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LTMSVAPTTRLWSRQFVAVIVAIGGMQLMVAMDGPVAVFALPKIQNEMGLSDAARSWVITAYMLTFGGLM LLGGRLGDTIGRKRAAFLVGVALFTFASGLCGIAWAGGTLIAARLLHGAAAAIIAPTNLALIATTFPRGS ARNAATAVFGAMTGLGGVLGLVVGGALTDVSWRLAFLVNVPIGLAVIYLVLITRQETQTERIKLDVTGAV LATVTGTAAVFGISMGPEAGWRSPITIGSGVVALAAFVAFVVVERTAENPIVPFNLFLDRNRLAAFAAMF LAGGVFFTLTVLVGLYVQTMMGYSPLRAGVAFIPFGLAMAIGVGVASKLVTWFPPRVVVIASGGLILGAT LYGSTFNRGMPYFPNLVVPLIVCAIGIGAVFVTLTLSVIASVDVDRIGPTSAIAVMLQTLGGPLVLVVVQ VAITSHALRLGGTLGPVKSMNAAQLHALDRGYTYGLLWLAGVVALLGGVTLLIGYTAAQVARAQEVKKAV DAGEL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2368 | - | - | 100% (495) | transporter, major facilitator family protein |
| M. avium 104 | MAV_3702 | - | 0.0 | 66.94% (484) | transporter, major facilitator family protein |
| M. avium 104 | MAV_1387 | - | 2e-41 | 30.13% (395) | drug transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2871c | efpA | 0.0 | 67.83% (488) | integral membrane efflux protein EfpA |
| M. gilvum PYR-GCK | Mflv_4046 | - | 0.0 | 68.74% (483) | EmrB/QacA family drug resistance transporter |
| M. tuberculosis H37Rv | Rv2846c | efpA | 0.0 | 67.83% (488) | integral membrane efflux protein EfpA |
| M. leprae Br4923 | MLBr_01562 | - | 0.0 | 66.33% (493) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_3142c | - | 1e-158 | 57.59% (481) | putative transmembrane efflux protein |
| M. marinum M | MMAR_1887 | efpA | 0.0 | 66.19% (488) | integral membrane efflux protein EfpA |
| M. smegmatis MC2 155 | MSMEG_2619 | - | 0.0 | 66.67% (480) | efflux protein |
| M. thermoresistible (build 8) | TH_2858 | - | 0.0 | 68.17% (487) | PUTATIVE major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_2115 | efpA | 0.0 | 65.78% (488) | integral membrane efflux protein EfpA |
| M. vanbaalenii PYR-1 | Mvan_2306 | - | 0.0 | 67.07% (492) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4046|M.gilvum_PYR-GCK MTALNDAERAAIQRDAEGRGKRGSDRASGRALPARVTGSGESAGGRGGDA
Mvan_2306|M.vanbaalenii_PYR-1 MTALNDAERAAIQRDAEGSGKRGSGRASDRALPARIPGLGETAGGRGGDG
TH_2858|M.thermoresistible__bu ---------------MEG--------------------------------
MSMEG_2619|M.smegmatis_MC2_155 MTALNDAERAAAR------------------------------------V
Mb2871c|M.bovis_AF2122/97 MTALNDTERAVRNWRAGRPHRPAPMRPPRSEETAS--------------E
Rv2846c|M.tuberculosis_H37Rv MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETAS--------------E
MMAR_1887|M.marinum_M MTALNDTERAVHNWTSGRQERPTSARATRETETAS--------------E
MUL_2115|M.ulcerans_Agy99 MTALNDTERAVHNWTSGRQERPTSARATRETETAS--------------E
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPAS--------------E
MAV_2368|M.avium_104 -------------------------------------------------M
MAB_3142c|M.abscessus_ATCC_199 MSGLS-------------------------------------------VE
Mflv_4046|M.gilvum_PYR-GCK GRRGRTPAWMPSR-----RFFAAVIAIGGMQLLATMDSTIAIVALPKIQD
Mvan_2306|M.vanbaalenii_PYR-1 ARAGRTPAWVPSR-----RFFAAVIAIGGMQLLATMDSTIAIVALPKIQD
TH_2858|M.thermoresistible__bu --ANKLPTWLPSR-----RFIAAVFAIGGMQLLATMDSTIAIVALPRIQD
MSMEG_2619|M.smegmatis_MC2_155 GLAARLPSWFPSW-----GFLSAVIAIGGMQLLATMDSTVAIVALPKIQD
Mb2871c|M.bovis_AF2122/97 RPSRYYPTWLPSR-----SFIAAVIAIGGMQLLATMDSTVAIVALPKIQN
Rv2846c|M.tuberculosis_H37Rv RPSRYYPTWLPSR-----SFIAAVIAIGGMQLLATMDSTVAIVALPKIQN
MMAR_1887|M.marinum_M RASRYYPTWLPSR-----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQD
MUL_2115|M.ulcerans_Agy99 RASRYYPTWLPSR-----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQD
MLBr_01562|M.leprae_Br4923 RTSK-YPTLLPSGRFPSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQN
MAV_2368|M.avium_104 TMSVAPTTRLWSR-----QFVAVIVAIGGMQLMVAMDGPVAVFALPKIQN
MAB_3142c|M.abscessus_ATCC_199 QLTQKAREFLPSR-----HYLYAVIAIAGMQFLATMDGTIAVVTLPKIQA
. * :. .:..*.***::.:**..:*:.:**:**
Mflv_4046|M.gilvum_PYR-GCK ELGLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTI
Mvan_2306|M.vanbaalenii_PYR-1 ELNLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVTLFTI
TH_2858|M.thermoresistible__bu ELNLTDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVTLFTI
MSMEG_2619|M.smegmatis_MC2_155 ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVMLFTI
Mb2871c|M.bovis_AF2122/97 ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTI
Rv2846c|M.tuberculosis_H37Rv ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTI
MMAR_1887|M.marinum_M ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTI
MUL_2115|M.ulcerans_Agy99 ELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTI
MLBr_01562|M.leprae_Br4923 ELSLSDAGRSWGITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTI
MAV_2368|M.avium_104 EMGLSDAARSWVITAYMLTFGGLMLLGGRLGDTIGRKRAAFLVGVALFTF
MAB_3142c|M.abscessus_ATCC_199 ELHLNDATRSWVITAYMLSFGGLMLLGGRLGDTFGRKR-VFIGGITLFTL
*: *.** *** ****:*:**************:**** .*: *: ***:
Mflv_4046|M.gilvum_PYR-GCK ASVLCGIAWDEATLVIARLLQGVGAAIASPTALALIATTFPKGPARNAAT
Mvan_2306|M.vanbaalenii_PYR-1 ASVLCGIAWDEATLVIARLLQGVGAAIASPTALALIATTFPKGPARNAAT
TH_2858|M.thermoresistible__bu ASVLCGIAWDEATLVIARLLQGVGAAIASPTGLALVATTFPKGPARNAAT
MSMEG_2619|M.smegmatis_MC2_155 ASVLCGIAWNETTLVTARLLQGVGAAIASPTGLALVATTFPKGPARNAAT
Mb2871c|M.bovis_AF2122/97 SSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAAT
Rv2846c|M.tuberculosis_H37Rv SSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAAT
MMAR_1887|M.marinum_M SSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAAT
MUL_2115|M.ulcerans_Agy99 SSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPTRNAAT
MLBr_01562|M.leprae_Br4923 SSVLCAVAWDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSARNTAT
MAV_2368|M.avium_104 ASGLCGIAWAGGTLIAARLLHGAAAAIIAPTNLALIATTFPRGSARNAAT
MAB_3142c|M.abscessus_ATCC_199 ASIGVGLAQEDIGLAIFRLIQGVGAAVASPTALALIATTFPKGPLRTAAV
:* .:* * ** :* .:*: :** ***:****.:*. *.:*.
Mflv_4046|M.gilvum_PYR-GCK AVFAAMTGVGSVMGLVVGGALTEVSWRLAFLVNVPIGLIMIYLARKTLRE
Mvan_2306|M.vanbaalenii_PYR-1 AVFAAMTGVGSVMGLVVGGALTEVSWRLAFLVNVPIGLIMIYLARKTLRE
TH_2858|M.thermoresistible__bu AVFAAMTGVGSVMGLVVGGALTEVSWRLAFLVNVPIGLLVIYLARRTLRE
MSMEG_2619|M.smegmatis_MC2_155 AVFGAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMVYLARTALQE
Mb2871c|M.bovis_AF2122/97 AVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRE
Rv2846c|M.tuberculosis_H37Rv AVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRE
MMAR_1887|M.marinum_M AVFAAMTAVGSVMGLVVGGALTEVSWRLAFMVNVPIGLVMIYLARTALRE
MUL_2115|M.ulcerans_Agy99 AVFAAMTAVGSVMGLVVGGALTEVSWRLAFMVNVPIGLVMIYLARTALRE
MLBr_01562|M.leprae_Br4923 AVFAAMTAIGSVMGLVVGGALTEVSWRLAFLVNVPIGLVMIYLARTALHE
MAV_2368|M.avium_104 AVFGAMTGLGGVLGLVVGGALTDVSWRLAFLVNVPIGLAVIYLVLITRQE
MAB_3142c|M.abscessus_ATCC_199 GVFGAMTGVGSIAGLIVGGALAEVSWRLAFLINVPAGALMIYLAVRSLTE
.**.***.:*.: **:*****::**** **::*** * ::**. : *
Mflv_4046|M.gilvum_PYR-GCK TNRERLKLDAAGALLATMGCTAAVFGFSMGPEAGWMSPVTIGSGIAAVGC
Mvan_2306|M.vanbaalenii_PYR-1 TNKERLKLDAAGALLATMGCTAAVFAFSMGPESGWASPVTVASAVAAVGC
TH_2858|M.thermoresistible__bu THRERLKLDAAGAILATLGCTAAVFAFSMGPERGWASVITIATGAAALVF
MSMEG_2619|M.smegmatis_MC2_155 TNRERMKLDAAGALLATLACTAAVFAFTQGPESGWLAPITLASGAAALVF
Mb2871c|M.bovis_AF2122/97 TNKERMKLDATGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAA
Rv2846c|M.tuberculosis_H37Rv TNKERMKLDATGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAA
MMAR_1887|M.marinum_M TNRERMKLDAAGAILATLACTAAVFAFSMGPEKGWLSITTIGSGAVAFAA
MUL_2115|M.ulcerans_Agy99 TNRERMKLDAAGAILATLACTAAVFAFSMGPEKGWLSITTIGSGAVAFAA
MLBr_01562|M.leprae_Br4923 THKERMKLDAAGAILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVA
MAV_2368|M.avium_104 TQTERIKLDVTGAVLATVTGTAAVFGISMGPEAGWRSPITIGSGVVALAA
MAB_3142c|M.abscessus_ATCC_199 TEREPMKLDVAGSVLATLGCTAAVFGFTQGPDRGWDSPYTIVSLIAAAAL
*. * :***.:*::***: *****.:: **: ** : *: : .*
Mflv_4046|M.gilvum_PYR-GCK LIAFLWVERTAENPVVPFELFLDRNRVATFAAVFLAGGVMFTLTVTIGLY
Mvan_2306|M.vanbaalenii_PYR-1 LLAFLWVERTAENPVVPFALFHDRNRVATFAAVFLAGGVMFTLTVTIGLY
TH_2858|M.thermoresistible__bu LLAFLYVERTADNPVVPFSLFRDRNRVATFGAIFLAGGVMFTLTVLIGLY
MSMEG_2619|M.smegmatis_MC2_155 GLAFLIAERNAENPVVPFALFRERNRVATFAAIFLAGGVLFTLTVLIGLY
Mb2871c|M.bovis_AF2122/97 AVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGLY
Rv2846c|M.tuberculosis_H37Rv AVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGLY
MMAR_1887|M.marinum_M ALGFVLVERTAENPVVPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCIGLY
MUL_2115|M.ulcerans_Agy99 ALGFVLVERTAENPVVPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCIGLY
MLBr_01562|M.leprae_Br4923 AIAFAVVERTAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLY
MAV_2368|M.avium_104 FVAFVVVERTAENPIVPFNLFLDRNRLAAFAAMFLAGGVFFTLTVLVGLY
MAB_3142c|M.abscessus_ATCC_199 LIAFLFVERTAENPVLPFSLFTDRNRVATFAAIFMAGGVLFTLTITIGLY
:.* .**.*:**::** ** :***:.:* *:::****:*:**: :***
Mflv_4046|M.gilvum_PYR-GCK VQDIMGYSALRAGVGFIPFVIALGIGLGVSSALVSKYPPRVLVIGGGVLV
Mvan_2306|M.vanbaalenii_PYR-1 VQDIMGYSALRAGIGFIPFVIALGIGLGLSSALVSKFPPRVLVIGGGVLV
TH_2858|M.thermoresistible__bu VQDIMGYSPLRAGIGFIPFVIALGIGLAASSQLVRLFPPRVLVFGGGVLV
MSMEG_2619|M.smegmatis_MC2_155 VQDILGYSALRAGVGFIPFVIGMGIGLGAASQLVRSIPPRVLVIAGGILV
Mb2871c|M.bovis_AF2122/97 VQDILGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLL
Rv2846c|M.tuberculosis_H37Rv VQDILGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLL
MMAR_1887|M.marinum_M VQDVLGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLL
MUL_2115|M.ulcerans_Agy99 VQDVLGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLL
MLBr_01562|M.leprae_Br4923 IQDILGYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLL
MAV_2368|M.avium_104 VQTMMGYSPLRAGVAFIPFGLAMAIGVGVASKLVTWFPPRVVVIASGGLI
MAB_3142c|M.abscessus_ATCC_199 MQDLMKYSPLRTGIAAIPFVVGMGIGLGLSSQLVTRLAPRVLILCGGVVV
:* :: **.**:*:. *** :.:.**:. :* ** .***: : .* ::
Mflv_4046|M.gilvum_PYR-GCK LAAMIYG-STLDANIPYFPNLVLPITIGGLGIGMIVVPLMISAIAGVGFD
Mvan_2306|M.vanbaalenii_PYR-1 LAAMIYG-STLDAGIPYFPNLVLPITIGGFGIGMIVVPLMISAIAGVGFD
TH_2858|M.thermoresistible__bu LGAMLYG-STLHADIPYFPNLVVPIVVGGIGIGVIVVPLTVSAIAGVGFD
MSMEG_2619|M.smegmatis_MC2_155 LGAMIYG-STLHRGIPYFPNLVLPITIGGIGIGTIVVPLTLSAIAGVNLD
Mb2871c|M.bovis_AF2122/97 FGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVGFD
Rv2846c|M.tuberculosis_H37Rv FGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVGFD
MMAR_1887|M.marinum_M VCAMIYGWAFMQRGVPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGVGFD
MUL_2115|M.ulcerans_Agy99 VCAMIYGWAFMQRGVPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGVGFD
MLBr_01562|M.leprae_Br4923 MVAMLYGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFD
MAV_2368|M.avium_104 LGATLYG-STFNRGMPYFPNLVVPLIVCAIGIGAVFVTLTLSVIASVDVD
MAB_3142c|M.abscessus_ATCC_199 FGAMLYG-STIDRTIAYFPDFATAIFVGGIGIGTIVVPVILSAITGVDAD
. * :** :. :.***:: .: : .:*** .*.: ::.*:.*. *
Mflv_4046|M.gilvum_PYR-GCK QIGPVSAIALMLQNLGGPVVLAIIQAVITSRTLYLGGTTGPVKDMNAAQM
Mvan_2306|M.vanbaalenii_PYR-1 QIGPVSAIALMLQNLGGPVVLAVIQAVITSRTLYLGGTTGPVKDMNAAQL
TH_2858|M.thermoresistible__bu QIGPVSAIALMLQNLGGPLVLAVVQAVITSRTLYLGGTTGPVQNMDTAQL
MSMEG_2619|M.smegmatis_MC2_155 RIGPASAIALMLQNLGGPLVLAVIQAVITSRTLFLGGTTGPVKAMNDEQI
Mb2871c|M.bovis_AF2122/97 QIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQL
Rv2846c|M.tuberculosis_H37Rv QIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQL
MMAR_1887|M.marinum_M RIGPVSALTLMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQL
MUL_2115|M.ulcerans_Agy99 RIGPVSALTLMLQSLGGPLVLAGIQAVITSRTLYLGGTTGPVKFMNDAQL
MLBr_01562|M.leprae_Br4923 RIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQL
MAV_2368|M.avium_104 RIGPTSAIAVMLQTLGGPLVLVVVQVAITSHALRLGGTLGPVKSMNAAQL
MAB_3142c|M.abscessus_ATCC_199 RIGPLSAISLMLQNLGGPIVLVIIQAIITSRTLYLGGATGPVQNMNRDQL
:*** **:::***.****:**. :*. ***::* ***: ***: *: *:
Mflv_4046|M.gilvum_PYR-GCK HALDQGYSYGLLWVAAVAVIVGAVALFIGYTAQQVAHAQEVKDAIDAG--
Mvan_2306|M.vanbaalenii_PYR-1 HALDQGYSYGLLWVAAVAVIVGGAALFIGYTAEQVAHAQEVKDAIDAG--
TH_2858|M.thermoresistible__bu HALDQGYTYGLLWVAAVAVLVGGAALFIGYTAKQVAHAQEVKDAIDAG--
MSMEG_2619|M.smegmatis_MC2_155 GALDAAYTYGLLWVAAVAVLVGAAALFIGYTSQQVAHAQDVKDAMDAG--
Mb2871c|M.bovis_AF2122/97 AALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAG--
Rv2846c|M.tuberculosis_H37Rv AALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAG--
MMAR_1887|M.marinum_M HALDHGYTYGLLWVAGAAVIVGGAAVFIGYTPEQVAHAQEVKEAIDAG--
MUL_2115|M.ulcerans_Agy99 HALDHGYTYGLLWVAGAAVIVGGAAVFIGYTPEQVAHAQEVKEAIDAG--
MLBr_01562|M.leprae_Br4923 RALDHGYTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAG--
MAV_2368|M.avium_104 HALDRGYTYGLLWLAGVVALLGGVTLLIGYTAAQVARAQEVKKAVDAG--
MAB_3142c|M.abscessus_ATCC_199 HALDHGYTYGMLWIAGTAVLVGVAALFITYSAADIAHAQKAQAAHDQGLD
*** .*:**:**:*... ::* :::* *:. ::* **..: * * *
Mflv_4046|M.gilvum_PYR-GCK --EL--------
Mvan_2306|M.vanbaalenii_PYR-1 --EL--------
TH_2858|M.thermoresistible__bu --EL--------
MSMEG_2619|M.smegmatis_MC2_155 --EIEVDQPPIG
Mb2871c|M.bovis_AF2122/97 --EL--------
Rv2846c|M.tuberculosis_H37Rv --EL--------
MMAR_1887|M.marinum_M --EL--------
MUL_2115|M.ulcerans_Agy99 --EL--------
MLBr_01562|M.leprae_Br4923 --EL--------
MAV_2368|M.avium_104 --EL--------
MAB_3142c|M.abscessus_ATCC_199 EDELE-------
*: