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EVSGALLLELGVILVALTVLGTAARRFALSPIPLYLVAGLALGEGGLAPVPATVEFVNTGASIGVVLLLL TLGLEFSIGEFASSLRRHLPSAWIDLVLNALPGAIAGWLLDLGAVGILALAGVTYISSSGVIARLLGDLR RLGNRETPAVLSILVLEDFAMAAYLPLLAVLAAGGTLLHALLGMAVAIAALVVAFVVSYRWGHHVTRFVS HPDNEQLLLRVLGLTLIVAALAEFIHASAAVGAFLVGLTLTGDSAHRARLVLSPLRDLFAAIFFLAIGLS VHPSDLIPMLPAAFVLAVVTAGTKVLTGQFAARRDGVARAGQLRAGTALIARGEFSLVIIGLVGQTYERL EAIATPYVFILAIAGPVLTRYLGARPVVRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3664 | - | - | 100% (381) | transporter, monovalent cation:proton antiporter-2 (CPA2) family protein |
| M. smegmatis MC2 155 | MSMEG_6769 | - | 3e-11 | 25.12% (406) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3264c | - | 1e-151 | 74.06% (374) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_0160 | - | 3e-05 | 24.17% (393) | potassium/proton antiporter |
| M. tuberculosis H37Rv | Rv3236c | - | 1e-151 | 74.06% (374) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_00782 | - | 1e-152 | 73.92% (372) | putative transmembrane transport protein |
| M. abscessus ATCC 19977 | MAB_2285 | - | 7e-16 | 25.18% (409) | Na+/H+ antiporter |
| M. marinum M | MMAR_1309 | - | 1e-150 | 73.75% (381) | membrane transporter |
| M. avium 104 | MAV_4198 | - | 1e-155 | 74.27% (377) | transporter, monovalent cation:proton antiporter-2 (CPA2) |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2572 | - | 1e-150 | 73.49% (381) | membrane transporter |
| M. vanbaalenii PYR-1 | Mvan_1424 | - | 2e-18 | 28.06% (392) | sodium/hydrogen exchanger |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3264c|M.bovis_AF2122/97 -------------MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYL
Rv3236c|M.tuberculosis_H37Rv -------------MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYL
MMAR_1309|M.marinum_M -------------MEVSRALLFEVGALLTTLALLGAIARRFALSPIPVYL
MUL_2572|M.ulcerans_Agy99 -------------MEVSRALLFEVGALLTTLALLGAIARRFALSPIPVYL
MLBr_00782|M.leprae_Br4923 -------------MEISGALLSQVGALLTTLAVLGAGARRYSLSPIPVYL
MAV_4198|M.avium_104 -------------MQISGTLLLQLGALLATLAVLGAAARRFALSPIPVYL
MSMEG_3664|M.smegmatis_MC2_155 -------------MEVSGALLLELGVILVALTVLGTAARRFALSPIPLYL
MAB_2285|M.abscessus_ATCC_1997 MSNTAVTAAAALSKDVSLIFFADLVILLVAALACGAVAGKIGLPKMVGEI
Mvan_1424|M.vanbaalenii_PYR-1 ---------------MDGHLFPTIAIILALATAAGVVATRLRQPLIVAFI
Mflv_0160|M.gilvum_PYR-GCK -----------MTLHQLYVALFLGGLVLLASIAATRLATGVGLPSLLLFL
: :* * . : :
Mb3264c|M.bovis_AF2122/97 LAGLSLG-----------NGGILG-VAAAGEFIATGAPIGVVLLLLALGL
Rv3236c|M.tuberculosis_H37Rv LAGLSLG-----------NGGILG-VAAAGEFIATGAPIGVVLLLLALGL
MMAR_1309|M.marinum_M LAGLSLG-----------KGGVLP-VAAADDFVATGAPIGIVLLLLTLGL
MUL_2572|M.ulcerans_Agy99 LAGLSLG-----------KGGVLP-VAAADDFVATGAPIGIVLLLLTLGL
MLBr_00782|M.leprae_Br4923 MAGLSLG-----------KGGIMP-VSAADEFITTGAPIGIVLLLLTLGL
MAV_4198|M.avium_104 LAGLALG-----------KGGLLP-LATGGQFITTSAPIGVVLLLLTLGC
MSMEG_3664|M.smegmatis_MC2_155 VAGLALG-----------EGGLAP-VPATVEFVNTGASIGVVLLLLTLGL
MAB_2285|M.abscessus_ATCC_1997 AAGVLLGPTVFGRLFPETKDALFPSAGTGSEIISGLCLLAVVLLVGVAGM
Mvan_1424|M.vanbaalenii_PYR-1 MVGVAVG-------------PVGAGWVSADSTMELLARLGLAVLLFLVGL
Mflv_0160|M.gilvum_PYR-GCK GVGVLVG------------EGGLGLQFDNAQLGQDLGTAALAVILVEGGL
.*: :* . .:.::: *
Mb3264c|M.bovis_AF2122/97 EFSATEFASSLRHHLPSAGVDIVLN-ATPGAVAGWLLGLDG--------V
Rv3236c|M.tuberculosis_H37Rv EFSATEFASSLRHHLPSAGVDIVLN-ATPGAVAGWLLGLDG--------V
MMAR_1309|M.marinum_M EFSATEFASSLRHHMPSAMVDIVLN-ATPGAVAGWLLGLDG--------V
MUL_2572|M.ulcerans_Agy99 EFSATEFASSLRHHMPSAMVDIVLN-ATPGAVAGWLLGLDG--------V
MLBr_00782|M.leprae_Br4923 EFSATEFASSLRRHLPSAGVDIILN-ATPGAVAGWLLGLDG--------V
MAV_4198|M.avium_104 EFSVAEFSSSMRHHLPSAAVDVVLN-AAPGAIAGWLLGLDG--------V
MSMEG_3664|M.smegmatis_MC2_155 EFSIGEFASSLRRHLPSAWIDLVLN-ALPGAIAGWLLDLGA--------V
MAB_2285|M.abscessus_ATCC_1997 HVDVDKLKQRLAGIATISVLGLAVP-LAGGMAVGYLVPEPLRPAAVDRTV
Mvan_1424|M.vanbaalenii_PYR-1 RLDLHMIRNTGPVAVITGLGQVLVT-FALGLLIALALGMDN--------V
Mflv_0160|M.gilvum_PYR-GCK TTRFSDIRKVLAPAAVLATLGVAVSTLVTAAAVHWLLGMNW--------Q
: . . : : . :
Mb3264c|M.bovis_AF2122/97 AILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYL
Rv3236c|M.tuberculosis_H37Rv AILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYL
MMAR_1309|M.marinum_M AILALAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDFAMAGYL
MUL_2572|M.ulcerans_Agy99 AILALAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDFAMAGYL
MLBr_00782|M.leprae_Br4923 AVLALAGVTYISSSGVIARLLADLRRLGNRETPAVLSVLVLEDFAMAAYL
MAV_4198|M.avium_104 AILCLAGVTYISSSGVVARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYL
MSMEG_3664|M.smegmatis_MC2_155 GILALAGVTYISSSGVIARLLGDLRRLGNRETPAVLSILVLEDFAMAAYL
MAB_2285|M.abscessus_ATCC_1997 FALFLGTAVAVSAIPVIARILMDLGLASHEIAQVILAAAIVDDVAGWLLL
Mvan_1424|M.vanbaalenii_PYR-1 TALYVAVALTFSSTIIIVKLLSDKRELEQLHGRIALGILIVQDIVVVVVM
Mflv_0160|M.gilvum_PYR-GCK LALLLGAVISSTDAAAVFSVLR-VVPLPRRLSGLLEAESGFNDAPAVILV
* :. . : : :* . . .:* :
Mb3264c|M.bovis_AF2122/97 PLFAVLATD--GSWLEAVVGMTVAIAALLGAFAASYR--WGHHVGRLVTH
Rv3236c|M.tuberculosis_H37Rv PLFAVLATD--GSWLEAVVGMTVAIAALLGAFAASYR--WGHHVGRLVTH
MMAR_1309|M.marinum_M PLFTVLALH--GDWLHALGGTLAAIAALLGAFAASFY--WGHHFGRLFAH
MUL_2572|M.ulcerans_Agy99 PLFTVLALH--GDWLHALGGTLAAIAALLGAFAASFY--WGHHFGRLFAH
MLBr_00782|M.leprae_Br4923 PLFAVLAAG--GSWLDAVVGMIVAVCALFAAFAASYH--WGHHVGRLVAH
MAV_4198|M.avium_104 PLFAVLASG--GGWLHAVVGMVVAVSALVAAFAASYR--WGHHVQRLVEH
MSMEG_3664|M.smegmatis_MC2_155 PLLAVLAAG--GTLLHALLGMAVAIAALVVAFVVSYR--WGHHVTRFVSH
MAB_2285|M.abscessus_ATCC_1997 SAVTGMASDS-GTGGVAVLKMAVAAIVAVVALTALTRPALRNRLARRCSR
Mvan_1424|M.vanbaalenii_PYR-1 IALTASGRGGEGSVGAGIAAVALKGIGLLATLWVLMR--FVLPWLMPQIA
Mflv_0160|M.gilvum_PYR-GCK MLFSVVPME---LNAVDIVGTLVYELGIGTVLGLGFG-VLGAMTLRRIAL
.: : .:
Mb3264c|M.bovis_AF2122/97 PDSEQLLLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGETADR---A
Rv3236c|M.tuberculosis_H37Rv PDSEQLLLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGETADR---A
MMAR_1309|M.marinum_M PDSEQLLLRVLGITLMVAALAETLHASAAVGAFLVGLTLTGETAER---A
MUL_2572|M.ulcerans_Agy99 PDSEQLLLRVLGITLMVAALAETLHASAAVGAFLVGLTLTGETAER---A
MLBr_00782|M.leprae_Br4923 PDSEQLLLRVLGVTLIVAAVAESLHASAAVGAFLVGLTLTGDTAER---A
MAV_4198|M.avium_104 PDSEQLMLRVLGITLIVAAMAESLHASAAVGAFLVGLTLTGETATR---T
MSMEG_3664|M.smegmatis_MC2_155 PDNEQLLLRVLGLTLIVAALAEFIHASAAVGAFLVGLTLTGDSAHR---A
MAB_2285|M.abscessus_ATCC_1997 WSAPTSTTVTVATIIVCATAGQLLGFEPVIGAFFAGILVIAATPAGSRVH
Mvan_1424|M.vanbaalenii_PYR-1 RSQELLVLFGVAYAVSVASFSEWLGFSSEVGAFLAGVSLAGTQFRD--AL
Mflv_0160|M.gilvum_PYR-GCK PAAGLYPLATFGLGMLAFAAAGTAHGSGFLAAYLASVVLANSGLPHRSAT
.. : : . . :.*::..: :
Mb3264c|M.bovis_AF2122/97 RMVLTPLRDLFATIFFLGIGLSVDPGKLVS--MLPVALALAAVTAATKVA
Rv3236c|M.tuberculosis_H37Rv RMVLTPLRDLFATIFFLGIGLSVDPGKLVS--MLPVALALAAVTAATKVA
MMAR_1309|M.marinum_M RRVLGPLRDLFAAIFFLGIGLSVAPKELIP--ALPVAMVLAVVTAATKVL
MUL_2572|M.ulcerans_Agy99 RRVLGPLRDLFAAIFFLGIGLSVAPKELIP--ALPVAILLAVVTAATKVL
MLBr_00782|M.leprae_Br4923 RKVLGPLRDLFAAIFFLAIGISVDPHKLLP--MFPTALILATVTAVTKVA
MAV_4198|M.avium_104 RQVLAPLRDLFAAIFFLAIGYSVDPHELIP--MLPAALILAAATAATKVA
MSMEG_3664|M.smegmatis_MC2_155 RLVLSPLRDLFAAIFFLAIGLSVHPSDLIP--MLPAAFVLAVVTAGTKVL
MAB_2285|M.abscessus_ATCC_1997 KPLHAMAVAFFGPIFFATIGLQLDLGRLLSGPVLALTASICVVAVFSKFL
Mvan_1424|M.vanbaalenii_PYR-1 GARLVSLRDFLLFFFFLNLGAGLDFSEAAG--QITAAIILSVFVLVAKPA
Mflv_0160|M.gilvum_PYR-GCK RSFAEGAGWLAQIGVFVILGLLVSPDQLLD-EVVPAIVAGLALLLLARPI
: .* :* : .. . ::
Mb3264c|M.bovis_AF2122/97 TGMFAARREGVARRGQLRAGTALVARGEFSLIIIGLAG----ASIPGVAA
Rv3236c|M.tuberculosis_H37Rv TGMFAARREGVARRGQLRAGTALVARGEFSLIIIGLAG----ASIPGVAA
MMAR_1309|M.marinum_M TGMFAARRDGVARRGQLRAGTALIARGEFSLIIIGLVG----ASIPAVAA
MUL_2572|M.ulcerans_Agy99 TGMFAARRDGVARRGQLRAGTALIARGEFSLIIIGLVG----ASIPAVAA
MLBr_00782|M.leprae_Br4923 TGILAARYDGVARRGQLRAGTALVARGEFSLIIIGLVG----TSTPAVAA
MAV_4198|M.avium_104 TGIFAARHDGVARRGQLRAGTALIARGEFSLIIIGLAG----SSLPAVAA
MSMEG_3664|M.smegmatis_MC2_155 TGQFAARRDGVARAGQLRAGTALIARGEFSLVIIGLVG----QTYERLEA
MAB_2285|M.abscessus_ATCC_1997 GAGMGARISGFSWPESVAVGAGLNTRGVIQIVIAMVGVRCGVFSPEVFTA
Mvan_1424|M.vanbaalenii_PYR-1 IVIAIMSVMRYPVRVGFLVGLPLAQISEFSLILAALGLSLGHISNATVSL
Mflv_0160|M.gilvum_PYR-GCK SVFLSLIGFRVPWREKMFLSWAGLRGAVPIVLCTYPIVAGVPDSWRLLHI
. . . . :: : .
Mb3264c|M.bovis_AF2122/97 LATAYVFVMAIVG-------------------------------------
Rv3236c|M.tuberculosis_H37Rv LATAYVFVMAIVG-------------------------------------
MMAR_1309|M.marinum_M LATAYVFIMAVAG-------------------------------------
MUL_2572|M.ulcerans_Agy99 LATAYVFIMAVAG-------------------------------------
MLBr_00782|M.leprae_Br4923 LATAYVFIMAIAG-------------------------------------
MAV_4198|M.avium_104 LATSYVFIMAIAG-------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 IATPYVFILAIAG-------------------------------------
MAB_2285|M.abscessus_ATCC_1997 LVVTTIATTAIAG-------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 ITVVGLITIAASTYMTMYSDGIFARSQRWLSHLERKHQRDHEVAGLSDGD
Mflv_0160|M.gilvum_PYR-GCK VFILVVLYTAIQG-------------------------------------
: : *
Mb3264c|M.bovis_AF2122/97 -------------PILARYTGGGLPAAAVASN------------------
Rv3236c|M.tuberculosis_H37Rv -------------PILARYTGGGLPAAAVASN------------------
MMAR_1309|M.marinum_M -------------PVLARYTGG--PVATTA--------------------
MUL_2572|M.ulcerans_Agy99 -------------PVLARYTGG--PVATTA--------------------
MLBr_00782|M.leprae_Br4923 -------------PVLARYTPGSLPTSSGSAN------------------
MAV_4198|M.avium_104 -------------PVLARYTGPR-PAAPAT--------------------
MSMEG_3664|M.smegmatis_MC2_155 -------------PVLTRYLGAR-PVVRT---------------------
MAB_2285|M.abscessus_ATCC_1997 -------------PVLKRTLTPRRQLPAVISKPPQEPALNR---------
Mvan_1424|M.vanbaalenii_PYR-1 FDIILFGLGRFGSHLADRLSGAGHRVLGVDFDPHGVRAHRRDGVTTTFGS
Mflv_0160|M.gilvum_PYR-GCK -------------PSLRRVAEWLNLIPRDTTREIQVDAAPLDVLG-----
*
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2285|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 AEDLDLLEALPLDRAKYVISAIPVLQTNLALLHGLRQHQFSGAVALTAHT
Mflv_0160|M.gilvum_PYR-GCK -AELLTMTVLPGSRLHNVTVLELRLPDPSVITLIIRDGQSFVPQPVTRLQ
Mb3264c|M.bovis_AF2122/97 --------------------------------------------------
Rv3236c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1309|M.marinum_M --------------------------------------------------
MUL_2572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00782|M.leprae_Br4923 --------------------------------------------------
MAV_4198|M.avium_104 --------------------------------------------------
MSMEG_3664|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2285|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_1424|M.vanbaalenii_PYR-1 RHDAERLRATGVEIVIEPFSSAAHTTSNTLHDLLTTEFEDTDDEGYSDDE
Mflv_0160|M.gilvum_PYR-GCK IGDELLIVTTSVTRDQAERRLRAVSRRGKLAYWFDEYGDPA---------
Mb3264c|M.bovis_AF2122/97 ---------
Rv3236c|M.tuberculosis_H37Rv ---------
MMAR_1309|M.marinum_M ---------
MUL_2572|M.ulcerans_Agy99 ---------
MLBr_00782|M.leprae_Br4923 ---------
MAV_4198|M.avium_104 ---------
MSMEG_3664|M.smegmatis_MC2_155 ---------
MAB_2285|M.abscessus_ATCC_1997 ---------
Mvan_1424|M.vanbaalenii_PYR-1 GGAQPRPSR
Mflv_0160|M.gilvum_PYR-GCK ---------