For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VNETVVERLSRRHKAFVLASCCLSVLIVSIDVTIANVAIPSIRADLSASPSQMQWVIDIYTLMVASLLLL SGAMADRFGRRRTLQIGLTIFASASLLCSVAPNVETLIGARFLQAIGGSMLTPAGLSIVTQVFTGRVERA RVIGIWGGVVGISMALGPIMGGILLEYVDWRAVFWINVPICALAVLLTAIFVPESKSVTMRHVDLIGLVL GMAFLFGLVFVLIEGPGMGWTDTRVVVSCCLAALAFATFLRYESRRLDPFVELRFFRSIPFASATAIAVC AFAAWGAFLFMMSIYLQGERGLSAVNTGLMFLPVAVGAFIFSPLSGRLVGRFGARPSLMIAGALIVAATL MFAQMSDATPQWQMLVAFAVFGVGTSMVNAPVTTAAVSGMPTDRAGAAAAITSTSRQVGVAIGVAICGPV AGAALGDTNVDFAVSAQPLWLVFAGVGVLIFTLGVYSTSKRALRSAEHLAPLIAGTDPRREAADVA
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_0523 | - | - | 100% (486) | EmrB/QacA family drug resistance transporter |
M. vanbaalenii PYR-1 | Mvan_5021 | - | 0.0 | 66.81% (467) | EmrB/QacA family drug resistance transporter |
M. vanbaalenii PYR-1 | Mvan_1284 | - | 4e-59 | 31.53% (406) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2361c | - | 1e-71 | 34.53% (417) | integral membrane transport protein |
M. gilvum PYR-GCK | Mflv_0642 | - | 0.0 | 100.00% (486) | EmrB/QacA family drug resistance transporter |
M. tuberculosis H37Rv | Rv2333c | - | 7e-71 | 34.53% (417) | integral membrane transport protein |
M. leprae Br4923 | MLBr_01562 | - | 3e-48 | 30.81% (396) | putative transmembrane efflux protein |
M. abscessus ATCC 19977 | MAB_0945 | - | 1e-174 | 62.89% (477) | EmrB/QacA family drug resistance transporter |
M. marinum M | MMAR_1146 | - | 1e-80 | 36.78% (416) | integral membrane transport protein |
M. avium 104 | MAV_1387 | - | 2e-55 | 31.49% (397) | drug transporter |
M. smegmatis MC2 155 | MSMEG_5670 | - | 0.0 | 72.30% (473) | efflux membrane protein |
M. thermoresistible (build 8) | TH_3412 | - | 5e-58 | 32.60% (411) | PUTATIVE putative major facilitator superfamily MFS_1 |
M. ulcerans Agy99 | MUL_0911 | - | 4e-81 | 36.54% (416) | integral membrane transport protein |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_0523|M.vanbaalenii_PYR-1 -----------------------------------------MNETVVERL Mflv_0642|M.gilvum_PYR-GCK -----------------------------------------MNETVVERL MSMEG_5670|M.smegmatis_MC2_155 -----------------------------------------MNETVGA-L MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL Mb2361c|M.bovis_AF2122/97 -------------------------------------------------- Rv2333c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1146|M.marinum_M --------------------------------------------MRIQPV MUL_0911|M.ulcerans_Agy99 --------------------------------------------MRIQPV TH_3412|M.thermoresistible__bu -------------------------------------------MTQCAVR MAV_1387|M.avium_104 -------------------------------------------------- MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF Mvan_0523|M.vanbaalenii_PYR-1 SRRHKAFVLASCCLSVLIVSIDVTIANVAIPSIRADLSASPSQMQWVIDI Mflv_0642|M.gilvum_PYR-GCK SRRHKAFVLASCCLSVLIVSIDVTIANVAIPSIRADLSASPSQMQWVIDI MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS MMAR_1146|M.marinum_M FRDHPIPALAVICLSVFVISVDATIVNVALPTLSRQLGADTAQLQWIVDA MUL_0911|M.ulcerans_Agy99 FRDHPILALAVICLSVFVISVDATIVNVALPTLSRELGADTAQLQWIVDA TH_3412|M.thermoresistible__bu AGAREWAGLGVLAVPTVLLGLDVTVLYLVLPAVAADLAPSPVQTLWIMDA MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA .: :* : :. * : .: * Mvan_0523|M.vanbaalenii_PYR-1 YTLMVASLLLLSGAMADRFGRRRTLQIGLTIFASASLLCSVAPNVETLIG Mflv_0642|M.gilvum_PYR-GCK YTLMVASLLLLSGAMADRFGRRRTLQIGLTIFASASLLCSVAPNVETLIG MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT MMAR_1146|M.marinum_M YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLIA MUL_0911|M.ulcerans_Agy99 YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLVA TH_3412|M.thermoresistible__bu YGFFIAGFLITMGTLGDRIGRRRLLTIGVTAFAGASVLAALAPSAELLIV MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI * : . .:: . .* * : *: *: * .. . * Mvan_0523|M.vanbaalenii_PYR-1 ARFLQAIGGSMLTPAGLSIVTQVFTGRVERARVIGIWGGVVGISMALGPI Mflv_0642|M.gilvum_PYR-GCK ARFLQAIGGSMLTPAGLSIVTQVFTGRVERARVIGIWGGVVGISMALGPI MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT MMAR_1146|M.marinum_M ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI MUL_0911|M.ulcerans_Agy99 ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI TH_3412|M.thermoresistible__bu ARALLGVAGATLMPSTLSLISNMFVDAAQRALAIGVWATMFAVGMAAGPV MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFP-AERRGVAVSVWSATAGAASLAGPL MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV ** .:... :. :: * : . ..: . . * Mvan_0523|M.vanbaalenii_PYR-1 MGGILLEYVDWRAVFWINVPICALAVLLTAIFVPESKSVTMRHVDLIGLV Mflv_0642|M.gilvum_PYR-GCK MGGILLEYVDWRAVFWINVPICALAVLLTAIFVPESKSVTMRHVDLIGLV MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQG MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSATMRDIDPVGQA Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL MMAR_1146|M.marinum_M TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM MUL_0911|M.ulcerans_Agy99 TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM TH_3412|M.thermoresistible__bu VGGALVDRFWWGAAFLLAVPVAAAVLLGARLLP-EYADPQAGRLDLRSVA MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVPVLPT-QSHRFDLVGVG MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHK-ERMKLDAAGAI ** * : * * : :*: . : .* . Mvan_0523|M.vanbaalenii_PYR-1 LGMAFLFGLVFVLIEGPGMGWTDTRVVVSCCLAALAFATFLRYESRRLDP Mflv_0642|M.gilvum_PYR-GCK LGMAFLFGLVFVLIEGPGMGWTDTRVVVSCCLAALAFATFLRYESRRLDP MSMEG_5670|M.smegmatis_MC2_155 LGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRHDP MAB_0945|M.abscessus_ATCC_1997 LAVLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRRHP Mb2361c|M.bovis_AF2122/97 LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP Rv2333c|M.tuberculosis_H37Rv LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP MMAR_1146|M.marinum_M LSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSHP MUL_0911|M.ulcerans_Agy99 LSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSHP TH_3412|M.thermoresistible__bu LSLLAILAAIYAVKHVAVHGVDGVAVAACALAAAAATV-FVHRQRRLDAP MAV_1387|M.avium_104 LSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREP MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP * :: . . . . * Mvan_0523|M.vanbaalenii_PYR-1 FVELRFFRSIPFASATAIAVCAFAAWGAFLFMMSIYLQGERGLSAVNTGL Mflv_0642|M.gilvum_PYR-GCK FVELRFFRSIPFASATAIAVCAFAAWGAFLFMMSIYLQGERGLSAVNTGL MSMEG_5670|M.smegmatis_MC2_155 FIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFTGL MAB_0945|M.abscessus_ATCC_1997 FIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHTGL Mb2361c|M.bovis_AF2122/97 MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL Rv2333c|M.tuberculosis_H37Rv MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL MMAR_1146|M.marinum_M MLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTGV MUL_0911|M.ulcerans_Agy99 MLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTGV TH_3412|M.thermoresistible__bu LLDVTLFADRAFTAALTVLLIGLIGVGGTMYLVTQFLQLVEGLTPVRAGW MAV_1387|M.avium_104 LIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSAL MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI .: . .* . . : * :. :. Mvan_0523|M.vanbaalenii_PYR-1 MFLPVAVGAFIFSPLSGRLVGRFGARPSLMIAGALIVAATLMFAQMS-DA Mflv_0642|M.gilvum_PYR-GCK MFLPVAVGAFIFSPLSGRLVGRFGARPSLMIAGALIVAATLMFAQMS-DA MSMEG_5670|M.smegmatis_MC2_155 IYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAGVLITAATVMLAQMT-AT MAB_0945|M.abscessus_ATCC_1997 IYLPIAVGALVFSPISGRMVGRFGARPSLLAAGTLFLTASLLLTRVS-EA Mb2361c|M.bovis_AF2122/97 MILPFSAAVAIVSPLVGHLVGRIGAR-VPILAGLCMLMLGLLMLIFS-EH Rv2333c|M.tuberculosis_H37Rv MILPFSAAVAIVSPLVGHLVGRIGAR-VPILAGLCMLMLGLLMLIFS-EH MMAR_1146|M.marinum_M RLLPVALSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWASTAD-AT MUL_0911|M.ulcerans_Agy99 RLLPVAFSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWASTAD-AT TH_3412|M.thermoresistible__bu WMGPPALAMFVAAIGAPLIARRVRPGVVMAATLGVSVLGYAVLASAGRGD MAV_1387|M.avium_104 LIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPA MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG * . : :. * . Mvan_0523|M.vanbaalenii_PYR-1 TPQWQ-MLVAFAVFGVGTSMVNAPVTTAAVSGMPTDRAGAAAAITSTSRQ Mflv_0642|M.gilvum_PYR-GCK TPQWQ-MLVAFAVFGVGTSMVNAPVTTAAVSGMPTDRAGAAAAITSTSRQ MSMEG_5670|M.smegmatis_MC2_155 TPVWL-LLVIFAVFGIGFALVNAPITTAAVSGMPLDRAGAASAVASTSRQ MAB_0945|M.abscessus_ATCC_1997 TPIWE-LLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ Mb2361c|M.bovis_AF2122/97 RSSAL-VLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA Rv2333c|M.tuberculosis_H37Rv RSSAL-VLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA MMAR_1146|M.marinum_M TPYTQ-IALQMLLLGGGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTRE MUL_0911|M.ulcerans_Agy99 TPYTQ-ITLQMLLLGGGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTRE TH_3412|M.thermoresistible__bu GPAVV-VAFAFVYLG--LGAIAALGTDIVVGAAPAAKSGSAAAMSETVQE MAV_1387|M.avium_104 TPIWR-LVLPFFAMGVGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVRQ MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS . : : * . * * :.: : Mvan_0523|M.vanbaalenii_PYR-1 VGVAIG------------------------VAICGPVAGAALGDTNVDFA Mflv_0642|M.gilvum_PYR-GCK VGVAIG------------------------VAICGPVAGAALGDTNVDFA MSMEG_5670|M.smegmatis_MC2_155 VGVSIG------------------------VALCGSVAGTALAGTGVDFA MAB_0945|M.abscessus_ATCC_1997 VGVSIG------------------------VALCGSIG------------ Mb2361c|M.bovis_AF2122/97 IGSTIG------------------------FAVLGSVLAAWLSATLEPHL Rv2333c|M.tuberculosis_H37Rv IGSTIG------------------------FAVLGSVLAAWLSATLEPHL MMAR_1146|M.marinum_M LGGTLG------------------------VAIAGSVFASVYSGQLGSAS MUL_0911|M.ulcerans_Agy99 LGGTLG------------------------VAIAGSVFASVYSGQLGSAS TH_3412|M.thermoresistible__bu LGIAVG------------------------VALLGSVTAAVYRSRMTGPE MAV_1387|M.avium_104 LGAVLGSAGMAAFMTWRIGAEMPGQPGGGGEDSAGPVLPEFLRGPFAAAM MLBr_01562|M.leprae_Br4923 LGGPLVLA--------------------VIQAVITSRTLYLGGTTGPVKF :* : . Mvan_0523|M.vanbaalenii_PYR-1 VSAQPLWLVFAGVGVLIFTLG----------------------------- Mflv_0642|M.gilvum_PYR-GCK VSAQPLWLVFAGVGVLIFTLG----------------------------- MSMEG_5670|M.smegmatis_MC2_155 AASRPLWLICTALGVVIVAIG----------------------------- MAB_0945|M.abscessus_ATCC_1997 --TPALWFMCAGLGLLIATLG----------------------------- Mb2361c|M.bovis_AF2122/97 ERAVPDPVQRHVLAEIIIDSAN---------------------------- Rv2333c|M.tuberculosis_H37Rv ERAVPDPVQRHVLAEIIIDSAN---------------------------- MMAR_1146|M.marinum_M TLAT-LPSDVRSAMKGSMAVAH---------------------------- MUL_0911|M.ulcerans_Agy99 ALAT-LPSDVRSAMKGSMAVAH---------------------------- TH_3412|M.thermoresistible__bu GVAEGVGGPDAERLAESLPAAV---------------------------- MAV_1387|M.avium_104 SQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYHDDY MLBr_01562|M.leprae_Br4923 MNDAQLRALDHGYTYGLLWVAG---------------------------- Mvan_0523|M.vanbaalenii_PYR-1 ------------------VYSTSKRALRSAEHLAPLIAGTDPRREAADVA Mflv_0642|M.gilvum_PYR-GCK ------------------VYSTSKRALRSAEHLAPLIAGTDPRREAADVA MSMEG_5670|M.smegmatis_MC2_155 ------------------IVSTSPWALRSAERLAPLIGQHHRPAEVAHAR MAB_0945|M.abscessus_ATCC_1997 ------------------IVSTSPAAVRSAQRLAPLIEGTTAR-EMSRVG Mb2361c|M.bovis_AF2122/97 ----------------PRAHVGGIVPRRHIEHRDPVAIAEEDFIEGIRVA Rv2333c|M.tuberculosis_H37Rv ----------------PRAHVGGIVPRRHIEHRDPVAIAEEDFIEGIRVA MMAR_1146|M.marinum_M ----------------KVIDQLPAGPAAGVRDAVNHAFLDGLQVATLVCA MUL_0911|M.ulcerans_Agy99 ----------------KVIDQLPAGPAAGVRDAVNHAFLDGLQVATLVCA TH_3412|M.thermoresistible__bu ----------------SVADRVPGEAVR----LAQDAFAAGVNIAALIGG MAV_1387|M.avium_104 DDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRDPVESRRS MLBr_01562|M.leprae_Br4923 ------------------AVVIVGVAALFIGYTPEQVAYAQEVKEAVDAG . Mvan_0523|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0642|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0945|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2361c|M.bovis_AF2122/97 LLVATATLAVVFLAGWRWFPRDVQTAGSDAKR--EAAYSDDRRVRG---- Rv2333c|M.tuberculosis_H37Rv LLVATATLAVVFLAGWRWFPRDVHTAGSDLSERLPTAMTVECAVSHMPGA MMAR_1146|M.marinum_M GIALAAAIVVGWLLPARAGQPTPAQTEPALAQA----------------- MUL_0911|M.ulcerans_Agy99 GIALAAAIVVGWLLPARAGQPTPAQTEPALAQV----------------- TH_3412|M.thermoresistible__bu ----AAVVVVAVVCATALRHLRPLD------------------------- MAV_1387|M.avium_104 VLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPR MLBr_01562|M.leprae_Br4923 EL------------------------------------------------ Mvan_0523|M.vanbaalenii_PYR-1 ---------------------------------------- Mflv_0642|M.gilvum_PYR-GCK ---------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 ---------------------------------------- MAB_0945|M.abscessus_ATCC_1997 ---------------------------------------- Mb2361c|M.bovis_AF2122/97 ---------------------------------------- Rv2333c|M.tuberculosis_H37Rv TWCRLWPA-------------------------------- MMAR_1146|M.marinum_M ---------------------------------------- MUL_0911|M.ulcerans_Agy99 ---------------------------------------- TH_3412|M.thermoresistible__bu ---------------------------------------- MAV_1387|M.avium_104 RHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN MLBr_01562|M.leprae_Br4923 ----------------------------------------