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VTLHQLYVALMIGGVVLLASIAATRLATGIGLPSLLLFLGVGVLVGEDGLGLPFDNAQLAQDLGTAALAV ILVEGGLTTRFSDIRKVLAPAGVLATVGVAVSTAVTAAAVHWILGMDWQLALLLGAVVSSTDAAAVFSVL RVVPLPRRLSGLLEAESGFNDAPAVILVTLFSVVPLDLDPVTIVGTLAYELAIGTVLGLAAGVLGAMALR RIALPATGLYPLATFGLGMLAFAAAGSAHGSGFLAAYLAGVVLANSGLPHRSATRSFAEGAGWLAQIGVF VILGLLVSPDELLDEVVPAIVAGLVLLLLARPLSVVLSLIGFRVPWREQLFLSWAGLRGAVPIVLCTYPI VAGVPDSWRLLNIVFILVVLFTVIQGPSLRPVAEWLHLIPRDTTREIQVDAAPLDVLGAELLTMTVSPGS RLHNVTVLELRLPDPSVITLIIRAGQPFVPQPVTRLRVGDELLIVTTSVTRDLAERRLRAVSRRGKLAYW FDEYGDQA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0746 | - | - | 100% (498) | potassium/proton antiporter |
| M. vanbaalenii PYR-1 | Mvan_4050 | - | 2e-21 | 26.83% (436) | sodium/hydrogen exchanger |
| M. vanbaalenii PYR-1 | Mvan_1424 | - | 2e-07 | 26.61% (327) | sodium/hydrogen exchanger |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2309 | yjcE | 3e-24 | 28.41% (433) | integral membrane transport protein YjcE |
| M. gilvum PYR-GCK | Mflv_0160 | - | 0.0 | 90.96% (498) | potassium/proton antiporter |
| M. tuberculosis H37Rv | Rv2287 | yjcE | 3e-24 | 28.41% (433) | integral membrane transport protein YjcE |
| M. leprae Br4923 | MLBr_00782 | - | 9e-07 | 23.44% (337) | putative transmembrane transport protein |
| M. abscessus ATCC 19977 | MAB_4717c | - | 0.0 | 75.81% (496) | potassium/proton antiporter |
| M. marinum M | MMAR_2583 | - | 0.0 | 74.60% (496) | sodium/hydrogen exchanger (antiporter) |
| M. avium 104 | MAV_2145 | - | 1e-23 | 30.21% (437) | Na+/H+ antiporter |
| M. smegmatis MC2 155 | MSMEG_4682 | - | 1e-21 | 25.55% (497) | Na+/H+ antiporter |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3177 | - | 0.0 | 74.40% (496) | potassium/proton antiporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2309|M.bovis_AF2122/97 MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSL
Rv2287|M.tuberculosis_H37Rv MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSL
MAV_2145|M.avium_104 ------------MFGLVLIVALVSTVIVGTVIGRRYRVGPPVLLIVLGVL
Mvan_0746|M.vanbaalenii_PYR-1 ------MTLHQLYVALMIGGVVLLASIAATRLATGIGLPSLLLFLGVGVL
Mflv_0160|M.gilvum_PYR-GCK ------MTLHQLYVALFLGGLVLLASIAATRLATGVGLPSLLLFLGVGVL
MMAR_2583|M.marinum_M ------MSLQQLYLAMLIGGFVLLASIVGTRLATRVGFPSMLLFLLVGVI
MUL_3177|M.ulcerans_Agy99 ------MSLQQLYLAMLIGGFVLLASIVGTRLATRVGFPSMLLFLLVGVI
MAB_4717c|M.abscessus_ATCC_199 ------MSLHQLYLDLLIGGLVLLASIVGTRVATRIGFPSLLFFLLVGVV
MSMEG_4682|M.smegmatis_MC2_155 ----------------MELLLVVVGAILVTAIAHHRGFEPALMIVVVGSA
MLBr_00782|M.leprae_Br4923 --------MEISGALLSQVGALLTTLAVLGAGARRYSLSPIPVYLMAGLS
:: . . . . : *
Mb2309|M.bovis_AF2122/97 LG---LIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLR-VIV
Rv2287|M.tuberculosis_H37Rv LG---LIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLR-VIV
MAV_2145|M.avium_104 LG---LVPQFGHVRIDGEIVLLLFLPAILYWEGLNISFREIRANAR-IIV
Mvan_0746|M.vanbaalenii_PYR-1 VGEDGLGLPFDNAQLA-QDLGTAALAVILVEGGLTTRFSDIRKVLAPAGV
Mflv_0160|M.gilvum_PYR-GCK VGEGGLGLQFDNAQLG-QDLGTAALAVILVEGGLTTRFSDIRKVLAPAAV
MMAR_2583|M.marinum_M VGEDGFGLRFDDVELA-RNMGTAALAVILVEGGLTTRFSDIRKVLAPAAT
MUL_3177|M.ulcerans_Agy99 VGEDGFGLRFDDVELA-RNMGTAALAVILVEGGLTTRFSDIRKVLAPAAT
MAB_4717c|M.abscessus_ATCC_199 LGEDGLGLEFDNVELA-RNVCTAALAVILVEGGLTTRFADIRKVLAPAGA
MSMEG_4682|M.smegmatis_MC2_155 VS---FLPDFEPPELDSHILLSVVLPPLLYSAALNFSFPTFLRHIRPILG
MLBr_00782|M.leprae_Br4923 LGKGGIMPVS---AADEFITTGAPIGIVLLLLTLGLEFSATEFASSLRRH
:. : : :* : *
Mb2309|M.bovis_AF2122/97 MFSIGLVIATAVAVSWTA---RALGMESHAAAVLGAVLSPTDAAAVAGLA
Rv2287|M.tuberculosis_H37Rv MFSIGLVIATAVAVSWTA---RALGMESHAAAVLGAVLSPTDAAAVAGLA
MAV_2145|M.avium_104 FLSVALVIATAVAVSWTA---RALGMDPHAAGVLGAVLSPTDAAAVAGLA
Mvan_0746|M.vanbaalenii_PYR-1 LATVGVAVSTAVTAAAVH---WILGMDWQLALLLGAVVSSTDAAAVFSVL
Mflv_0160|M.gilvum_PYR-GCK LATLGVAVSTLVTAAAVH---WLLGMNWQLALLLGAVISSTDAAAVFSVL
MMAR_2583|M.marinum_M LATVGVMVSMVVTAVGVH---LVLGVSWQAALLLGAIVSSTDAAAVFSVL
MUL_3177|M.ulcerans_Agy99 LATVGVMVSMVVTAVGVH---LVLGVSWQPALLLGAIVSSTDAAAVFSVL
MAB_4717c|M.abscessus_ATCC_199 LATVGVVVSTVVTAFGAH---VLLRMDWQLALLLGAIVSSTDAAAVFSVL
MSMEG_4682|M.smegmatis_MC2_155 LG-VGLVVVSAFAVAAVSSWLVIVPLTFGTALVLGAIVAPPDAVTAVAVG
MLBr_00782|M.leprae_Br4923 LPSAGVDIILNATPGAVAG--WLLGLDGVAVLALAGVTYISSSGVIARLL
: .: : : . : : . *..: ..: . :
Mb2309|M.bovis_AF2122/97 KRLP---RRALTVLRGESLINDGTALVLFAVTVAVAEGAAGIGPAALVGR
Rv2287|M.tuberculosis_H37Rv KRLP---RRALTVLRGESLINDGTALVLFAVTVAVAEGAAGIGPAALVGR
MAV_2145|M.avium_104 KKLP---RRSLTVLKAESLINDGTALVLFAVSVHVAIGAPAISPPEVTLR
Mvan_0746|M.vanbaalenii_PYR-1 RVVPLP-RRLSGLLEAESGFNDAPAVILVTLFSVVPLDLD---PVTIVGT
Mflv_0160|M.gilvum_PYR-GCK RVVPLP-RRLSGLLEAESGFNDAPAVILVMLFSVVPMELN---AVDIVGT
MMAR_2583|M.marinum_M RVLPLP-RRVAGLLEAESGFNDAPAVILVLMFSEVPFAFR---PAAALEA
MUL_3177|M.ulcerans_Agy99 RVLPLP-RRVAGLLEAESGFNDAPAVILVLMFSEVPFAFR---PAAALEA
MAB_4717c|M.abscessus_ATCC_199 RVLPLP-RRLAGLLEAESGFNDAPAVILVLMFSIVPFVFE---PKSTAVQ
MSMEG_4682|M.smegmatis_MC2_155 RKLGLP-KRMMAILTGESLINDAAALTLFSIAVTQVAGGH-IFIENPLLL
MLBr_00782|M.leprae_Br4923 ADLRRLGNRETPAVLSVLVLEDFAMAAYLPLFAVLAAGGSWLDAVVGMIV
: .* : . ::* . . :
Mb2309|M.bovis_AF2122/97 FVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTP---FAAFLLA
Rv2287|M.tuberculosis_H37Rv FVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTP---FAAFLLA
MAV_2145|M.avium_104 FIGSYLGGIAAGLLVGGAVTLVRKRIDAPQEEGALSLVTP---FAAFLLA
Mvan_0746|M.vanbaalenii_PYR-1 LAYELAIGTVLGLAAGVLGAMALRRIALP-ATGLYPLATFGLGMLAFAAA
Mflv_0160|M.gilvum_PYR-GCK LVYELGIGTVLGLGFGVLGAMTLRRIALP-AAGLYPLATFGLGMLAFAAA
MMAR_2583|M.marinum_M LVFELLVGAAIGLAIGYLGAFTLRRIALP-ASGLYPIATFGLGLVAFAAA
MUL_3177|M.ulcerans_Agy99 LVFELLVGAAIGLAIGYLGAFTLRRIALP-ASGLYPIATFGLGLVAFAAA
MAB_4717c|M.abscessus_ATCC_199 IVYELLAGSAIGLLCGFLGAMALRRVALP-ASGLYPIATFGIGLVAFAAS
MSMEG_4682|M.smegmatis_MC2_155 FGYSATVGPLVGAVLGYVTLWIRKRLANPGLETVQGLVVP---FAAFITA
MLBr_00782|M.leprae_Br4923 AVCALFAAFAASYHWG---HHVGRLVAHP-DSEQLLLRVLGVTLIVAAVA
. . * : : * : . : . :
Mb2309|M.bovis_AF2122/97 QSLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLINGSLW
Rv2287|M.tuberculosis_H37Rv QSLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLINGSLW
MAV_2145|M.avium_104 QSVECSGVVAVVVSALVLAYSGPVVIRARSRLQSYAFWDIATFLLNGSLW
Mvan_0746|M.vanbaalenii_PYR-1 GSAHGSGFLAAYLAGVVLANSG-----LPHRSATRSFAEGAGWLAQIGVF
Mflv_0160|M.gilvum_PYR-GCK GTAHGSGFLAAYLASVVLANSG-----LPHRSATRSFAEGAGWLAQIGVF
MMAR_2583|M.marinum_M GESHASGFIAAYLAAVVLANTG-----LPHRAATRSFAEGVGWLAQIGLF
MUL_3177|M.ulcerans_Agy99 GESHASGFIAAYLAAVVLANTG-----LPHRAATRSFAEGVGWLAQIGLF
MAB_4717c|M.abscessus_ATCC_199 GTVHASGFIAAYLAAVVLANSG-----LPHRSATRSFAEGLGWLAQIGLF
MSMEG_4682|M.smegmatis_MC2_155 EELHASGVLAVVVAGFVVGNGNLG-AGYQTRLQERYVWNSVDVLLEAFVF
MLBr_00782|M.leprae_Br4923 ESLHASAAVGAFLVGLTLTGDT--------AERARKVLGPLRDLFAAIFF
. *. :.. : ...: . * .:
Mb2309|M.bovis_AF2122/97 VFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATR---IAWVQATT
Rv2287|M.tuberculosis_H37Rv VFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATR---IAWVQATT
MAV_2145|M.avium_104 VFVGVQIPGALRGIAGVDGGVRHALFVALVITGVVIVSR---IFWGEFTT
Mvan_0746|M.vanbaalenii_PYR-1 VILGLLVS--------------PDELLDEVVPAIVAG---------LVLL
Mflv_0160|M.gilvum_PYR-GCK VILGLLVS--------------PDQLLDEVVPAIVAG---------LALL
MMAR_2583|M.marinum_M VLLGLLVE--------------PIEVIHDLIAAIVVG---------LLLL
MUL_3177|M.ulcerans_Agy99 VLLGLLVE--------------PIEVIHDLIAAIVVG---------LLLL
MAB_4717c|M.abscessus_ATCC_199 VLLGLLVN--------------PSELMDDLLPAILVG---------LVLL
MSMEG_4682|M.smegmatis_MC2_155 AYIGLHLRFVLEHLNEAHESLTEVITASAVVLLIVLVIRPLSVFAIFGRN
MLBr_00782|M.leprae_Br4923 LAIGISVD--------------PHKLLPMFPTALILA-------------
:*: : ::
Mb2309|M.bovis_AF2122/97 VLGHTVDRVLKKPT------------------------------RHVGFR
Rv2287|M.tuberculosis_H37Rv VLGHTVDRVLKKPT------------------------------RHVGFR
MAV_2145|M.avium_104 MLIRLIDRRAVQRE------------------------------RRVGWR
Mvan_0746|M.vanbaalenii_PYR-1 LLARPLSVVLSLIG------------------------------FRVPWR
Mflv_0160|M.gilvum_PYR-GCK LLARPISVFLSLIG------------------------------FRVPWR
MMAR_2583|M.marinum_M LVARPLSVVLSLSG------------------------------FRIPWR
MUL_3177|M.ulcerans_Agy99 LVARPLSVVLSLSG------------------------------FRIPWR
MAB_4717c|M.abscessus_ATCC_199 LVARPLSVVVSLIG------------------------------FGVPWR
MSMEG_4682|M.smegmatis_MC2_155 KLSRHVEKKLSVPAPDGSRSSLGAAVRKQRKKKRRANWRTMVDRRTLSWQ
MLBr_00782|M.leprae_Br4923 ----TVTAVTKVAT------------------------------------
:
Mb2309|M.bovis_AF2122/97 QRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVVILVTV
Rv2287|M.tuberculosis_H37Rv QRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVVILVTV
MAV_2145|M.avium_104 QRFVTAWAGFRGAVSLAAAVAVPMTTLSGAPFPDRSLLIFIVTVVILVTV
Mvan_0746|M.vanbaalenii_PYR-1 EQLFLSWAGLRGAVPIVLCTYPIVAG-----VPDSWRLLNIVFILVVLFT
Mflv_0160|M.gilvum_PYR-GCK EKMFLSWAGLRGAVPIVLCTYPIVAG-----VPDSWRLLHIVFILVVLYT
MMAR_2583|M.marinum_M DQVFLSWAGLRGAVPIVLATFPIVAG-----VPDSYRLLNIVFMLVVVFT
MUL_3177|M.ulcerans_Agy99 DQVFLSWAGLRGAVPIVLATFPIVAG-----VPDSYRLLNIVFMLVVVFT
MAB_4717c|M.abscessus_ATCC_199 EQAFLSWAGLRGAVPVVLATFPIVAG-----VPDSYRLLNIVFVLVVVFT
MSMEG_4682|M.smegmatis_MC2_155 ENVVLSWTGMRGVVTLAAAAAIPAYTESGEPFPERATIQAIAFVVAVGTL
MLBr_00782|M.leprae_Br4923 GILAARYDGVARRGQLRAGTALVARG-----------------EFSLIII
: *. : . :
Mb2309|M.bovis_AF2122/97 LVQGTSLPTVVRWARMP-EDVAHANE--LQLARTRSAQAALDALPTVADE
Rv2287|M.tuberculosis_H37Rv LVQGTSLPTVVRWARMP-EDVAHANE--LQLARTRSAQAALDALPTVADE
MAV_2145|M.avium_104 LVQGSTLPAVVRWARLP-ADVAHAEE--LQLARTRAARAALDALPAVADE
Mvan_0746|M.vanbaalenii_PYR-1 VIQGPSLRPVAEWLHLIPRDTTREIQ--VDAAPLDVLGAELLTMTVSPGS
Mflv_0160|M.gilvum_PYR-GCK AIQGPSLRRVAEWLNLIPRDTTREIQ--VDAAPLDVLGAELLTMTVLPGS
MMAR_2583|M.marinum_M LVQGPSLRPIAHLLGLISREATREIQ--VEAAPLDVLDAELVTMTVQPPS
MUL_3177|M.ulcerans_Agy99 LVQGPSLRPIAHLLGLISREATREIQ--VEAAPLDVLDAELVTMTVQPPS
MAB_4717c|M.abscessus_ATCC_199 LVQGPSLRPVAHLLGLITREATREIQ--VEAAPLDVLDAELLTMKVQPAS
MSMEG_4682|M.smegmatis_MC2_155 LLQGSTLPWLIRKLHISRFNDDHEADRAEEVKAERVAHDAAEKILVEFQA
MLBr_00782|M.leprae_Br4923 GLVGTSTPAVAALATAYVFIMAIAGP-----VLARYTPGSLPTSSGSAN-
: *.: :
Mb2309|M.bovis_AF2122/97 LGVAPDLVKHLEKEYEERAVLVMADGADSATSDLAERNDLVRRVRLGVLQ
Rv2287|M.tuberculosis_H37Rv LGVAPDLVKHLEKEYEERAVLVMADGADSATSDLAERNDLVRRVRLGVLQ
MAV_2145|M.avium_104 VGVSDELRRRLHKEYEEKAALVLATENGSPDNRILKTREKVRQVRLGVLE
Mvan_0746|M.vanbaalenii_PYR-1 R---LHNVTVLELRLPDPSVITLIIRAGQPFVPQPVTRLRVGDELLIVTT
Mflv_0160|M.gilvum_PYR-GCK R---LHNVTVLELRLPDPSVITLIIRDGQSFVPQPVTRLQIGDELLIVTT
MMAR_2583|M.marinum_M R---LHNVTVLELRLPDPAVITLIIRKGHTFVPMPDTRIQRGDELLIVTT
MUL_3177|M.ulcerans_Agy99 R---LHNVTMLELRLPDPAVITLIIRKGHTFVPMPDTRIQRGDELLIVTT
MAB_4717c|M.abscessus_ATCC_199 R---LRNVTILELRLPDPAVVTLIIRQGNTFVPLPDTRIEPGDELMIVTT
MSMEG_4682|M.smegmatis_MC2_155 NPPANLNPALVEEIYIRIARHTQDVDEMPDPEAPIKRAAAFTTLYREVLA
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
Mb2309|M.bovis_AF2122/97 HQRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLDPADAE------
Rv2287|M.tuberculosis_H37Rv HQRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLDPADAE------
MAV_2145|M.avium_104 HKRREVTALRNQNRIDDTVLRELQNEMDLEEVQLLAAAADEDDGDTE
Mvan_0746|M.vanbaalenii_PYR-1 SVTRDLAERRLR-----AVSRRGKLAYWFDEYGDQA-----------
Mflv_0160|M.gilvum_PYR-GCK SVTRDQAERRLR-----AVSRRGKLAYWFDEYGDPA-----------
MMAR_2583|M.marinum_M STTRAAAESRLR-----AVSRRGKLAYWFDEYGEPD-----------
MUL_3177|M.ulcerans_Agy99 STTRAAAESRLR-----AVSRRGKLAYWFDEYGEPD-----------
MAB_4717c|M.abscessus_ATCC_199 SKTRALTESRLR-----AVSRRGKLAYWFDEYGDVG-----------
MSMEG_4682|M.smegmatis_MC2_155 AQRAALIDQRDAGHIEDEAVRAMLERLDLQEAGVTARLESRL-----
MLBr_00782|M.leprae_Br4923 -----------------------------------------------