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KWILAAVATALFCVQIDYFAMNLALPRIAQEFGESPSDLQWVISVYMLALGAFMVPAGRMGDIFGRRRAL LTGVALFGGASVACALAPSVSLLVAFRAVQGLGAALIFPVSVSVLTNAYDAAKAGRAIGLAYGIAGLGNA AGPLVGGLLTGTVGWRWIFWLNVPLALASFVLGARHITESFDETAPRRIDITGLALVTAGIALFTLAFDR APDWGWLSVPTLGVFTGAVLALAVFVAVENRVRRPLIDLSLFRAGRFTILVVAGTVANVAYAVVIFLSTL ELQQVRGLDPLAAGLVFLGPSTGAAIGGVMAGRLATGRSPVAVMGNTSVVAALCLAALAAGGPWWFHVAA LSACGFSLGLVYAFTTVATQAVVRPERAGEAAGVTLTALVTAGGVGIAMAATIFEVLQREGMSPAAAIAV ILGAVSALLLPAGAAVLLIKAPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1284 | - | - | 100% (444) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_5021 | - | 4e-62 | 33.10% (423) | EmrB/QacA family drug resistance transporter |
| M. vanbaalenii PYR-1 | Mvan_0523 | - | 4e-59 | 31.53% (406) | EmrB/QacA family drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2361c | - | 3e-57 | 32.46% (422) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1730 | - | 8e-61 | 32.92% (407) | EmrB/QacA family drug resistance transporter |
| M. tuberculosis H37Rv | Rv2333c | - | 2e-56 | 32.46% (422) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 2e-39 | 28.18% (433) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_0945 | - | 5e-59 | 32.35% (405) | EmrB/QacA family drug resistance transporter |
| M. marinum M | MMAR_3642 | - | 5e-61 | 33.57% (420) | integral membrane transport protein |
| M. avium 104 | MAV_2368 | - | 1e-45 | 32.10% (458) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_5670 | - | 7e-61 | 33.58% (405) | efflux membrane protein |
| M. thermoresistible (build 8) | TH_3965 | - | 3e-45 | 31.05% (438) | PUTATIVE drug transporter |
| M. ulcerans Agy99 | MUL_4170 | - | 1e-56 | 31.44% (439) | integral membrane transport protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1284|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4170|M.ulcerans_Agy99 -----------------------------------------------MNR
Mb2361c|M.bovis_AF2122/97 --------------------------------------------------
Rv2333c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3642|M.marinum_M --------------------------------------------------
Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M
MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL
MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MAV_2368|M.avium_104 --------------------------MTMSVAPT-------------TRL
TH_3965|M.thermoresistible__bu ----------------------------VTSVDAGRSTMSEVFTAYAPRS
Mvan_1284|M.vanbaalenii_PYR-1 ----MKWILAAVATALFCVQIDYFAMNLALPRIAQEFGESPSDLQWVISV
MUL_4170|M.ulcerans_Agy99 GNVRPKLVLGVIVLGSFIASIDLTIVNVALPTLSRALQASNAELQWIVDS
Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
MMAR_3642|M.marinum_M MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAA
Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLSASPAQMQWVVDI
MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV
MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
MAV_2368|M.avium_104 WSRQFVAVIVAIGGMQLMVAMDGPVAVFALPKIQNEMGLSDAARSWVITA
TH_3965|M.thermoresistible__bu AAANPWHALWAMLIGFFMILVDATIVPVANLEIMADLGADYTAVIWVTSA
: : :* .* : : *
Mvan_1284|M.vanbaalenii_PYR-1 YMLALGAFMVPAGRMGDIFGRRR-ALLTGVALFGGASVACALAPSVSLLV
MUL_4170|M.ulcerans_Agy99 YAIAAAGLLLAAGNLGDRYGRRG-WLTIGLVIVGASSAVAASAGSAQAVI
Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRR-WYLIGVSLFTLGSIACGLAPSIAVLT
Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRR-WYLIGVSLFTLGSIACGLAPSIAVLT
MMAR_3642|M.marinum_M YSLGMAVFIMSAATLADRYGRRR-WYLMGIALFTLGSIACGLAPSIAMLT
Mflv_1730|M.gilvum_PYR-GCK YTLVLASLLMLSGATGDRFGRRR-LFQIGLTVFALGSLACSLAPTIDTLI
MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRR-TFHLGLTVFAVASLLCSVAPNIETLI
MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRK-VFHLGLSIFAIGSLLCSVAPTVGLLI
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTISSVLCAVAWDEVTLV
MAV_2368|M.avium_104 YMLTFGGLMLLGGRLGDTIGRKRAAFLVGVALFTFASGLCGIAWAGGTLI
TH_3965|M.thermoresistible__bu YLLAYAVPLLIAGRLGDRFGPRT-MYLIGLAIFTAASLWCGLAGTIGMLI
* : . :: .. .* * : *: :. .* .. * :
Mvan_1284|M.vanbaalenii_PYR-1 AFRAVQGLGAALIFPVSVSVLTNAY-DAAKAGRAIGLAYGIAGLGNAAGP
MUL_4170|M.ulcerans_Agy99 GARAVMGVGAAIIFPTSLALVTNVFVDSTHRARAIGVWSAVTGIAVVIGP
Mb2361c|M.bovis_AF2122/97 TARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGP
Rv2333c|M.tuberculosis_H37Rv TARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGP
MMAR_3642|M.marinum_M AARGIQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVASVGTATGP
Mflv_1730|M.gilvum_PYR-GCK GARFLQGVGGSMLNPVALSIISQIFTKPVERARALGIWGGVTGISMAAGP
MSMEG_5670|M.smegmatis_MC2_155 AARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGP
MAB_0945|M.abscessus_ATCC_1997 AARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGP
MLBr_01562|M.leprae_Br4923 IARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGL
MAV_2368|M.avium_104 AARLLHGAAAAIIAPTNLALIATTFPRGSARNAATAVFGAMTGLGGVLGL
TH_3965|M.thermoresistible__bu AARVLQGLGAALLTPQTLSMITRIFPADRR-GVPMGVWGATAGVATLIGP
* . ..: ::::: : . .. . ..:. *
Mvan_1284|M.vanbaalenii_PYR-1 LVGGLLTGTVGWRWIFWLNVPLALASFVLGARHITESFDETAPRRIDITG
MUL_4170|M.ulcerans_Agy99 ILGGWLIEHFSVGSVFWVNVPIAVVAIVSVNMFVPTSRNPDRPP-LDLPG
Mb2361c|M.bovis_AF2122/97 TLGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNE-RARRFDLSG
Rv2333c|M.tuberculosis_H37Rv TLGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNE-RARRFDLSG
MMAR_3642|M.marinum_M TLGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNA-RAGRLDLSG
Mflv_1730|M.gilvum_PYR-GCK IVGGLLIETVGWRSVFWINLPICAAAIILTAVFVPESKSQ-TMRNVDPIG
MSMEG_5670|M.smegmatis_MC2_155 LVGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSS-TMRDVDPVG
MAB_0945|M.abscessus_ATCC_1997 IVGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSA-TMRDIDPVG
MLBr_01562|M.leprae_Br4923 VVGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKE--RMKLDAAG
MAV_2368|M.avium_104 VVGGALTDVS-WRLAFLVNVPIGLAVIYLVLITRQETQTE--RIKLDVTG
TH_3965|M.thermoresistible__bu LAGGVLVDGLGWQWIFIVNVPIGIAGLVLGARLMPRLPRQ--DQGFDVLG
** * * :*:*: : .* *
Mvan_1284|M.vanbaalenii_PYR-1 LALVTAGIALFTLAFDRAPDWGWLSVPTLGVFTGAVLALAVFVAVENRVR
MUL_4170|M.ulcerans_Agy99 LLVSTVGVTVLTYTLIETPNIGWASARTAAGFALAVVLLAVFLWLERRTW
Mb2361c|M.bovis_AF2122/97 QLLFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSS
Rv2333c|M.tuberculosis_H37Rv QLLFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSS
MMAR_3642|M.marinum_M QALFIVTVGAFVYAVIEGPQIGWTSPLILTLLMTAAVGCALFLWLEGRSA
Mflv_1730|M.gilvum_PYR-GCK QGLGILFLFGTVFTLIEGPVLGWTNPRVLAIAAVAVVALIAFLRFESRRH
MSMEG_5670|M.smegmatis_MC2_155 QGLGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRH
MAB_0945|M.abscessus_ATCC_1997 QALAVLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRR
MLBr_01562|M.leprae_Br4923 AILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAE
MAV_2368|M.avium_104 AVLATVTGTAAVFGISMGPEAGWRSPITIGSGVVALAAFVAFVVVERTAE
TH_3965|M.thermoresistible__bu MVLSAVGLFLIVFALQEAQTHRWAPWIWGTLAGGAGVMAMFVIWQSANRR
: . . * * . .
Mvan_1284|M.vanbaalenii_PYR-1 RPLIDLSLFRAGRFTILVVAGTVANVAYAVVIFLSTLELQQVRGLDPLAA
MUL_4170|M.ulcerans_Agy99 HPILDLSIFANRRFSGGTAAVTTAYLVMCGFIFVATQYLQFVAAYRAFDT
Mb2361c|M.bovis_AF2122/97 NPMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVT
Rv2333c|M.tuberculosis_H37Rv NPMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVT
MMAR_3642|M.marinum_M DPMMDLTLFRDSSYALSIGTICTVFFAVYGMLLLTTQFLQNVRGYTPGAT
Mflv_1730|M.gilvum_PYR-GCK DPFLDLRFFRSIPFTTATINAISAFAAWGAFLFMMSLYLQGERGFSAMQT
MSMEG_5670|M.smegmatis_MC2_155 DPFIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFT
MAB_0945|M.abscessus_ATCC_1997 HPFIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHT
MLBr_01562|M.leprae_Br4923 NPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRA
MAV_2368|M.avium_104 NPIVPFNLFLDRNRLAAFAAMFLAGGVFFTLTVLVGLYVQTMMGYSPLRA
TH_3965|M.thermoresistible__bu HPLVPLQIFADRNFMLANVGVATIGFVVTAMVLPAMFFAQAVCGLSPTGS
*.: : :* . . . * . :
Mvan_1284|M.vanbaalenii_PYR-1 GLVFLGPSTGAAIGGVMAGRLATGRSPVAVMGN---TSVVAALCLAALAA
MUL_4170|M.ulcerans_Agy99 GVRLVPLAFSYAGLSVIAPRIVERVGTTAVVTSGLVMVAVSVACAGGFDA
Mb2361c|M.bovis_AF2122/97 GLMILPFSAAVAIVSPLVGHLVGRIGAR-VPILAGLCMLMLGLLMLIFSE
Rv2333c|M.tuberculosis_H37Rv GLMILPFSAAVAIVSPLVGHLVGRIGAR-VPILAGLCMLMLGLLMLIFSE
MMAR_3642|M.marinum_M GLMILPFSAGVAVVSPLVGSLVARVGAR-VLILIGLGLLMLGLLTLIASE
Mflv_1730|M.gilvum_PYR-GCK GLIYLPIALGALFCSPLSGRLVGRYGARPSLVAAGILITTAATLLTLLTA
MSMEG_5670|M.smegmatis_MC2_155 GLIYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAGVLITAATVMLAQMTA
MAB_0945|M.abscessus_ATCC_1997 GLIYLPIAVGALVFSPISGRMVGRFGARPSLLAAGTLFLTASLLLTRVSE
MLBr_01562|M.leprae_Br4923 GIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMN
MAV_2368|M.avium_104 GVAFIPFGLAMAIGVGVASKLVTWFPPRVVVIASGGLILGATLYGSTFN-
TH_3965|M.thermoresistible__bu ALLIAPMAVASGVLAPMAGRIVDRSHPTPVVGFGFSVVAVGLTWLAVEMA
.: . : :. .
Mvan_1284|M.vanbaalenii_PYR-1 GGPWWF--HVAALSACGFSLGLVYAFTTVATQAVVRPERAGEAAGVTLTA
MUL_4170|M.ulcerans_Agy99 GTPYWL--IAAVMAALGSGLGLTMAPASEAIMGSLSPTAAGVGSAVTGVA
Mb2361c|M.bovis_AF2122/97 HRSSAL--VLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQ
Rv2333c|M.tuberculosis_H37Rv HRSSAL--VLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQ
MMAR_3642|M.marinum_M HRSWAL--VLVGLGFCGTGVALCLTPITTVAMTAVPPERAGMASGIMSAQ
Mflv_1730|M.gilvum_PYR-GCK TTPVWH--LLIVFAVFGVGFSMVNAPITNAAVSGMPLDRAGAASAVTSTS
MSMEG_5670|M.smegmatis_MC2_155 TTPVWL--LLVIFAVFGIGFALVNAPITTAAVSGMPLDRAGAASAVASTS
MAB_0945|M.abscessus_ATCC_1997 ATPIWE--LLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTS
MLBr_01562|M.leprae_Br4923 RGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALML
MAV_2368|M.avium_104 RGMPYFPNLVVPLIVCAIGIGAVFVTLTLSVIASVDVDRIGPTSAIAVML
TH_3965|M.thermoresistible__bu PTTPIWR-LVLPFVAVGVGMAFIWSPLATTATRQLPLHLSGAGSGVYNTT
: . ... : : * :.:
Mvan_1284|M.vanbaalenii_PYR-1 LVTAGGVGIAMAATIFEVLQREGMSP------------------------
MUL_4170|M.ulcerans_Agy99 RQLGACLGVAIVGSVFASVYLRSMSS---------------------NAA
Mb2361c|M.bovis_AF2122/97 RAIGSTIGFAVLGSVLAAWLSATLEP---------------------HLE
Rv2333c|M.tuberculosis_H37Rv RAIGSTIGFAVLGSVLAAWLSATLEP---------------------HLE
MMAR_3642|M.marinum_M RAIGSTIGFAVLGSVLAAWLSATLEP---------------------HLE
Mflv_1730|M.gilvum_PYR-GCK RQVGVSIGVALCGSVAGAAMAGSGTD---------------------FAT
MSMEG_5670|M.smegmatis_MC2_155 RQVGVSIGVALCGSVAGTALAGTGVD---------------------FAA
MAB_0945|M.abscessus_ATCC_1997 RQVGVSIGVALCGSIG----------------------------------
MLBr_01562|M.leprae_Br4923 QSLGGPLVLAVIQAVITSRTLYLGG-------------------------
MAV_2368|M.avium_104 QTLGGPLVLVVVQVAITSHALRLGG-------------------------
TH_3965|M.thermoresistible__bu RQIGSVLGSAGMAAFLTGRLSAELPFGATAVPAGEQTRVLPEFLHAPYAA
. : .
Mvan_1284|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_4170|M.ulcerans_Agy99 LHGLDPAARAAMRQSMAAAKQVLDQLPVGEAPAIRHAVESAFLESFGVGC
Mb2361c|M.bovis_AF2122/97 RAVPDPVQRHVLAEIIIDSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIE
Rv2333c|M.tuberculosis_H37Rv RAVPDPVQRHVLAEIIIDSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIE
MMAR_3642|M.marinum_M PAVPDPVQRHTIAEVIIDSANPRAHVGGIVPRREIVHRDPVAIAEEDFIE
Mflv_1730|M.gilvum_PYR-GCK AARPLWFVCIALGLVILAVG---FFSTSQRAVRSAERLAPLVAGAPDPVN
MSMEG_5670|M.smegmatis_MC2_155 ASRPLWLICTALGVVIVAIG---IVSTSPWALRSAERLAPLIGQHHRPAE
MAB_0945|M.abscessus_ATCC_1997 -TPALWFMCAGLGLLIATLG---IVSTSPAAVRSAQRLAPLIEGTT-ARE
MLBr_01562|M.leprae_Br4923 ------------------------TTGPVKFMNDAQLRALDHGYTYGLLW
MAV_2368|M.avium_104 ------------------------TLGPVKSMNAAQLHALDRGYTYGLLW
TH_3965|M.thermoresistible__bu AMAQSMLLPAFVALFGVLAAIFLAGIVLSTPQPDADAQYLDEHDDYLVIE
Mvan_1284|M.vanbaalenii_PYR-1 --AAAIAVILGAVSALLLPAG-----AAVLLIKAPA--------------
MUL_4170|M.ulcerans_Agy99 LACAVFAAVGAVVVAFLLPARGEVRDDVAVSVAASAIGPAEGGK------
Mb2361c|M.bovis_AF2122/97 GIRVALLVATATLAVVFLAGWRWFPRDVQTAGSDAKR--EAAYSDDRRVR
Rv2333c|M.tuberculosis_H37Rv GIRVALLVATATLAVVFLAGWRWFPRDVHTAGSDLSERLPTAMTVECAVS
MMAR_3642|M.marinum_M GIRVAFFIATASLGFVFLAGWRWFPRGGAGMLGDAER--------EADAV
Mflv_1730|M.gilvum_PYR-GCK GAHVR---------------------------------------------
MSMEG_5670|M.smegmatis_MC2_155 VAHAR---------------------------------------------
MAB_0945|M.abscessus_ATCC_1997 MSRVG---------------------------------------------
MLBr_01562|M.leprae_Br4923 VAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL-------------
MAV_2368|M.avium_104 LAGVVALLGGVTLLIGYTAAQVARAQEVKKAVDAGEL-------------
TH_3965|M.thermoresistible__bu LARPDPNPRTDIAVTAVIPALRPTLRPTLRPSLGPPGGPVVQPNNTAALR
Mvan_1284|M.vanbaalenii_PYR-1 -------------
MUL_4170|M.ulcerans_Agy99 -------------
Mb2361c|M.bovis_AF2122/97 G------------
Rv2333c|M.tuberculosis_H37Rv HMPGATWCRLWPA
MMAR_3642|M.marinum_M GL-----------
Mflv_1730|M.gilvum_PYR-GCK -------------
MSMEG_5670|M.smegmatis_MC2_155 -------------
MAB_0945|M.abscessus_ATCC_1997 -------------
MLBr_01562|M.leprae_Br4923 -------------
MAV_2368|M.avium_104 -------------
TH_3965|M.thermoresistible__bu -------------