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STDDAVSVRKVKSAVRTVELLEYLAARPDRPTRIREICAALDMPRSSAHALLRTLVAQGWVRSDEAGTQY SIGIRALLVGTSYLDADPYLPLITPFLDDLRGELDETFHLARLDGYDVVYLATRESRQYVRTTNKVGRRL PAYTTALGKALLAERFGADLDAHVPQTLTPMTPHTITDRAVLDDALGEARVRGYATENEENTLGTKCFAV ALRYRQPAQDAISASVPLSRLTPEHEREIVDALRMVCDKVSRVVRPVANGDKWFA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6118 | - | - | 100% (266) | IclR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2890 | - | 3e-22 | 31.58% (209) | putative transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5475 | - | 2e-20 | 31.82% (242) | acetate operon repressor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 5e-21 | 33.46% (257) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4551 | - | 2e-22 | 35.10% (208) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 6e-21 | 33.46% (257) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0077 | - | 5e-18 | 32.52% (206) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 9e-15 | 27.27% (253) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 2e-24 | 32.77% (235) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3251 | - | 1e-20 | 33.94% (221) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_1967 | - | 2e-08 | 28.71% (209) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1018 | - | 1e-114 | 76.52% (264) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1748|M.bovis_AF2122/97 --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGG-LSQ
Rv1719|M.tuberculosis_H37Rv --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGG-LSQ
MSMEG_6118|M.smegmatis_MC2_155 ---------------MSTDDAVSVRKVKSAVRTVELLEYLAARPDRPTRI
Mvan_1018|M.vanbaalenii_PYR-1 ----------------MTEPDISVRKVKSAVRTVELLEYLAARPDDPARL
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLADLGK--AGV
MAV_3513|M.avium_104 MPAKRARVAGPAAAAPAADALAPQYPIESVDNALKLLLLLGEQPE--IRL
Mflv_4551|M.gilvum_PYR-GCK ------MTTP------------VETPSAVIDRVSLVLDAFDGPGR--LTL
TH_3251|M.thermoresistible__bu MTATLDQPTPNTTVKRTGTERTGETPSAVLDRISLVLDAFDGPGR--LTL
MAB_0077|M.abscessus_ATCC_1997 MTITAD----------------SATPSAVIDRVSLLLDAFDGPGR--LTL
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAKSPCG---L
. :*
Mb1748|M.bovis_AF2122/97 AEIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR
Rv1719|M.tuberculosis_H37Rv AEIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR
MSMEG_6118|M.smegmatis_MC2_155 REICAALDMPRSSAHALLRTLVAQGWVRSDEAGTQYSIGIRALLVGTSYL
Mvan_1018|M.vanbaalenii_PYR-1 REISDALDMPRSSAHALLRTLVCQGWVRSDPTGTLYGIGIRALLVGTSYL
MMAR_4423|M.marinum_M TEVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGIGVSRLARARS
MAV_3513|M.avium_104 SEATRYLGVASSTAHRLLAMLAYRGFVRQDPVSKAYLPGPSLTGVAFAIF
Mflv_4551|M.gilvum_PYR-GCK AQIVRRTGLPRSSAHRMLERLVQLRWLRRT--GRDYELGMRLVELGSLAV
TH_3251|M.thermoresistible__bu AQVVRRTGLPRSSAHRMLERLVQLRWLRRD--GRDYELGMRLVELGSLAV
MAB_0077|M.abscessus_ATCC_1997 AQLVRRTGLPRSSVHRMLERLVQLRWLRRD--GRDYELGTRLVELGSLAV
MUL_1967|M.ulcerans_Agy99 AELCERTGLPRATAYRLAAALEVHRLLGRD-EDGRWGLGPAITELAAHVD
: .: ::. : * : : * :.
Mb1748|M.bovis_AF2122/97 --LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVS
Rv1719|M.tuberculosis_H37Rv --LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVS
MSMEG_6118|M.smegmatis_MC2_155 DADPYLPLITPFLDDLRGELDETFHLARLDGYDVVYLATRESRQYVRTTN
Mvan_1018|M.vanbaalenii_PYR-1 DSDPYLPLITPFLEDLRAEQDETFHLGRLDGTDIVYLATRESTQYTRTSS
MMAR_4423|M.marinum_M GHSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEAVSTAEIALQT
MAV_3513|M.avium_104 GRLDIARSAAPIMRALSEQLRETVHVGMLDGASVRFVAAVEGPAAVRVAS
Mflv_4551|M.gilvum_PYR-GCK HQDRVHRAATPLLHDLHRATGLVVHLAVLDGSDVVYLDKIGDGMASAIPT
TH_3251|M.thermoresistible__bu HQDRLHRAAIPRLHELHAATGLVVHLAVLDGSDVVYLEKVGSRLAAAIPT
MAB_0077|M.abscessus_ATCC_1997 HQDRLHAAALPMLHELHRATGLVVHLSILDGADVVYLEKIGAGIGAAVAT
MUL_1967|M.ulcerans_Agy99 --DPLLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTV
* .: : :
Mb1748|M.bovis_AF2122/97 AVGESFPLYCCANGKALLAALPPERQARALP-SRLAPLTANTITDRAALR
Rv1719|M.tuberculosis_H37Rv AVGESFPLYCCANGKALLAALPPERQARALP-SRLAPLTANTITDRAALR
MSMEG_6118|M.smegmatis_MC2_155 KVGRRLPAYTTALGKALLAERFGADLDAHVP-QTLTPMTPHTITDRAVLD
Mvan_1018|M.vanbaalenii_PYR-1 RVGRRLPAYATSLGKALLAERFGTERDEHVP-AALKSLTPHTITDRTELD
MMAR_4423|M.marinum_M WVGQSCPVHATSSGKVLLAGLDADEVRQRVG-ATLDSFTENTIVTIDALE
MAV_3513|M.avium_104 RLGRALPAHCTSTGKVMLAQLSAAELRALLPRERLKRITAHSIGSRAALE
Mflv_4551|M.gilvum_PYR-GCK RVGGRQPAHCTAVGKAMLAFNDDVDVDLQS------RMTKYSIGTAAQLA
TH_3251|M.thermoresistible__bu RVGGRRPANCAAVGKAILAYAEDDGVLSGTG--PLPRNTKYSISDPARLR
MAB_0077|M.abscessus_ATCC_1997 RIGGRQPAHCTASGKAILAYR--AQILDGCT--ALARKTRYSIGSAAQLR
MUL_1967|M.ulcerans_Agy99 PVGARLPMTAGSGAKVLLAHSDPATQQAVLP-------------TAKFTD
:* * : .*.:**
Mb1748|M.bovis_AF2122/97 DELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELVAVSVPVPAQRFY
Rv1719|M.tuberculosis_H37Rv DELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELVAVSVPVPAQRFY
MSMEG_6118|M.smegmatis_MC2_155 DALGEARVRGYATENEENTLGTKCFAVALRYRQP-AQDAISASVPLSRLT
Mvan_1018|M.vanbaalenii_PYR-1 HALDEVRIRGYACDDEENTTGLRCFAVPLRYCRP-AQDAISASVPVERLD
MMAR_4423|M.marinum_M AQLAATRAAGWASAREELEIGLNAVAAPVYDSTGRVAAALSVSGPAYRLP
MAV_3513|M.avium_104 TELAAIRERGYATNREESEEGVASVAVPIPTRAPGLRLALNAAAPQNRLD
Mflv_4551|M.gilvum_PYR-GCK AELAKVRAHGVAYEREESLPGFGCVAAAIG-RPGEAVAAVSVCGPMNRMA
TH_3251|M.thermoresistible__bu AELAKVRAHGVAFDREESLPGIGCVAAPIG-DPGEAVAAISVCGPMNQMA
MAB_0077|M.abscessus_ATCC_1997 PELDKVRGHGVAFDREELQQGIGCVAAPIG-SIGDAVAAVSVCGPMTRMT
MUL_1967|M.ulcerans_Agy99 RVLAEVRRRGWAQSVAEREPGVASVSAPVRDGRGVVVAAISVSGPIDRIG
* * * * * * .... : *:.. * ::
Mb1748|M.bovis_AF2122/97 G-REAELAGALLAW---------VSKVDAWFNGTEDRK------------
Rv1719|M.tuberculosis_H37Rv G-REAELAGALLAW---------VSKVDAWFNGTEDRK------------
MSMEG_6118|M.smegmatis_MC2_155 PEHEREIVDALRMV---------CDKVSRVVRPVANGDKWFA--------
Mvan_1018|M.vanbaalenii_PYR-1 PQRQREIIDALRAV---------GDKVSRVVRPLANGDKWFAS-------
MMAR_4423|M.marinum_M AADFEEVAQQTIAA---------ADAVSRGLGWTDRIS------------
MAV_3513|M.avium_104 AARYPAVAAALVAA---------AKEIGDQLG------------------
Mflv_4551|M.gilvum_PYR-GCK FER-LAAPVRVTAMGIWRNAEDGPARVTPTLQPLRPLRGGPAAR------
TH_3251|M.thermoresistible__bu FDHRLVAPVRMAALGIWRAMEGARQRVVPTLQQVRPLRPGPTAQSLSHSA
MAB_0077|M.abscessus_ATCC_1997 FDQRLAAPVRMTAMGIWRNVENGPSRVAPTLQPIRPLRCGPAASS-----
MUL_1967|M.ulcerans_Agy99 RRPGARWAADLLAA---------ADELARRL-------------------
: .
Mb1748|M.bovis_AF2122/97 ---------------------
Rv1719|M.tuberculosis_H37Rv ---------------------
MSMEG_6118|M.smegmatis_MC2_155 ---------------------
Mvan_1018|M.vanbaalenii_PYR-1 ---------------------
MMAR_4423|M.marinum_M ---------------------
MAV_3513|M.avium_104 ---------------------
Mflv_4551|M.gilvum_PYR-GCK ---------PVAVRNDALQYA
TH_3251|M.thermoresistible__bu LSHPAQSHPARSHRADTRRFA
MAB_0077|M.abscessus_ATCC_1997 --------TGREMNSPALQYA
MUL_1967|M.ulcerans_Agy99 ---------------------