For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
AEVDVCVVGAGFAGLTAALRLKQAGHSVALLEARDRVGGRTFTVVREDGSWIDKGGAWIGPTQHRIYALM KEFGVAAFKQYTDGEAMMVVDGKQYRYQGTIPRTLSPLASMNLGTAMFEISQMCKTIPLEAPWEAKRAAK WDRMTLAQWLRNNVKSKAAHDLLETAIAGCYTSDASEVSMLFVLYQMASGGGPGFVLGSKGAAQDARPIG GMGAVYGPMAAELGDAIHLSQPVRSITQDSGGVTVQAEGLTVRANRTIVAVPLAIASQIVYEPMLPTDRS FLHQRMPSGAVVKISAVYDEPFWRADGLCGQSAAPTSLATLTIDASPNSGTPGVLCVVIEGPVARQYERL DDDGRRQAVLAALVERFGAKAAKPIDYFEQNWSRERYSGGGMLSHTPPGVLTQFGHALRRPCGRIHWAGT EISAKMCGWIDGAIRSGERAASEVMANQTMTMASDS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1281 | aofH_1 | - | 100% (457) | flavin-containing monoamine oxidase AofH_1 |
| M. ulcerans Agy99 | MUL_2487 | aofH | 3e-83 | 38.96% (444) | flavin-containing monoamine oxidase AofH (amine oxidase) |
| M. ulcerans Agy99 | MUL_2489 | - | 5e-21 | 26.80% (444) | monoamine oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 5e-80 | 37.39% (444) | flavin-containing monoamine oxidase |
| M. gilvum PYR-GCK | Mflv_4501 | - | 3e-75 | 37.64% (441) | amine oxidase |
| M. tuberculosis H37Rv | Rv3170 | aofH | 5e-80 | 37.39% (444) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 2e-06 | 22.97% (344) | protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_2659 | - | 7e-72 | 35.14% (444) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_3362 | aofH_1 | 0.0 | 99.78% (457) | flavin-containing monoamine oxidase AofH_1 |
| M. avium 104 | MAV_4062 | - | 8e-84 | 39.86% (444) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 5e-73 | 36.20% (442) | amine oxidase |
| M. thermoresistible (build 8) | TH_2921 | - | 1e-100 | 44.20% (448) | PUTATIVE putative flavin-containing monoamine oxidase AofH_1 |
| M. vanbaalenii PYR-1 | Mvan_1178 | - | 1e-180 | 66.96% (451) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3195|M.bovis_AF2122/97 ------MTNPPWTVDVVVVGAGFAGLAAARELTRQG---HEVLVFEGRDR
Rv3170|M.tuberculosis_H37Rv ------MTNPPWTVDVVVVGAGFAGLAAARELTRQG---HEVLVFEGRDR
MAV_4062|M.avium_104 ------MSGPPRIVDVVVVGAGFAGLAAARELNRQG---HDVVVFEGRDR
Mflv_4501|M.gilvum_PYR-GCK ------------MAEVVVVGAGFAGLAAARELSRLG---RDVVVVEGRDR
MSMEG_2035|M.smegmatis_MC2_155 -------MSIPTSADVVVVGAGFAGLTAARRLVQLG---YDVVVLEGRDR
MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMG---VSVLVIDARER
MUL_1281|M.ulcerans_Agy99 ----------MAEVDVCVVGAGFAGLTAALRLKQAG---HSVALLEARDR
MMAR_3362|M.marinum_M ----------MAEVDVCVVGAGFAGLTAALRLKQAG---HSVALLEARDR
Mvan_1178|M.vanbaalenii_PYR-1 ----------MVDLDYCVVGAGFAGLTAALRLKQAG---HSVTLLEARDR
TH_2921|M.thermoresistible__bu ---------------VVVVGAGLAGLTAARTLRRAG---VDVVVLEARDR
MLBr_01044|M.leprae_Br4923 ----------MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDR
:**.*::**:** * : :.: :*
Mb3195|M.bovis_AF2122/97 VGGRSLTG-RVAG------VPADMGGSFIGPTQDAVLALATELGIPTTPT
Rv3170|M.tuberculosis_H37Rv VGGRSLTG-RVAG------VPADMGGSFIGPTQDAVLALATELGIPTTPT
MAV_4062|M.avium_104 VGGRSFTG-SVAG------LPADLGGTFVGPTQDAVLALAAELEVPTTPT
Mflv_4501|M.gilvum_PYR-GCK VGGRSYTG-SVGG------VPVDFGATFVGPTQDAVLALAAELGVESVPT
MSMEG_2035|M.smegmatis_MC2_155 VGGRSSTA-TIAG------VPVDLGGTFVGPTQDAVLGLAAELGCATVPT
MAB_2659|M.abscessus_ATCC_1997 VGGRSFTG-EVAG------VKVDLGATWVAKRHTAIRDLMDRLGCSLTPQ
MUL_1281|M.ulcerans_Agy99 VGGRTFTVVREDG------SWIDKGGAWIGPTQHRIYALMKEFGVAAFKQ
MMAR_3362|M.marinum_M VGGRTFTVVREDG------SWIDKGGAWIGPTQHRIYALMKEFGVAAFKQ
Mvan_1178|M.vanbaalenii_PYR-1 IGGRTFTVNRDDG------TWIDRGGAWIGPGQDRIDALMEEFGIPSYKQ
TH_2921|M.thermoresistible__bu VGGRTLNHFLEHGPDPENDAVVELGGQWIGPGHQRIRALIDELGLSTFDT
MLBr_01044|M.leprae_Br4923 LGG-VLRTECVGG------QPMDLGAEAFLLRRPEVPALLAELGLSERQR
:** * : *. . : : * .:
Mb3195|M.bovis_AF2122/97 HRDGRNVIQWRGSARSYRGTIPK-LSLTGLIDIGRLRWQFERIARGVPVA
Rv3170|M.tuberculosis_H37Rv HRDGRNVIQWRGSARSYRGTIPK-LSLTGLIDIGRLRWQFERIARGVPVA
MAV_4062|M.avium_104 HHEGKNLIHWRGWTHAYHGTIPK-LSLTGLLDIGRLRWQFDRIARSIPLA
Mflv_4501|M.gilvum_PYR-GCK YGEGKNLIRWRGRVRSYRSTIPR-LSILELLDVSRIQWRFDRISKRVPVD
MSMEG_2035|M.smegmatis_MC2_155 YNRGKNLIRWHGRVRSYRSTIPR-LSIIELLDVSRIQWRFERLFRHVDVA
MAB_2659|M.abscessus_ATCC_1997 YDEGVNLLWMAGKRKTWTGTLPT-VDPVDLEDLGRITIEMGKLLETINVD
MUL_1281|M.ulcerans_Agy99 YTDGEAMMVVDGKQYRYQGTIPRTLSPLASMNLGTAMFEISQMCKTIPLE
MMAR_3362|M.marinum_M YTDGEAMMVVDGKQYRYQGTIPRTLSPLASMNLGTAMFEISQMCKTIPLE
Mvan_1178|M.vanbaalenii_PYR-1 YVDGDAMMFIDGKTYRYHGTIPMSMSPFAVANLGVVFLELTRMCKSIPPE
TH_2921|M.thermoresistible__bu YDRGAKLWEHNGRVRRYTGEIPR-ANPLHLADLQIALTRLERMARRIDPA
MLBr_01044|M.leprae_Br4923 ATTDARPLIYS--QQRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAE
. . * :
Mb3195|M.bovis_AF2122/97 APWDARRARELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSM
Rv3170|M.tuberculosis_H37Rv APWDARRARELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSM
MAV_4062|M.avium_104 APWEARRAAELDGLSLGGWLRSVRATASSHALLAMVARVTWGCEPDEVSM
Mflv_4501|M.gilvum_PYR-GCK QPWASPLAGQLDDISLDAWLRSVHAGASTRDLMAIMARVTWGAEPGDVSM
MSMEG_2035|M.smegmatis_MC2_155 EPWNGSLAHKLDQYSMERWLRYVHANASTRNLMAIMSRVTWGAEPDQVSM
MAB_2659|M.abscessus_ATCC_1997 AAWKSPNADQLDSISFGEWLSQQQAVTSTNALMYIVTRVQWGCSPLDVSL
MUL_1281|M.ulcerans_Agy99 APWEAKRAAKWDRMTLAQWLRNNVKSKAAHDLLETAIAGCYTSDASEVSM
MMAR_3362|M.marinum_M APWEAKRAAKWDRMTLAQWLRNNVKSKAAHDLLETAIAGCYTSDASEVSM
Mvan_1178|M.vanbaalenii_PYR-1 APWTAPKAHKWDQVTWAKWLDGNTLSTPARQLLESAVSGLYTSAASELSL
TH_2921|M.thermoresistible__bu APWAAPRAAQWDRQTVAGWIDRHVRTAVGRAFIELVCEAVWAADAADLSL
MLBr_01044|M.leprae_Br4923 AVRPLSWEPGSD-PAMAELVADRFGEQAVARLVDPLLGGVYAGSAATIGL
* : : :: : . :.:
Mb3195|M.bovis_AF2122/97 LHAARYVRAA---GGLDRLLDVKNGAQQDRVPGGTQQIAQAAAAQLGARV
Rv3170|M.tuberculosis_H37Rv LHAARYVRAA---GGLDRLLDVKNGAQQDRVPGGTQQIAQAAAAQLGARV
MAV_4062|M.avium_104 LHAARYAHAA---GGLDRLLDVEDGAQQDRFPGGTQQIAAAAAAELGARV
Mflv_4501|M.gilvum_PYR-GCK LHAVRYVNAA---GGLNRMLDVEGGAQQDRFPAGTQKIADLMAAELGDRV
MSMEG_2035|M.smegmatis_MC2_155 LHAVRYVKAA---GGLTRLLDVEGGAQQDRLVEGTQQIALRMADELGQRI
MAB_2659|M.abscessus_ATCC_1997 LHVLRYVQAV---GGLDHMLAVEHGQQEYRVTETTQEIAKRLAAQIGDQI
MUL_1281|M.ulcerans_Agy99 LFVLYQMASG---GGPGFVLGSKGAAQDARPIGGMGAVYGPMAAELGDAI
MMAR_3362|M.marinum_M LFVLYQMASG---GGPGFVLGSKGAAQDARPIGGMGAVYGPMAAELGDAI
Mvan_1178|M.vanbaalenii_PYR-1 LFCLYQMAAA---GGPSFVLGVKDAAEDARPVGGMGAIHRAVAAELGDVV
TH_2921|M.thermoresistible__bu LHLLTYTSSN---QGLSQLITTRGGAQQSRIIGGAQQISTAMADELGDAV
MLBr_01044|M.leprae_Br4923 RAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELV
: . : . . : :. :
Mb3195|M.bovis_AF2122/97 LLN------AAVRRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRVAIE
Rv3170|M.tuberculosis_H37Rv LLN------AAVRRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRVAIE
MAV_4062|M.avium_104 VLG------APVRRIERHGAG-VTVRTDLGDTEAGFVIVAIPPAHRAAIE
Mflv_4501|M.gilvum_PYR-GCK VVG------APVRRITRNPDRTVTVTTAGAEYQAGAVIVAVPPEHRSGIE
MSMEG_2035|M.smegmatis_MC2_155 ALD------APVQRIERHSGGDIGVTFTTGHVRARAVVIAIAPQHRGDIE
MAB_2659|M.abscessus_ATCC_1997 VLN------TRVRQISQDDNG-VTVSTDSGVINAKYAIVTAAPEHRAYIE
MUL_1281|M.ulcerans_Agy99 HLS------QPVRSITQDSGG-VTVQAEGLTVRANRTIVAVPLAIASQIV
MMAR_3362|M.marinum_M HLS------QPVRSITQDSGG-VTVQAEGLTVRANRTIVAVPLAIASQIV
Mvan_1178|M.vanbaalenii_PYR-1 QLS------QPVRSIAQDAEG-VTVRSEDRVVRARRAIVTVPIAIASHIL
TH_2921|M.thermoresistible__bu RLG------APVREIR-TRDG-VQVVADTATVRAERVVVAMSPTLAGRLH
MLBr_01044|M.leprae_Br4923 RRSRLQWVAATVVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLL
. * : * * .::: . :
Mb3195|M.bovis_AF2122/97 FDPPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASG---YSGQALSDEA
Rv3170|M.tuberculosis_H37Rv FDPPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASG---YSGQALSDEA
MAV_4062|M.avium_104 FAPPLPAEYEQLARHWPQGRLSKAYAAYSTPFWRADG---FSGQALSDEG
Mflv_4501|M.gilvum_PYR-GCK FDPPLPAEHRELSRHWPQGRLSKAYAAYETPFWRADG---HSGESLSDEG
MSMEG_2035|M.smegmatis_MC2_155 FDPPLPPEYTELAARWPQGRLSKAYAAYDRPFWRANG---CSGEALSDEG
MAB_2659|M.abscessus_ATCC_1997 YQPALPAKIEGLTTSFPMGALSKAFVAYDKPFWRAEG---LSGEALTDTA
MUL_1281|M.ulcerans_Agy99 YEPMLPTDRSFLHQRMPSGAVVKISAVYDEPFWRADG---LCGQSAAPTS
MMAR_3362|M.marinum_M YEPMLPTDRSFLHQRMPSGAVVKISAVYDEPFWRADG---LCGQSAAPTS
Mvan_1178|M.vanbaalenii_PYR-1 YEPMLPVDRSFLHQRMPSGAVFKIAMVFDEPFWRADG---LSGQSFAPGS
TH_2921|M.thermoresistible__bu YDEPLPADRDQLTQRMPNGSVVKCMAIYDEPFWRADG---LSGQGVGFTG
MLBr_01044|M.leprae_Br4923 QQIAPRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLVASGERLRAKA
. . : . .* : .* .*: .
Mb3195|M.bovis_AF2122/97 PVFITFDVSPHADGPGILMGFVD---ARGFDSLPIEERRRDALRCFASLF
Rv3170|M.tuberculosis_H37Rv PVFITFDVSPHADGPGILMGFVD---ARGFDSLPIEERRRDALRCFASLF
MAV_4062|M.avium_104 PVFITFDVSPHPDGPGILMGFVD---ARAFDSLPADQRRRDALRCFATLF
Mflv_4501|M.gilvum_PYR-GCK PVFITFDCSPGDDGPGVLLGFTD---PRSFDPLPGEQRREIALAGFSALF
MSMEG_2035|M.smegmatis_MC2_155 PVFITFDVSPGDEGPGILLGFTD---ARTFDALPPEQRRQRALGGFATFF
MAB_2659|M.abscessus_ATCC_1997 PVFITFDVSPSDDGPGILMVFCT---ARVYDGFGPEVRRKLVLKQLVDLY
MUL_1281|M.ulcerans_Agy99 LATLTIDASPNSGTPGVLCVVIEGPVARQYERLDDDGRRQAVLAALVERF
MMAR_3362|M.marinum_M LATLTIDASPNSGTPGVLCVVIEGPVARQYERLDDDGRRQAVLAALVERF
Mvan_1178|M.vanbaalenii_PYR-1 AANLTIDSCTDTGSPGILTAITEGLEARELCKLSDADRRKAVLAAVAERF
TH_2921|M.thermoresistible__bu PVKVFFDNSPPSGRPGVLLGFLEGSQARELGRADTRTRREAVIGCFARMF
MLBr_01044|M.leprae_Br4923 VTLSSRKWGLQGDTQLVRLSFGKFG-DQVASTASDDELLAWAVSDLAAVF
. . : . : .: . :
Mb3195|M.bovis_AF2122/97 GDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHW
Rv3170|M.tuberculosis_H37Rv GDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHW
MAV_4062|M.avium_104 GDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGSWTRFGRWLREPVGPIHW
Mflv_4501|M.gilvum_PYR-GCK GAAAAHPIDYVDHCWGAEPFSPGGPTAAVPPGAWTAHGRWLRAPVDGIFW
MSMEG_2035|M.smegmatis_MC2_155 GDAARDPIDYLDHCWGTEAFAPGGPTAAVPPEAWTAYGPWLRKPIDGIHW
MAB_2659|M.abscessus_ATCC_1997 GEQANTPIDYIDHCWGTEPFAAGGPHPAAPPFASVNYGEALREPHGRIHW
MUL_1281|M.ulcerans_Agy99 GAKAAKPIDYFEQNWSRERYSGGGMLSHTPPGVLTQFGHALRRPCGRIHW
MMAR_3362|M.marinum_M GAKAAKPIDYFEQNWSRERYSGGGMLSHTPPGVLTQFGHALRRPCGRIHW
Mvan_1178|M.vanbaalenii_PYR-1 GDKALSPLDYIEHNWTVERYSGGGMIAHTPPGVLTEYGPALRRPCGRIHW
TH_2921|M.thermoresistible__bu GPRAARPVDYVEKVWAADQWTRGCYGAFLPPNTWTQVGPALRRAVGPIHW
MLBr_01044|M.leprae_Br4923 -DVTVDPVDVCVQRWIDAMPQYGPGHADLVAEVRAGLPPTLVVAGSHMDG
: *:* * * . . . * . . :
Mb3195|M.bovis_AF2122/97 ASTETADEWTGYFDGAVRSGQRAAAEVAALL--------
Rv3170|M.tuberculosis_H37Rv ASTETADEWTGYFDGAVRSGQRAAAEVAALL--------
MAV_4062|M.avium_104 AGTETADEWTGFLDGAIRSGRRAAAEVTALL--------
Mflv_4501|M.gilvum_PYR-GCK AGTETADSWTGFLDGAVRSGLRAADEAHRELARA-----
MSMEG_2035|M.smegmatis_MC2_155 AGTETADVWTGFLDGAVRSGQRAATEVAEALKSSAAAG-
MAB_2659|M.abscessus_ATCC_1997 AGTETAGEWVGTMNGAILMGLHTADQIAQQLGVTGEVSK
MUL_1281|M.ulcerans_Agy99 AGTEISAKMCGWIDGAIRSGERAASEVMANQTMTMASDS
MMAR_3362|M.marinum_M AGTETSAKMCGWIDGAIRSGERAASEVMANQTMTMASDS
Mvan_1178|M.vanbaalenii_PYR-1 AGTESSALMYGFIDGAVRSGERAAAEVVEHEAMATS---
TH_2921|M.thermoresistible__bu AGAETAVRSMGYMDGAVASGERAAAEVLTALGSGA----
MLBr_01044|M.leprae_Br4923 IG----------VPACISAAGRAIEALQAEVAR------
. . ..: . ::