible__bu ---DYRVIAFDHRGHGRSSVPRRRWQYSLDHLASDLDAVLDATLDPGERA
MSMEG_2036|M.smegmatis_MC2_155 ---DYRVIAYDHRGHGRSETPRGRNRYSLNHLAADLDAVLDATLRPGERA
MAB_3738c|M.abscessus_ATCC_199 WGDNVRMVFYDQRGHGRSGLP-APASCTVGQLGDDLESVLR-VLVPRGNA
MLBr_00862|M.leprae_Br4923 ---RFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVID-ELSPDRPV
*:: :*:** *:* * :: :. *: :*: : * .
Rv3171c|M.tuberculosis_H37Rv VVAGHSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVP
Mb3196c|M.bovis_AF2122/97 VVAGHSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVP
MMAR_1388|M.marinum_M LIAGHSMGGIAISAWSERYRHKVHRRADAVALINTATGDLLRKIRMLSVP
MUL_2488|M.ulcerans_Agy99 LIAGHSMGGIAISAWSERYRHKVHRRADAVALINTATGDLLRKIRMLSVP
MAV_4061|M.avium_104 VLAGHSMGGITIAAWSNRYRHKVSRRADAVALINTTSGELIRQVQLLSVP
Mflv_4502|M.gilvum_PYR-GCK VIAGHSMGGIAISSWSERLPHRVAERADGVALINTTTGDLLRNVNLLPVP
Mvan_1865|M.vanbaalenii_PYR-1 VIAGHSMGGIAISSWSERLPHRVEQRADAVALINTTTGDLLRNVNLLPVP
TH_0684|M.thermoresistible__bu VIAGHSMGGIAISSWAERYPERVSERAAAVALINTTTGDLLHNVQLLPVP
MSMEG_2036|M.smegmatis_MC2_155 VIAGHSMGGIAITSWAQRYPSRVQTCADGVALINTSTGDLLRDVQLAQVP
MAB_3738c|M.abscessus_ATCC_199 VLVGHSMGGMTVLAHARRHPEQYGRRIVGVGLIASAAEGLS-HTAIGEGL
MLBr_00862|M.leprae_Br4923 HVLAHDWG--SVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSGLR
: .*. * :: .. : .: . :
Rv3171c|M.tuberculosis_H37Rv RELSPVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAADADPSATR
Mb3196c|M.bovis_AF2122/97 RELSPVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAADADPSATR
MMAR_1388|M.marinum_M RELSAARDFAGRGLINAFGGFPLPSAVRIPTQYLIAMMAVGADAHPTAAR
MUL_2488|M.ulcerans_Agy99 RELSAARDFAGRGLINAFGGFPLPSAVRIPTQYLIAMMAVGADAHPTAAR
MAV_4061|M.avium_104 PGLSPARVLAGRVLIGAFAGFAVPRAARVPSRHLVALLATGRDADPAIAR
Mflv_4502|M.gilvum_PYR-GCK ARFADARVRAAGGVIRTFGGTSMVRVADLPSRRFVSMIAVGRDADPAIAD
Mvan_1865|M.vanbaalenii_PYR-1 PALADVRVRAAGEVLRRFGGVPLVRAVDRPNRRFVSSIAVGRDADPAIAD
TH_0684|M.thermoresistible__bu DRFAAVRVRTASAVIKTVAGMP-ARLAAVPSRYVVSMMAVGRDADPAITN
MSMEG_2036|M.smegmatis_MC2_155 TRLSTTRIRTAGTILKTFGSTPVPKLADAANRRFVAHLAVGRDADPWVAD
MAB_3738c|M.abscessus_ATCC_199 RNPALRVLRTAVHYAPGPAHHGRGAIKSLVGPVLQAASYGGHRVSPTLVK
MLBr_00862|M.leprae_Br4923 RPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMVDN
. . . .
Rv3171c|M.tuberculosis_H37Rv LVYELFTQTSAAGR----------GGCAKMLVEEVGSAHLNLDGLTVPTL
Mb3196c|M.bovis_AF2122/97 LVYELFTQMSAAGR----------GGCAKMLVEEVGSAHLNLDGLTVPTL
MMAR_1388|M.marinum_M LLYELFAQTSAAGR----------GGCARMLVGEVGSRHISLDGLTVPTL
MUL_2488|M.ulcerans_Agy99 LLYELFAQTSAAGR----------GGCARMLVGEVGSRHISLDGLTVPTL
MAV_4061|M.avium_104 LVYELFENTAPAGR----------AGCARALVSALGSRYLDLAGLTVPTL
Mflv_4502|M.gilvum_PYR-GCK FVFELFHRTPPAGR----------GGWARVLVDHLGPRHIGLDNLTVPAL
Mvan_1865|M.vanbaalenii_PYR-1 FVFELFNSTSPAGR----------GGWARVLVDHLGPRHIALKNLTVPTL
TH_0684|M.thermoresistible__bu FVHELFTETPPAAR----------DGWARTLVDAMGPRHIGLHNLTVPTL
MSMEG_2036|M.smegmatis_MC2_155 FVYRLFATTPPTGR----------GAWGRVLVDNLGPKHIPLHNLTVPTL
MAB_3738c|M.abscessus_ATCC_199 FSERMIHQTPVTTI----------VDFLRALEQHDETAALPTIAP-LPSL
MLBr_00862|M.leprae_Br4923 ISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQLI
: : . : : : : :
Rv3171c|M.tuberculosis_H37Rv VIGGV----------RDRLTPISQSR--------------RIARTAPNVV
Mb3196c|M.bovis_AF2122/97 VIGGV----------RDRLTPISQSR--------------RIARTAPNVV
MMAR_1388|M.marinum_M VIGSE----------RDRLTPISQTR--------------KIASTAPNVF
MUL_2488|M.ulcerans_Agy99 VIGSE----------RDRLTPISQTR--------------KIASTAPNVF
MAV_4061|M.avium_104 VIGSE----------RDRLTPIRQSR--------------RIAEGLPNLI
Mflv_4502|M.gilvum_PYR-GCK VIGST----------HDRLLPVSSAR--------------HIASAAPNLA
Mvan_1865|M.vanbaalenii_PYR-1 VIGST----------KDRLLPMASAR--------------RIAATAPNLA
TH_0684|M.thermoresistible__bu VIGSD----------RDRLLPLVSSR--------------RIAEAAPNLF
MSMEG_2036|M.smegmatis_MC2_155 VIGSA----------QDRLLPINASR--------------RIADTVPNLA
MAB_3738c|M.abscessus_ATCC_199 VICGD----------TDMLTPHTQSESMAA----------RLAASGHNEL
MLBr_00862|M.leprae_Br4923 VNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDLA
* * . :* :
Rv3171c|M.tuberculosis_H37Rv GLVELPGGHCSMLERHQ-----EVNSHLRALAESVTRHVRDRRISS----
Mb3196c|M.bovis_AF2122/97 GLVELPGGHCSMLERHQ-----EVNSHLRALAESVTRHVRDRRISS----
MMAR_1388|M.marinum_M DLVELPGGHCSMLEQHH-----EVNRHLRTLVDSVGGRSRAR-ISS----
MUL_2488|M.ulcerans_Agy99 DLVELPGGHCSMLEQHH-----EVNRHLRTLVDSVGGRSRAR-ISS----
MAV_4061|M.avium_104 ELVELPGGHCSMLEHPR-----EVNRRLRALAESATRNLPTHRISS----
Mflv_4502|M.gilvum_PYR-GCK RFVELAGGHCAILERPE-----EVNQQLRWLVDSVSRSTRASAATGDQAR
Mvan_1865|M.vanbaalenii_PYR-1 RFVEVPGGHCAILERPD-----DVNDHLRWLVRSVTGQGDATGATG----
TH_0684|M.thermoresistible__bu DFVELPGGHCAILECPD-----RVNDHLRALAAAAADARRATS-------
MSMEG_2036|M.smegmatis_MC2_155 AFVELRGGHCGILERPD-----EVNAQLRKLAEAVISPQRLNS-------
MAB_3738c|M.abscessus_ATCC_199 ILVRESG-HLVQLEHPE-----IVNDGIDRLVRRSTPPLFAAIKQRLRDR
MLBr_00862|M.leprae_Br4923 DLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALARRG
:* *. .. : :.
Rv3171c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3196c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1388|M.marinum_M --------------------------------------------------
MUL_2488|M.ulcerans_Agy99 --------------------------------------------------
MAV_4061|M.avium_104 --------------------------------------------------
Mflv_4502|M.gilvum_PYR-GCK ASEATGDQARASAATGDQARASSR--------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
MSMEG_2036|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3738c|M.abscessus_ATCC_199 TGL-----------------------------------------------
MLBr_00862|M.leprae_Br4923 AEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVSAK
Rv3171c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3196c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1388|M.marinum_M --------------------------------------------------
MUL_2488|M.ulcerans_Agy99 --------------------------------------------------
MAV_4061|M.avium_104 --------------------------------------------------
Mflv_4502|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
MSMEG_2036|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3738c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 HGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLV
Rv3171c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3196c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1388|M.marinum_M --------------------------------------------------
MUL_2488|M.ulcerans_Agy99 --------------------------------------------------
MAV_4061|M.avium_104 --------------------------------------------------
Mflv_4502|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
MSMEG_2036|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3738c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 ERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVG
Rv3171c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3196c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1388|M.marinum_M --------------------------------------------------
MUL_2488|M.ulcerans_Agy99 --------------------------------------------------
MAV_4061|M.avium_104 --------------------------------------------------
Mflv_4502|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
MSMEG_2036|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3738c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKV
Rv3171c|M.tuberculosis_H37Rv --------------------------------------------
Mb3196c|M.bovis_AF2122/97 --------------------------------------------
MMAR_1388|M.marinum_M --------------------------------------------
MUL_2488|M.ulcerans_Agy99 --------------------------------------------
MAV_4061|M.avium_104 --------------------------------------------
Mflv_4502|M.gilvum_PYR-GCK --------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------
MSMEG_2036|M.smegmatis_MC2_155 --------------------------------------------
MAB_3738c|M.abscessus_ATCC_199 --------------------------------------------
MLBr_00862|M.leprae_Br4923 ADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI